BR9911898A - Molécula de ácido nucleico codificando pelo menos parte de uma policetìdeo sintase, ventor, célula hospedeira, processos para a produção de um ácido nucleico codificando uma nova policetìdeo sintase, para a produção de um produto de fermentação contendo um policetìdeo e para a produção de um policetìdeo, e, produto de fermentação - Google Patents

Molécula de ácido nucleico codificando pelo menos parte de uma policetìdeo sintase, ventor, célula hospedeira, processos para a produção de um ácido nucleico codificando uma nova policetìdeo sintase, para a produção de um produto de fermentação contendo um policetìdeo e para a produção de um policetìdeo, e, produto de fermentação

Info

Publication number
BR9911898A
BR9911898A BR9911898-0A BR9911898A BR9911898A BR 9911898 A BR9911898 A BR 9911898A BR 9911898 A BR9911898 A BR 9911898A BR 9911898 A BR9911898 A BR 9911898A
Authority
BR
Brazil
Prior art keywords
production
nucleic acid
polyketide
encoding
fermentation product
Prior art date
Application number
BR9911898-0A
Other languages
English (en)
Other versions
BR9911898B1 (pt
Inventor
Johannes Laurenz Kellenberger
Peter Francis Leadlay
James Staunton
Kim Jonelle Stutzman-Engwall
Hamish Alastair Irvin Mcarthur
Original Assignee
Biotica Technology Ltd E Pfize
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Technology Ltd E Pfize filed Critical Biotica Technology Ltd E Pfize
Publication of BR9911898A publication Critical patent/BR9911898A/pt
Publication of BR9911898B1 publication Critical patent/BR9911898B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

"MOLéCULA DE áCIDO NUCLEICO CODIFICANDO PELO MENOS PARTE DE UMA POLICETìDEO SINTASE, VETOR, CéLULA HOSPEDEIRA, PROCESSOS PARA A PRODUçãO DE UM áCIDO NUCLEICO CODIFICANDO UMA NOVA POLICETìDEO SINTASE, PARA A PRODUçãO DE UM PRODUTO DE FERMENTAçãO CONTENDO UM POLICETìDEO E PARA A PRODUçãO DE UM POLICETìDEO, E, PRODUTO DE FERMENTAçãO". Moléculas de ácido nucleico codificando pelo menos parte de um policetídeo sintase Tipo I, e tendo um poli-ligante com sítios múltiplos de enzima de restrição no lugar de uma ou mais enzimas codificando genes PKS associadas com a redução, opcionalmente ainda incluindo ácido nucleico incorporando no poli-ligante, o outro ácido nucleico codificando uma ou mais enzimas redutivas; plasmídeos incorporando tais ácidos nucleicos; células hospedeiras transfectadas com tais plasmídeos; processos relacionados a isso.
BRPI9911898-0A 1998-07-06 1999-07-06 processos para a produção de uma segunda molécula de ácido nucléico útil para a preparação de policetìdeo sintases, para a produção de um produto de fermentação contendo um policetìdeo, e para a produção de um policetìdeo. BR9911898B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9814622.8 1998-07-06
GBGB9814622.8A GB9814622D0 (en) 1998-07-06 1998-07-06 Polyketides,their preparation,and materials for use therein
PCT/GB1999/002158 WO2000001827A2 (en) 1998-07-06 1999-07-06 Polyketides, their preparation, and materials for use therein

Publications (2)

Publication Number Publication Date
BR9911898A true BR9911898A (pt) 2001-03-27
BR9911898B1 BR9911898B1 (pt) 2010-11-30

Family

ID=10835024

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9911898-0A BR9911898B1 (pt) 1998-07-06 1999-07-06 processos para a produção de uma segunda molécula de ácido nucléico útil para a preparação de policetìdeo sintases, para a produção de um produto de fermentação contendo um policetìdeo, e para a produção de um policetìdeo.

Country Status (23)

Country Link
US (1) US7001747B1 (pt)
EP (1) EP1095147B1 (pt)
JP (1) JP2002519066A (pt)
KR (1) KR20010074652A (pt)
CN (1) CN1316002A (pt)
AT (1) ATE321138T1 (pt)
AU (1) AU762185B2 (pt)
BR (1) BR9911898B1 (pt)
CA (1) CA2332491A1 (pt)
CZ (1) CZ200123A3 (pt)
DE (1) DE69930515T2 (pt)
GB (1) GB9814622D0 (pt)
HK (1) HK1034535A1 (pt)
HU (1) HUP0105464A2 (pt)
ID (1) ID27760A (pt)
IL (1) IL140439A0 (pt)
MX (1) MXPA00012894A (pt)
NZ (1) NZ509602A (pt)
PL (1) PL345851A1 (pt)
TR (1) TR200100027T2 (pt)
WO (1) WO2000001827A2 (pt)
YU (1) YU1001A (pt)
ZA (1) ZA200100775B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000245457A (ja) 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
CA2402398A1 (en) * 2000-02-24 2001-08-30 Kyowa Hakko Kogyo Co., Ltd. Process for producing avermectin derivative
KR20020012395A (ko) * 2000-08-07 2002-02-16 김종하 사이버 카드 매매제어방법
AT4929U1 (de) * 2001-03-29 2002-01-25 Plansee Tizit Ag Verfahren zur herstellung von hartmetallgranulat
US20030225006A1 (en) * 2002-02-19 2003-12-04 Burns Lesley S Novel spinosyn-producing polyketide synthases
JP2005532809A (ja) 2002-07-16 2005-11-04 バイオチカ テクノロジー リミテッド ポリケチド、及び他の天然物の製造
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
JP5789190B2 (ja) 2008-09-24 2015-10-07 シャンハイ インスティテュート オブ オーガニック ケミストリー，チャイニーズ アカデミー オブ サイエンシズ 新規の遺伝子クラスター
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
BR112012019866A8 (pt) 2010-02-09 2017-12-26 Biotica Tech Limited Composto, uso do mesmo, composição farmacêutica, e, processo para preparar um composto
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
CN106916836B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN106619540A (zh) * 2016-10-10 2017-05-10 东莞市麦亘生物科技有限公司 一种抗肝癌纳米核酸类冻干粉及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
DE69023036T2 (de) * 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
NZ240150A (en) * 1990-10-15 1993-07-27 Merck & Co Inc Fermentation medium and its use in the production of ivermectin derivatives
JP2000511063A (ja) * 1996-07-05 2000-08-29 バイオティカ テクノロジー リミティド ポリケチド類及びそれらの合成
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis

