BR112013014003A2 - Métodos de redução de produção de sebo na pele - Google Patents

Métodos de redução de produção de sebo na pele Download PDF

Info

Publication number
BR112013014003A2
BR112013014003A2 BR112013014003-8A BR112013014003A BR112013014003A2 BR 112013014003 A2 BR112013014003 A2 BR 112013014003A2 BR 112013014003 A BR112013014003 A BR 112013014003A BR 112013014003 A2 BR112013014003 A2 BR 112013014003A2
Authority
BR
Brazil
Prior art keywords
methods
seed production
reducing skin
skin seed
nitric oxide
Prior art date
Application number
BR112013014003-8A
Other languages
English (en)
Other versions
BR112013014003B1 (pt
Inventor
Bauman Susanne
Stasko Nathan
Original Assignee
Novan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novan, Inc. filed Critical Novan, Inc.
Publication of BR112013014003A2 publication Critical patent/BR112013014003A2/pt
Publication of BR112013014003B1 publication Critical patent/BR112013014003B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

métodos de redução de produção de sebo na pele a presente invenção refere-se a métodos de uso de óxido nítrico gasoso e/ou pelo menos uma fonte de óxido nítrico ou reduzir a produção de sebo na pele de um indivíduo. em algumas modalidades, a fonte de óxido nítrico inclui compostos que liberam no de pequenas moléculas e/ou macromoleculares.
BR112013014003-8A 2010-12-15 2011-12-15 métodos não-terapêuticos para redução da produção de sebo na pele de um indivíduo BR112013014003B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US42329210P 2010-12-15 2010-12-15
US61/423,292 2010-12-15
US201161504634P 2011-07-05 2011-07-05
US61/504,634 2011-07-05
US13/325,826 2011-12-14
US13/325,826 US8591876B2 (en) 2010-12-15 2011-12-14 Methods of decreasing sebum production in the skin
PCT/US2011/065043 WO2012082976A1 (en) 2010-12-15 2011-12-15 Methods of decreasing sebum production in the skin

Publications (2)

Publication Number Publication Date
BR112013014003A2 true BR112013014003A2 (pt) 2020-06-16
BR112013014003B1 BR112013014003B1 (pt) 2020-12-29

Family

ID=46234713

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013014003-8A BR112013014003B1 (pt) 2010-12-15 2011-12-15 métodos não-terapêuticos para redução da produção de sebo na pele de um indivíduo

Country Status (11)

Country Link
US (2) US8591876B2 (pt)
EP (2) EP2651381B1 (pt)
JP (1) JP5980804B2 (pt)
KR (1) KR101874141B1 (pt)
CN (1) CN103379892B (pt)
AU (1) AU2011343779B2 (pt)
BR (1) BR112013014003B1 (pt)
CA (1) CA2821962C (pt)
ES (2) ES2589682T3 (pt)
MX (1) MX348078B (pt)
WO (1) WO2012082976A1 (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018237A1 (en) 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
EP1871433B1 (en) 2005-03-24 2009-04-22 NOLabs AB Cosmetic treatment with nitric oxide, device for performing said treatment and manufacturing method therefor
JP5548121B2 (ja) 2007-05-14 2014-07-16 リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク バイオフィルム中の細菌細胞における生理学的分散応答の誘導
BR112012003792B1 (pt) 2009-08-21 2020-05-19 Novan Inc composição tópica, e, uso da composição tópica
US8591876B2 (en) * 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
EP2685962A1 (en) 2011-03-17 2014-01-22 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
ES2804263T3 (es) 2011-07-05 2021-02-05 Novan Inc Composiciones tópicas
WO2013029009A1 (en) 2011-08-24 2013-02-28 Novan, Inc. Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures
CN104302175B (zh) 2012-03-14 2017-04-12 诺万公司 释放一氧化氮的药物组合物
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9241899B2 (en) * 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9314417B2 (en) * 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9387159B2 (en) * 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9295637B2 (en) * 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9393264B2 (en) * 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
WO2016022170A1 (en) 2014-08-08 2016-02-11 Novan, Inc. Topical emulsions
US11813284B2 (en) * 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
US10322081B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
WO2016010988A1 (en) 2014-07-14 2016-01-21 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
JP2018524351A (ja) * 2015-07-02 2018-08-30 エーオーバイオーム， エルエルシー．ＡＯＢｉｏｍｅ， ＬＬＣ． ざ瘡の処置のためのアンモニア酸化細菌
WO2017019614A1 (en) 2015-07-28 2017-02-02 Novan, Inc. Combinations and methods for the treatment and/or prevention of fungal infections
EP3423100A4 (en) 2016-03-02 2019-10-16 Novan, Inc. COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION AND METHOD FOR THE TREATMENT THEREOF
EP3442502A4 (en) 2016-04-13 2019-11-06 Novan, Inc. COMPOSITIONS, SYSTEMS, KITS AND METHODS FOR TREATING INFECTION
GB201614961D0 (en) * 2016-09-02 2016-10-19 Relaxsol Ltd Compounds and compositions for use
US11534382B2 (en) 2017-06-19 2022-12-27 Novan, Inc. Topical compositions and methods of using the same
CA3085013A1 (en) 2017-12-13 2019-06-20 Onquality Pharmaceuticals China Ltd. A method for preventing or treating egfr-inhibition associated diseases
EP3758679A4 (en) 2018-03-01 2021-12-15 Novan, Inc. NITRIC OXIDE RELEASING SUPPOSITORIES AND THEIR METHODS OF USE
AU2019254237A1 (en) 2018-04-16 2020-12-03 Onquality Pharmaceuticals China Ltd. Method for preventing or treating side effects of cancer therapy
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance

