BR9815677A - Uso de bactérias dotadas de arginina deiminase para indução de apoptose e/ou redução de uma reação inflamatória e composições farmacêuticas ou dietéticas contendo tais bactérias - Google Patents

Uso de bactérias dotadas de arginina deiminase para indução de apoptose e/ou redução de uma reação inflamatória e composições farmacêuticas ou dietéticas contendo tais bactérias

Info

Publication number
BR9815677A
BR9815677A BR9815677-2A BR9815677A BR9815677A BR 9815677 A BR9815677 A BR 9815677A BR 9815677 A BR9815677 A BR 9815677A BR 9815677 A BR9815677 A BR 9815677A
Authority
BR
Brazil
Prior art keywords
bacteria
pharmaceutical
arginine deiminase
compositions containing
reduce
Prior art date
Application number
BR9815677-2A
Other languages
English (en)
Inventor
Claudio De Simone
Original Assignee
Mendes Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mendes Srl filed Critical Mendes Srl
Publication of BR9815677A publication Critical patent/BR9815677A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C12R2001/24—Lactobacillus brevis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção<B>"USO DE BACTéRIAS DOTADAS DE ARGININA DEIMINASE PARA INDUçãO DE APOPTOSE E/OU REDUçãO DE UMA REAçãO INFLAMATóRIA E COMPOSIçõES FARMACêUTICAS OU DIETéTICAS CONTENDO TAIS BACTéRIAS"<D>. Apresenta-se o uso de bactérias dotadas de arginina deiminase para induzir apoptose e/ou reduzir uma resposta inflamatória e composições farmacêuticas ou dietéticas contendo tais bactérias. Também se inclui uma cepa de Lactobacillus brevis altamente dotada de arginina deiminase.
BR9815677-2A 1998-02-20 1998-10-13 Uso de bactérias dotadas de arginina deiminase para indução de apoptose e/ou redução de uma reação inflamatória e composições farmacêuticas ou dietéticas contendo tais bactérias BR9815677A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98RM000103A IT1298918B1 (it) 1998-02-20 1998-02-20 Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche
PCT/IT1998/000275 WO1999042568A1 (en) 1998-02-20 1998-10-13 Use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction and pharmaceutical or dietetic compositions containing such bacteria

Publications (1)

Publication Number Publication Date
BR9815677A true BR9815677A (pt) 2000-10-24

Family

ID=11405583

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9815677-2A BR9815677A (pt) 1998-02-20 1998-10-13 Uso de bactérias dotadas de arginina deiminase para indução de apoptose e/ou redução de uma reação inflamatória e composições farmacêuticas ou dietéticas contendo tais bactérias

Country Status (25)

