MX9803447A - 2-azetidinonas substituidas con azucares, utiles como agentes hipocolesterolemicos. - Google Patents

2-azetidinonas substituidas con azucares, utiles como agentes hipocolesterolemicos.

Info

Publication number
MX9803447A
MX9803447A MX9803447A MX9803447A MX9803447A MX 9803447 A MX9803447 A MX 9803447A MX 9803447 A MX9803447 A MX 9803447A MX 9803447 A MX9803447 A MX 9803447A MX 9803447 A MX9803447 A MX 9803447A
Authority
MX
Mexico
Prior art keywords
sugar
substituted
hypocholesterolemic
gents
cholesterol
Prior art date
Application number
MX9803447A
Other languages
English (en)
Inventor
Nathan P Yumibe
Kevin B Alton
Margaret Van Heek
Harry R Davis
Wayne D Vaccaro
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26677904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9803447(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX9803447A publication Critical patent/MX9803447A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se descubren 2-azetidionas hipocolesterolémicas, substituidas con azucares, así como también un método para la disminucion de colesterol, administrando dichos composiciones farmacéuticas que los contienen, y la combinacion de un agente de 2-azetidinona substituida con azucar, reductor del colesterol, y un inhibidor de la biosíntesis del colesterol, para el tratamiento y prevencion de arterosclerosis.
MX9803447A 1995-10-31 1998-04-30 2-azetidinonas substituidas con azucares, utiles como agentes hipocolesterolemicos. MX9803447A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US818595P 1995-10-31 1995-10-31
US57084795A 1995-12-12 1995-12-12

Publications (1)

Publication Number Publication Date
MX9803447A true MX9803447A (es) 1998-09-30

Family

ID=26677904

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803447A MX9803447A (es) 1995-10-31 1998-04-30 2-azetidinonas substituidas con azucares, utiles como agentes hipocolesterolemicos.

Country Status (28)

Country Link
EP (1) EP0877750B1 (es)
JP (2) JP3385031B2 (es)
KR (1) KR100311554B1 (es)
CN (1) CN1103780C (es)
AR (1) AR004701A1 (es)
AT (1) ATE219495T1 (es)
AU (1) AU712158B2 (es)
BR (2) BR9611401B1 (es)
CA (1) CA2235943C (es)
CY (1) CY2353B1 (es)
CZ (1) CZ293957B6 (es)
DE (1) DE69621952T2 (es)
DK (1) DK0877750T3 (es)
ES (1) ES2175141T3 (es)
GE (1) GEP20033006B (es)
HK (1) HK1012507A1 (es)
HU (1) HU226822B1 (es)
ID (1) ID16177A (es)
IL (1) IL124268A (es)
MX (1) MX9803447A (es)
MY (1) MY114803A (es)
NO (1) NO311692B1 (es)
NZ (1) NZ321766A (es)
PL (1) PL184698B1 (es)
PT (1) PT877750E (es)
SK (1) SK283552B6 (es)
TW (1) TW448181B (es)
WO (1) WO1997016455A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (de) * 2000-08-29 2002-03-28 Aventis Pharma Gmbh Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports
CN100475829C (zh) * 2000-12-20 2009-04-08 先灵公司 作为降血胆甾醇剂的糖取代的2-氮杂环丁烷酮
EP1510521A1 (en) * 2000-12-20 2005-03-02 Schering Corporation Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents
AU1609702A (en) * 2000-12-21 2002-07-01 Aventis Pharma Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
RU2756946C2 (ru) * 2001-01-26 2021-10-07 Мерк Шарп И Доум Корп. Применение замещенных азетидинонов для лечения ситостеролемии
AU2005246926B2 (en) * 2001-01-26 2008-02-28 Merck Sharp & Dohme Corp. The use of substituted azetidinone compounds for the treatment of sitosterolemia
PT1353694E (pt) * 2001-01-26 2008-03-12 Schering Corp Combinações de ezetimiba com aspirina para o tratamento de doenças vasculares
TWI291957B (en) * 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
RS50386B (sr) 2001-03-28 2009-12-31 Schering Corporation, Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona
EP1429756B1 (en) * 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7671047B2 (en) 2002-06-19 2010-03-02 Sanofi-Aventis Deutschland Gmbh Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176193B2 (en) 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
DE10227506A1 (de) * 2002-06-19 2004-01-08 Aventis Pharma Deutschland Gmbh Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7176194B2 (en) 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
AR041089A1 (es) 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
JP2005015434A (ja) 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
EP1522541A1 (en) * 2003-10-07 2005-04-13 Lipideon Biotechnology AG Novel hypocholesterolemic compounds
CN1870988A (zh) * 2003-10-30 2006-11-29 默克公司 作为抗高胆固醇血症药的2－氮杂环丁烷酮
WO2005061452A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US20080194494A1 (en) * 2005-04-26 2008-08-14 Microbia, Inc. 4-Biarylyl-1-Phenylazetidin-2-One Glucuronide Derivatives for Hypercholesterolemia
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
RU2008119687A (ru) 2005-10-21 2009-11-27 Новартис АГ (CH) Комбинации органических соединений
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
US20080319221A1 (en) 2007-06-22 2008-12-25 Bernd Junker Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
WO2010100255A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
CN103102297A (zh) * 2012-09-28 2013-05-15 北京赛林泰医药技术有限公司 一种新的依折麦布的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3595B (en) * 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
CA2120221A1 (en) * 1993-04-23 1994-10-24 Allan W. Rey N-substituted 2-azetidinones
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

Also Published As

Publication number Publication date
NO981950D0 (no) 1998-04-29
JP3385031B2 (ja) 2003-03-10
HU226822B1 (en) 2009-11-30
ATE219495T1 (de) 2002-07-15
JPH10512592A (ja) 1998-12-02
CZ129498A3 (cs) 1998-10-14
EP0877750A1 (en) 1998-11-18
CA2235943C (en) 2002-10-01
ES2175141T3 (es) 2002-11-16
NO311692B1 (no) 2002-01-07
MY114803A (en) 2003-01-31
SK283552B6 (sk) 2003-09-11
SK48398A3 (en) 1998-11-04
NO981950L (no) 1998-06-26
KR100311554B1 (ko) 2002-06-20
HK1012507A1 (en) 1999-08-06
CZ293957B6 (cs) 2004-08-18
PT877750E (pt) 2002-09-30
WO1997016455A1 (en) 1997-05-09
ID16177A (id) 1997-09-11
JP2001048895A (ja) 2001-02-20
CY2353B1 (en) 2004-06-04
PL184698B1 (pl) 2002-12-31
DE69621952D1 (de) 2002-07-25
GEP20033006B (en) 2003-07-10
DK0877750T3 (da) 2002-07-15
CA2235943A1 (en) 1997-05-09
IL124268A (en) 2005-08-31
AU7517996A (en) 1997-05-22
BR9612998B1 (pt) 2010-03-23
NZ321766A (en) 1999-07-29
CN1103780C (zh) 2003-03-26
HUP9802539A2 (hu) 1998-11-30
CN1205707A (zh) 1999-01-20
BR9611401A (pt) 1999-01-05
BR9611401B1 (pt) 2010-08-10
KR19990067202A (ko) 1999-08-16
PL327987A1 (en) 1999-01-04
TW448181B (en) 2001-08-01
DE69621952T2 (de) 2003-01-16
AU712158B2 (en) 1999-10-28
AR004701A1 (es) 1999-03-10
EP0877750B1 (en) 2002-06-19
HUP9802539A3 (en) 1999-12-28

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