BR9100767A - Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalino - Google Patents
Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalinoInfo
- Publication number
- BR9100767A BR9100767A BR919100767A BR9100767A BR9100767A BR 9100767 A BR9100767 A BR 9100767A BR 919100767 A BR919100767 A BR 919100767A BR 9100767 A BR9100767 A BR 9100767A BR 9100767 A BR9100767 A BR 9100767A
- Authority
- BR
- Brazil
- Prior art keywords
- amino
- preparation
- tetrahidrobenz
- hypurate
- propil
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000002131 composite material Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- YTOJFUORFUYGSV-UHFFFAOYSA-N 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide Chemical compound C1=C(C(N)=O)C(CC(N(CCC)CCC)C2)=C3C2=CNC3=C1 YTOJFUORFUYGSV-UHFFFAOYSA-N 0.000 abstract 1
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48518590A | 1990-02-26 | 1990-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9100767A true BR9100767A (pt) | 1991-10-29 |
Family
ID=23927224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR919100767A BR9100767A (pt) | 1990-02-26 | 1991-02-26 | Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalino |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5397799A (cs) |
| EP (1) | EP0444852B1 (cs) |
| JP (1) | JP3157007B2 (cs) |
| KR (1) | KR100208114B1 (cs) |
| CN (1) | CN1027503C (cs) |
| AT (1) | ATE126506T1 (cs) |
| AU (1) | AU629453B2 (cs) |
| BR (1) | BR9100767A (cs) |
| CA (1) | CA2037099C (cs) |
| CY (1) | CY1887A (cs) |
| DE (1) | DE69112099T2 (cs) |
| DK (1) | DK0444852T3 (cs) |
| ES (1) | ES2077796T3 (cs) |
| FI (1) | FI95464C (cs) |
| GR (1) | GR3017940T3 (cs) |
| HK (1) | HK175495A (cs) |
| HU (1) | HU217118B (cs) |
| IE (1) | IE67801B1 (cs) |
| IL (1) | IL97306A (cs) |
| LV (1) | LV10251B (cs) |
| NO (1) | NO174149C (cs) |
| NZ (1) | NZ237181A (cs) |
| PT (1) | PT96852B (cs) |
| RU (2) | RU2034837C1 (cs) |
| SG (1) | SG69975A1 (cs) |
| TW (1) | TW219933B (cs) |
| YU (1) | YU47594B (cs) |
| ZA (1) | ZA911258B (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL97308A (en) * | 1990-02-26 | 1996-10-31 | Lilly Co Eli | 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them |
| IL97309A (en) * | 1990-02-26 | 1996-11-14 | Lilly Co Eli | Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof |
| US5302612A (en) * | 1990-02-26 | 1994-04-12 | Eli Lilly And Company | 6-substituted-hexahydrobenz[cd]indoles |
| US5364856A (en) * | 1991-03-28 | 1994-11-15 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles |
| US5643910A (en) * | 1991-03-28 | 1997-07-01 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[CD]indoles |
| TW248556B (cs) * | 1993-01-18 | 1995-06-01 | Takeda Pharm Industry Co | |
| UA53205C2 (en) * | 2002-04-03 | 2006-06-15 | Pharmatech Close Joint Stock C | Antidepressant formulation and method for its manufacture |
| US7588924B2 (en) | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
| NZ601730A (en) | 2006-06-26 | 2014-04-30 | Akebia Therapeutics Inc | Prolyl hydroxylase inhibitors and methods of use |
| NZ600400A (en) | 2009-11-06 | 2014-09-26 | Aerpio Therapeutics Inc | Methods for increasing the stabilization of hypoxia inducible factor-1 alpha |
| NO2686520T3 (cs) | 2011-06-06 | 2018-03-17 | ||
| CN103717214A (zh) | 2011-06-06 | 2014-04-09 | 阿克比治疗有限公司 | 用于稳定低氧诱导因子-2α作为治疗癌症的方法的化合物和组合物 |
| PL3007695T3 (pl) | 2013-06-13 | 2024-07-01 | Akebia Therapeutics, Inc. | Kompozycje i sposoby leczenia niedokrwistości |
| AR099354A1 (es) | 2013-11-15 | 2016-07-20 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos |
