JOP20180127A1 - صيغ صلبة من منشط محلقة غوانيليل قابل للذوبان (sGC) - Google Patents
صيغ صلبة من منشط محلقة غوانيليل قابل للذوبان (sGC)Info
- Publication number
- JOP20180127A1 JOP20180127A1 JOP/2018/0127A JOP20180127A JOP20180127A1 JO P20180127 A1 JOP20180127 A1 JO P20180127A1 JO P20180127 A JOP20180127 A JO P20180127A JO P20180127 A1 JOP20180127 A1 JO P20180127A1
- Authority
- JO
- Jordan
- Prior art keywords
- sgc
- solid formulations
- guanylyl cyclase
- soluble guanylyl
- forms
- Prior art date
Links
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 title abstract 5
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 title abstract 5
- 239000007787 solid Substances 0.000 title abstract 4
- 239000012190 activator Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- ZOOGRGPOEVQQDX-KHLHZJAASA-N cyclic guanosine monophosphate Chemical compound C([C@H]1O2)O[P@](O)(=O)O[C@@H]1[C@H](O)[C@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-KHLHZJAASA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Applications Claiming Priority (2)
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| US201662359466P | 2016-07-07 | 2016-07-07 | |
| PCT/US2017/040827 WO2018009609A1 (en) | 2016-07-07 | 2017-07-06 | Solid forms of an sgc stimulator |
Publications (1)
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| JOP20180127A1 true JOP20180127A1 (ar) | 2019-01-30 |
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| EP (1) | EP3481820B1 (enExample) |
| JP (3) | JP2019524710A (enExample) |
| KR (2) | KR20190025989A (enExample) |
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| BR (1) | BR112019000293A2 (enExample) |
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| EA (1) | EA039753B1 (enExample) |
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| JO (1) | JOP20180127A1 (enExample) |
| MA (1) | MA45588A (enExample) |
| MX (2) | MX389964B (enExample) |
| TW (1) | TWI774683B (enExample) |
| WO (1) | WO2018009609A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017292811B2 (en) | 2016-07-07 | 2021-10-21 | Cyclerion Therapeutics, Inc. | Novel processes for preparation of soluble guanylate cyclase stimulators |
| EA201990237A1 (ru) | 2016-07-07 | 2019-08-30 | Сайклерион Терапьютикс, Инк. | Новые способы получения стимуляторов растворимой гуанилатциклазы |
| EP3481820B1 (en) | 2016-07-07 | 2023-10-18 | Cyclerion Therapeutics, Inc. | Solid forms of an sgc stimulator |
| WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
| CN109503574B (zh) * | 2018-12-14 | 2021-07-06 | 中国人民解放军军事科学院军事医学研究院 | 抗肺动脉高压药物sgc-003的多晶型晶体变体及其制备方法 |
| CN110862424A (zh) * | 2019-12-03 | 2020-03-06 | 海南顿斯医药科技有限公司 | 一种硫酸阿米卡星化合物 |
| EP4376843A1 (en) * | 2021-07-28 | 2024-06-05 | Cyclerion Therapeutics, Inc. | Treatment of hfpef in post-menopausal women with an sgc stimulator |
| CN114199812A (zh) * | 2021-12-28 | 2022-03-18 | 南通联亚药业有限公司 | 一种盐酸美金刚缓释制剂中盐酸美金刚的检测方法 |
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-
2017
- 2017-07-06 EP EP17739833.6A patent/EP3481820B1/en active Active
- 2017-07-06 BR BR112019000293-6A patent/BR112019000293A2/pt not_active Application Discontinuation
- 2017-07-06 MX MX2019000115A patent/MX389964B/es unknown
- 2017-07-06 KR KR1020197003464A patent/KR20190025989A/ko not_active Ceased
- 2017-07-06 JP JP2019500453A patent/JP2019524710A/ja active Pending
- 2017-07-06 AU AU2017292818A patent/AU2017292818B2/en active Active
- 2017-07-06 IL IL263996A patent/IL263996B2/en unknown
- 2017-07-06 EA EA201990235A patent/EA039753B1/ru unknown
- 2017-07-06 US US16/315,226 patent/US10889577B2/en active Active
- 2017-07-06 KR KR1020237017060A patent/KR102803160B1/ko active Active
- 2017-07-06 MA MA045588A patent/MA45588A/fr unknown
- 2017-07-06 CN CN201780048867.6A patent/CN109563087A/zh active Pending
- 2017-07-06 WO PCT/US2017/040827 patent/WO2018009609A1/en not_active Ceased
- 2017-07-07 TW TW106122962A patent/TWI774683B/zh not_active IP Right Cessation
-
2018
- 2018-12-24 JO JOP/2018/0127A patent/JOP20180127A1/ar unknown
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2019
- 2019-01-04 CL CL2019000018A patent/CL2019000018A1/es unknown
- 2019-01-07 MX MX2022001565A patent/MX2022001565A/es unknown
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2020
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2022
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2023
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- 2023-11-02 US US18/500,565 patent/US20240246947A1/en not_active Abandoned
-
2024
- 2024-08-28 US US18/818,111 patent/US20250129060A1/en not_active Abandoned
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2025
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- 2025-04-30 JP JP2025075532A patent/JP2025118738A/ja active Pending
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