BR9815828A - Derivados de sais de protoberberina farmaceuticamente disponìveis, e derivados de protoberberina e sais dos mesmos - Google Patents

Derivados de sais de protoberberina farmaceuticamente disponìveis, e derivados de protoberberina e sais dos mesmos

Info

Publication number
BR9815828A
BR9815828A BR9815828-7A BR9815828A BR9815828A BR 9815828 A BR9815828 A BR 9815828A BR 9815828 A BR9815828 A BR 9815828A BR 9815828 A BR9815828 A BR 9815828A
Authority
BR
Brazil
Prior art keywords
salts
protoberberine
derivatives
alkoxy
alkyl
Prior art date
Application number
BR9815828-7A
Other languages
English (en)
Inventor
Jung Ho Kim
Tae Neung Jhong
Young Ki Paik
Joon Seo Park
Eui Deok Kim
You Suk Lee
Seung Un Kim
Original Assignee
Hanwha Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanwha Chemical Corp filed Critical Hanwha Chemical Corp
Publication of BR9815828A publication Critical patent/BR9815828A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE SAIS DE PROTOBERBERINA FARMACEUTICAMENTE DISPONìVEIS, E DERIVADOS DE PROTOBERBERINA E SAIS DOS MESMOS"<D>. Os novos compostos de fórmulas químicas (I) e (II) exibem atividade antifúngica in vitro contra fungos, incluindo o fungo filamentoso cutâneo, tais como Epidermophyton, Microsporum, Trichophyton, Sporothrix schenckii, Aspergillus ou Candida. Os compostos da presente invenção exibem atividade antifúngica in vitro na concentração de 1 - 100 Ág/ml, nas fórmulas (I) e (II) R¹, R², e R^ 4^ podem ser iguais ou diferentes, e representam C~ 1~-C~ 5~ alcóxi, R³ representa hidrogênio ou C~ 1~-C~ 10~ alquila, A^ -^ representa íon de ácido inorgânico, íon de ácido orgânico ou halogeneto, R^ 5^ representa hidrogênio, piridilmetila, piridilmetila substituída ou um grupo tendo a fórmula química (XI), na qual Z¹, Z², Z³, Z^ 4^ e Z^ 5^ podem ser iguais ou diferentes, e independentemente um do outro representam hidrogênio, halogênio, grupos C~ 1~-C~ 5~ alquila, triflúormetila, fenila, fenila substituída, nitro, C~ 1~-C~ 4~ alcóxi, trifluormetóxi, hidróxi, fenóxi, vinila, metoxicarboxila.
BR9815828-7A 1998-04-24 1998-10-20 Derivados de sais de protoberberina farmaceuticamente disponìveis, e derivados de protoberberina e sais dos mesmos BR9815828A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019980014795A KR100258849B1 (ko) 1998-04-24 1998-04-24 약학적으로 유용한 프로토베르베린염 유도체 및프로토베르베린유도체와 이의 염
PCT/KR1998/000320 WO1999055704A1 (en) 1998-04-24 1998-10-20 Pharmaceutically available protoberberine salts derivatives, and protoberberine derivatives and salts thereof

Publications (1)

Publication Number Publication Date
BR9815828A true BR9815828A (pt) 2000-12-12

Family

ID=19536689

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815828-7A BR9815828A (pt) 1998-04-24 1998-10-20 Derivados de sais de protoberberina farmaceuticamente disponìveis, e derivados de protoberberina e sais dos mesmos

Country Status (12)

