BR112019000293A2 - formas sólidas de um estimulador de sgc - Google Patents
formas sólidas de um estimulador de sgcInfo
- Publication number
- BR112019000293A2 BR112019000293A2 BR112019000293-6A BR112019000293A BR112019000293A2 BR 112019000293 A2 BR112019000293 A2 BR 112019000293A2 BR 112019000293 A BR112019000293 A BR 112019000293A BR 112019000293 A2 BR112019000293 A2 BR 112019000293A2
- Authority
- BR
- Brazil
- Prior art keywords
- solid forms
- sgc
- disorders
- sgc stimulator
- diseases
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 4
- 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 abstract 1
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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| US201662359466P | 2016-07-07 | 2016-07-07 | |
| US62/359,466 | 2016-07-07 | ||
| PCT/US2017/040827 WO2018009609A1 (en) | 2016-07-07 | 2017-07-06 | Solid forms of an sgc stimulator |
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| BR112019000293A2 true BR112019000293A2 (pt) | 2019-04-16 |
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| KR (2) | KR102803160B1 (enExample) |
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| BR112019000293A2 (pt) | 2016-07-07 | 2019-04-16 | Ironwood Pharmaceuticals, Inc. | formas sólidas de um estimulador de sgc |
| EP3481818B1 (en) | 2016-07-07 | 2023-09-06 | Cyclerion Therapeutics, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| BR112019000292A2 (pt) | 2016-07-07 | 2019-04-16 | Ironwood Pharmaceuticals, Inc. | processos inovadores para a preparação de estimuladores de guanilato ciclase solúvel |
| WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
| CN109503574B (zh) * | 2018-12-14 | 2021-07-06 | 中国人民解放军军事科学院军事医学研究院 | 抗肺动脉高压药物sgc-003的多晶型晶体变体及其制备方法 |
| CN110862424A (zh) * | 2019-12-03 | 2020-03-06 | 海南顿斯医药科技有限公司 | 一种硫酸阿米卡星化合物 |
| WO2023009710A1 (en) * | 2021-07-28 | 2023-02-02 | Cyclerion Therapeutics, Inc. | Treatment of hfpef in post-menopausal women with an sgc stimulator |
| CN114199812A (zh) * | 2021-12-28 | 2022-03-18 | 南通联亚药业有限公司 | 一种盐酸美金刚缓释制剂中盐酸美金刚的检测方法 |
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2017
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- 2017-07-06 AU AU2017292818A patent/AU2017292818B2/en active Active
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- 2017-07-06 EP EP17739833.6A patent/EP3481820B1/en active Active
- 2017-07-06 KR KR1020237017060A patent/KR102803160B1/ko active Active
- 2017-07-06 EA EA201990235A patent/EA039753B1/ru unknown
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- 2017-07-06 MA MA045588A patent/MA45588A/fr unknown
- 2017-07-06 CN CN201780048867.6A patent/CN109563087A/zh active Pending
- 2017-07-06 KR KR1020197003464A patent/KR20190025989A/ko not_active Ceased
- 2017-07-06 JP JP2019500453A patent/JP2019524710A/ja active Pending
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- 2020-12-29 US US17/136,473 patent/US11572358B2/en active Active
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- 2022-07-04 JP JP2022107994A patent/JP2022130689A/ja active Pending
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- 2023-06-02 US US18/204,997 patent/US20240059683A1/en not_active Abandoned
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2024
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