BR9712100A - Intermediários e processo para preparar olanzapina. - Google Patents

Intermediários e processo para preparar olanzapina.

Info

Publication number
BR9712100A
BR9712100A BR9712100-2A BR9712100A BR9712100A BR 9712100 A BR9712100 A BR 9712100A BR 9712100 A BR9712100 A BR 9712100A BR 9712100 A BR9712100 A BR 9712100A
Authority
BR
Brazil
Prior art keywords
intermediates
preparing
preparing olanzapine
olanzapine
olazapine
Prior art date
Application number
BR9712100-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Charles A Bunnell
Samuel D Larsen
John R Nichols
Susan M Reutzel
Gregory A Stephenson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9712100(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9712100A publication Critical patent/BR9712100A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR9712100-2A 1996-09-23 1997-09-18 Intermediários e processo para preparar olanzapina. BR9712100A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23
PCT/US1997/016499 WO1998012199A1 (en) 1996-09-23 1997-09-18 Intermediates and process for preparing olanzapine

Publications (1)

Publication Number Publication Date
BR9712100A true BR9712100A (pt) 1999-08-31

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712100-2A BR9712100A (pt) 1996-09-23 1997-09-18 Intermediários e processo para preparar olanzapina.

Country Status (35)

Country Link
US (1) US6020487A (instruction)
EP (1) EP0831098B1 (instruction)
JP (2) JP2001500877A (instruction)
KR (1) KR100560015B1 (instruction)
CN (1) CN1122036C (instruction)
AR (1) AR013838A1 (instruction)
AT (1) ATE209208T1 (instruction)
AU (1) AU719441B2 (instruction)
BR (1) BR9712100A (instruction)
CA (1) CA2265712C (instruction)
CO (1) CO4910140A1 (instruction)
CZ (1) CZ299248B6 (instruction)
DE (1) DE69708428T2 (instruction)
DK (1) DK0831098T3 (instruction)
EA (1) EA001642B1 (instruction)
EG (1) EG23861A (instruction)
ES (1) ES2166051T3 (instruction)
HU (1) HU226484B1 (instruction)
ID (1) ID27275A (instruction)
IL (1) IL128962A (instruction)
IN (1) IN187156B (instruction)
MY (1) MY125565A (instruction)
NO (1) NO323980B1 (instruction)
NZ (1) NZ334448A (instruction)
PE (1) PE110398A1 (instruction)
PL (3) PL196068B1 (instruction)
PT (1) PT831098E (instruction)
RS (1) RS49598B (instruction)
SI (1) SI0831098T1 (instruction)
SV (1) SV1997000081A (instruction)
TR (1) TR199900640T2 (instruction)
TW (1) TW470746B (instruction)
UA (1) UA59371C2 (instruction)
WO (1) WO1998012199A1 (instruction)
ZA (1) ZA978515B (instruction)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004507548A (ja) * 2000-08-31 2004-03-11 ドクター・レディーズ・ラボラトリーズ・リミテッド オランザピン水和物の調製方法、及びこれを結晶形態のオランザピンに変換する方法
US6740753B2 (en) * 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
AU2002340328A1 (en) * 2001-10-29 2003-05-12 Janet I. Cord Olanzapine dihydrate-ii a process for its preparation and use thereof
JP4530664B2 (ja) 2001-12-24 2010-08-25 サン・ファーマシューティカル・インダストリーズ・リミテッド ２−メチル−４−（４−メチル−１−ピペラジニル）−１０Ｈ−チエノ［２，３−ｂ］［１，５］ベンゾジアゼピンの結晶形Ｉ、この結晶形Ｉの製造方法、及び医薬組成物
AU2003243153A1 (en) * 2002-04-23 2003-11-10 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
AU2003237305A1 (en) * 2002-05-31 2003-12-19 Geneva Pharmaceuticals, Inc. Process of preparation of olanzapine form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
JP2007511605A (ja) * 2003-11-18 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー オランザピン含有経皮薬物送達組成物
JP2007515428A (ja) * 2003-12-22 2007-06-14 テバ ファーマシューティカル インダストリーズ リミティド オランザピンの合成方法
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
US20070072845A1 (en) * 2004-02-19 2007-03-29 Davuluri Rammohan Rao Process for the preparation of olanzapine form 1 useful as antipsychotic drug
WO2006006185A1 (en) * 2004-07-14 2006-01-19 Shasun Chemicals And Drugs Limited Improved process for making form i of olanzapine.
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
US7829700B2 (en) 2004-09-06 2010-11-09 Shasun Chemicals And Drugs Limited Process for preparation of a pharmaceutically pure polymorphic form I of Olanzapine
KR20130030305A (ko) * 2004-11-16 2013-03-26 엘란 파마 인터내셔널 리미티드 주사가능한 나노입자형 올란자핀 제형
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
EP0582368B1 (en) * 1992-05-29 2001-01-24 Eli Lilly And Company Limited Thienobenzodiazepine derivatives for treatment of CNS disorders
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
IL128956A0 (en) * 1996-09-23 2000-02-17 Lilly Co Eli Olanzapine dihydrate D