Country Link
US (2) US6572854B1 (pt)
EP (1) EP1058725B1 (pt)
JP (1) JP4253439B2 (pt)
KR (1) KR100594569B1 (pt)
CN (1) CN1189560C (pt)
AR (2) AR020053A1 (pt)
AT (1) ATE391774T1 (pt)
AU (1) AU754483B2 (pt)
BR (1) BR9815677A (pt)
CA (1) CA2321263C (pt)
CY (1) CY1108112T1 (pt)
DE (1) DE69839351T2 (pt)
DK (1) DK1058725T3 (pt)
EA (1) EA006018B1 (pt)
ES (1) ES2303357T3 (pt)
HK (1) HK1033338A1 (pt)
IL (1) IL137799A (pt)
IN (2) IN1999KO00116A (pt)
IT (1) IT1298918B1 (pt)
MX (1) MX237377B (pt)
PT (1) PT1058725E (pt)
SI (1) SI1058725T1 (pt)
TR (1) TR200002326T2 (pt)
WO (1) WO1999042568A1 (pt)
ZA (1) ZA9811619B (pt)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296148B1 (it) * 1996-11-22 1999-06-09 Renata Maria Anna Ve Cavaliere Uso di batteri lattici per accrescere il livello delle ceramidi della pelle e delle mucose, e composizioni dermatologiche e cosmetiche atte
IT1311495B1 (it) * 1999-06-09 2002-03-13 Mendes S U R L Composizione comprendente sfingomielinasi alcalina, utilizzabile qualeprodotto dietetico, integratore alimentare o medicamento.
US8697051B2 (en) 1999-06-09 2014-04-15 Vsl Pharmaceuticals Inc. Composition comprising alkaline sphingomyelinase for use as a dietetic preparation, food supplement or pharmaceutical product
IT1306716B1 (it) * 1999-06-21 2001-10-02 Mendes S U R L Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori.
AUPQ415899A0 (en) * 1999-11-19 1999-12-16 Vasse Research Institute Pty Ltd Compositions for and methods of treatment of allergic diseases
HU227086B1 (en) * 1999-11-25 2010-06-28 Vakcina Kft Lactobacillus vaccine for treating prostata inflammatory and benign prostata hyperplasia
FR2809312B1 (fr) * 2000-05-25 2002-07-12 Gervais Danone Sa Utilisation de l. casei dans des compositions immunostimulantes
US6767537B2 (en) * 2000-05-26 2004-07-27 Phil Arnold Nicolay Composition and method for the treatment of sinusitis
WO2003022255A2 (en) * 2001-09-05 2003-03-20 Vsl Pharmaceuticals, Inc. Lactic acid bacteria comprising unmethylated cytosine-guanine dinucleotides for use in therapy
ITRM20010763A1 (it) 2001-12-21 2003-06-21 Simone Claudio De Nuovo ceppo di batterio lattico e composizioni commestibili, farmaci e prodotti veterinari che lo contengono.
AU2003282883B2 (en) * 2002-11-18 2008-12-04 Polaris Group Methods for inhibiting viral replication in vivo
US20050158294A1 (en) 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
US8877178B2 (en) 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
TW200700074A (en) * 2005-03-04 2007-01-01 Calpis Co Ltd Inducer of t cell apoptosis
AR052472A1 (es) 2005-05-31 2007-03-21 Iams Company Lactobacilos probioticos para felinos
EP1885383B1 (en) 2005-05-31 2016-09-21 IAMS Europe B.V. Feline probiotic bifidobacteria
KR20090092315A (ko) 2006-12-21 2009-08-31 칼피스가부시키가이샤 ＩｇＡ 생산 촉진제
CN100584940C (zh) * 2007-05-17 2010-01-27 江南大学 一株产精氨酸脱亚氨酶的菌种及其应用
JP5247120B2 (ja) * 2007-11-02 2013-07-24 雪印メグミルク株式会社 Ｌ−オルニチン含有物の製造方法
EE05341B1 (et) * 2008-05-13 2010-08-16 O� Tervisliku Piima Biotehnoloogiate Arenduskeskus Isoleeritud mikroorganismi tvi Lactobacillus plantarum Inducia DSM 21379 kui organismi loomulikku kaitsev?imet t?stev probiootik, seda sisaldav toiduaine ja kompositsioon ning mikroorganismi kasutamine rakulist immuunsust t?stva ravimi valmistamisek
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
CN101606952B (zh) * 2008-06-17 2012-09-19 上海交通大学医学院附属第三人民医院 乳双歧杆菌在制备预防泌尿系统结石药物中的应用
JP5526320B2 (ja) * 2008-09-04 2014-06-18 国立大学法人旭川医科大学 腸管保護剤
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
CN102548565A (zh) * 2009-10-22 2012-07-04 株式会社益力多本社 癌症发病风险降低剂
WO2011125619A1 (ja) * 2010-04-08 2011-10-13 国立大学法人旭川医科大学 腸管保護剤
KR101062779B1 (ko) 2010-04-28 2011-09-06 삼육대학교산학협력단 충치 유발 세균의 성장 억제 활성을 나타내는 비피도박테리움 아돌레센티스 ｓｐｍ1005 균주 및 상기 비피도박테리움 아돌레센티스 ｓｐｍ1005 균주 또는 이의 배양물을 유효 성분으로 하는 충치 예방용 식품 및 약제학 조성물
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
CN102433290B (zh) * 2012-01-16 2013-06-12 江南大学 一株产瓜氨酸的菌株及用该菌株生物合成瓜氨酸的方法