| AU2016209126A1 (en) | 2015-01-23 | 2017-08-10 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| UA123308C2 (uk) | 2015-04-01 | 2021-03-17 | Екебіа Терапьютікс, Інк. | Композиції і способи для лікування анемії |
| MX2020011845A (es) | 2018-05-09 | 2021-01-15 | Akebia Therapeutics Inc | Proceso para preparar acido 2-[[5-(3-clorofenil)-3-hidroxipiridina -2-carbonil]amino]acetico. |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110339A (en) * | 1977-11-25 | 1978-08-29 | Eli Lilly And Company | 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole |
| US4576959A (en) * | 1984-02-06 | 1986-03-18 | Eli Lilly And Company | 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles |
| US4745126A (en) * | 1987-03-12 | 1988-05-17 | Eli Lilly And Company | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides |
| DE3809155A1 (de) * | 1988-03-18 | 1989-09-28 | Bayer Ag | 1,3,4,5-tetrahydrobenz-(c,d)-indole |
| US5204340A (en) * | 1989-04-11 | 1993-04-20 | Eli Lilly And Company | Tetrahydrobenz(c,d)indole serotonin agonists |
| US5229409A (en) * | 1990-08-15 | 1993-07-20 | Eli Lilly And Company | 6-substituted-tetrahydrobenz[cd]indoles |
-
1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
-
1991
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active Expired - Fee Related
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
-
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
-
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
-
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/en not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9100767A (pt) | Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalino | |
| GR3030668T3 (en) | Condensed indole derivatives as 5ht 4?-receptor antagonists. | |
| AU2965889A (en) | 3 (3-indoyl) pyrrole-2,5-dione derivatives | |
| AU4024689A (en) | Substituted 4-azatricyclo (22.3.1.0 4,9) octacos-18-ene derivatives | |
| NO902933L (no) | Fremgangsmaate for fremstilling av 2-(aminoaryl)indoler ogindoliner samt anvendelse som medikamenter. | |
| FI921347A7 (fi) | 6-heterosyklinen-4-amino-1,3,4,5-tetrahydrobents/cd/indoleja | |
| AU1462095A (en) | Indole derivatives as 5-ht1 agonists | |
| NO913745D0 (no) | Fremgangsmaate for fremstilling av 1,3-benzoksazinderivater | |
| RU92004575A (ru) | Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры | |
| HU9302749D0 (en) | 6-heterocyclic-4-amino-1`,3,4,5-tetrahydrobenz/cd/indoles | |
| AU6791790A (en) | 5-(2-methyl-4,4,4-trifluorobutyl-carbamoyl)indole derivatives | |
| AU8240791A (en) | 6-substituted-hexahydrobenz(cd)indoles | |
| NZ239333A (en) | 6-substituted-1,3,4,5-tetrahydrobenz(c,d)indole derivatives and pharmaceutical compositions | |
| AU590603B2 (en) | A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof | |
| AU625135B2 (en) | 3,4-(Cis-1(3-substituted benzyl)-3- halogeno-4- (1-halogenoalkyl)-2-pyrrolidinone derivatives and herbicides containing them | |
| EP0714659A3 (en) | Indole derivatives in the treatment of emesis | |
| AU644451B2 (en) | Indole derivative | |
| HK1003940A (en) | Indole derivatives as 5-ht1 agonists | |
| HK1004220A (en) | Indole derivatives as nmda antagonists | |
| AR243206A1 (es) | Procedimiento para la obtencion de polimerizados de propileno-etileno | |
| IE862252L (en) | "a method of preparing indoles or indole derivatives,¹coupled via position 4,5,6, or 7, the indoles or indole¹derivatives concerned, as well as the use thereof" | |
| ZA908041B (en) | Indole derivatives,their preparation and use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal |