BR112015004190A2 - composição farmacêutica de liberação sustentada, e, método para produzir uma composição farmacêutica de liberação sustentada - Google Patents
composição farmacêutica de liberação sustentada, e, método para produzir uma composição farmacêutica de liberação sustentadaInfo
- Publication number
- BR112015004190A2 BR112015004190A2 BR112015004190A BR112015004190A BR112015004190A2 BR 112015004190 A2 BR112015004190 A2 BR 112015004190A2 BR 112015004190 A BR112015004190 A BR 112015004190A BR 112015004190 A BR112015004190 A BR 112015004190A BR 112015004190 A2 BR112015004190 A2 BR 112015004190A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- release pharmaceutical
- sustained release
- sustained
- producing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 6
- 238000013268 sustained release Methods 0.000 title abstract 6
- 239000012730 sustained-release form Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- DYUTXEVRMPFGTH-UHFFFAOYSA-N 4-(2,5-dimethylphenyl)-5-methyl-1,3-thiazol-2-amine Chemical compound S1C(N)=NC(C=2C(=CC=C(C)C=2)C)=C1C DYUTXEVRMPFGTH-UHFFFAOYSA-N 0.000 abstract 2
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 abstract 2
- 229960002738 hydromorphone hydrochloride Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960002085 oxycodone Drugs 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
Abstract
1 / 1 resumo âcomposiãão farmacãutica de liberaãão sustentada, e, mãtodo para produzir uma composiãão farmacãutica de liberaãão sustentadaâ um objetivo ã© fornecer uma composiã§ã£o farmacãªutica de liberaã§ã£o sustentada contendo cloridrato de hidromorfona ou hidrato de cloridrato de oxicodona para administraã§ã£o oral que apresenta confiavelmente seu principal efeito farmacolã³gico e tem excelente estabilidade de formulaã§ã£o que evita liberaã§ã£o rã¡pida da dose do principal medicamento, tal como resistãªncia a ã¡lcool. a presente invenã§ã£o fornece uma composiã§ã£o farmacãªutica de liberaã§ã£o sustentada compreendendo (a) cloridrato de hidromorfona ou hidrato de cloridrato de oxicodona, (b) succinato do acetato de hidroxipropil metilcelulose com um tamanho mediano (d ) de 40 ïm ou 50 menos, (c) hidroxipropil celulose e (d) um sacarãdeo, em que a razã£o do teor do componente (c) para o componente (b) em peso na composiã§ã£o, (c)/(b), ã© 11/3 a 3/11.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012192783 | 2012-09-03 | ||
PCT/JP2013/073519 WO2014034929A1 (ja) | 2012-09-03 | 2013-09-02 | ヒドロモルフォン塩酸塩含有の経口用徐放性医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015004190A2 true BR112015004190A2 (pt) | 2017-07-04 |
Family
ID=50183727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015004190A BR112015004190A2 (pt) | 2012-09-03 | 2013-09-02 | composição farmacêutica de liberação sustentada, e, método para produzir uma composição farmacêutica de liberação sustentada |
Country Status (12)
Country | Link |
---|---|
US (1) | US9827199B2 (pt) |
EP (1) | EP2893928B1 (pt) |
JP (1) | JP6129184B2 (pt) |
KR (1) | KR102127625B1 (pt) |
CN (1) | CN104768552A (pt) |
BR (1) | BR112015004190A2 (pt) |
CA (1) | CA2883077C (pt) |
ES (1) | ES2706994T3 (pt) |
HK (1) | HK1210053A1 (pt) |
RU (1) | RU2665372C2 (pt) |
TW (1) | TWI566786B (pt) |
WO (1) | WO2014034929A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2706880T3 (es) | 2010-02-22 | 2019-04-01 | Daiichi Sankyo Co Ltd | Preparación sólida de liberación sostenida para uso oral |
JP7365157B2 (ja) * | 2018-07-17 | 2023-10-19 | 沢井製薬株式会社 | イミダフェナシン含有錠剤の製造方法 |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI89457C (fi) | 1986-04-30 | 1993-10-11 | Chugai Pharmaceutical Co Ltd | Foerfarande foer framstaellning av ett preparat som innehaoller ett aluminiumsalt av en sackarossulfatester |
US5547943A (en) | 1986-04-30 | 1996-08-20 | Chugai Seiyaku Kabushiki Kaisha | Sucralfate preparation |
GB8626098D0 (en) * | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
US5567439A (en) | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
US5783212A (en) | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
DE19637082A1 (de) | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Schnellzerfallende Pellets |
