BR112014012543A2 - métodos e materiais para síntese enzimática de compostos de mogrosídeo - Google Patents
métodos e materiais para síntese enzimática de compostos de mogrosídeoInfo
- Publication number
- BR112014012543A2 BR112014012543A2 BR112014012543A BR112014012543A BR112014012543A2 BR 112014012543 A2 BR112014012543 A2 BR 112014012543A2 BR 112014012543 A BR112014012543 A BR 112014012543A BR 112014012543 A BR112014012543 A BR 112014012543A BR 112014012543 A2 BR112014012543 A2 BR 112014012543A2
- Authority
- BR
- Brazil
- Prior art keywords
- materials
- methods
- enzymatic synthesis
- mogroside compounds
- compounds
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000002255 enzymatic effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229930189775 mogroside Natural products 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/20—Preparation of steroids containing heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161563303P | 2011-11-23 | 2011-11-23 | |
| PCT/IB2012/002857 WO2013076577A1 (en) | 2011-11-23 | 2012-11-19 | Methods and materials for enzymatic synthesis of mogroside compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014012543A2 true BR112014012543A2 (pt) | 2017-06-13 |
Family
ID=47624376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014012543A BR112014012543A2 (pt) | 2011-11-23 | 2012-11-19 | métodos e materiais para síntese enzimática de compostos de mogrosídeo |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9920349B2 (https=) |
| EP (1) | EP2783009B1 (https=) |
| JP (1) | JP6084983B2 (https=) |
| KR (1) | KR101791597B1 (https=) |
| CN (1) | CN103958693B (https=) |
| AU (2) | AU2012342114B2 (https=) |
| BR (1) | BR112014012543A2 (https=) |
| CA (1) | CA2853677C (https=) |
| IN (1) | IN2014CN03557A (https=) |
| MX (1) | MX342851B (https=) |
| MY (1) | MY170686A (https=) |
| RU (1) | RU2633644C2 (https=) |
| SG (1) | SG11201401927PA (https=) |
| WO (1) | WO2013076577A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| CN108396044A (zh) | 2011-08-08 | 2018-08-14 | 埃沃尔瓦公司 | 甜菊醇糖苷类的重组生产 |
| KR101791597B1 (ko) | 2011-11-23 | 2017-10-30 | 에볼바 에스아 | 모그로사이드 화합물을 효소에 의해 합성하기 위한 방법 및 재료 |
| TW201402599A (zh) * | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
| EP2929043A1 (en) | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
| CA2900882A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinants hosts |
| AU2015303294A1 (en) | 2014-08-11 | 2017-02-02 | Evolva Sa. | Production of steviol glycosides in recombinant hosts |
| AU2015314251A1 (en) | 2014-09-09 | 2017-03-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US20170283844A1 (en) | 2014-09-11 | 2017-10-05 | The State of Israel, Ministry of Agriculture & Rural Development, Argricultural Research Organiza | Methods of producing mogrosides and compositions comprising same and uses thereof |
| EP3201315A2 (en) | 2014-10-01 | 2017-08-09 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
| EP3208342A4 (en) | 2014-10-17 | 2018-07-04 | Suntory Holdings Limited | Mogrol glycosyltransferase and gene encoding same |
| US10626430B2 (en) | 2015-01-20 | 2020-04-21 | Suntory Holdings Limited | Method for preparing mogroside having no β-1,6-glucoside bond |
| SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2979931A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| AU2016307066A1 (en) | 2015-08-07 | 2018-02-08 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN108473528B (zh) | 2015-10-29 | 2026-01-16 | 弗门尼舍公司 | 高强度甜味剂 |
| CN106924274B (zh) * | 2015-12-29 | 2019-01-04 | 成都普睿法药物研发有限公司 | 葫芦烷型四环三萜类化合物抗肺纤维化应用 |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201809483UA (en) * | 2016-05-16 | 2018-11-29 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN109477126B (zh) | 2016-07-19 | 2023-06-20 | 三得利控股株式会社 | 罗汉果醇或罗汉果醇糖苷的生产方法 |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| SG11201910136RA (en) * | 2017-05-03 | 2019-11-28 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CN111246749A (zh) | 2017-05-19 | 2020-06-05 | 可口可乐公司 | 翅子罗汉果i甜味化的组合物及其用途 |
| RU2762719C2 (ru) | 2017-06-02 | 2021-12-22 | Живодан Са | Композиция, модифицирующая сладость |
| EP3638804A1 (en) | 2017-06-15 | 2020-04-22 | Evolva SA | Production of mogroside compounds in recombinant hosts |
| CN107189976B (zh) * | 2017-07-28 | 2022-03-11 | 李华政 | 促进罗汉果ugt72b21基因表达的方法 |
| MX2021005219A (es) | 2018-11-07 | 2021-06-18 | Firmenich Incorporated | Metodos para hacer edulcorantes de alta intensidad. |
