ATE453662T1 - Verfahren zur verringerung der aggregatmengen des pegylierten proteins - Google Patents
Verfahren zur verringerung der aggregatmengen des pegylierten proteinsInfo
- Publication number
- ATE453662T1 ATE453662T1 AT03754774T AT03754774T ATE453662T1 AT E453662 T1 ATE453662 T1 AT E453662T1 AT 03754774 T AT03754774 T AT 03754774T AT 03754774 T AT03754774 T AT 03754774T AT E453662 T1 ATE453662 T1 AT E453662T1
- Authority
- AT
- Austria
- Prior art keywords
- amounts
- reducing
- pegylated protein
- desired pegylated
- protein
- Prior art date
Links
- 108091006006 PEGylated Proteins Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000011176 pooling Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/32—Extraction; Separation; Purification by precipitation as complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41222702P | 2002-09-20 | 2002-09-20 | |
| US10/646,798 US20040048315A1 (en) | 2002-08-28 | 2003-08-25 | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| US66288403A | 2003-09-16 | 2003-09-16 | |
| PCT/US2003/029546 WO2004026251A2 (en) | 2002-09-20 | 2003-09-22 | Process for decreasing aggregate levels of pegylated protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453662T1 true ATE453662T1 (de) | 2010-01-15 |
Family
ID=32034217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03754774T ATE453662T1 (de) | 2002-09-20 | 2003-09-22 | Verfahren zur verringerung der aggregatmengen des pegylierten proteins |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1545428B1 (enExample) |
| JP (1) | JP4633463B2 (enExample) |
| KR (1) | KR101120130B1 (enExample) |
| AT (1) | ATE453662T1 (enExample) |
| AU (1) | AU2003272585B2 (enExample) |
| BR (1) | BRPI0314120B8 (enExample) |
| CA (1) | CA2498886C (enExample) |
| DE (1) | DE60330787D1 (enExample) |
| DK (1) | DK1545428T3 (enExample) |
| ES (1) | ES2337041T3 (enExample) |
| HK (1) | HK1079798B (enExample) |
| IL (1) | IL167538A (enExample) |
| MX (1) | MXPA05003121A (enExample) |
| PL (1) | PL212726B1 (enExample) |
| PT (1) | PT1545428E (enExample) |
| SI (1) | SI1545428T1 (enExample) |
| WO (1) | WO2004026251A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06007848A (es) * | 2004-02-09 | 2006-09-04 | Pharmacia Corp | Conjugados de antagonistas del receptor de hormona del crecimiento humana modificados quimicamente. |
| WO2006073846A2 (en) * | 2004-12-22 | 2006-07-13 | Ambrx, Inc. | Methods for expression and purification of recombinant human growth hormone |
| WO2011018515A1 (en) * | 2009-08-14 | 2011-02-17 | Novo Nordisk Health Care Ag | Method of purifying pegylated proteins |
| EP2707383B1 (en) * | 2011-05-13 | 2018-04-18 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| WO2013026803A1 (en) * | 2011-08-25 | 2013-02-28 | F. Hoffmann-La Roche Ag | Cation and anion exchange chromatography method |
| WO2019129877A1 (en) * | 2017-12-29 | 2019-07-04 | F. Hoffmann-La Roche Ag | Process for providing pegylated protein composition |
| CN112107880B (zh) * | 2020-09-16 | 2022-08-09 | 珠海中科先进技术研究院有限公司 | 一种低共熔混合物及利用其萃取鲟鱼鱼籽蛋白质的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3641115A1 (de) * | 1986-12-02 | 1988-06-16 | Lentia Gmbh | Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins |
