HK1079798B - 降低peg化蛋白的聚集體水平的方法 - Google Patents

降低peg化蛋白的聚集體水平的方法

Info

Publication number
HK1079798B
HK1079798B HK05112085.6A HK05112085A HK1079798B HK 1079798 B HK1079798 B HK 1079798B HK 05112085 A HK05112085 A HK 05112085A HK 1079798 B HK1079798 B HK 1079798B
Authority
HK
Hong Kong
Prior art keywords
pegylated protein
aggregate levels
decreasing aggregate
decreasing
desired pegylated
Prior art date
Application number
HK05112085.6A
Other languages
English (en)
Other versions
HK1079798A1 (en
Inventor
丹尼斯．M．布瓦萊
約翰．J．巴克利
加里．V．約翰遜
大衛．E．斯坦邁耶
米凱萊．托阿
塞爾達爾．艾肯特
亞努拉戈．S．拉特爾
Original Assignee
法瑪西亞公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/646,798 external-priority patent/US20040048315A1/en
Application filed by 法瑪西亞公司 filed Critical 法瑪西亞公司
Publication of HK1079798A1 publication Critical patent/HK1079798A1/xx
Publication of HK1079798B publication Critical patent/HK1079798B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
HK05112085.6A 2002-09-20 2005-12-29 降低peg化蛋白的聚集體水平的方法 HK1079798B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41222702P 2002-09-20 2002-09-20
US10/646,798 US20040048315A1 (en) 2002-08-28 2003-08-25 Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US66288403A 2003-09-16 2003-09-16
PCT/US2003/029546 WO2004026251A2 (en) 2002-09-20 2003-09-22 Process for decreasing aggregate levels of pegylated protein

Publications (2)

Publication Number Publication Date
HK1079798A1 HK1079798A1 (en) 2006-04-13
HK1079798B true HK1079798B (zh) 2010-11-19

Family

ID=32034217

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05112085.6A HK1079798B (zh) 2002-09-20 2005-12-29 降低peg化蛋白的聚集體水平的方法

Country Status (17)

Country Link
EP (1) EP1545428B1 (zh)
JP (1) JP4633463B2 (zh)
KR (1) KR101120130B1 (zh)
AT (1) ATE453662T1 (zh)
AU (1) AU2003272585B2 (zh)
BR (1) BRPI0314120B8 (zh)
CA (1) CA2498886C (zh)
DE (1) DE60330787D1 (zh)
DK (1) DK1545428T3 (zh)
ES (1) ES2337041T3 (zh)
HK (1) HK1079798B (zh)
IL (1) IL167538A (zh)
MX (1) MXPA05003121A (zh)
PL (1) PL212726B1 (zh)
PT (1) PT1545428E (zh)
SI (1) SI1545428T1 (zh)
WO (1) WO2004026251A2 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007522198A (ja) * 2004-02-09 2007-08-09 ファルマシア コーポレーション 化学修飾されたヒト成長ホルモン受容体アンタゴニスト結合体
GB2438760A (en) * 2004-12-22 2007-12-05 Ambrx Inc Methods for expression and purification of recombinant human growth hormone
WO2011018515A1 (en) * 2009-08-14 2011-02-17 Novo Nordisk Health Care Ag Method of purifying pegylated proteins
EP3388443A1 (en) * 2011-05-13 2018-10-17 Biogen MA Inc. Methods of preventing and removing trisulfide bonds
CA2838814A1 (en) * 2011-08-25 2013-02-28 F.Hoffmann-La Roche Ag Cation and anion exchange chromatography method
SG11202006140TA (en) * 2017-12-29 2020-07-29 Hoffmann La Roche Process for providing pegylated protein composition
CN112107880B (zh) * 2020-09-16 2022-08-09 珠海中科先进技术研究院有限公司 一种低共熔混合物及利用其萃取鲟鱼鱼籽蛋白质的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3641115A1 (de) * 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5153265A (en) * 1988-01-20 1992-10-06 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5969109A (en) * 1990-02-28 1999-10-19 Bona; Constantin Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
AU6255096A (en) * 1995-06-07 1996-12-30 Mount Sinai School Of Medicine Of The City University Of New York, The Pegylated modified proteins
CA2658039A1 (en) * 1995-09-21 1997-03-27 Genentech, Inc. Human growth hormone variants
SE9802454D0 (sv) * 1998-07-08 1998-07-08 Pharmacia & Upjohn Ab Production of peptides
SE9904502D0 (sv) * 1999-12-09 1999-12-09 Pharmacia & Upjohn Ab Production of peptides

Also Published As

Publication number Publication date
EP1545428B1 (en) 2009-12-30
JP4633463B2 (ja) 2011-02-16
JP2006516021A (ja) 2006-06-15
PL375443A1 (en) 2005-11-28
ATE453662T1 (de) 2010-01-15
EP1545428A2 (en) 2005-06-29
CA2498886A1 (en) 2004-04-01
SI1545428T1 (sl) 2010-03-31
ES2337041T3 (es) 2010-04-20
WO2004026251A2 (en) 2004-04-01
AU2003272585A1 (en) 2004-04-08
CA2498886C (en) 2013-06-25
PL212726B1 (pl) 2012-11-30
BR0314120A (pt) 2005-07-12
BRPI0314120B1 (pt) 2020-12-29
KR101120130B1 (ko) 2012-04-18
HK1079798A1 (en) 2006-04-13
BRPI0314120B8 (pt) 2021-05-25
DK1545428T3 (da) 2010-05-03
AU2003272585B2 (en) 2009-12-10
DE60330787D1 (de) 2010-02-11
EP1545428A4 (en) 2006-03-01
MXPA05003121A (es) 2005-06-22
IL167538A (en) 2015-10-29
KR20050046011A (ko) 2005-05-17
WO2004026251A3 (en) 2004-09-02
PT1545428E (pt) 2010-02-25

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Effective date: 20230921