AU7375598A (en) | 1997-05-09 | 1998-11-27 | Sage Pharmaceuticals, Inc. | Stable oral pharmaceutical dosage forms |
US5910319A (en) | 1997-05-29 | 1999-06-08 | Eli Lilly And Company | Fluoxetine enteric pellets and methods for their preparation and use |
US20020054911A1 (en) | 2000-05-11 | 2002-05-09 | Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi | Novel oral dosage form for carvedilol |
IL136028A0 (en) | 1997-11-12 | 2001-05-20 | Boehringer Mannheim Pharm Corp | Novel oral dosage form for carvedilol |
EP1027885B1 (en) | 1999-02-09 | 2008-07-09 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
US6485746B1 (en) | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
ES2199857T3 (es) | 1999-08-26 | 2004-03-01 | Neurocrine Biosciences, Inc. | Composiciones sedantes-hipnoticas de liberacion controlada y metodos relacionados con ellas. |
JP4641696B2 (ja) | 1999-09-30 | 2011-03-02 | 大塚製薬株式会社 | 消化管下部溶解性コーティング製剤 |
JP2001270821A (ja) | 2000-03-23 | 2001-10-02 | Eisai Co Ltd | 服用感が優れた散剤 |
US6287599B1 (en) | 2000-12-20 | 2001-09-11 | Shire Laboratories, Inc. | Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles |
IN191028B (pt) | 2001-05-17 | 2003-09-13 | Sun Pharmaceutical Ind Ltd | |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
CA2451605C (en) | 2001-06-20 | 2010-08-10 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
AU2002328596B2 (en) | 2001-08-09 | 2007-09-20 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
JP4644397B2 (ja) | 2001-09-05 | 2011-03-02 | 信越化学工業株式会社 | 難溶性薬物を含む医薬用固形製剤の製造方法 |
HRP20020124A2 (en) | 2002-02-11 | 2003-10-31 | Pliva D D | Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping |
US7125563B2 (en) | 2002-04-12 | 2006-10-24 | Dava Pharmaceuticals, Inc. | Sustained release pharmaceutical preparations and methods for producing the same |
JP2004026750A (ja) | 2002-06-27 | 2004-01-29 | Nippon Shinyaku Co Ltd | 薬物の安定化法 |
EP1537880A4 (en) | 2002-09-11 | 2009-07-01 | Takeda Pharmaceutical | PREPARATION FOR PROLONGED RELEASE |
US20040052844A1 (en) | 2002-09-16 | 2004-03-18 | Fang-Hsiung Hsiao | Time-controlled, sustained release, pharmaceutical composition containing water-soluble resins |
WO2004041252A1 (en) | 2002-11-08 | 2004-05-21 | Egalet A/S | Controlled release carvedilol compositions |
AU2003292828B9 (en) | 2002-12-25 | 2009-10-01 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
EP1640006A4 (en) | 2003-06-27 | 2012-04-04 | Otsuka Pharma Co Ltd | PARTICLES WITH DELAYED MEDICAMENT RELIEF AND MANUFACTURING METHOD THEREFOR |
WO2005048979A2 (en) | 2003-10-06 | 2005-06-02 | Torrent Pharmaceuticals Limited | Pharmaceutical composition having casing with multiple micro tablets |
US9173847B2 (en) | 2003-10-10 | 2015-11-03 | Veloxis Pharmaceuticals A/S | Tablet comprising a fibrate |
US20050096365A1 (en) | 2003-11-03 | 2005-05-05 | David Fikstad | Pharmaceutical compositions with synchronized solubilizer release |
WO2005051325A2 (en) | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Carvedilol compositions methods of treatment and delivery |
US8007826B2 (en) | 2003-12-11 | 2011-08-30 | Acorda Therapeutics, Inc. | Sustained release aminopyridine composition |
DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
US20060008418A1 (en) | 2004-07-12 | 2006-01-12 | Solidtech Animal Health, Inc. | Packaging and method for solid dose administration of an electronic identification chip and medicaments |
GB2418854B (en) | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
US20060280789A1 (en) | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
US20060159753A1 (en) | 2004-12-27 | 2006-07-20 | Eisai Co. Ltd. | Matrix type sustained-release preparation containing basic drug or salt thereof |
US20090208579A1 (en) | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
AU2006263337A1 (en) | 2005-06-29 | 2007-01-04 | Panacea Biotec Ltd. | Modified release pharmaceutical compositions on the basis of two polymers and processes thereof |
RU2433821C2 (ru) | 2005-08-30 | 2011-11-20 | Пирамал Лайф Сайнсис Лимитед | Фармацевтическая композиция метформина с длительным высвобождением и способ ее получения |
HUE029336T2 (en) | 2005-09-16 | 2017-02-28 | Daiichi Sankyo Co Ltd | For the preparation of an optically active diamine derivative and process |
