BR9401482A - 1H-Indol-3-acetamida, formulação farmacêutica, utilização de um composto e processo para a preparação de 1h-indol-3-acetamida - Google Patents
1H-Indol-3-acetamida, formulação farmacêutica, utilização de um composto e processo para a preparação de 1h-indol-3-acetamidaInfo
- Publication number
- BR9401482A BR9401482A BR9401482A BR9401482A BR9401482A BR 9401482 A BR9401482 A BR 9401482A BR 9401482 A BR9401482 A BR 9401482A BR 9401482 A BR9401482 A BR 9401482A BR 9401482 A BR9401482 A BR 9401482A
- Authority
- BR
- Brazil
- Prior art keywords
- acetamide
- indole
- indol
- compound
- preparation
- Prior art date
Links
- ZOAMBXDOGPRZLP-UHFFFAOYSA-N indole-3-acetamide Chemical compound C1=CC=C2C(CC(=O)N)=CNC2=C1 ZOAMBXDOGPRZLP-UHFFFAOYSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 abstract 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4862993A | 1993-04-16 | 1993-04-16 | |
| US20872194A | 1994-03-15 | 1994-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9401482A true BR9401482A (pt) | 1994-10-18 |
Family
ID=26726342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9401482A BR9401482A (pt) | 1993-04-16 | 1994-04-14 | 1H-Indol-3-acetamida, formulação farmacêutica, utilização de um composto e processo para a preparação de 1h-indol-3-acetamida |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5684034A (OSRAM) |
| EP (1) | EP0620215B1 (OSRAM) |
| JP (1) | JPH0725850A (OSRAM) |
| KR (1) | KR100317755B1 (OSRAM) |
| CN (1) | CN1068588C (OSRAM) |
| AT (1) | ATE183503T1 (OSRAM) |
| AU (1) | AU676884B2 (OSRAM) |
| BR (1) | BR9401482A (OSRAM) |
| CA (1) | CA2121323A1 (OSRAM) |
| CO (1) | CO4230092A1 (OSRAM) |
| CZ (1) | CZ289750B6 (OSRAM) |
| DE (1) | DE69420068T2 (OSRAM) |
| DK (1) | DK0620215T3 (OSRAM) |
| ES (1) | ES2138648T3 (OSRAM) |
| FI (1) | FI941767A7 (OSRAM) |
| GR (1) | GR3031783T3 (OSRAM) |
| HU (1) | HUT70836A (OSRAM) |
| IL (1) | IL109311A0 (OSRAM) |
| NO (1) | NO300732B1 (OSRAM) |
| NZ (1) | NZ260298A (OSRAM) |
| PL (1) | PL181319B1 (OSRAM) |
| RU (1) | RU2162463C2 (OSRAM) |
| TW (1) | TW268942B (OSRAM) |
| UA (1) | UA44218C2 (OSRAM) |
| YU (1) | YU20194A (OSRAM) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| US6252084B1 (en) | 1994-03-15 | 2001-06-26 | Eli Lilly And Company | 1H-indole-3-acetamide sPLA2 inhibitors |
| JP3109974B2 (ja) * | 1994-04-01 | 2000-11-20 | イーライ・リリー・アンド・カンパニー | １Ｈ−インドール−３−グリオキシルアミドｓＰＬＡ２阻害剤 |
| US6214876B1 (en) | 1994-07-21 | 2001-04-10 | Eli Lilly And Company | Indene-1-acetamide sPLA2 inhibitors |
| US5641800A (en) * | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
| US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
| EP0922028A1 (en) * | 1996-08-26 | 1999-06-16 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
| KR20000049210A (ko) * | 1996-10-30 | 2000-07-25 | 피터 지. 스트링거 | 치환된 트리시클릭류 |
| US6569539B2 (en) | 1996-10-30 | 2003-05-27 | Tetra Level Holdings & Finance S.A. | Gas barrier packaging laminate method for production thereof and packaging containers |
| US6713645B1 (en) * | 1996-10-30 | 2004-03-30 | Eli Lilly And Company | Substituted tricyclics |
| US5919774A (en) * | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
| WO1998037069A1 (en) * | 1997-02-20 | 1998-08-27 | Shionogi & Co., Ltd. | Indole dicarboxylic acid derivatives |
| PL343007A1 (en) * | 1998-02-25 | 2001-07-30 | Genetics Inst | Inhibitors of phospholipase enzymes |
| US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| CA2322163A1 (en) * | 1998-02-25 | 1999-09-02 | John Mckew | Inhibitors of phospholipase a2 |
| SK12742000A3 (sk) * | 1998-02-25 | 2001-05-10 | Genetics Institute, Inc. | Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie |
| US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| HUP0102981A3 (en) | 1998-03-31 | 2002-10-28 | Shionogi & Co | Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof |
| DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
| IL129484A0 (en) * | 1998-04-17 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
