CY1122772T1 - Πολυμορφα του υδροχλωρικου 4-μεθυλβενζοϊκου 4-[2-διμεθυλαμινο-1-(1-υδροξυκυκλοεξυλ)αιθυλ]φαινυλεστερα, μεθοδοι για την παρασκευη αυτων και χρηση αυτων - Google Patents
Πολυμορφα του υδροχλωρικου 4-μεθυλβενζοϊκου 4-[2-διμεθυλαμινο-1-(1-υδροξυκυκλοεξυλ)αιθυλ]φαινυλεστερα, μεθοδοι για την παρασκευη αυτων και χρηση αυτωνInfo
- Publication number
- CY1122772T1 CY1122772T1 CY20201100094T CY201100094T CY1122772T1 CY 1122772 T1 CY1122772 T1 CY 1122772T1 CY 20201100094 T CY20201100094 T CY 20201100094T CY 201100094 T CY201100094 T CY 201100094T CY 1122772 T1 CY1122772 T1 CY 1122772T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydroxycyclohexyl
- dimethylamino
- ethyl
- preparation
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Neurology (AREA)
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- Neurosurgery (AREA)
- Psychiatry (AREA)
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- Hematology (AREA)
- Obesity (AREA)
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- Cardiology (AREA)
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- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
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Abstract
Η παρούσα αποκάλυψη αφορά πολύμορφα του υδροχλωρικού 4-μεθυλοβενζοϊκού 4-[2-διμεθυλαμινο-1-(1-υδροξυκυκλοεξυλ)αιθυλ] φαινυλεστέρα, μεθόδους για την Παρασκευή αυτών και χρήση αυτών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010503737 | 2010-10-01 | ||
PCT/CN2011/001637 WO2012041013A1 (en) | 2010-10-01 | 2011-09-28 | Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122772T1 true CY1122772T1 (el) | 2021-05-05 |
Family
ID=45891856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100094T CY1122772T1 (el) | 2010-10-01 | 2020-02-03 | Πολυμορφα του υδροχλωρικου 4-μεθυλβενζοϊκου 4-[2-διμεθυλαμινο-1-(1-υδροξυκυκλοεξυλ)αιθυλ]φαινυλεστερα, μεθοδοι για την παρασκευη αυτων και χρηση αυτων |
Country Status (17)
Country | Link |
---|---|
US (2) | US8741952B2 (el) |
EP (1) | EP2621891B1 (el) |
JP (7) | JP2014500234A (el) |
KR (3) | KR101640808B1 (el) |
CN (3) | CN103025705B (el) |
AU (1) | AU2011307952B2 (el) |
BR (3) | BR122014004636B1 (el) |
CA (3) | CA2812227C (el) |
CY (1) | CY1122772T1 (el) |
DK (1) | DK2621891T3 (el) |
ES (1) | ES2769581T3 (el) |
MY (1) | MY160607A (el) |
PL (1) | PL2621891T3 (el) |
PT (1) | PT2621891T (el) |
RU (1) | RU2576665C2 (el) |
SG (1) | SG188637A1 (el) |
WO (1) | WO2012041013A1 (el) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104672097B (zh) * | 2013-12-03 | 2016-06-29 | 山东绿叶制药有限公司 | 化合物对甲基苯甲酸4-(2-二甲胺基-1-环己烯基乙基)苯酯制备方法及应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4535186A (en) | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
WO1999002522A1 (fr) * | 1997-07-11 | 1999-01-21 | Dainippon Pharmaceutical Co., Ltd. | (r)-n-(1-ethyl-1h-hexahydroazepine-3-yl)-6-methoxy-1h-benzotriazole-5-carbooxamide monofumarate monohydrate et son procede de production |
ES2305606T3 (es) * | 1999-04-06 | 2008-11-01 | Sepracor Inc. | Succinato de o-desmetilvenlafaxina. |
US20020022662A1 (en) | 1999-06-15 | 2002-02-21 | American Home Products Corporation | Enantiomers of O-desmethyl venlafaxine |
US7291646B2 (en) | 1999-11-24 | 2007-11-06 | Wyeth | Ethers of O-desmethyl venlafaxine |
US6348494B1 (en) * | 2000-11-21 | 2002-02-19 | American Home Products Corporation | Ethers of o-desmethyl venlafaxine |
BR0015795A (pt) * | 1999-11-24 | 2002-07-23 | Wyeth Corp | éteres de 0-desmetil venlafaxina |
YU30203A (sh) * | 2000-10-19 | 2006-08-17 | Teva Pharmaceutical Industries Ltd. | Kristalna venlafaksin baza i novi polimorfi venlafaksin hidrohlorida, postupci za njegovo pripremanje |