PL116330U1 (en) * | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
US8652529B2 (en) * | 2005-11-10 | 2014-02-18 | Flamel Technologies | Anti-misuse microparticulate oral pharmaceutical form |
WO2007113857A2 (en) | 2006-04-05 | 2007-10-11 | Cadila Healthcare Limited | Modified release clopidogrel formulation |
CN101489560B (zh) | 2006-04-26 | 2015-11-25 | 苏佩努斯制药公司 | 具有s形释放曲线的奥卡西平控释制剂 |
US20080004260A1 (en) | 2006-06-29 | 2008-01-03 | Transcept Pharmaceuticals, Inc. | Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions |
US8765178B2 (en) * | 2006-07-19 | 2014-07-01 | Watson Laboratories, Inc. | Controlled release formulations and associated methods |
US20080181947A1 (en) | 2006-09-26 | 2008-07-31 | Astellas Pharma Inc. | Controlled release dosage form of tacrolimus |
CN100563637C (zh) | 2006-10-13 | 2009-12-02 | 北京红林制药有限公司 | 一种控释给药的药芯组合物和控释制剂及其制备方法 |
JP2008169173A (ja) | 2007-01-15 | 2008-07-24 | Kissei Pharmaceut Co Ltd | 炭水化物分解酵素阻害剤の胃内滞留型徐放性製剤 |
US20100112053A1 (en) | 2007-01-15 | 2010-05-06 | Kissei Pharmaceutical Co., Ltd. | Gastric retention-type sustained-release levodopa preparation |
KR20080076382A (ko) | 2007-02-15 | 2008-08-20 | (주)아모레퍼시픽 | 실로스타졸의 제어방출 제제 및 그 제조방법 |
CN101652139A (zh) | 2007-03-29 | 2010-02-17 | 第一三共株式会社 | 药物组合物 |
JP2011500553A (ja) | 2007-10-10 | 2011-01-06 | ルピン・リミテッド | 5−アミノサリチル酸またはその塩もしくは代謝産物の新規な結腸を標的とする調節放出性生体接着性製剤 |
JP2011502140A (ja) | 2007-10-29 | 2011-01-20 | ルピン・リミテッド | トルテロジンの制御放出型医薬組成物 |
SI2057984T1 (sl) * | 2007-11-09 | 2010-04-30 | Acino Pharma Ag | Retardne tablete s hidromorfonom |
AU2008338207A1 (en) * | 2007-12-17 | 2009-06-25 | Labopharm (Barbados) Limited | Misuse preventative, controlled release formulation |
SI22849A (sl) | 2008-08-01 | 2010-02-26 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Ropinirolni pripravek |
FR2951378B1 (fr) | 2009-10-16 | 2012-06-01 | Flamel Tech Sa | Forme pharmaceutique orale solide anti-mesusage et dotee d'un profil specifique de liberation modifiee |
WO2011084593A2 (en) * | 2009-12-17 | 2011-07-14 | Cima Labs Inc. | Abuse-resistant formulations |
JP5714562B2 (ja) | 2010-02-22 | 2015-05-07 | 第一三共株式会社 | 経口用徐放性固形製剤 |
EP2540317A4 (en) | 2010-02-22 | 2014-04-16 | Daiichi Sankyo Co Ltd | SOLID PREPARATION WITH DELAYED RELEASE FOR ORAL ADMINISTRATION |
ES2706880T3 (es) * | 2010-02-22 | 2019-04-01 | Daiichi Sankyo Co Ltd | Preparación sólida de liberación sostenida para uso oral |
EP2538928B1 (en) * | 2010-02-24 | 2017-05-03 | Cima Labs Inc. | Abuse-resistant formulations |
SE1251371A1 (sv) * | 2010-05-10 | 2012-12-27 | Euro Celtique Sa | Farmaceutiska kompositioner innefattande hydromorfon och naloxon |
-
2013
- 2013-09-02 EP EP13832279.7A patent/EP2893928B1/en active Active
- 2013-09-02 ES ES13832279T patent/ES2706994T3/es active Active
- 2013-09-02 CA CA2883077A patent/CA2883077C/en not_active Expired - Fee Related
- 2013-09-02 KR KR1020157004945A patent/KR102127625B1/ko active IP Right Grant
- 2013-09-02 BR BR112015004190A patent/BR112015004190A2/pt not_active Application Discontinuation
- 2013-09-02 CN CN201380057382.5A patent/CN104768552A/zh active Pending
- 2013-09-02 JP JP2014533151A patent/JP6129184B2/ja active Active
- 2013-09-02 TW TW102131481A patent/TWI566786B/zh not_active IP Right Cessation
- 2013-09-02 WO PCT/JP2013/073519 patent/WO2014034929A1/ja unknown
- 2013-09-02 RU RU2015112122A patent/RU2665372C2/ru active
-
2015
- 2015-03-02 US US14/635,813 patent/US9827199B2/en active Active
- 2015-11-09 HK HK15111028.6A patent/HK1210053A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW201414509A (zh) | 2014-04-16 |
RU2665372C2 (ru) | 2018-08-29 |
KR20150045446A (ko) | 2015-04-28 |
KR102127625B1 (ko) | 2020-06-29 |
TWI566786B (zh) | 2017-01-21 |
US9827199B2 (en) | 2017-11-28 |
HK1210053A1 (en) | 2016-04-15 |
CA2883077C (en) | 2017-03-07 |
JP6129184B2 (ja) | 2017-05-17 |
ES2706994T3 (es) | 2019-04-02 |
CA2883077A1 (en) | 2014-03-06 |
CN104768552A (zh) | 2015-07-08 |
US20150231083A1 (en) | 2015-08-20 |
EP2893928A1 (en) | 2015-07-15 |
EP2893928B1 (en) | 2018-10-24 |
EP2893928A4 (en) | 2016-04-27 |
JPWO2014034929A1 (ja) | 2016-08-08 |
RU2015112122A (ru) | 2016-10-20 |
WO2014034929A1 (ja) | 2014-03-06 |
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