ATE321138T1 - Polyketide, ihre herstellung, und darin benutzte materialien - Google Patents

Polyketide, ihre herstellung, und darin benutzte materialien

Info

Publication number
ATE321138T1
ATE321138T1 AT99929580T AT99929580T ATE321138T1 AT E321138 T1 ATE321138 T1 AT E321138T1 AT 99929580 T AT99929580 T AT 99929580T AT 99929580 T AT99929580 T AT 99929580T AT E321138 T1 ATE321138 T1 AT E321138T1
Authority
AT
Austria
Prior art keywords
nucleic acid
polylinker
polyketides
preparation
plasmids
Prior art date
Application number
AT99929580T
Other languages
English (en)
Inventor
Johannes Laurenz Kellenberger
Peter Francis Leadlay
James Staunton
Kim Jonelle Stutzman-Engwall
Hamish Alastair Irvin Mcarthur
Original Assignee
Biotica Tech Ltd
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd, Pfizer filed Critical Biotica Tech Ltd
Application granted granted Critical
Publication of ATE321138T1 publication Critical patent/ATE321138T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/001Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623Avermectin; Milbemycin; Ivermectin; C-076
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
AT99929580T 1998-07-06 1999-07-06 Polyketide, ihre herstellung, und darin benutzte materialien ATE321138T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9814622.8A GB9814622D0 (en) 1998-07-06 1998-07-06 Polyketides,their preparation,and materials for use therein

Publications (1)

Publication Number Publication Date
ATE321138T1 true ATE321138T1 (de) 2006-04-15

Family

ID=10835024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99929580T ATE321138T1 (de) 1998-07-06 1999-07-06 Polyketide, ihre herstellung, und darin benutzte materialien

Country Status (23)

Country Link
US (1) US7001747B1 (de)
EP (1) EP1095147B1 (de)
JP (1) JP2002519066A (de)
KR (1) KR20010074652A (de)
CN (1) CN1316002A (de)
AT (1) ATE321138T1 (de)
AU (1) AU762185B2 (de)
BR (1) BR9911898B1 (de)
CA (1) CA2332491A1 (de)
CZ (1) CZ200123A3 (de)
DE (1) DE69930515T2 (de)
GB (1) GB9814622D0 (de)
HK (1) HK1034535A1 (de)
HU (1) HUP0105464A2 (de)
ID (1) ID27760A (de)
IL (1) IL140439A0 (de)
MX (1) MXPA00012894A (de)
NZ (1) NZ509602A (de)
PL (1) PL345851A1 (de)
TR (1) TR200100027T2 (de)
WO (1) WO2000001827A2 (de)
YU (1) YU1001A (de)
ZA (1) ZA200100775B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000245457A (ja) * 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
US20040101936A1 (en) * 2000-02-24 2004-05-27 Hirofumi Endo Process for producing avermectin derivative
KR20020012395A (ko) * 2000-08-07 2002-02-16 김종하 사이버 카드 매매제어방법
AT4929U1 (de) * 2001-03-29 2002-01-25 Plansee Tizit Ag Verfahren zur herstellung von hartmetallgranulat
IL163529A0 (en) * 2002-02-19 2005-12-18 Dow Agrosciences Llc Novel spinosyn-producing polyketidesynthases
ES2296063T3 (es) 2002-07-16 2008-04-16 Biotica Technology Limited Produccion de poliquetidos y otros productos naturales.
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
GB0327720D0 (en) 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US8962329B2 (en) 2008-09-24 2015-02-24 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Gene cluster
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
AU2011214135B2 (en) 2010-02-09 2014-07-31 Neurovive Pharmaceutical Ab Sanglifehrin based compounds
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
CN106916836B (zh) * 2015-12-24 2022-08-12 武汉合生科技有限公司 化合物的生物合成基因簇及其应用
CN106619540A (zh) * 2016-10-10 2017-05-10 东莞市麦亘生物科技有限公司 一种抗肝癌纳米核酸类冻干粉及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
DE69023036T2 (de) * 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
NZ240150A (en) * 1990-10-15 1993-07-27 Merck & Co Inc Fermentation medium and its use in the production of ivermectin derivatives
JP2000511063A (ja) * 1996-07-05 2000-08-29 バイオティカ テクノロジー リミティド ポリケチド類及びそれらの合成
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis

Also Published As

Publication number Publication date
TR200100027T2 (tr) 2001-07-23
MXPA00012894A (es) 2002-07-02
KR20010074652A (ko) 2001-08-04
CZ200123A3 (cs) 2001-12-12
BR9911898B1 (pt) 2010-11-30
DE69930515D1 (de) 2006-05-11
EP1095147A2 (de) 2001-05-02
WO2000001827A3 (en) 2000-04-27
JP2002519066A (ja) 2002-07-02
AU4636599A (en) 2000-01-24
PL345851A1 (en) 2002-01-14
CN1316002A (zh) 2001-10-03
HK1034535A1 (en) 2001-10-26
BR9911898A (pt) 2001-03-27
DE69930515T2 (de) 2006-12-14
AU762185B2 (en) 2003-06-19
YU1001A (sh) 2003-04-30
NZ509602A (en) 2003-12-19
HUP0105464A2 (hu) 2002-04-29
WO2000001827A2 (en) 2000-01-13
ZA200100775B (en) 2001-11-05
ID27760A (id) 2001-04-26
IL140439A0 (en) 2002-02-10
EP1095147B1 (de) 2006-03-22
US7001747B1 (en) 2006-02-21
GB9814622D0 (en) 1998-09-02
CA2332491A1 (en) 2000-01-13

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