BR122014004636B1 - Forma cristalina i de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], seu uso e seus métodos de preparação, bem como composição farmacêutica - Google Patents

Forma cristalina i de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], seu uso e seus métodos de preparação, bem como composição farmacêutica Download PDF

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BR122014004636B1
BR122014004636B1 BR122014004636-7A BR122014004636A BR122014004636B1 BR 122014004636 B1 BR122014004636 B1 BR 122014004636B1 BR 122014004636 A BR122014004636 A BR 122014004636A BR 122014004636 B1 BR122014004636 B1 BR 122014004636B1
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Brazil
Prior art keywords
crystalline form
ethyl
dimethylamino
phenyl
hydroxycyclohexyl
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BR122014004636-7A
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English (en)
Portuguese (pt)
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BR122014004636A2 (pt
Inventor
Youxin Li
Wanhui Liu
Yang Lv
Guanhua Du
Qingguo Meng
Mina Yang
Fengmei Zhou
Ju Li
Xuemei Zhang
Original Assignee
Shan Dong Luye Pharmaceutical Co., Ltd.
Youxin Li
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Publication date
Application filed by Shan Dong Luye Pharmaceutical Co., Ltd., Youxin Li filed Critical Shan Dong Luye Pharmaceutical Co., Ltd.
Publication of BR122014004636A2 publication Critical patent/BR122014004636A2/pt
Publication of BR122014004636B1 publication Critical patent/BR122014004636B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings

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BR122014004636-7A 2010-10-01 2011-09-28 Forma cristalina i de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], seu uso e seus métodos de preparação, bem como composição farmacêutica BR122014004636B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201010503737 2010-10-01
CN201010503737.7 2010-10-01
BR112013008664-5A BR112013008664B1 (pt) 2010-10-01 2011-09-28 Forma cristalina ii de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], seus métodos de preparação e seu uso, e composição farmacêutica
PCT/CN2011/001637 WO2012041013A1 (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same

Publications (2)

Publication Number Publication Date
BR122014004636A2 BR122014004636A2 (pt) 2019-08-13
BR122014004636B1 true BR122014004636B1 (pt) 2021-11-30

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BR122014004636-7A BR122014004636B1 (pt) 2010-10-01 2011-09-28 Forma cristalina i de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], seu uso e seus métodos de preparação, bem como composição farmacêutica
BR122014004640-5A BR122014004640B1 (pt) 2010-10-01 2011-09-28 Forma cristalina iii de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], sua utilização e seu método de preparação, e composição farmacêutica
BR112013008664-5A BR112013008664B1 (pt) 2010-10-01 2011-09-28 Forma cristalina ii de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], seus métodos de preparação e seu uso, e composição farmacêutica

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BR122014004640-5A BR122014004640B1 (pt) 2010-10-01 2011-09-28 Forma cristalina iii de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], sua utilização e seu método de preparação, e composição farmacêutica
BR112013008664-5A BR112013008664B1 (pt) 2010-10-01 2011-09-28 Forma cristalina ii de [cloridrato de 4-metilbenzoato de 4-[2-dimetilamino-1-(1-hidroxiciclohexil)etil]fenila], seus métodos de preparação e seu uso, e composição farmacêutica

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US (2) US8741952B2 (https=)
EP (1) EP2621891B1 (https=)
JP (7) JP2014500234A (https=)
KR (3) KR101477154B1 (https=)
CN (3) CN103025705B (https=)
AU (1) AU2011307952B2 (https=)
BR (3) BR122014004636B1 (https=)
CA (3) CA2860747C (https=)
CY (1) CY1122772T1 (https=)
DK (1) DK2621891T3 (https=)
ES (1) ES2769581T3 (https=)
MY (1) MY160607A (https=)
PL (1) PL2621891T3 (https=)
PT (1) PT2621891T (https=)
RU (1) RU2576665C2 (https=)
SG (1) SG188637A1 (https=)
WO (1) WO2012041013A1 (https=)

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CN104672097B (zh) * 2013-12-03 2016-06-29 山东绿叶制药有限公司 化合物对甲基苯甲酸4-（2-二甲胺基-1-环己烯基乙基）苯酯制备方法及应用
US12346500B1 (en) 2023-04-17 2025-07-01 Snap Inc. EMG speech signal detection

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US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
AU7938798A (en) * 1997-07-11 1999-02-08 Dainippon Pharmaceutical Co. Ltd. (r)-n-(1-ethyl-1h-hexahydroazepin-3-yl)-6-methoxy-1h-benzotr azole-5-carboxamidemonofumarate monohydrate and process for producing the same
DE60039132D1 (de) * 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
US20020022662A1 (en) 1999-06-15 2002-02-21 American Home Products Corporation Enantiomers of O-desmethyl venlafaxine
US7291646B2 (en) 1999-11-24 2007-11-06 Wyeth Ethers of O-desmethyl venlafaxine
EP1232141B1 (en) * 1999-11-24 2004-10-06 Wyeth Ethers of o-desmethyl venlafaxine
US6348494B1 (en) * 2000-11-21 2002-02-19 American Home Products Corporation Ethers of o-desmethyl venlafaxine
SK5762003A3 (en) * 2000-10-19 2003-11-04 Teva Pharma Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
AU2001235970A1 (en) * 2000-12-07 2002-06-18 Dr. Reddy's Research Foundation Novel crystalline polymorphic forms of venlafaxine hydrochloride and a process for their preparation
EP1864967A1 (en) 2001-02-12 2007-12-12 Wyeth Method for preparing O-desmethyl-venlafaxine
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CN1630631A (zh) 2001-12-05 2005-06-22 惠氏公司 新的文拉法星盐酸盐多晶型物及其制备方法
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US20030195170A1 (en) * 2002-04-11 2003-10-16 Judith Aronhime Novel polymorphs and pseudopolymorphs of risedronate sodium
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PT2621891T (pt) 2020-02-04
WO2012041013A1 (en) 2012-04-05
JP2018048204A (ja) 2018-03-29
US20130281531A1 (en) 2013-10-24
KR20140041961A (ko) 2014-04-04
BR122014004640A2 (pt) 2019-08-13
JP2017210494A (ja) 2017-11-30
CN103588652A (zh) 2014-02-19
AU2011307952A1 (en) 2013-05-09
US20140235728A1 (en) 2014-08-21
JP6908657B2 (ja) 2021-07-28
CA2812227A1 (en) 2012-04-05
CA2860747C (en) 2015-08-11
MY160607A (en) 2017-03-15
CN103588653A (zh) 2014-02-19
BR122014004636A2 (pt) 2019-08-13
KR101477155B1 (ko) 2014-12-29
EP2621891B1 (en) 2019-11-06
BR122014004640B1 (pt) 2021-11-30
US8741952B2 (en) 2014-06-03
EP2621891A1 (en) 2013-08-07
CY1122772T1 (el) 2021-05-05
AU2011307952B2 (en) 2015-02-26
CA2812227C (en) 2015-11-24
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