BR9713388B1 - processos de produÇço de vÍrus e de adenovÍrus recombinantes defectivos, e baculovÍrus recombinante. - Google Patents
processos de produÇço de vÍrus e de adenovÍrus recombinantes defectivos, e baculovÍrus recombinante.Info
- Publication number
- BR9713388B1 BR9713388B1 BRPI9713388-4A BR9713388A BR9713388B1 BR 9713388 B1 BR9713388 B1 BR 9713388B1 BR 9713388 A BR9713388 A BR 9713388A BR 9713388 B1 BR9713388 B1 BR 9713388B1
- Authority
- BR
- Brazil
- Prior art keywords
- recombinant
- adenoviruses
- production processes
- defective
- baculoviruses
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 241000701447 unidentified baculovirus Species 0.000 title abstract 2
- 230000002950 deficient Effects 0.000 title 1
- 241000701161 unidentified adenovirus Species 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pens And Brushes (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614278A FR2756297B1 (fr) | 1996-11-22 | 1996-11-22 | Procede de production de virus recombinants |
| PCT/FR1997/002073 WO1998022607A1 (fr) | 1996-11-22 | 1997-11-18 | Procede de production de virus recombinants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9713388A BR9713388A (pt) | 2000-03-21 |
| BR9713388B1 true BR9713388B1 (pt) | 2009-01-13 |
Family
ID=9497899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9713388-4A BR9713388B1 (pt) | 1996-11-22 | 1997-11-18 | processos de produÇço de vÍrus e de adenovÍrus recombinantes defectivos, e baculovÍrus recombinante. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6387670B1 (https=) |
| EP (1) | EP0946741B1 (https=) |
| JP (1) | JP4686670B2 (https=) |
| KR (1) | KR100719645B1 (https=) |
| AT (1) | ATE317908T1 (https=) |
| AU (1) | AU731106B2 (https=) |
| BR (1) | BR9713388B1 (https=) |
| CA (1) | CA2271438C (https=) |
| CZ (1) | CZ293947B6 (https=) |
| DE (1) | DE69735274T2 (https=) |
| ES (1) | ES2260803T3 (https=) |
| FR (1) | FR2756297B1 (https=) |
| HU (1) | HU224713B1 (https=) |
| IL (1) | IL129686A (https=) |
| NO (2) | NO323937B1 (https=) |
| SK (1) | SK286900B6 (https=) |
| WO (1) | WO1998022607A1 (https=) |
| ZA (1) | ZA9710516B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003501042A (ja) * | 1999-05-27 | 2003-01-14 | ジェノボ， インコーポレイテッド | 非哺乳動物ウイルス由来のキャリアベクターを使用する、組換えウイルスの産生のための組成物および方法 |
| US6793926B1 (en) * | 1999-05-27 | 2004-09-21 | Genovo, Inc. | Methods for production of a recombinant adeno-associated virus |
| WO2000073424A1 (en) * | 1999-05-28 | 2000-12-07 | Mount Sinai School Of Medicine | A novel baculovirus/adenovirus hybrid vector for the rescue, production and titration of high-capacity adenovirus amplicon vectors |
| GB9919409D0 (en) * | 1999-08-18 | 1999-10-20 | Univ Oxford Brookes | Baculovirus expression system |
| WO2004020605A2 (en) * | 2002-08-29 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Circular nucleic acid vectors, and methods for making and using the same |
| GB0702695D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Production of vectors |
| GB0702694D0 (en) * | 2007-02-12 | 2007-03-21 | Ark Therapeutics Ltd | Vectors |
| EP2019143A1 (en) | 2007-07-23 | 2009-01-28 | Genethon | CNS gene delivery using peripheral administration of AAV vectors |
| EP2058401A1 (en) | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
| EP2249950B1 (en) * | 2008-03-05 | 2014-10-15 | Council of Scientific & Industrial Research | A polymeric hybrid membrane |
