BR112022009110A2 - Polipeptídeos de citocina ativáveis e métodos de uso destes - Google Patents

Polipeptídeos de citocina ativáveis e métodos de uso destes

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Publication number
BR112022009110A2
BR112022009110A2 BR112022009110A BR112022009110A BR112022009110A2 BR 112022009110 A2 BR112022009110 A2 BR 112022009110A2 BR 112022009110 A BR112022009110 A BR 112022009110A BR 112022009110 A BR112022009110 A BR 112022009110A BR 112022009110 A2 BR112022009110 A2 BR 112022009110A2
Authority
BR
Brazil
Prior art keywords
cytokine
activable
methods
polypeptides
fusion proteins
Prior art date
Application number
BR112022009110A
Other languages
English (en)
Portuguese (pt)
Inventor
Winston William
Hicklin Daniel
Andres Salmeron Garcia Jose
Brodkin Heather
Seidel-Dugan Cynthia
Original Assignee
Werewolf Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Werewolf Therapeutics Inc filed Critical Werewolf Therapeutics Inc
Publication of BR112022009110A2 publication Critical patent/BR112022009110A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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