EP3782653A1 (en) 2012-04-04 2021-02-24 Polaris Group Composition comprising pegylated arginine deiminase
EP3744341A1 (en) 2013-03-15 2020-12-02 TDW Group Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
WO2015111597A1 (ja) * 2014-01-22 2015-07-30 株式会社明治 シトルリンの調製方法
JP6612316B2 (ja) 2014-03-18 2019-11-27 ティーディーダブリュ グループ 操作されたキメラｐｅｇ化ａｄｉ及び使用方法
AU2015317848B2 (en) 2014-09-16 2021-04-22 Polaris Group Arginine deiminase with reduced cross-reactivity toward ADI - PEG 20 antibodies for cancer treatment
EP3395351A1 (en) 2014-12-23 2018-10-31 4D Pharma Research Limited Immune modulation
JP6427278B2 (ja) 2014-12-23 2018-11-21 フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ ｐｉｒｉｎポリペプチド及び免疫モジュレーション
CN107847529B (zh) 2015-06-15 2022-05-03 4D制药研究有限公司 包含细菌菌株的组合物
BR112017025005A2 (pt) 2015-06-15 2018-08-07 4D Pharma Research Limited composições compreendendo cepas baterianas
PT3650033T (pt) 2015-06-15 2022-05-25 4D Pharma Res Ltd Composições compreendendo estirpes bacterianas
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
MA41013A (fr) 2015-11-20 2017-08-30 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
CN106994134B (zh) * 2016-01-25 2020-08-25 深圳华大生命科学研究院 肠道益生菌在预防和/或治疗糖尿病及其相关疾病中的应用
EA035949B1 (ru) 2016-03-04 2020-09-04 4Д ФАРМА ПиЭлСи Применение композиции, содержащей бактериальный штамм вида blautia hydrogenotrophica, и способ лечения или предотвращения висцеральной гиперчувствительности
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
TW201821093A (zh) 2016-07-13 2018-06-16 英商４Ｄ製藥有限公司 包含細菌菌株之組合物
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
WO2018125735A1 (en) * 2016-12-29 2018-07-05 Kibow Biotech, Inc. Composition and method for maintaining healthy kidney function
CN108265068B (zh) * 2016-12-31 2021-06-15 江苏众红生物工程创药研究院有限公司 重组精氨酸脱亚胺酶及其产业化制备方法和应用
MA48939B1 (fr) 2017-05-22 2021-06-30 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
WO2018215782A1 (en) 2017-05-24 2018-11-29 4D Pharma Research Limited Compositions comprising bacterial strain
HUE053488T2 (hu) 2017-06-14 2021-06-28 4D Pharma Res Ltd Baktériumtörzseket tartalmazó készítmények
MD3600364T2 (ro) 2017-06-14 2020-12-31 4D Pharma Res Ltd Compoziții care conţin tulpină bacteriană din genul Megasphaera și utilizări ale acestora
LT3638271T (lt) 2017-06-14 2021-01-11 4D Pharma Research Limited Kompozicijos, apimančios bakterines padermes
RU2675110C1 (ru) * 2018-04-09 2018-12-17 Федеральное государственное бюджетное учреждение науки Институт общей генетики им. Н.И. Вавилова Российской академии наук (ИОГЕН РАН) Фармацевтическая композиция для терапии воспалительных заболеваний слизистых оболочек кишечника на основе штамма Lactobacillus brevis 47f, проявляющая местную противовоспалительную активность
FR3082207B1 (fr) * 2018-06-06 2022-03-25 Agronomique Inst Nat Rech Nouvelle souche probiotique de lactobacillus brevis
KR102069622B1 (ko) * 2019-06-25 2020-01-23 한국식품연구원 락토바실러스 퍼멘텀 WiKim0102를 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물
JPWO2021261423A1 (pt) * 2020-06-22 2021-12-30
KR102363111B1 (ko) * 2021-06-29 2022-02-15 (주)바이오일레븐 항염 및 항산화 활성을 갖는 락토바실러스 퍼멘텀 균주 및 이의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415550A (en) * 1983-03-04 1983-11-15 Pakhomov Gennady N Treatment-and-prophylactic tooth paste possessing anticarious effect
JP2900279B2 (ja) 1989-08-02 1999-06-02 株式会社ジャパンエナジー 新規なアルギニンデイミナーゼ、その製造法及び該酵素を有効成分とする制癌剤
US5196195A (en) 1990-03-27 1993-03-23 Cornell Research Foundation, Inc. Use of arginase to control nitric oxide formation
GB9107305D0 (en) 1991-04-08 1991-05-22 Unilever Plc Probiotic
AUPM596894A0 (en) * 1994-05-30 1994-06-23 Hybrid Scientific Pty Ltd Composition for treating gastrointestinal disorders - a combination of bismuth salts plus lactobacillus or bifidobacteria species bacteria for treating gastrointestinal disorders
US5599795A (en) * 1994-08-19 1997-02-04 Mccann; Michael Method for treatment of idiopathic inflammatory bowel disease (IIBD)