| KR20010034881A (ko) | 1998-05-21 | 2001-04-25 | 시오노 요시히코 | ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체 |
| US6608099B1 (en) | 1998-08-03 | 2003-08-19 | Eli Lilly And Company | Indole sPLA2 inhibitors |
| JP2002522385A (ja) | 1998-08-03 | 2002-07-23 | イーライ・リリー・アンド・カンパニー | インドールｓＰＬＡ２インヒビター |
| AU6240099A (en) | 1998-08-24 | 2000-03-14 | Susan E Draheim | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2 |
| ATE329619T1 (de) | 1998-10-14 | 2006-07-15 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
| US6448284B1 (en) | 1998-12-22 | 2002-09-10 | Eli Lilly And Company | Substituted tricyclics |
| AU6015600A (en) | 1999-07-19 | 2001-02-05 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
| CA2379208A1 (en) * | 1999-07-19 | 2001-01-25 | Eli Lilly & Company | Spla2 inhibitors |
| US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
| US6673781B1 (en) | 1999-08-02 | 2004-01-06 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
| US6787545B1 (en) | 1999-08-23 | 2004-09-07 | Shiongi & Co., Ltd. | Pyrrolotriazine derivatives having spla2-inhibitory activities |
| WO2001021587A2 (en) * | 1999-09-20 | 2001-03-29 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as spla2 inhibitors |
| US6831095B1 (en) | 1999-09-20 | 2004-12-14 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors |
| AU7559600A (en) * | 1999-10-15 | 2001-04-23 | Shionogi & Co., Ltd. | V type and/or x type spla2 inhibitors |
| US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| WO2002000646A1 (en) * | 2000-06-27 | 2002-01-03 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
| WO2002000256A1 (fr) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes contre la cirrhose |
| JPWO2002000621A1 (ja) * | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | Ｘ型ｓＰＬＡ２阻害作用を有する化合物 |
| US20050203166A1 (en) * | 2000-06-30 | 2005-09-15 | Cancer Research Technology Limited | Indole-3-acetic acid derivatives |
| GB0016162D0 (en) * | 2000-06-30 | 2000-08-23 | Cancer Res Campaign Tech | Indole-3-acetic acid derivatives |
| EP1303262A2 (en) * | 2000-07-14 | 2003-04-23 | Eli Lilly And Company | Use of a spla2 inhibitor for the treatment of sepsis |
| WO2002020478A1 (en) * | 2000-08-24 | 2002-03-14 | Dublin City University | N-benzylindole-3-acetic acid derivatives for use in the treatment of drug resistan cancer |
| ATE354567T1 (de) | 2000-12-18 | 2007-03-15 | Lilly Co Eli | Benz(g)indole und deren verwendung als spla2 inhibitoren |
| JP2004518658A (ja) * | 2000-12-18 | 2004-06-24 | イーライ・リリー・アンド・カンパニー | 新規なｓＰＬＡ２インヒビター |
| TWI314457B (OSRAM) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US7129264B2 (en) * | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
| US20070161698A1 (en) * | 2003-05-30 | 2007-07-12 | Microbia, Inc. | Modulators of CRTH2 Activity |
| JP2007527397A (ja) * | 2003-07-01 | 2007-09-27 | マイクロバイア インコーポレイテッド | Ｃｏｘ−２及びｆａａｈ阻害剤 |
| WO2005037227A2 (en) * | 2003-10-16 | 2005-04-28 | Microbia, Inc. | Selective cox-2 inhibitors |
| US7417063B2 (en) * | 2004-04-13 | 2008-08-26 | Bristol-Myers Squibb Company | Bicyclic heterocycles useful as serine protease inhibitors |
| US20050234244A1 (en) * | 2004-04-20 | 2005-10-20 | Wilmin Bartolini | Synthesis of COX-2 and FAAH inhibitors |
| US20050234030A1 (en) * | 2004-04-20 | 2005-10-20 | Wilmin Bartolini | Modulators of CRTH2, COX-2 and FAAH |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| US20070203209A1 (en) * | 2005-08-18 | 2007-08-30 | Wilmin Bartolini | Useful indole compounds |
| US7666898B2 (en) | 2005-11-03 | 2010-02-23 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors |
| CA2627352A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US8048880B2 (en) * | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
| NZ720946A (en) | 2009-04-29 | 2017-09-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| CN105384619B (zh) * | 2014-08-22 | 2020-05-29 | 四川海思科制药有限公司 | 一种异丙基苯酚衍生物及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2825734A (en) * | 1955-04-11 | 1958-03-04 | Upjohn Co | Reduction of carbonylic radicals in indolyl-3 compounds |