Family Cites Families (407)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631337A (en) 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4558120A (en) 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4507466A (en) 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4568737A (en) 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4737550A (en) 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4587329A (en) 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4871779A (en) 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
US4694064A (en) 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
US4713975A (en) 1986-05-30 1987-12-22 The Dow Chemical Company Dense star polymers for calibrating/characterizing sub-micron apertures
US4857599A (en) 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
US4985023A (en) 1988-05-09 1991-01-15 Dow Corning Corporation Antimicrobial superabsorbent articles
US5045322A (en) 1988-05-09 1991-09-03 Dow Corning Corporation Antimicrobial superabsorbent sanitary napkin
US5061487A (en) 1988-05-09 1991-10-29 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US4990338A (en) 1988-05-09 1991-02-05 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5035892A (en) 1988-05-09 1991-07-30 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5079004A (en) 1990-08-06 1992-01-07 Dow Corning Corporation Antimicrobial superabsorbent compositions and method
US5380758A (en) 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US6291424B1 (en) 1991-11-14 2001-09-18 Brigham And Women's Hospital Nitrosated and nitrosylated heme proteins
DK0676964T3 (da) 1991-11-14 2001-02-05 Brigham & Womens Hospital Nitrosylering af enzym-SH-grupper som en terapeutisk modalitet
SE468771B (sv) 1992-02-26 1993-03-15 Perstorp Ab Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5650447A (en) 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5525357A (en) 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5852058A (en) 1993-06-11 1998-12-22 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US5891459A (en) 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
US5861168A (en) 1993-06-11 1999-01-19 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US5428070A (en) 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity
EP0724436B1 (en) 1993-09-17 2004-01-07 Brigham And Women's Hospital Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces
US6087479A (en) 1993-09-17 2000-07-11 Nitromed, Inc. Localized use of nitric oxide-adducts to prevent internal tissue damage
US6255277B1 (en) 1993-09-17 2001-07-03 Brigham And Women's Hospital Localized use of nitric oxide-adducts to prevent internal tissue damage
CA2173738A1 (en) 1993-10-08 1995-04-20 James B. Mitchell Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
US5840759A (en) 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
ATE192922T1 (de) 1993-11-02 2000-06-15 Us Health Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden
US5726156A (en) 1995-03-06 1998-03-10 Trega Biosciences, Inc. Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels
US5786332A (en) 1995-03-06 1998-07-28 Trega Biosciences, Inc. Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels
US6008255A (en) 1994-01-21 1999-12-28 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US5599984A (en) 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US6709681B2 (en) 1995-02-17 2004-03-23 Aberdeen University Acidified nitrite as an antimicrobial agent
EP0746327B1 (en) 1994-02-21 2004-04-21 Aberdeen University Acidified nitrite as an antimicrobial agent
US5935924A (en) 1994-04-15 1999-08-10 Genentech, Inc. Treatment of congestive heart failure
US5504117A (en) 1994-05-27 1996-04-02 Neptune Pharmaceutical Corporation Pharmacologic preparation for the treatment of anal disorders
ES2092460T3 (es) 1994-05-27 2001-02-01 Cellegy Pharma Inc Composicion dadora de oxido nitrico para el tratamiento de trastornos anales.