| EP2287323A1 (en) | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
| EP2292781A1 (en) | 2009-08-17 | 2011-03-09 | Genethon | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
| CN102884196B (zh) * | 2010-04-01 | 2015-05-06 | 肖卫东 | 重组病毒载体的结构及其制备 |
| BR112012026095A2 (pt) | 2010-04-14 | 2015-09-15 | Emd Millipore Corp | métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos. |
| WO2013170078A1 (en) | 2012-05-09 | 2013-11-14 | Oregon Health & Science University | Adeno associated virus plasmids and vectors |
| TWI698240B (zh) | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| US20150182637A1 (en) | 2012-06-21 | 2015-07-02 | Association Institut De Myologie | Widespread gene delivery of gene therapy vectors |
| WO2015031686A1 (en) * | 2013-08-30 | 2015-03-05 | Amgen Inc. | High titer recombinant aav vector production in adherent and suspension cells |
| EP3800191B1 (en) | 2014-03-17 | 2025-08-20 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
| US11021519B2 (en) | 2015-03-02 | 2021-06-01 | Adverum Biotechnologies, Inc. | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| US10538571B2 (en) | 2017-11-27 | 2020-01-21 | Coda Biotherapeutics, Inc. | Compositions and methods for neurological diseases |
| US20190256867A1 (en) | 2018-02-01 | 2019-08-22 | Homology Medicines, Inc. | Adeno-associated virus compositions for restoring pah gene function and methods of use thereof |
| US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
| JP7244547B2 (ja) | 2018-02-19 | 2023-03-22 | ホモロジー・メディシンズ・インコーポレイテッド | Ｆ８遺伝子機能を回復させるためのアデノ随伴ウイルス組成物及びその使用の方法 |
| US12215338B2 (en) | 2018-05-08 | 2025-02-04 | Neuracle Science Co., Ltd. | Adeno-associated virus (AAV) delivery of anti-FAM19A5 antibodies |
| WO2020160508A1 (en) | 2019-01-31 | 2020-08-06 | Oregon Health & Science University | Methods for using transcription-dependent directed evolution of aav capsids |
| AU2020334147A1 (en) | 2019-08-21 | 2022-03-31 | Trames Bio, Inc. | Compositions and methods for neurological diseases |
| TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
| TW202208632A (zh) | 2020-05-27 | 2022-03-01 | 美商同源醫藥公司 | 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法 |
| GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
| CA3195177A1 (en) | 2020-10-07 | 2022-04-14 | Asklepios Biopharmaceutical, Inc. | Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy disorders including limb girdle 2i (lgmd2i) |
| US20250296996A1 (en) | 2022-04-29 | 2025-09-25 | Broadwing Bio, Inc. | Angiopoietin-related protein 7-specific antibodies and uses thereof |
| EP4514844A1 (en) | 2022-04-29 | 2025-03-05 | Broadwing Bio LLC | Complement factor h related 4-specific antibodies and uses thereof |
| KR20250018169A (ko) | 2022-04-29 | 2025-02-04 | 브로드윙 바이오 엘엘씨 | 이중특이적 항체 및 안구 질환의 치료 방법 |
| WO2024227154A1 (en) | 2023-04-28 | 2024-10-31 | Broadwing Bio Llc | Complement component 3 (c3)-specific antibodies and uses thereof |
| WO2025040613A1 (en) * | 2023-08-21 | 2025-02-27 | Vector Biopharma Ag | Cell line for production of helper-dependent adenoviruses |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2755817B2 (ja) * | 1988-11-14 | 1998-05-25 | アメリカ合衆国 | パルボウイルスキャプシド |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| JPH10506530A (ja) * | 1994-09-23 | 1998-06-30 | ザ ジェネラル ホスピタル コーポレーション | 哺乳類細胞において外来遺伝子を発現する非哺乳類ｄｎａウイルスの使用 |
-