Also Published As

Publication number Publication date
US7147847B2 (en) 2006-12-12
EP1058725A1 (en) 2000-12-13
PT1058725E (pt) 2008-06-19
KR100594569B1 (ko) 2006-06-30
US20030215429A1 (en) 2003-11-20
CA2321263C (en) 2009-08-11
ES2303357T3 (es) 2008-08-01
WO1999042568A1 (en) 1999-08-26
SI1058725T1 (sl) 2008-08-31
DE69839351D1 (de) 2008-05-21
ZA9811619B (en) 1999-06-23
CN1189560C (zh) 2005-02-16
JP4253439B2 (ja) 2009-04-15
AU9644198A (en) 1999-09-06
ATE391774T1 (de) 2008-04-15
ITRM980103A0 (it) 1998-02-20
CY1108112T1 (el) 2014-02-12
DK1058725T3 (da) 2008-08-18
DE69839351T2 (de) 2009-06-25
IL137799A (en) 2005-08-31
EA200000856A1 (ru) 2001-02-26
US6572854B1 (en) 2003-06-03
AR071841A2 (es) 2010-07-21
MX237377B (es) 2006-05-31
EA006018B1 (ru) 2005-08-25
EP1058725B1 (en) 2008-04-09
IT1298918B1 (it) 2000-02-07
AU754483B2 (en) 2002-11-14
AR020053A1 (es) 2002-04-10
MXPA00007990A (es) 2001-03-01
ITRM980103A1 (it) 1999-08-20
CN1284994A (zh) 2001-02-21
IN188450B (pt) 2002-09-28
IN1999KO00116A (pt) 2005-03-11
KR20010106092A (ko) 2001-11-29
IL137799A0 (en) 2001-10-31
TR200002326T2 (tr) 2000-11-21
JP2002504324A (ja) 2002-02-12
CA2321263A1 (en) 1999-08-26
HK1033338A1 (en) 2001-08-24

Similar Documents

Publication Publication Date Title
BR9815677A (pt) Uso de bactérias dotadas de arginina deiminase para indução de apoptose e/ou redução de uma reação inflamatória e composições farmacêuticas ou dietéticas contendo tais bactérias
DE69501591D1 (de) Lactobazillusstämme menschlichen ursprungs, ihre zusammensetzung und deren verwendung
BG103995A (en) Reverse hydroxamate inhibitors of matrix metalloprreverse hydroxamate inhibitors of matrix metallprooteinases teinases
NZ326610A (en) Inhibitors of interleukin-1B or beta converting enzyme and use thereof
BR0109161A (pt) Beta-carbolinas substituìdas com atividade de inibição de ikb-quinase
ATE267168T1 (de) Beta-alanin-derivate als zell-adhäsions- inhibitoren
MY111201A (en) New imidazopyridines
IL164568A0 (en) Compounds and methods for the inhibition of the expression of vcam-1
MXPA04003668A (es) Inhibidores de fosfodiesteresa de tipo 4 y usos de los mismos.
YU53899A (sh) Primena inhibitora ciklooksigenaze-2 u prevenciji kardiovaskularnih poremećaja
AU2002221702A1 (en) Pharmaceutical compositions
MXPA04004300A (es) Analogos de lipoxina a4.
DE69722656D1 (de) Bicyclische arylcarboxamide und ihre therapeutische verwendung
AU5186799A (en) Peptides of il-2 and derivatives thereof and their use as therapeutic agents
BR9814885A (pt) Combinação de um inibidor da enzima de conversão da angiotensina e de um diurético para o tratamento das desordens microcirculatórias
AP1795A (en) Peptide deformylase inhibitors.
AU4179399A (en) Use of nmda antagonists and/or sodium channel antagonists for the treatment of inflammatory disorders
AU4583597A (en) Novel tricyclic compounds for the inhibition of the ice/ced-3 protease family of enzymes
BR0012675A (pt) Uso de inibidores de il-18
BR9909252A (pt) Proteìnas de interação caspase-8
MD2053B1 (en) Remedy with interferon inducing action
BR9812489A (pt) Uso de 6,7-substituìdas-2-aminotetralinas adequadas para a preparação de uma composição farmacêutica para o tratamento terapêutico de patologias inflamatórias e/ou autoimunes
MXPA03004436A (es) Proteinas bcl-2 mutantes y sus usos.
WO2000027881A3 (de) Menschliche interleukin -10 mutantenproteine
ITMI20001316A0 (it) Composizioni farmaceutiche e/o dietetiche dotate di attiviata&#39; antiossidante e antiglicosilante e contenenti ceppi di lactobacilli eubiotici

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: VSL PHARMACEUTICALS, INC. (US)

Free format text: TRANSFERIDO DE: MENDES S.R.L.

B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: ATRAVES DA PETICAO NO 048410 DE 04/10/2001, O REQUERENTE APRESENTOU O PEDIDO DE EXAME (FOLHA 40) DE UM QUADRO COM 13 (TREZE) REIVINDICACOES, ENTRETANTO, ATRAVES DA PETICAO NO020070104808 DE 30/07/2007 O REQUERENTE DEPOSITOU NOVO QUADRO COM 18 (DEZOITO) REIVINDICACOES (FOLHAS 87 A 90). DE ACORDO COM O ACIMA EXPOSTO, PEDE-SE QUE O REQUERENTE COMPLEMENTE A TAXA RELATIVA AS 5 (CINCO) REIVINDICACOES EXCEDENTES APRESENTADAS EM 30/07/2007.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time