US6190704B1 (en) 1994-09-23 2001-02-20 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US6747062B2 (en) 1994-09-26 2004-06-08 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US5519020A (en) 1994-10-28 1996-05-21 The University Of Akron Polymeric wound healing accelerators
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
US5700830A (en) 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
US5961466A (en) 1995-01-03 1999-10-05 Omnicorder Technologies, Inc. Method of detection of cancerous lesions by their effect on the spatial distribution of modulation of temperature and homogeneity of tissue
US6035225A (en) 1995-01-03 2000-03-07 Omnicorder Technologies Detection of cancerous lesions by measuring nitric oxide concentrations in tissue
US5999843A (en) 1995-01-03 1999-12-07 Omnicorder Technologies, Inc. Detection of cancerous lesions by their effect on the spatial homogeneity of skin temperature
US5810010A (en) 1995-01-03 1998-09-22 Anbar; Michael Detection of cancerous lesions by their effect on the periodic modulation of perfusion in the surrounding tissues
DE69630514D1 (de) 1995-01-05 2003-12-04 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
US5665077A (en) 1995-04-24 1997-09-09 Nitrosci Pharmaceuticals Llc Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
DE69637676D1 (de) 1995-11-09 2008-10-23 Univ R Verwendung von lokal verabreichten Lysine zur VERBESSERUNG DER VASKULAREN FUNKTION
US5821261A (en) 1995-12-08 1998-10-13 Merck & Co., Inc. Substituted saturated aza heterocycles as inhibitors of nitric oxide synthase
US20050065161A1 (en) 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US6294517B1 (en) 1996-02-02 2001-09-25 Nitromed, Inc. Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
US20020061879A1 (en) 1996-02-02 2002-05-23 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US5994294A (en) 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US6323211B1 (en) 1996-02-02 2001-11-27 Nitromed, Inc. Compositions and methods for treating sexual dysfunctions
US5932538A (en) 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
IT1282686B1 (it) 1996-02-26 1998-03-31 Nicox Sa Composti in grado di ridurre la tossicita' da farmaci
WO1997034014A1 (en) 1996-03-15 1997-09-18 Yale University Methods and means of detecting nitric oxide synthase
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6232434B1 (en) 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US5770645A (en) 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US20030093143A1 (en) 1999-03-01 2003-05-15 Yiju Zhao Medical device having surface depressions containing nitric oxide releasing compound
US5797887A (en) 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
AU3986097A (en) 1996-08-27 1998-03-19 University Of Akron, The Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use
EP2292630B1 (en) 1996-09-27 2015-11-25 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services O2-substituted 1- (2-carboxylato)pyrrolidin-1-yl diazen-1-ium-1,2-diolates
GB9622997D0 (en) 1996-11-05 1997-01-08 Univ St Andrews Nitric oxide donor drugs
US5958427A (en) 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
US5891472A (en) 1996-11-19 1999-04-06 Meri Charmyne Russell Treatment of equine laminitis
US6896899B2 (en) 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
DE69739663D1 (de) 1996-12-31 2009-12-31 Antioxidant Pharmaceuticals Co Pharmazeutische glutathionpräparate und methoden zu dern verabreichung
EP0952935B1 (en) 1997-01-17 2003-10-29 CASCADE ENGINEERING, Inc. Mat with integrally molded door
EP1001677A4 (en) 1997-02-04 2003-01-08 Gen Hospital Corp METHOD FOR TREATING EPIDERMAL OR DERMAL SKIN CONDITIONS
US6034752A (en) 1997-03-22 2000-03-07 Kent Displays Incorporated Display device reflecting visible and infrared radiation
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US6171232B1 (en) 1997-06-26 2001-01-09 Cordis Corporation Method for targeting in vivo nitric oxide release