1996
- 1996-11-22 FR FR9614278A patent/FR2756297B1/fr not_active Expired - Lifetime
-
1997
- 1997-11-18 ES ES97947083T patent/ES2260803T3/es not_active Expired - Lifetime
- 1997-11-18 BR BRPI9713388-4A patent/BR9713388B1/pt not_active IP Right Cessation
- 1997-11-18 JP JP52328298A patent/JP4686670B2/ja not_active Expired - Lifetime
- 1997-11-18 DE DE69735274T patent/DE69735274T2/de not_active Expired - Lifetime
- 1997-11-18 HU HU0001762A patent/HU224713B1/hu active Protection Beyond IP Right Term
- 1997-11-18 IL IL12968697A patent/IL129686A/xx not_active IP Right Cessation
- 1997-11-18 CZ CZ19991822A patent/CZ293947B6/cs not_active IP Right Cessation
- 1997-11-18 US US09/308,398 patent/US6387670B1/en not_active Expired - Lifetime
- 1997-11-18 SK SK666-99A patent/SK286900B6/sk not_active IP Right Cessation
- 1997-11-18 KR KR1019997004531A patent/KR100719645B1/ko not_active Expired - Lifetime
- 1997-11-18 AU AU52261/98A patent/AU731106B2/en not_active Expired
- 1997-11-18 EP EP97947083A patent/EP0946741B1/fr not_active Expired - Lifetime
- 1997-11-18 AT AT97947083T patent/ATE317908T1/de not_active IP Right Cessation
- 1997-11-18 WO PCT/FR1997/002073 patent/WO1998022607A1/fr not_active Ceased
- 1997-11-18 CA CA2271438A patent/CA2271438C/fr not_active Expired - Lifetime
- 1997-11-21 ZA ZA9710516A patent/ZA9710516B/xx unknown
-
1999
- 1999-05-21 NO NO19992464A patent/NO323937B1/no not_active IP Right Cessation
-
2002
- 2002-05-09 US US10/141,491 patent/US20030022356A1/en not_active Abandoned
-
2013
- 2013-04-15 NO NO2013009C patent/NO2013009I1/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO323937B1 (no) | 2007-07-23 |
| FR2756297A1 (fr) | 1998-05-29 |
| DE69735274D1 (de) | 2006-04-20 |
| BR9713388A (pt) | 2000-03-21 |
| HU224713B1 (en) | 2006-01-30 |
| NO992464D0 (no) | 1999-05-21 |
| ZA9710516B (en) | 1998-06-10 |
| CA2271438A1 (fr) | 1998-05-28 |
| DE69735274T2 (de) | 2006-10-12 |
| ES2260803T3 (es) | 2006-11-01 |
| CZ182299A3 (cs) | 1999-08-11 |
| AU5226198A (en) | 1998-06-10 |
| CA2271438C (fr) | 2010-10-26 |
| ATE317908T1 (de) | 2006-03-15 |
| EP0946741B1 (fr) | 2006-02-15 |
| FR2756297B1 (fr) | 1999-01-08 |
| AU731106B2 (en) | 2001-03-22 |
| SK286900B6 (sk) | 2009-07-06 |
| NO2013009I1 (no) | 2013-04-29 |
| KR20000057202A (ko) | 2000-09-15 |
| EP0946741A1 (fr) | 1999-10-06 |
| WO1998022607A1 (fr) | 1998-05-28 |
| US20030022356A1 (en) | 2003-01-30 |
| KR100719645B1 (ko) | 2007-05-17 |
| CZ293947B6 (cs) | 2004-08-18 |
| IL129686A0 (en) | 2000-02-29 |
| HUP0001762A2 (hu) | 2000-09-28 |
| SK66699A3 (en) | 2000-02-14 |
| IL129686A (en) | 2005-12-18 |
| JP4686670B2 (ja) | 2011-05-25 |
| JP2001503993A (ja) | 2001-03-27 |
| US6387670B1 (en) | 2002-05-14 |
| HUP0001762A3 (en) | 2002-01-28 |
| NO992464L (no) | 1999-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B25A | Requested transfer of rights approved |
Free format text: GENCELL S.A. (FR) |
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| B25D | Requested change of name of applicant approved |
Owner name: GENCELL SAS (FR) Free format text: ALTERADO DE: GENCELL S.A. |
|
| B25D | Requested change of name of applicant approved |
Owner name: CENTELION (FR) Free format text: ALTERADO DE: GENCELL SAS |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/03/2009, OBSERVADAS AS CONDICOES LEGAIS. |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 10.03.2019 |