AU2011307952B2 - Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same - Google Patents

Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same Download PDF

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AU2011307952B2
AU2011307952B2 AU2011307952A AU2011307952A AU2011307952B2 AU 2011307952 B2 AU2011307952 B2 AU 2011307952B2 AU 2011307952 A AU2011307952 A AU 2011307952A AU 2011307952 A AU2011307952 A AU 2011307952A AU 2011307952 B2 AU2011307952 B2 AU 2011307952B2
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crystal form
ethyl
phenyl
hydroxycyclohexyl
dimethylamino
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AU2011307952A1 (en
Inventor
Guanhua Du
Ju Li
Youxin Li
Wanhui Liu
Yang LV
Qingguo Meng
Mina Yang
Xuemei Zhang
Fengmei Zhou
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Shandong Luye Pharmaceutical Co Ltd
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Shandong Luye Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/02—Nutrients, e.g. vitamins, minerals
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings

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AU2011307952A 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same Active AU2011307952B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201010503737 2010-10-01
CN201010503737.7 2010-10-01
PCT/CN2011/001637 WO2012041013A1 (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same

Publications (2)

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AU2011307952A1 AU2011307952A1 (en) 2013-05-09
AU2011307952B2 true AU2011307952B2 (en) 2015-02-26

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AU2011307952A Active AU2011307952B2 (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same

Country Status (17)

Country Link
US (2) US8741952B2 (https=)
EP (1) EP2621891B1 (https=)
JP (7) JP2014500234A (https=)
KR (3) KR101477154B1 (https=)
CN (3) CN103025705B (https=)
AU (1) AU2011307952B2 (https=)
BR (3) BR122014004636B1 (https=)
CA (3) CA2860747C (https=)
CY (1) CY1122772T1 (https=)
DK (1) DK2621891T3 (https=)
ES (1) ES2769581T3 (https=)
MY (1) MY160607A (https=)
PL (1) PL2621891T3 (https=)
PT (1) PT2621891T (https=)
RU (1) RU2576665C2 (https=)
SG (1) SG188637A1 (https=)
WO (1) WO2012041013A1 (https=)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
CN104672097B (zh) * 2013-12-03 2016-06-29 山东绿叶制药有限公司 化合物对甲基苯甲酸4-（2-二甲胺基-1-环己烯基乙基）苯酯制备方法及应用
US12346500B1 (en) 2023-04-17 2025-07-01 Snap Inc. EMG speech signal detection

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AU2006257558A1 (en) * 2005-06-17 2006-12-21 Li, Youxin Compounds for inhibition of 5-hydroxytryptamine and norepinephrine reuptake or for treatment of depression disorders, their preparation processes and uses thereof

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US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
AU7938798A (en) * 1997-07-11 1999-02-08 Dainippon Pharmaceutical Co. Ltd. (r)-n-(1-ethyl-1h-hexahydroazepin-3-yl)-6-methoxy-1h-benzotr azole-5-carboxamidemonofumarate monohydrate and process for producing the same
DE60039132D1 (de) * 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
US20020022662A1 (en) 1999-06-15 2002-02-21 American Home Products Corporation Enantiomers of O-desmethyl venlafaxine
US7291646B2 (en) 1999-11-24 2007-11-06 Wyeth Ethers of O-desmethyl venlafaxine
EP1232141B1 (en) * 1999-11-24 2004-10-06 Wyeth Ethers of o-desmethyl venlafaxine
US6348494B1 (en) * 2000-11-21 2002-02-19 American Home Products Corporation Ethers of o-desmethyl venlafaxine
SK5762003A3 (en) * 2000-10-19 2003-11-04 Teva Pharma Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
AU2001235970A1 (en) * 2000-12-07 2002-06-18 Dr. Reddy's Research Foundation Novel crystalline polymorphic forms of venlafaxine hydrochloride and a process for their preparation
EP1864967A1 (en) 2001-02-12 2007-12-12 Wyeth Method for preparing O-desmethyl-venlafaxine
US20040242594A1 (en) * 2001-11-17 2004-12-02 Dan Peters Prodrugs of antidepressants and their use for treating depressions
CN1630631A (zh) 2001-12-05 2005-06-22 惠氏公司 新的文拉法星盐酸盐多晶型物及其制备方法
US20030190352A1 (en) 2002-03-28 2003-10-09 Synthon Bv Compositions of venlafaxine base
US20030195170A1 (en) * 2002-04-11 2003-10-16 Judith Aronhime Novel polymorphs and pseudopolymorphs of risedronate sodium
US7875642B2 (en) * 2004-01-26 2011-01-25 Merck Sharp & Dohme Corp. Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1
CN100455560C (zh) * 2004-06-09 2009-01-28 中国人民解放军军事医学科学院放射医学研究所 含长链脂肪酰基取代的文拉法辛前体药物及其制备方法和用途
GT200600397A (es) * 2005-09-07 2007-08-28 Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales

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PT2621891T (pt) 2020-02-04
WO2012041013A1 (en) 2012-04-05
JP2018048204A (ja) 2018-03-29
US20130281531A1 (en) 2013-10-24
KR20140041961A (ko) 2014-04-04
BR122014004640A2 (pt) 2019-08-13
JP2017210494A (ja) 2017-11-30
CN103588652A (zh) 2014-02-19
AU2011307952A1 (en) 2013-05-09
US20140235728A1 (en) 2014-08-21
JP6908657B2 (ja) 2021-07-28
CA2812227A1 (en) 2012-04-05
CA2860747C (en) 2015-08-11
MY160607A (en) 2017-03-15
CN103588653A (zh) 2014-02-19
BR122014004636A2 (pt) 2019-08-13
KR101477155B1 (ko) 2014-12-29
EP2621891B1 (en) 2019-11-06
BR122014004640B1 (pt) 2021-11-30
US8741952B2 (en) 2014-06-03
EP2621891A1 (en) 2013-08-07
CY1122772T1 (el) 2021-05-05
BR122014004636B1 (pt) 2021-11-30
CA2812227C (en) 2015-11-24
JP2017218451A (ja) 2017-12-14
DK2621891T3 (da) 2020-02-17
BR112013008664A2 (pt) 2016-06-21
KR20140041960A (ko) 2014-04-04
JP6522094B2 (ja) 2019-05-29
KR101640808B1 (ko) 2016-07-19
SG188637A1 (en) 2013-05-31
CA2860748A1 (en) 2012-04-05
CN103025705B (zh) 2014-01-22
JP6434591B2 (ja) 2018-12-05
CN103588653B (zh) 2015-04-22
BR112013008664B1 (pt) 2021-11-03
JP2016188233A (ja) 2016-11-04
KR101477154B1 (ko) 2014-12-29
RU2013119806A (ru) 2014-11-20
JP2015205932A (ja) 2015-11-19
CA2860748C (en) 2015-08-25
JP2019203010A (ja) 2019-11-28
CA2860747A1 (en) 2012-04-05
PL2621891T3 (pl) 2020-11-16
RU2576665C2 (ru) 2016-03-10
CN103025705A (zh) 2013-04-03
CN103588652B (zh) 2015-04-22
EP2621891A4 (en) 2016-05-18
US9199912B2 (en) 2015-12-01
KR20130099132A (ko) 2013-09-05
ES2769581T3 (es) 2020-06-26
JP2014500234A (ja) 2014-01-09

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