ATE499343T1 (de) 1997-07-03 2011-03-15 Us Gov Health & Human Serv Stickoxid freistetzende amidin- und enaminverwandte diazeniumdiolate, zubereitungen und verwendungen davon und verfahren zu ihrer herstellung
US6796966B2 (en) 1997-10-15 2004-09-28 Jeffrey E. Thomas Apparatus, and kits for preventing of alleviating vasoconstriction or vasospasm in a mammal
AU9596698A (en) 1997-10-15 1999-05-03 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US5994444A (en) 1997-10-16 1999-11-30 Medtronic, Inc. Polymeric material that releases nitric oxide
CA2219867A1 (en) 1997-10-31 1999-04-30 Jiangping Wu The use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
ATE277038T1 (de) 1997-12-23 2004-10-15 Amersham Health As Stickstoffoxid freisetzende chelatbildner und ihre therapeutische verwendung
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1298338B1 (it) 1998-03-05 1999-12-20 Nicox Sa Composizioni farmaceutiche per l'ulcera
US6560478B1 (en) 1998-03-16 2003-05-06 The Research Foundation Of City University Of New York Method and system for examining biological materials using low power CW excitation Raman spectroscopy
US6151522A (en) 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
US5962520A (en) 1998-04-02 1999-10-05 The University Of Akron Hydrolytically unstable, biocompatible polymer
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US6207855B1 (en) 1998-06-23 2001-03-27 Duke University Medical Center Stable no-delivering compounds
US20020068365A1 (en) 1998-07-28 2002-06-06 Eric H. Kuhrts Controlled release nitric oxide producing agents
US6299980B1 (en) 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US6379691B1 (en) 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
US20040043068A1 (en) 1998-09-29 2004-03-04 Eugene Tedeschi Uses for medical devices having a lubricious, nitric oxide-releasing coating
CA2254645A1 (en) 1998-11-23 2000-05-23 Pulmonox Medical Corporation Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US20070275100A1 (en) 1998-11-23 2007-11-29 Miller Christopher C Use of gaseous nitric oxide as an anti-cancer agent
US20070086954A1 (en) 1998-11-23 2007-04-19 Miller Christopher C Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
US7179475B1 (en) 1998-12-04 2007-02-20 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US6238683B1 (en) 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US20050142218A1 (en) 2000-03-09 2005-06-30 Queen Mary & Westfield College Pharmaceutical composition containing nitrate source and an acidifying agent for treating skin ischaemia
GB9905425D0 (en) 1999-03-09 1999-05-05 Queen Mary & Westfield College Pharmaceutical composition
US6312663B1 (en) 1999-03-19 2001-11-06 Joseph V. Boykin, Jr. Prediction of diabetes impaired wound healing by urinary nitrate assay
US6562785B1 (en) 1999-03-23 2003-05-13 Howard M. Shapiro Method for overcoming bacterial antibiotic resistance
US7655423B2 (en) 1999-06-14 2010-02-02 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
US7135498B1 (en) 1999-06-14 2006-11-14 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
DE60040299D1 (de) 1999-06-14 2008-10-30 Ford Henry Health System Stickstoffmonoxid-donoren zum induzieren von neurogenese
US20010012851A1 (en) 1999-07-29 2001-08-09 Kristin M. Lundy Nitric oxide releasing oxindole prodrugs for anagesic, anti-inflammatory and disease-modifying use
US20020049157A1 (en) 1999-08-25 2002-04-25 Jiangping Wu Use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock
WO2001015738A2 (en) 1999-09-02 2001-03-08 Rice University Nitric oxide-producing hydrogel materials
US7052711B2 (en) 1999-09-02 2006-05-30 Rice University Nitric oxide-producing hydrogel materials
US7279176B1 (en) 1999-09-02 2007-10-09 Rice University Nitric oxide-producing hydrogel materials
US6737447B1 (en) 1999-10-08 2004-05-18 The University Of Akron Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
