BR9611401B1 - 2-azetidinonas substituìdas com açúcar úteis como agentes hipocolesterolêmicos, composição farmacêutica e kit contendo as mesmas . - Google Patents

2-azetidinonas substituìdas com açúcar úteis como agentes hipocolesterolêmicos, composição farmacêutica e kit contendo as mesmas .

Info

Publication number
BR9611401B1
BR9611401B1 BRPI9611401-0A BR9611401A BR9611401B1 BR 9611401 B1 BR9611401 B1 BR 9611401B1 BR 9611401 A BR9611401 A BR 9611401A BR 9611401 B1 BR9611401 B1 BR 9611401B1
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
kit containing
hypocholesterolemic agents
sugar substituted
azetidinones useful
Prior art date
Application number
BRPI9611401-0A
Other languages
English (en)
Other versions
BR9611401A (pt
Inventor
Nathan P Yumibe
Kevin B Alton
Margaret Van Heek
Harry R Davis
Wayne D Vaccaro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26677904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9611401(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of BR9611401A publication Critical patent/BR9611401A/pt
Publication of BR9611401B1 publication Critical patent/BR9611401B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
BRPI9611401-0A 1995-10-31 1996-10-29 2-azetidinonas substituìdas com açúcar úteis como agentes hipocolesterolêmicos, composição farmacêutica e kit contendo as mesmas . BR9611401B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US818595P 1995-10-31 1995-10-31
US57084795A 1995-12-12 1995-12-12
PCT/US1996/016823 WO1997016455A1 (en) 1995-10-31 1996-10-29 Sugar-substituted 2-azetidinones useful as hypocholesterolemic a gents

Publications (2)

Publication Number Publication Date
BR9611401A BR9611401A (pt) 1999-01-05
BR9611401B1 true BR9611401B1 (pt) 2010-08-10

Family

ID=26677904

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9612998-0A BR9612998B1 (pt) 1995-10-31 1996-10-29 2-azetidinonas substituÍdas com aÇécar éteis como agentes hipocolesterolÊmicos, composiÇço farmacÊutica e kit contendo as mesmas.
BRPI9611401-0A BR9611401B1 (pt) 1995-10-31 1996-10-29 2-azetidinonas substituìdas com açúcar úteis como agentes hipocolesterolêmicos, composição farmacêutica e kit contendo as mesmas .

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI9612998-0A BR9612998B1 (pt) 1995-10-31 1996-10-29 2-azetidinonas substituÍdas com aÇécar éteis como agentes hipocolesterolÊmicos, composiÇço farmacÊutica e kit contendo as mesmas.

Country Status (28)

Country Link
EP (1) EP0877750B1 (pt)
JP (2) JP3385031B2 (pt)
KR (1) KR100311554B1 (pt)
CN (1) CN1103780C (pt)
AR (1) AR004701A1 (pt)
AT (1) ATE219495T1 (pt)
AU (1) AU712158B2 (pt)
BR (2) BR9612998B1 (pt)
CA (1) CA2235943C (pt)
CY (1) CY2353B1 (pt)
CZ (1) CZ293957B6 (pt)
DE (1) DE69621952T2 (pt)
DK (1) DK0877750T3 (pt)
ES (1) ES2175141T3 (pt)
GE (1) GEP20033006B (pt)
HK (1) HK1012507A1 (pt)
HU (1) HU226822B1 (pt)
ID (1) ID16177A (pt)
IL (1) IL124268A (pt)
MX (1) MX9803447A (pt)
MY (1) MY114803A (pt)
NO (1) NO311692B1 (pt)
NZ (1) NZ321766A (pt)
PL (1) PL184698B1 (pt)
PT (1) PT877750E (pt)
SK (1) SK283552B6 (pt)
TW (1) TW448181B (pt)
WO (1) WO1997016455A1 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (de) * 2000-08-29 2002-03-28 Aventis Pharma Gmbh Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
EP1510521A1 (en) * 2000-12-20 2005-03-02 Schering Corporation Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents
EP1347987B1 (en) * 2000-12-20 2004-10-13 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
RS50864B (sr) * 2000-12-21 2010-08-31 Sanofi-Aventis Deutschland Gmbh. Novi 1,2-difenil-azetidinoni, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena za lečenje poremećaja u metabolizmu lipida
KR100820983B1 (ko) * 2001-01-26 2008-04-10 쉐링 코포레이션 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
CN1658903A (zh) * 2001-01-26 2005-08-24 先灵公司 用于治疗血管性疾病的固醇吸收抑制剂与血液调节剂的组合
AU2005246926B2 (en) * 2001-01-26 2008-02-28 Merck Sharp & Dohme Corp. The use of substituted azetidinone compounds for the treatment of sitosterolemia
TWI291957B (en) * 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
DE60206365T2 (de) 2001-03-28 2006-07-06 Schering Corporation, Kenilworth Verfahren für die enantioselektive synthese von azetidinon-zwischenprodukten
CA2460340C (en) * 2001-09-21 2011-02-15 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
DE10227506A1 (de) * 2002-06-19 2004-01-08 Aventis Pharma Deutschland Gmbh Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7176193B2 (en) 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176194B2 (en) 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7671047B2 (en) 2002-06-19 2010-03-02 Sanofi-Aventis Deutschland Gmbh Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
AR041089A1 (es) 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
JP2005015434A (ja) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
WO2005044256A1 (en) * 2003-10-30 2005-05-19 Merck & Co., Inc. 2-azetidinones as anti-hypercholesterolemic agents
US7871998B2 (en) 2003-12-23 2011-01-18 Astrazeneca Ab Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
JP2008539255A (ja) * 2005-04-26 2008-11-13 マイクロビア インコーポレーテッド 高コレステロール血症のための４−ビアリーリル−１−フェニルアゼチジン−２−オングルクロニド誘導体
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
JP2009512715A (ja) 2005-10-21 2009-03-26 ノバルティス アクチエンゲゼルシャフト レニン阻害剤と抗異脂肪血症剤および／または抗肥満症剤の組み合わせ
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
US20080319221A1 (en) 2007-06-22 2008-12-25 Bernd Junker Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
WO2010100255A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
CN103102297A (zh) * 2012-09-28 2013-05-15 北京赛林泰医药技术有限公司 一种新的依折麦布的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
CA2120221A1 (en) * 1993-04-23 1994-10-24 Allan W. Rey N-substituted 2-azetidinones
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