AU2001235970A1 (en) * | 2000-12-07 | 2002-06-18 | Dr. Reddy's Research Foundation | Novel crystalline polymorphic forms of venlafaxine hydrochloride and a process for their preparation |
EP1360169B2 (en) | 2001-02-12 | 2017-05-24 | Wyeth LLC | Succinate salt of o-desmethyl-venlafaxine |
EP1448512A1 (en) * | 2001-11-17 | 2004-08-25 | NeuroSearch A/S | Prodrugs of antidepressants and their use for treating depressions |
CN1630631A (zh) * | 2001-12-05 | 2005-06-22 | 惠氏公司 | 新的文拉法星盐酸盐多晶型物及其制备方法 |
US20030190352A1 (en) | 2002-03-28 | 2003-10-09 | Synthon Bv | Compositions of venlafaxine base |
AU2003209167A1 (en) * | 2002-04-11 | 2003-10-27 | Teva Pharmaceutical Industries Ltd | Novel polymorphs and pseudopolymorphs of risedronate sodium |
CA2553345C (en) * | 2004-01-26 | 2011-11-15 | Merck & Co., Inc. | Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 |
CN100455560C (zh) * | 2004-06-09 | 2009-01-28 | 中国人民解放军军事医学科学院放射医学研究所 | 含长链脂肪酰基取代的文拉法辛前体药物及其制备方法和用途 |
CN1955159B (zh) | 2005-06-17 | 2010-11-24 | 山东绿叶制药有限公司 | 用于阻断5-羟色胺以及去甲基肾上腺素再摄取的化合物,其制备方法及其用途 |
GT200600397A (es) * | 2005-09-07 | 2007-08-28 | Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales |
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2011
- 2011-09-28 CA CA2812227A patent/CA2812227C/en active Active
- 2011-09-28 CN CN201180036015.8A patent/CN103025705B/zh active Active
- 2011-09-28 AU AU2011307952A patent/AU2011307952B2/en active Active
- 2011-09-28 CN CN201310462622.1A patent/CN103588652B/zh active Active
- 2011-09-28 CN CN201310464696.9A patent/CN103588653B/zh active Active
- 2011-09-28 DK DK11827911.6T patent/DK2621891T3/da active
- 2011-09-28 ES ES11827911T patent/ES2769581T3/es active Active
- 2011-09-28 EP EP11827911.6A patent/EP2621891B1/en active Active
- 2011-09-28 KR KR1020137011253A patent/KR101640808B1/ko active IP Right Grant
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- 2011-09-28 BR BR122014004636-7A patent/BR122014004636B1/pt active IP Right Grant
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- 2011-09-28 SG SG2013021472A patent/SG188637A1/en unknown
- 2011-09-28 PL PL11827911T patent/PL2621891T3/pl unknown
- 2011-09-28 WO PCT/CN2011/001637 patent/WO2012041013A1/en active Application Filing
- 2011-09-28 BR BR122014004640-5A patent/BR122014004640B1/pt active IP Right Grant
- 2011-09-28 PT PT118279116T patent/PT2621891T/pt unknown
- 2011-09-28 KR KR1020147007372A patent/KR101477155B1/ko active IP Right Grant
- 2011-09-28 JP JP2013530528A patent/JP2014500234A/ja active Pending
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2013
- 2013-03-18 US US13/846,773 patent/US8741952B2/en active Active
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2014
- 2014-04-23 US US14/259,964 patent/US9199912B2/en active Active
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2015
- 2015-08-07 JP JP2015156966A patent/JP2015205932A/ja active Pending
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2016
- 2016-06-23 JP JP2016124043A patent/JP2016188233A/ja active Pending
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2017
- 2017-09-08 JP JP2017172806A patent/JP6434591B2/ja active Active
- 2017-09-08 JP JP2017172815A patent/JP2017210494A/ja active Pending
- 2017-12-14 JP JP2017239299A patent/JP6522094B2/ja active Active
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2019
- 2019-07-19 JP JP2019133324A patent/JP6908657B2/ja active Active
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2020
- 2020-02-03 CY CY20201100094T patent/CY1122772T1/el unknown
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