BRPI0314120B8 - processo para diminuição de um nível de agregado de um antagonista de hormônio do crescimento (gh) peguilado e isoformas do mesmo - Google Patents

processo para diminuição de um nível de agregado de um antagonista de hormônio do crescimento (gh) peguilado e isoformas do mesmo

Info

Publication number
BRPI0314120B8
BRPI0314120B8 BRPI0314120A BR0314120A BRPI0314120B8 BR PI0314120 B8 BRPI0314120 B8 BR PI0314120B8 BR PI0314120 A BRPI0314120 A BR PI0314120A BR 0314120 A BR0314120 A BR 0314120A BR PI0314120 B8 BRPI0314120 B8 BR PI0314120B8
Authority
BR
Brazil
Prior art keywords
isoforms
antagonist
decreasing
growth hormone
aggregate level
Prior art date
Application number
BRPI0314120A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0314120A (pt
BRPI0314120B1 (pt
Inventor
S Rathore Anurag
E Steinmeyer David
M Boyle Denis
V Johnson Gary
j buckley John
Toal Michele
Aykent Serdar
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/646,798 external-priority patent/US20040048315A1/en
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0314120A publication Critical patent/BR0314120A/pt
Publication of BRPI0314120B1 publication Critical patent/BRPI0314120B1/pt
Publication of BRPI0314120B8 publication Critical patent/BRPI0314120B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
BRPI0314120A 2002-09-20 2003-09-22 processo para diminuição de um nível de agregado de um antagonista de hormônio do crescimento (gh) peguilado e isoformas do mesmo BRPI0314120B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41222702P 2002-09-20 2002-09-20
US60/412,227 2002-09-20
US10/646,798 US20040048315A1 (en) 2002-08-28 2003-08-25 Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US10/646,798 2003-08-25
US66288403A 2003-09-16 2003-09-16
US10/662,884 2003-09-16
PCT/US2003/029546 WO2004026251A2 (en) 2002-09-20 2003-09-22 Process for decreasing aggregate levels of pegylated protein

Publications (3)

Publication Number Publication Date
BR0314120A BR0314120A (pt) 2005-07-12
BRPI0314120B1 BRPI0314120B1 (pt) 2020-12-29
BRPI0314120B8 true BRPI0314120B8 (pt) 2021-05-25

Family

ID=32034217

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0314120A BRPI0314120B8 (pt) 2002-09-20 2003-09-22 processo para diminuição de um nível de agregado de um antagonista de hormônio do crescimento (gh) peguilado e isoformas do mesmo

Country Status (17)

Country Link
EP (1) EP1545428B1 (enExample)
JP (1) JP4633463B2 (enExample)
KR (1) KR101120130B1 (enExample)
AT (1) ATE453662T1 (enExample)
AU (1) AU2003272585B2 (enExample)
BR (1) BRPI0314120B8 (enExample)
CA (1) CA2498886C (enExample)
DE (1) DE60330787D1 (enExample)
DK (1) DK1545428T3 (enExample)
ES (1) ES2337041T3 (enExample)
HK (1) HK1079798B (enExample)
IL (1) IL167538A (enExample)
MX (1) MXPA05003121A (enExample)
PL (1) PL212726B1 (enExample)
PT (1) PT1545428E (enExample)
SI (1) SI1545428T1 (enExample)
WO (1) WO2004026251A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075021A2 (en) * 2004-02-09 2005-08-18 Pharmacia Corporation Chemically-modified human growth hormone receptor antagonist conjugates
MX2007007591A (es) * 2004-12-22 2007-07-25 Ambrx Inc Metodos para expresion y purificacion de hormona de crecimiento humano recombinante.
WO2011018515A1 (en) * 2009-08-14 2011-02-17 Novo Nordisk Health Care Ag Method of purifying pegylated proteins
WO2012158551A1 (en) * 2011-05-13 2012-11-22 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
CN103703015B (zh) * 2011-08-25 2019-07-05 霍夫曼-拉罗奇有限公司 阳离子和阴离子交换层析法
HRP20220041T1 (hr) * 2017-12-29 2022-04-15 F. Hoffmann - La Roche Ag Postupak za dobivanje pegiliranog proteinskog pripravka
CN112107880B (zh) * 2020-09-16 2022-08-09 珠海中科先进技术研究院有限公司 一种低共熔混合物及利用其萃取鲟鱼鱼籽蛋白质的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5153265A (en) * 1988-01-20 1992-10-06 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5969109A (en) * 1990-02-28 1999-10-19 Bona; Constantin Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
AU6255096A (en) * 1995-06-07 1996-12-30 Mount Sinai School Of Medicine Of The City University Of New York, The Pegylated modified proteins
DK0851925T3 (da) * 1995-09-21 2005-11-28 Genentech Inc Humane Væksthormonvarianter
SE9802454D0 (sv) * 1998-07-08 1998-07-08 Pharmacia & Upjohn Ab Production of peptides
SE9904502D0 (sv) * 1999-12-09 1999-12-09 Pharmacia & Upjohn Ab Production of peptides

Also Published As

Publication number Publication date
BR0314120A (pt) 2005-07-12
IL167538A (en) 2015-10-29
WO2004026251A3 (en) 2004-09-02
WO2004026251A2 (en) 2004-04-01
PL375443A1 (en) 2005-11-28
HK1079798A1 (zh) 2006-04-13
PT1545428E (pt) 2010-02-25
CA2498886A1 (en) 2004-04-01
PL212726B1 (pl) 2012-11-30
KR101120130B1 (ko) 2012-04-18
DE60330787D1 (de) 2010-02-11
JP4633463B2 (ja) 2011-02-16
CA2498886C (en) 2013-06-25
EP1545428A4 (en) 2006-03-01
SI1545428T1 (sl) 2010-03-31
KR20050046011A (ko) 2005-05-17
ES2337041T3 (es) 2010-04-20
EP1545428A2 (en) 2005-06-29
MXPA05003121A (es) 2005-06-22
HK1079798B (zh) 2010-11-19
AU2003272585B2 (en) 2009-12-10
AU2003272585A1 (en) 2004-04-08
EP1545428B1 (en) 2009-12-30
DK1545428T3 (da) 2010-05-03
ATE453662T1 (de) 2010-01-15
JP2006516021A (ja) 2006-06-15
BRPI0314120B1 (pt) 2020-12-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/09/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2793 DE 16-07-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.