BR9814257A - Sistemas integrados microeletrÈnicos de auto-montagem, auto-endereçáveis, dispositivos de componente, mecanismos, métodos e procedimentos para análise biológica molecular e diagnósticos - Google Patents

Sistemas integrados microeletrÈnicos de auto-montagem, auto-endereçáveis, dispositivos de componente, mecanismos, métodos e procedimentos para análise biológica molecular e diagnósticos

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Publication number
BR9814257A
BR9814257A BR9814257-7A BR9814257A BR9814257A BR 9814257 A BR9814257 A BR 9814257A BR 9814257 A BR9814257 A BR 9814257A BR 9814257 A BR9814257 A BR 9814257A
Authority
BR
Brazil
Prior art keywords
self
addressing
reactions
control
micro
Prior art date
Application number
BR9814257-7A
Other languages
English (en)
Inventor
Ronald G Sosnowski
William F Butler
Eugene Tu
Michael I Nerenberg
Michael J Heller
Carl F Edman
Original Assignee
Nanogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanogen Inc filed Critical Nanogen Inc
Publication of BR9814257A publication Critical patent/BR9814257A/pt

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • H01L29/772—Field effect transistors
    • H01L29/78—Field effect transistors with field effect produced by an insulated gate
    • H01L29/7833—Field effect transistors with field effect produced by an insulated gate with lightly doped drain or source extension, e.g. LDD MOSFET's; DDD MOSFET's
    • H01L29/7834—Field effect transistors with field effect produced by an insulated gate with lightly doped drain or source extension, e.g. LDD MOSFET's; DDD MOSFET's with a non-planar structure, e.g. the gate or the source or the drain being non-planar
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Abstract

Patente de Invenção: <B>"SISTEMAS INTEGRADOS MICROELETRÈNICOS DE AUTO-MONTAGEM, AUTO-ENDEREçáVEIS, DISPOSITIVOS DE COMPONENTE, MECANISMOS, MéTODOS E PROCEDIMENTOS PARA ANáLISE BIOLóGICA MOLECULAR E DIAGNóSTICOS"<D>. Um dispositivo microeletrónico de auto-montagem, auto-endereçável, é projetado para ativamente realizar e controlar reações biológicas moleculares multiplex e de múltiplas etapas em formatos microscópicos. Estas reações incluem hibridizações de ácido nucléico, reações de anticorpo/antígeno, diagnósticos, e síntese de biopolímero. O dispositivo pode ser fabricado usando-se tanto técnicas micro-litográficas quanto técnicas de micro-usinagem. O dispositivo pode eletronicamente controlar o transporte e a ligação de entidades de ligação específicas a microlocais específicos. As entidades de ligação específicas incluem moléculas biológicas, tais como ácidos nucléico e polipeptídeos. O dispositivo pode subseq³entemente controlar o transporte e a reação de analisados ou reagentes nos microlocais específicos endereçados. O dispositivo é capaz de concentrar analisados e reagentes, remover moléculas não especificamente ligadas, prover controle de estringência para reações de hibridização de DNA e aperfeiçoar a detecção de analisados. O dispositivo pode ser eletronicamente replicado.
BR9814257-7A 1997-12-05 1998-12-01 Sistemas integrados microeletrÈnicos de auto-montagem, auto-endereçáveis, dispositivos de componente, mecanismos, métodos e procedimentos para análise biológica molecular e diagnósticos BR9814257A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/986,065 US6051380A (en) 1993-11-01 1997-12-05 Methods and procedures for molecular biological analysis and diagnostics
PCT/US1998/025475 WO1999029711A1 (en) 1997-12-05 1998-12-01 Self-addressable self-assembling microelectronic integrated systems, component devices, mechanisms, methods, and procedures for molecular biological analysis and diagnostics

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BR9814257A true BR9814257A (pt) 2000-10-03

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BR9814257-7A BR9814257A (pt) 1997-12-05 1998-12-01 Sistemas integrados microeletrÈnicos de auto-montagem, auto-endereçáveis, dispositivos de componente, mecanismos, métodos e procedimentos para análise biológica molecular e diagnósticos

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US (4) US6051380A (pt)
EP (1) EP1036085A4 (pt)
JP (1) JP2001525193A (pt)
KR (1) KR20010032789A (pt)
CN (1) CN1268634C (pt)
AU (1) AU738493B2 (pt)
BR (1) BR9814257A (pt)
CA (1) CA2312568A1 (pt)
HK (1) HK1034519A1 (pt)
WO (1) WO1999029711A1 (pt)

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