| US5153265A (en) * | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| US5969109A (en) * | 1990-02-28 | 1999-10-19 | Bona; Constantin | Chimeric antibodies comprising antigen binding sites and B and T cell epitopes |
| DK44593D0 (da) * | 1993-04-20 | 1993-04-20 | Novo Nordisk As | Fremgangsmaade til fremstilling af et polypeptid |
| ZA955789B (en) * | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
| WO1996040731A1 (en) * | 1995-06-07 | 1996-12-19 | Mount Sinai School Of Medicine Of The City University Of New York | Pegylated modified proteins |
| DE69635026T2 (de) * | 1995-09-21 | 2006-05-24 | Genentech Inc., San Francisco | Varianten des menschlichen wachstumshormons |
| SE9802454D0 (sv) * | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
| SE9904502D0 (sv) * | 1999-12-09 | 1999-12-09 | Pharmacia & Upjohn Ab | Production of peptides |
-
2003
- 2003-09-22 WO PCT/US2003/029546 patent/WO2004026251A2/en not_active Ceased
- 2003-09-22 PL PL375443A patent/PL212726B1/pl unknown
- 2003-09-22 AU AU2003272585A patent/AU2003272585B2/en not_active Expired
- 2003-09-22 HK HK05112085.6A patent/HK1079798B/zh not_active IP Right Cessation
- 2003-09-22 EP EP03754774A patent/EP1545428B1/en not_active Expired - Lifetime
- 2003-09-22 MX MXPA05003121A patent/MXPA05003121A/es active IP Right Grant
- 2003-09-22 AT AT03754774T patent/ATE453662T1/de active
- 2003-09-22 BR BRPI0314120A patent/BRPI0314120B8/pt not_active IP Right Cessation
- 2003-09-22 SI SI200331730T patent/SI1545428T1/sl unknown
- 2003-09-22 KR KR1020057004785A patent/KR101120130B1/ko not_active Expired - Fee Related
- 2003-09-22 DK DK03754774.2T patent/DK1545428T3/da active
- 2003-09-22 CA CA2498886A patent/CA2498886C/en not_active Expired - Fee Related
- 2003-09-22 DE DE60330787T patent/DE60330787D1/de not_active Expired - Lifetime
- 2003-09-22 PT PT03754774T patent/PT1545428E/pt unknown
- 2003-09-22 JP JP2004538262A patent/JP4633463B2/ja not_active Expired - Lifetime
- 2003-09-22 ES ES03754774T patent/ES2337041T3/es not_active Expired - Lifetime
-
2005
- 2005-03-20 IL IL167538A patent/IL167538A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR101120130B1 (ko) | 2012-04-18 |
| HK1079798A1 (zh) | 2006-04-13 |
| EP1545428A4 (en) | 2006-03-01 |
| JP4633463B2 (ja) | 2011-02-16 |
| PL375443A1 (en) | 2005-11-28 |
| SI1545428T1 (sl) | 2010-03-31 |
| HK1079798B (zh) | 2010-11-19 |
| DE60330787D1 (de) | 2010-02-11 |
| JP2006516021A (ja) | 2006-06-15 |
| WO2004026251A2 (en) | 2004-04-01 |
| EP1545428B1 (en) | 2009-12-30 |
| ES2337041T3 (es) | 2010-04-20 |
| BRPI0314120B8 (pt) | 2021-05-25 |
| EP1545428A2 (en) | 2005-06-29 |
| BRPI0314120B1 (pt) | 2020-12-29 |
| IL167538A (en) | 2015-10-29 |
| PL212726B1 (pl) | 2012-11-30 |
| MXPA05003121A (es) | 2005-06-22 |
| KR20050046011A (ko) | 2005-05-17 |
| CA2498886C (en) | 2013-06-25 |
| DK1545428T3 (da) | 2010-05-03 |
| BR0314120A (pt) | 2005-07-12 |
| WO2004026251A3 (en) | 2004-09-02 |
| CA2498886A1 (en) | 2004-04-01 |
| PT1545428E (pt) | 2010-02-25 |
| AU2003272585A1 (en) | 2004-04-08 |
| AU2003272585B2 (en) | 2009-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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