Country Link
US (2) US6008356A (pt)
EP (1) EP1073655B1 (pt)
JP (1) JPH11302282A (pt)
KR (1) KR100258849B1 (pt)
CN (1) CN1134436C (pt)
AT (1) ATE264325T1 (pt)
AU (1) AU758757B2 (pt)
BR (1) BR9815828A (pt)
CA (1) CA2329434A1 (pt)
DE (1) DE69823238T2 (pt)
RU (1) RU2204559C2 (pt)
WO (1) WO1999055704A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU752059B2 (en) 1997-10-27 2002-09-05 Dr. Reddy's Laboratories Limited Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
IT1316994B1 (it) * 2000-02-25 2003-05-26 Michelangelo Leis Uso di benzoderivati di piperidina come fungicidi.
KR20010112798A (ko) * 2000-06-15 2001-12-22 송기원 마이토젠에 의해 활성화되는 단백질에 대한 인산화 효소의활성을 억제하는 프로토베르베린 유도체
US6365198B1 (en) * 2001-01-28 2002-04-02 Gulf Pharmaceutical Industries Pharmaceutical preparation for the treatment of gastrointestinal ulcers and hemorrhoids
CN100387596C (zh) * 2003-12-15 2008-05-14 李耐三 13-己基小檗碱盐的制备及其抗病毒和抗菌作用
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
KR20060106958A (ko) * 2005-04-07 2006-10-12 (주)한국바이오케미칼 식물 병원균 방제용 조성물 및 그의 제조방법
CN100441183C (zh) * 2005-08-29 2008-12-10 中国医学科学院皮肤病研究所 盐酸13-己基小檗碱和盐酸13-己基巴马汀制备治疗湿疹、皮炎和银屑病的药物用途
KR100706309B1 (ko) * 2006-02-14 2007-04-12 한국생명공학연구원 항진균 활성이 우수한 베르베루빈 유도체
US20080124404A1 (en) * 2006-06-19 2008-05-29 Jingwen Liu Hypolipidemic and/or hypocholesteremic compounds obtainable from the goldenseal plant
CN101153039B (zh) * 2006-09-30 2010-12-01 中国科学院上海药物研究所 13，13a-二氢小檗碱衍生物及其药物组合物和用途
CN101161652B (zh) * 2006-10-14 2011-03-23 山东轩竹医药科技有限公司 具有抗菌活性的喹嗪类衍生物
US8121186B2 (en) 2008-06-06 2012-02-21 Lsi Corporation Systems and methods for speculative signal equalization
AU2009300385B2 (en) * 2008-09-30 2014-07-10 SpecGx LLC Berberine compounds and processes for the preparation of berberine compounds
US8188109B2 (en) * 2009-07-20 2012-05-29 Naxospharma S.R.L. Benzoquinolizinium salt derivatives as anticancer agents
CN102603755B (zh) * 2012-02-08 2015-09-09 中国人民解放军第二军医大学 一类具有协同氟康唑抗耐药真菌作用的化合物
CN103622958B (zh) * 2012-08-25 2017-05-24 北京以岭药业有限公司 四氢原小檗碱类化合物在制备抗抑郁药物中的应用
CN104211697B (zh) * 2013-06-04 2016-08-10 中山大学 小檗碱衍生物及其用途
TW201538156A (zh) * 2013-12-19 2015-10-16 Twi Biotechnology Inc 小蘗鹼配方及其用途
US20160263092A1 (en) 2013-12-19 2016-09-15 Twi Biotechnology, Inc. Therapeutic uses of berberine formulations
EP3313520A4 (en) * 2015-06-24 2019-01-02 TWI Biotechnology, Inc. Therapeutic uses of berberine formulations
CN109180673B (zh) * 2018-09-30 2021-06-01 常州方圆制药有限公司 一种具有抗菌活性的小檗碱衍生物及其制备方法和应用
CN111662281B (zh) * 2019-03-05 2023-01-06 中国医学科学院药物研究所 水杨酸类小檗碱型生物碱季铵盐及其制备药物的用途
WO2021015544A1 (ko) * 2019-07-23 2021-01-28 재단법인 대구경북첨단의료산업진흥재단 벤조퀴놀리지늄계 화합물, 이의 제조 방법 및 이를 포함하는 조영제 조성물
CN113880830B (zh) * 2021-10-25 2023-09-22 南京中医药大学 9-o-胺烷基-13-烷基双取代小檗碱衍生物及其制备方法和用途
CN114711243B (zh) * 2022-04-25 2023-09-05 兰州大学 一种小檗碱衍生物在抗植物病原菌中的用途
CN115317393A (zh) * 2022-08-30 2022-11-11 南京纽邦生物科技有限公司 用于改善哺乳动物毛囊、头皮或毛发健康的方法和组合物
CN117105930B (zh) * 2023-10-23 2024-02-13 中国医学科学院医药生物技术研究所 一类3,13-双取代小檗碱衍生物及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004077A (en) * 1962-09-21 1965-09-08 Smith Kline French Lab Pharmaceutical compositions containing dibenzoquinolizines
GB1265627A (pt) * 1970-08-26 1972-03-01
DE2043218A1 (de) * 1970-09-01 1972-03-02 Dainippon Pharmaceutical Co , Ltd, Osaka (Japan) Pharmazeutische Zubereitungen zur Behandlung von Magengeschwüren
US3920665A (en) * 1972-10-19 1975-11-18 Kanebo Ltd Berbine compounds
JPH0231054B2 (ja) * 1979-04-26 1990-07-11 Seisan Kaihatsu Kagaku Kenkyusho Koseishinshinkeishozai
US4749708A (en) * 1982-05-14 1988-06-07 Maroko Peter R Composition for improving circulatory performance
US4761417A (en) * 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
US5153178A (en) * 1982-05-14 1992-10-06 Maroko Peter R Compositions and method of treatment for improving circulatory performance
US4980344A (en) * 1982-05-14 1990-12-25 Maroko Peter R Compositions for improving circulatory performance
IE55519B1 (en) * 1982-05-14 1990-10-10 Maroko Peter R Use of a protoberberine alkaloid and composition containing same
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
JPH0395116A (ja) * 1989-09-07 1991-04-19 Takeda Chem Ind Ltd 逆転写酵素阻害組成物
AU3583797A (en) * 1996-06-28 1998-01-21 Regents Of The University Of California, The Enhancement of cancer cell death
AU3511197A (en) * 1996-07-03 1998-01-21 Prm Pharmaceuticals, Inc. Berberine alkaloids as a treatment for chronic, protozoally-induced diarrhea