Also Published As

Publication number Publication date
ID27275A (id) 2001-03-22
WO1998012199A1 (en) 1998-03-26
NZ334448A (en) 2000-08-25
HU226484B1 (en) 2009-03-02
JP2009242407A (ja) 2009-10-22
UA59371C2 (uk) 2003-09-15
ATE209208T1 (de) 2001-12-15
KR20000048520A (ko) 2000-07-25
PL332482A1 (en) 1999-09-13
TR199900640T2 (xx) 1999-06-21
CA2265712C (en) 2006-10-31
EP0831098B1 (en) 2001-11-21
US6020487A (en) 2000-02-01
KR100560015B1 (ko) 2006-03-15
CA2265712A1 (en) 1998-03-26
EA199900326A1 (ru) 1999-08-26
EA001642B1 (ru) 2001-06-25
IL128962A0 (en) 2000-02-17
NO991382L (no) 1999-03-22
EP0831098A3 (en) 1998-04-29
CO4910140A1 (es) 2000-04-24
ES2166051T3 (es) 2002-04-01
YU15599A (sh) 2001-12-26
DK0831098T3 (da) 2002-05-21
EG23861A (en) 2007-11-18
DE69708428D1 (de) 2002-01-03
CZ299248B6 (cs) 2008-05-28
EP0831098A2 (en) 1998-03-25
JP2001500877A (ja) 2001-01-23
SI0831098T1 (en) 2002-04-30
PL196069B1 (pl) 2007-12-31
SV1997000081A (es) 1999-01-14
HUP0000066A3 (en) 2000-11-28
AU719441B2 (en) 2000-05-11
HUP0000066A2 (hu) 2000-06-28
RS49598B (sr) 2007-06-04
ZA978515B (en) 1999-03-23
DE69708428T2 (de) 2002-07-04
CN1234802A (zh) 1999-11-10
PE110398A1 (es) 1999-01-14
IN187156B (instruction) 2002-02-16
MY125565A (en) 2006-08-30
PL194565B1 (pl) 2007-06-29
CZ99099A3 (cs) 1999-11-17
PT831098E (pt) 2002-04-29
TW470746B (en) 2002-01-01
HK1009807A1 (en) 1999-06-11
AR013838A1 (es) 2001-01-31
NO323980B1 (no) 2007-07-30
CN1122036C (zh) 2003-09-24
AU4484197A (en) 1998-04-14
NO991382D0 (no) 1999-03-22
PL196068B1 (pl) 2007-12-31
IL128962A (en) 2003-01-12

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL.7: C07D 415/04, C07D 243/10, A61K 31/55

Ipc: C07D 495/04 (2007.01), C07D 243/10 (2007.01), A61K

B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: COM A PETICAO NO020070092567, DE 09/07/2007, A REQUERENTE APRESENTOU MANIFESTACAO SOBRE O PARECER PUBLICADO NA RPI 1892, DE 10/04/2007, COM NOVAS VIAS DO QUADRO REIVINDICATORIO (TOTAL DE 15 REIVINDICACOES). NO ENTANTO, NA PETICAO NO 035063, DE 14/09/2000, ONDE A REQUERENTE SOLICITOU O EXAME DO PRESENTE PEDIDO, E INDICADO O PAGAMENTO RELATIVO A 13 REIVINDICACOES. DESSE MODO, A FIM DE DAR CONTINUIDADE AO EXAME DO PEDIDO, A REQUERENTE DEVERA COMPLEMENTAR A RETRIBUICAO EQUIVALENTE A 02 (DUAS) REIVINDICACOES EXCEDENTES

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO UMA VEZ QUE ESTE NAO ATENDE AOS ARTIGOS 8O E 13 DA LEI 9279/96 (LPI).

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.