Also Published As

Publication number Publication date
CY2353B1 (en) 2004-06-04
BR9611401A (pt) 1999-01-05
CN1103780C (zh) 2003-03-26
EP0877750B1 (en) 2002-06-19
NO981950L (no) 1998-06-26
AU712158B2 (en) 1999-10-28
EP0877750A1 (en) 1998-11-18
JPH10512592A (ja) 1998-12-02
HU226822B1 (en) 2009-11-30
MX9803447A (es) 1998-09-30
AR004701A1 (es) 1999-03-10
KR100311554B1 (ko) 2002-06-20
JP3385031B2 (ja) 2003-03-10
SK283552B6 (sk) 2003-09-11
SK48398A3 (en) 1998-11-04
ID16177A (id) 1997-09-11
ES2175141T3 (es) 2002-11-16
PL327987A1 (en) 1999-01-04
AU7517996A (en) 1997-05-22
HUP9802539A2 (hu) 1998-11-30
PT877750E (pt) 2002-09-30
IL124268A (en) 2005-08-31
CZ293957B6 (cs) 2004-08-18
WO1997016455A1 (en) 1997-05-09
CZ129498A3 (cs) 1998-10-14
PL184698B1 (pl) 2002-12-31
NO311692B1 (no) 2002-01-07
NO981950D0 (no) 1998-04-29
CA2235943C (en) 2002-10-01
GEP20033006B (en) 2003-07-10
HK1012507A1 (en) 1999-08-06
DE69621952D1 (de) 2002-07-25
CN1205707A (zh) 1999-01-20
DE69621952T2 (de) 2003-01-16
KR19990067202A (ko) 1999-08-16
MY114803A (en) 2003-01-31
DK0877750T3 (da) 2002-07-15
ATE219495T1 (de) 2002-07-15
BR9612998B1 (pt) 2010-03-23
CA2235943A1 (en) 1997-05-09
NZ321766A (en) 1999-07-29
JP2001048895A (ja) 2001-02-20
HUP9802539A3 (en) 1999-12-28
TW448181B (en) 2001-08-01

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE NAO ATENDE AO REQUISITO DA SUFICIENCIA DESCRITIVA ( ART. 24 COMBINADO COM O ART. 25 DA LPI)

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI-52400.061553/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132273-17.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU:OSI PHARMACEUTICALS, LLC , PFIZER, SANOFI-AVERTI, , SANOFI-AVERTI DEUTCHLAND GMBH, SCHERING CORPORATION.

B25G Requested change of headquarter approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

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B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

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Free format text: INPI NO 52402.005802/2020-39 TRIBUNAL REGIONAL FEDERAL DA 2A REGIAO PROCESSO : NO 5004917-81.2020.4.02.0000/RJ REQUERENTE: MERCK SHARP AND DOHME CORPORATION REQUERENTE: PFIZER PRODUCTS REQUERENTE: OSI PHARMACEUTICALS, LLC. REQUERIDO: INPI-INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL MPF: MINISTERIO PUBLICO FEDERAL AMICUS CURIAE: ASSOCIACAO BRAS DAS IND DE Q FINA B E SUAS ESP ABIFINA AMICUS CURIAE: INTERFARMA ASSOCIACAO DA INDUSTRIA FARMACEUTICA DE PESQUISA INTERESSADO: SANOFI-AVENTIS DEUTSCHLAND GMBM INTERESSADO: SANOFI AVENTIS INTERESSADO: ZOETIS LLC DECISAO: ANTE O EXPOSTO, ATRIBUO EFEITO SUSPENSIVO A APELACAO INTERPOSTA NO PROCESSO NO 0132273-17.2013.4.02.5101 POR OSI PHARMA

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Free format text: INPI NO 52400.061553/2013-52 NUP: 00848.000587/2019-11 (REF. 00408.129415/2017-38) INTERESSADOS: THE PROVOST FELLOWS AND SCHOLARS OF THE HOLY UNDIVIDED TRINITYOF QUEEN ELIZABETH NEAR DUBLIN E OUTROS DECISAO: ?EM FACE DO EXPOSTO, CONCEDO A TUTELA PROVISORIA POSTULADA PARA DETERMINAR O EFEITO SUSPENSIVO AO RECURSO ESPECIAL, MANTENDO A VIGENCIA DAS PATENTES TIPO MAILBOX CONCEDIDAS PELO INPI, CONFORME O ENTENDIMENTO ANTERIOR, ATE POSTERIOR SOLUCAO DA CAUSA".