| EP3860363A1 (en) | 2018-11-07 | 2021-08-11 | Firmenich Incorporated | Methods for making high intensity sweeteners |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| CN110669094B (zh) * | 2019-10-14 | 2021-12-21 | 上海交通大学 | 罗汉果新苷及其制备方法 |
| KR102362135B1 (ko) * | 2019-10-25 | 2022-02-14 | 고려대학교 산학협력단 | 테르펜 당쇄 부가 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| CN120230785A (zh) * | 2020-03-17 | 2025-07-01 | 可口可乐公司 | 新的罗汉果苷生产系统和方法 |
| CA3179775A1 (en) | 2020-04-20 | 2021-10-28 | Givaudan Sa | Compositions |
| GB202007984D0 (en) | 2020-05-28 | 2020-07-15 | Givaudan Sa | Compositions |
| CN112063647B (zh) * | 2020-09-17 | 2023-05-02 | 云南农业大学 | 酿酒酵母重组菌Cuol01的构建方法、酿酒酵母重组菌Cuol02及应用 |
| CN116064712B (zh) * | 2022-10-08 | 2025-05-06 | 中国药科大学 | 一种罗汉果醇的生物合成方法 |
| WO2024218244A1 (en) | 2023-04-20 | 2024-10-24 | Dsm Ip Assets B.V. | Strains and methods for the production of mogrosides |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399321B1 (en) * | 1999-08-18 | 2002-06-04 | National Research Council Of Canada | Methods for screening UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity and nucleic acid encoding for UGGT |
| EP1510573A1 (en) | 2003-09-01 | 2005-03-02 | Austria Wirtschaftsservice Gesellschaft mit beschränkter Haftung | Method for detoxification of mycotoxins |
| US20080148432A1 (en) * | 2005-12-21 | 2008-06-19 | Mark Scott Abad | Transgenic plants with enhanced agronomic traits |
| WO2006092449A2 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| US8257948B1 (en) * | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8956677B2 (en) | 2005-11-23 | 2015-02-17 | The Coca-Cola Company | High-potency sweetener composition with glucosamine and compositions sweetened therewith |
| RU2008122901A (ru) * | 2005-11-23 | 2009-12-27 | Дзе Кока-Кола Компани (US) | Композиция интенсивного подсластителя с сапонином и подслащенные ею композиции |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| US20100143975A1 (en) * | 2006-11-22 | 2010-06-10 | The University Of York | Monoterpenoid modifying enzymes |
| US20100132073A1 (en) | 2006-12-01 | 2010-05-27 | The University Of York | Sesquiterpenoid modifying enzymes |
| GB0904639D0 (en) * | 2009-03-18 | 2009-04-29 | Univ York | Assay |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| KR101791597B1 (ko) | 2011-11-23 | 2017-10-30 | 에볼바 에스아 | 모그로사이드 화합물을 효소에 의해 합성하기 위한 방법 및 재료 |
| EP2929043A1 (en) | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
-
2012
- 2012-11-19 KR KR1020147016910A patent/KR101791597B1/ko active Active
- 2012-11-19 EP EP12819015.4A patent/EP2783009B1/en active Active
- 2012-11-19 JP JP2014542951A patent/JP6084983B2/ja active Active
- 2012-11-19 US US14/356,782 patent/US9920349B2/en active Active
- 2012-11-19 MY MYPI2014001482A patent/MY170686A/en unknown
- 2012-11-19 SG SG11201401927PA patent/SG11201401927PA/en unknown
- 2012-11-19 MX MX2014006276A patent/MX342851B/es active IP Right Grant
- 2012-11-19 BR BR112014012543A patent/BR112014012543A2/pt unknown
- 2012-11-19 CN CN201280057518.8A patent/CN103958693B/zh active Active
- 2012-11-19 WO PCT/IB2012/002857 patent/WO2013076577A1/en not_active Ceased
- 2012-11-19 AU AU2012342114A patent/AU2012342114B2/en active Active
- 2012-11-19 CA CA2853677A patent/CA2853677C/en active Active
- 2012-11-19 IN IN3557CHN2014 patent/IN2014CN03557A/en unknown
- 2012-11-19 RU RU2014125216A patent/RU2633644C2/ru not_active IP Right Cessation
-
2017
- 2017-09-26 AU AU2017235907A patent/AU2017235907A1/en not_active Withdrawn
-
2018
- 2018-02-06 US US15/889,743 patent/US10738340B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2783009B1 (en) | 2016-04-13 |
| US9920349B2 (en) | 2018-03-20 |
| CA2853677C (en) | 2019-01-29 |
| JP6084983B2 (ja) | 2017-02-22 |
| RU2014125216A (ru) | 2015-12-27 |
| SG11201401927PA (en) | 2014-09-26 |
| KR101791597B1 (ko) | 2017-10-30 |
| EP2783009A1 (en) | 2014-10-01 |
| IN2014CN03557A (https=) | 2015-10-09 |
| US10738340B2 (en) | 2020-08-11 |
| RU2633644C2 (ru) | 2017-10-16 |
| MX342851B (es) | 2016-10-14 |
| WO2013076577A1 (en) | 2013-05-30 |
| US20140308698A1 (en) | 2014-10-16 |
| CN103958693B (zh) | 2016-08-24 |
| AU2012342114B2 (en) | 2017-12-21 |
| US20180237819A1 (en) | 2018-08-23 |
| JP2014533518A (ja) | 2014-12-15 |
| CN103958693A (zh) | 2014-07-30 |
| KR20140099281A (ko) | 2014-08-11 |
| CA2853677A1 (en) | 2013-05-30 |
| MY170686A (en) | 2019-08-26 |
| AU2012342114A1 (en) | 2014-05-22 |
| AU2017235907A1 (en) | 2017-10-12 |
| MX2014006276A (es) | 2014-10-13 |
| HK1200494A1 (zh) | 2015-08-07 |
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