Also Published As

Publication number Publication date
ATE321138T1 (de) 2006-04-15
DE69930515T2 (de) 2006-12-14
WO2000001827A2 (en) 2000-01-13
MXPA00012894A (es) 2002-07-02
CN1316002A (zh) 2001-10-03
CZ200123A3 (cs) 2001-12-12
YU1001A (sh) 2003-04-30
NZ509602A (en) 2003-12-19
IL140439A0 (en) 2002-02-10
GB9814622D0 (en) 1998-09-02
CA2332491A1 (en) 2000-01-13
ZA200100775B (en) 2001-11-05
KR20010074652A (ko) 2001-08-04
ID27760A (id) 2001-04-26
HK1034535A1 (en) 2001-10-26
DE69930515D1 (de) 2006-05-11
TR200100027T2 (tr) 2001-07-23
WO2000001827A3 (en) 2000-04-27
BR9911898B1 (pt) 2010-11-30
US7001747B1 (en) 2006-02-21
JP2002519066A (ja) 2002-07-02
HUP0105464A2 (hu) 2002-04-29
AU4636599A (en) 2000-01-24
EP1095147A2 (en) 2001-05-02
AU762185B2 (en) 2003-06-19
PL345851A1 (en) 2002-01-14
EP1095147B1 (en) 2006-03-22

Similar Documents

Publication Publication Date Title
BR9911898A (pt) Molécula de ácido nucleico codificando pelo menos parte de uma policetìdeo sintase, ventor, célula hospedeira, processos para a produção de um ácido nucleico codificando uma nova policetìdeo sintase, para a produção de um produto de fermentação contendo um policetìdeo e para a produção de um policetìdeo, e, produto de fermentação
Mootz et al. Construction of hybrid peptide synthetases by module and domain fusions
CA2343880A1 (en) Polyketide synthase enzymes and recombinant dna constructs therefor
Cox Why does RecA protein hydrolyse ATP?
BR0009550A (pt) Bactéria methylophilus, métodos para produzir um l-aminoácido e para produzir células bacterianas de uma bactéria methylophilus com um teor aumentado de um l-aminoácido, e, dna
BR0003943A (pt) Sequências de nucleotìdeo que codificam para o gene thre e processo para a produção enzimática de l-treonina usando bactérias corineforma
BR9906426A (pt) Penicillium funiculosum, mistura de enzimas, beta-glucanase, esterases de feruloila, composição lìquida e em pó, usos do produto e do processo, polipeptìdeo, sequência de ácido nucleico, vetores, uso dos vetores, célula hospedeira, e, uso da célula hospedeira
AU1926899A (en) Exploiting genomics in the search for new drugs
AU2003234196A1 (en) Functionalized nanoparticles and methods of use
BRPI0814781A8 (pt) ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase''
BRPI9913360B8 (pt) proteína de uricase recombinante quimérica, molécula de ácido nucléico isolada e purificada, vetor e célula hospedeira transformada.
AU2434195A (en) Thymidine kinase mutants
BR9803982A (pt) Polietilenoiminas de baixo peso molecular, toleráveis biologicamente.
BR0213774A (pt) Molécula de ácido nucleio isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina
BR0213779A (pt) Molécula de ácido nucleico isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina
Schray et al. Binding of human glutaminyl-tRNA synthetase to a specific site of its mRNA
ATE412056T1 (de) Nucleinsäuremoleküle codierend enzyme, die fructosyltransferaseaktivität besitzen und deren verwendung
CN1415015B (zh) L-六氢吡啶羧酸的生物学制备方法
Liu et al. A single base substitution in the variable pocket of yeast tRNAArg eliminates species-specific aminoacylation
Li et al. Archaeal‐Bacterial Chimeric RNase P RNAs: Towards Understanding RNA's Architecture, Function and Evolution
AU2002355157A1 (en) Genes and proteins for the biosynthesis of rosaramicin
EP0916731A4 (en) NEW GENE, GROUP OF GENES AND NEW BETA-GLUCOSIDASE
AU5018496A (en) New dna molecules
WO1999064562A3 (en) Expression control elements from genes encoding starch branching enzymes
DE69015843T2 (de) Cytochrom-C-Gen aus einer Wasserstoffbakterie.

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/11/2010, OBSERVADAS AS CONDICOES LEGAIS.

B24C Patent annual fee: request for for restoration

Free format text: REFERENTE A 13A ANUIDADE.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 13A, 14A, 15A E 16A ANUIDADES. PAGAR RESTAURACAO.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.