Also Published As

Publication number Publication date
CA2329434A1 (en) 1999-11-04
US6008356A (en) 1999-12-28
JPH11302282A (ja) 1999-11-02
EP1073655A1 (en) 2001-02-07
KR100258849B1 (ko) 2000-08-01
KR19990081079A (ko) 1999-11-15
RU2204559C2 (ru) 2003-05-20
CN1134436C (zh) 2004-01-14
AU9764298A (en) 1999-11-16
DE69823238T2 (de) 2005-04-07
ATE264325T1 (de) 2004-04-15
DE69823238D1 (de) 2004-05-19
EP1073655B1 (en) 2004-04-14
AU758757B2 (en) 2003-03-27
WO1999055704A1 (en) 1999-11-04
CN1295573A (zh) 2001-05-16
US6030978A (en) 2000-02-29

Similar Documents

Publication Publication Date Title
BR9815828A (pt) Derivados de sais de protoberberina farmaceuticamente disponìveis, e derivados de protoberberina e sais dos mesmos
Orubite-Okorosaye et al. Corrosion inhibition of zinc on HCl using Nypa fruticans Wurmb extract and 1, 5 diphenyl carbazonen
GB2442148A (en) FK 228 derivates as HDAC inhibitors
CA2338569A1 (en) Method for treating wood against the attack of harmful fungi
EA200602067A1 (ru) Производные хиноксалин-2-она, содержащие их средства защиты полезных растений и способ их получения и их применение
ES2107557T3 (es) Derivado de acido hidroxamico a base de sulfonamida aromatica.
BRPI0616799B8 (pt) derivado de piridina e derivado de pirimidina, composições farmacêuticas, usos, inibidores de angiogênese, contra receptor de fator de crescimento de hepatócito e contra metástase de câncer, e agente antitumor
BR0206433A (pt) Composto, composição farmacêutica, processo para a prepapação de um composto, e, uso de um composto
HUP0301336A2 (hu) Réztartalmú amin-oxidázok inhibitorai és alkalmazásuk gyógyszerkészítmények előállítására
HUP9802433A2 (hu) 8-Azabiciklo[3.2.1]okt-2-én-származékok, eljárás előállításukra és alkalmazásuk
PT976748E (pt) Derivados de pirrolidina com actividade inibidora de fosfolipase a2
MY146042A (en) Water-soluble benzoazepine compound and its pharmaceutical composition
DK1452528T3 (da) Xanthinoxidaserinhibitorer
ATE305777T1 (de) Mittel zur verhinderung der chronischen abstossreaktion infolge einer organtransplantation
JP2005325442A5 (pt)
ATE315550T1 (de) Fungizide phenylamidinderivative
WO2004052891A8 (fr) Composes heterocyclique, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
BR0211291A (pt) Derivados de diamina, processo para produção dos derivados de diamina e fungicidas contendo os derivados de diamina como ingrediente ativo
BR0313215A (pt) Derivados de 1,2,4-triazol e de amidrazona, métodos de preparação de derivados de 1,2,4-triazol ou amidrazona ou sais não toxicos dos mesmos e composições farmacêuticas
NO20045630L (no) Forbindelser for behandling av antraks og inhibering av letal faktor
ES470459A1 (es) Procedimiento para la obtencion de complejos metalicos de derivados de 1-fenil-2-triazolil-etilo, de efecto fungicida
NO20014374D0 (no) Aminometylpyrrolidin-derivater som har aromatiske substituenter
HUP0303249A2 (hu) Gombaellenes hatású vízoldékony triazolvegyületek és ezeket tartalmazó gyógyszerkészítmények
RU2007146932A (ru) Производное соли 3,4-дигидроизохинолиния
DE3668888D1 (de) Ein imidazolidintrion-derivat oder ein seiner pharmazeutisch akzeptierbaren salze enthaltende pharmazeutische zusammenstellung.

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI