CA2860747C - Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same - Google Patents

Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same Download PDF

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CA2860747C
CA2860747C CA2860747A CA2860747A CA2860747C CA 2860747 C CA2860747 C CA 2860747C CA 2860747 A CA2860747 A CA 2860747A CA 2860747 A CA2860747 A CA 2860747A CA 2860747 C CA2860747 C CA 2860747C
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crystal form
central nervous
nervous system
system diseases
diseases comprise
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French (fr)
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CA2860747A1 (en
Inventor
Youxin Li
Wanhui Liu
Yang LV
Guanhua Du
Qingguo Meng
Mina Yang
Fengmei Zhou
Ju Li
Xuemei Zhang
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Shandong Luye Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P39/00—General protective or antinoxious agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings

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CA2860747A 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same Active CA2860747C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201010503737 2010-10-01
CN201010503737.7 2010-10-01
CA2812227A CA2812227C (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same

Related Parent Applications (1)

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CA2812227A Division CA2812227C (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same

Publications (2)

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CA2860747A1 CA2860747A1 (en) 2012-04-05
CA2860747C true CA2860747C (en) 2015-08-11

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ID=45891856

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Application Number Title Priority Date Filing Date
CA2860747A Active CA2860747C (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same
CA2812227A Active CA2812227C (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same
CA2860748A Active CA2860748C (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same

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CA2812227A Active CA2812227C (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same
CA2860748A Active CA2860748C (en) 2010-10-01 2011-09-28 Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methylbenzoate hydrochloride, methods for preparing the same and use of the same

Country Status (17)

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US (2) US8741952B2 (https=)
EP (1) EP2621891B1 (https=)
JP (7) JP2014500234A (https=)
KR (3) KR101477154B1 (https=)
CN (3) CN103025705B (https=)
AU (1) AU2011307952B2 (https=)
BR (3) BR122014004636B1 (https=)
CA (3) CA2860747C (https=)
CY (1) CY1122772T1 (https=)
DK (1) DK2621891T3 (https=)
ES (1) ES2769581T3 (https=)
MY (1) MY160607A (https=)
PL (1) PL2621891T3 (https=)
PT (1) PT2621891T (https=)
RU (1) RU2576665C2 (https=)
SG (1) SG188637A1 (https=)
WO (1) WO2012041013A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104672097B (zh) * 2013-12-03 2016-06-29 山东绿叶制药有限公司 化合物对甲基苯甲酸4-（2-二甲胺基-1-环己烯基乙基）苯酯制备方法及应用
US12346500B1 (en) 2023-04-17 2025-07-01 Snap Inc. EMG speech signal detection

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
AU7938798A (en) * 1997-07-11 1999-02-08 Dainippon Pharmaceutical Co. Ltd. (r)-n-(1-ethyl-1h-hexahydroazepin-3-yl)-6-methoxy-1h-benzotr azole-5-carboxamidemonofumarate monohydrate and process for producing the same
DE60039132D1 (de) * 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
US20020022662A1 (en) 1999-06-15 2002-02-21 American Home Products Corporation Enantiomers of O-desmethyl venlafaxine
US7291646B2 (en) 1999-11-24 2007-11-06 Wyeth Ethers of O-desmethyl venlafaxine
EP1232141B1 (en) * 1999-11-24 2004-10-06 Wyeth Ethers of o-desmethyl venlafaxine
US6348494B1 (en) * 2000-11-21 2002-02-19 American Home Products Corporation Ethers of o-desmethyl venlafaxine
SK5762003A3 (en) * 2000-10-19 2003-11-04 Teva Pharma Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof
AU2001235970A1 (en) * 2000-12-07 2002-06-18 Dr. Reddy's Research Foundation Novel crystalline polymorphic forms of venlafaxine hydrochloride and a process for their preparation
EP1864967A1 (en) 2001-02-12 2007-12-12 Wyeth Method for preparing O-desmethyl-venlafaxine
US20040242594A1 (en) * 2001-11-17 2004-12-02 Dan Peters Prodrugs of antidepressants and their use for treating depressions
CN1630631A (zh) 2001-12-05 2005-06-22 惠氏公司 新的文拉法星盐酸盐多晶型物及其制备方法
US20030190352A1 (en) 2002-03-28 2003-10-09 Synthon Bv Compositions of venlafaxine base
US20030195170A1 (en) * 2002-04-11 2003-10-16 Judith Aronhime Novel polymorphs and pseudopolymorphs of risedronate sodium
US7875642B2 (en) * 2004-01-26 2011-01-25 Merck Sharp & Dohme Corp. Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1
CN100455560C (zh) * 2004-06-09 2009-01-28 中国人民解放军军事医学科学院放射医学研究所 含长链脂肪酰基取代的文拉法辛前体药物及其制备方法和用途
CN1955159B (zh) * 2005-06-17 2010-11-24 山东绿叶制药有限公司 用于阻断5-羟色胺以及去甲基肾上腺素再摄取的化合物,其制备方法及其用途
GT200600397A (es) * 2005-09-07 2007-08-28 Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales

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PT2621891T (pt) 2020-02-04
WO2012041013A1 (en) 2012-04-05
JP2018048204A (ja) 2018-03-29
US20130281531A1 (en) 2013-10-24
KR20140041961A (ko) 2014-04-04
BR122014004640A2 (pt) 2019-08-13
JP2017210494A (ja) 2017-11-30
CN103588652A (zh) 2014-02-19
AU2011307952A1 (en) 2013-05-09
US20140235728A1 (en) 2014-08-21
JP6908657B2 (ja) 2021-07-28
CA2812227A1 (en) 2012-04-05
MY160607A (en) 2017-03-15
CN103588653A (zh) 2014-02-19
BR122014004636A2 (pt) 2019-08-13
KR101477155B1 (ko) 2014-12-29
EP2621891B1 (en) 2019-11-06
BR122014004640B1 (pt) 2021-11-30
US8741952B2 (en) 2014-06-03
EP2621891A1 (en) 2013-08-07
CY1122772T1 (el) 2021-05-05
BR122014004636B1 (pt) 2021-11-30
AU2011307952B2 (en) 2015-02-26
CA2812227C (en) 2015-11-24
JP2017218451A (ja) 2017-12-14
DK2621891T3 (da) 2020-02-17
BR112013008664A2 (pt) 2016-06-21
KR20140041960A (ko) 2014-04-04
JP6522094B2 (ja) 2019-05-29
KR101640808B1 (ko) 2016-07-19
SG188637A1 (en) 2013-05-31
CA2860748A1 (en) 2012-04-05
CN103025705B (zh) 2014-01-22
JP6434591B2 (ja) 2018-12-05
CN103588653B (zh) 2015-04-22
BR112013008664B1 (pt) 2021-11-03
JP2016188233A (ja) 2016-11-04
KR101477154B1 (ko) 2014-12-29
RU2013119806A (ru) 2014-11-20
JP2015205932A (ja) 2015-11-19
CA2860748C (en) 2015-08-25
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