| US2890223A (en) * | 1956-03-22 | 1959-06-09 | Research Corp | 1-benzyl, 2-methyl, 5-methoxy tryptamine |
| US3242193A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
| US3242162A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
| US3242163A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
| US3196162A (en) * | 1961-03-13 | 1965-07-20 | Merck & Co Inc | Indolyl aliphatic acids |
| US3271416A (en) * | 1961-10-24 | 1966-09-06 | Merck & Co Inc | Indolyl aliphatic acids |
| US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
| US4428962A (en) * | 1981-10-30 | 1984-01-31 | Schering Corporation | Indoles in treatment of peptic ulcers |
| WO1988005432A1 (fr) * | 1987-01-23 | 1988-07-28 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de 5-hydroxyindole-3-carboxamide et son usage en medecine |
| US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
-
1994
- 1994-04-12 IL IL10931194A patent/IL109311A0/xx unknown
- 1994-04-13 TW TW083103301A patent/TW268942B/zh active
- 1994-04-13 NZ NZ260298A patent/NZ260298A/en unknown
- 1994-04-13 HU HU9401060A patent/HUT70836A/hu unknown
- 1994-04-14 EP EP94302666A patent/EP0620215B1/en not_active Expired - Lifetime
- 1994-04-14 CO CO94014981A patent/CO4230092A1/es unknown
- 1994-04-14 DK DK94302666T patent/DK0620215T3/da active
- 1994-04-14 BR BR9401482A patent/BR9401482A/pt not_active Application Discontinuation
- 1994-04-14 AT AT94302666T patent/ATE183503T1/de not_active IP Right Cessation
- 1994-04-14 CA CA002121323A patent/CA2121323A1/en not_active Abandoned
- 1994-04-14 CZ CZ1994893A patent/CZ289750B6/cs not_active IP Right Cessation
- 1994-04-14 DE DE69420068T patent/DE69420068T2/de not_active Expired - Fee Related
- 1994-04-14 ES ES94302666T patent/ES2138648T3/es not_active Expired - Lifetime
- 1994-04-15 CN CN94104434A patent/CN1068588C/zh not_active Expired - Fee Related
- 1994-04-15 KR KR1019940007935A patent/KR100317755B1/ko not_active Expired - Fee Related
- 1994-04-15 AU AU59492/94A patent/AU676884B2/en not_active Ceased
- 1994-04-15 PL PL94303028A patent/PL181319B1/pl unknown
- 1994-04-15 JP JP6077650A patent/JPH0725850A/ja active Pending
- 1994-04-15 NO NO941361A patent/NO300732B1/no not_active IP Right Cessation
- 1994-04-15 YU YU20194A patent/YU20194A/sh unknown
- 1994-04-15 UA UA94005180A patent/UA44218C2/uk unknown
- 1994-04-15 RU RU94012930/04A patent/RU2162463C2/ru active
- 1994-04-15 FI FI941767A patent/FI941767A7/fi unknown
-
1995
- 1995-05-05 US US08/435,256 patent/US5684034A/en not_active Expired - Lifetime
-
1999
- 1999-11-08 GR GR990402875T patent/GR3031783T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE183503T1 (de) | 1999-09-15 |
| RU2162463C2 (ru) | 2001-01-27 |
| ES2138648T3 (es) | 2000-01-16 |
| HU9401060D0 (en) | 1994-07-28 |
| HUT70836A (en) | 1995-11-28 |
| PL181319B1 (pl) | 2001-07-31 |
| CZ289750B6 (cs) | 2002-03-13 |
| TW268942B (OSRAM) | 1996-01-21 |
| DK0620215T3 (da) | 1999-12-06 |
| YU20194A (sh) | 1997-09-30 |
| IL109311A0 (en) | 1994-07-31 |
| JPH0725850A (ja) | 1995-01-27 |
| AU676884B2 (en) | 1997-03-27 |
| US5684034A (en) | 1997-11-04 |
| EP0620215B1 (en) | 1999-08-18 |
| UA44218C2 (uk) | 2002-02-15 |
| NO941361L (no) | 1994-10-17 |
| NZ260298A (en) | 1996-05-28 |
| AU5949294A (en) | 1994-10-20 |
| CN1068588C (zh) | 2001-07-18 |
| DE69420068D1 (de) | 1999-09-23 |
| FI941767L (fi) | 1994-10-17 |
| GR3031783T3 (en) | 2000-02-29 |
| CZ89394A3 (en) | 1994-12-15 |
| FI941767A0 (fi) | 1994-04-15 |
| EP0620215A1 (en) | 1994-10-19 |
| DE69420068T2 (de) | 1999-12-23 |
| NO300732B1 (no) | 1997-07-14 |
| CA2121323A1 (en) | 1994-10-17 |
| FI941767A7 (fi) | 1994-10-17 |
| NO941361D0 (no) | 1994-04-15 |
| CO4230092A1 (es) | 1995-10-19 |
| KR100317755B1 (ko) | 2002-08-09 |
| CN1098715A (zh) | 1995-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EE | Request for examination | ||
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal | ||
| FC | Decision: refusal | ||
| HIFC | Refusal cancelled |