BR112014026643B1 - Derivados de imidazotiadiazol e imidazopirazina como inibidores de receptor 4 ativado por protease (par4) para o tratamento de agregação de plaqueta, seus usos e composição farmacêutica - Google Patents

Derivados de imidazotiadiazol e imidazopirazina como inibidores de receptor 4 ativado por protease (par4) para o tratamento de agregação de plaqueta, seus usos e composição farmacêutica Download PDF

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Publication number
BR112014026643B1
BR112014026643B1 BR112014026643-3A BR112014026643A BR112014026643B1 BR 112014026643 B1 BR112014026643 B1 BR 112014026643B1 BR 112014026643 A BR112014026643 A BR 112014026643A BR 112014026643 B1 BR112014026643 B1 BR 112014026643B1
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BR
Brazil
Prior art keywords
alkyl
halo
group
alkoxy
independently selected
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BR112014026643-3A
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English (en)
Portuguese (pt)
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BR112014026643A2 (pt
BR112014026643A8 (pt
Inventor
Jacques Banville
Roger Rémillard
Edward H. Ruediger
Daniel H. Deon
Marc Gagnon
Laurence Dubé
Julia Guy
Eldon Scott Priestley
Shoshana L. Posy
Brad D. Maxwell
Pancras C. Wong
Michael R. Lawrence
Michael M. Miller
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Universite De Montreal
Bristol-Myers Squibb Company
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Publication of BR112014026643A2 publication Critical patent/BR112014026643A2/pt
Publication of BR112014026643A8 publication Critical patent/BR112014026643A8/pt
Publication of BR112014026643B1 publication Critical patent/BR112014026643B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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BR112014026643-3A 2012-04-26 2013-04-24 Derivados de imidazotiadiazol e imidazopirazina como inibidores de receptor 4 ativado por protease (par4) para o tratamento de agregação de plaqueta, seus usos e composição farmacêutica BR112014026643B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261638577P 2012-04-26 2012-04-26
US61/638,577 2012-04-26
US201361787680P 2013-03-15 2013-03-15
US61/787,680 2013-03-15
PCT/US2013/037956 WO2013163279A1 (en) 2012-04-26 2013-04-24 Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation

Publications (3)

Publication Number Publication Date
BR112014026643A2 BR112014026643A2 (pt) 2017-06-27
BR112014026643A8 BR112014026643A8 (pt) 2021-06-15
BR112014026643B1 true BR112014026643B1 (pt) 2023-03-07

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MX2014012741A (es) 2012-04-26 2015-04-13 Bristol Myers Squibb Co Derivados de imidazotiadiazol e imidazopirazina como inhibidores del receptor 4 activado de proteasa (par4) para tratamiento de agregacion plaquetaria.
EA201491967A1 (ru) * 2012-04-26 2015-03-31 Бристол-Майерс Сквибб Компани Производные имидазотиадиазола в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов
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