BR0016554A (pt) 1999-12-20 2003-02-11 Majeste La Reine Du Chef Du Ca Método e composição para tratamento e/ou prevenção de infecções de microorganismo resistentes à antibióticos
US6492405B2 (en) 1999-12-30 2002-12-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nitric oxide donors and pharmaceutical compositions containing them
US20020132234A1 (en) 2000-01-24 2002-09-19 Moskowitz David W. Nitric oxide synthase gene diagnostic polymorphisms
US6758214B2 (en) 2000-01-28 2004-07-06 Cyterra Corporation Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment
US6699846B2 (en) 2000-03-17 2004-03-02 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders
MXPA02009236A (es) 2000-03-20 2004-04-05 Novovascular Inc Matrices que contienen donadores de oxido nitrico y agentes reductores, y su uso.
US20010038832A1 (en) 2000-04-11 2001-11-08 Benjamin Bonavida Nitric oxide and analogues thereof effectuate sensitization of neoplasm and immunologically undesired tissues to cytotoxicity
US20050142217A1 (en) 2000-04-26 2005-06-30 Adams Michael A. Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
AU5022101A (en) 2000-04-26 2001-11-07 Univ Kingston Formulations and methods of using nitric oxide mimetics against a malignant cellphenotype
US7678391B2 (en) 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US20010053772A1 (en) 2000-04-28 2001-12-20 Benjamin Bonavida Aza analogues of alkyl lysophospholipids exert immunomodulatory effects
US6270779B1 (en) 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
WO2001089519A1 (en) 2000-05-22 2001-11-29 Nitromed, Inc. Thromboxane inhibitors, compositions and methods of use related applications
US6623728B2 (en) 2000-06-30 2003-09-23 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Cosmetic skin care compositions and containing gum mastic
US6538033B2 (en) 2000-08-29 2003-03-25 Huntington Medical Research Institutes Nitric oxide donor compounds
GB0021317D0 (en) 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
JP4841066B2 (ja) 2000-09-01 2011-12-21 ライスユニバーシティ 酸化窒素生成ヒドロゲル物質
GB0022084D0 (en) 2000-09-08 2000-10-25 Univ Aberdeen Treatment of multiply antibiotic-resistant organisms
US6410622B1 (en) 2000-09-11 2002-06-25 Gregory W. Endres Method of preventing fouling organisms in marine environments and polymer-bound nitric oxide/nitric oxide-releasing compositions usable therefor
AU1122202A (en) 2000-10-16 2002-04-29 Univ Duke Therapeutic use of aerosolized s-nitrosoglutathione in cystic fibrosis
AU2002211776A1 (en) 2000-10-17 2002-04-29 Board Of Regents, The University Of Texas System A method to incorporate n-(4-hydroxyphenyl) retinamide in liposomes
US6359182B1 (en) 2000-10-26 2002-03-19 Duke University C-nitroso compounds and use thereof
US7049308B2 (en) 2000-10-26 2006-05-23 Duke University C-nitroso compounds and use thereof
KR100383149B1 (ko) 2000-12-12 2003-05-12 한국생명공학연구원 디테르펜계 화합물을 염증질환, 면역질환 및 암 치료제로사용하는 신규한 용도
DE10063937A1 (de) 2000-12-20 2002-07-18 Bayer Ag Verfahren zur Herstellung von Trimethylolverbindungen und Ameisensäure
US6780849B2 (en) 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US7329412B2 (en) 2000-12-22 2008-02-12 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
US20040009238A1 (en) 2002-07-09 2004-01-15 Chris Miller Exogenenous nitric oxide gas (gNO) therapy in wound healing
US7122018B2 (en) 2000-12-26 2006-10-17 Sensormedics Corporation Device and method for treatment of wounds with nitric oxide
US6432077B1 (en) 2000-12-26 2002-08-13 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US7128904B2 (en) 2001-01-16 2006-10-31 The Regents Of The University Of Michigan Material containing metal ion ligand complex producing nitric oxide in contact with blood
US7335383B2 (en) 2001-01-16 2008-02-26 The Regents Of The University Of Michigan Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
CA2433803A1 (en) 2001-01-16 2002-07-25 Mark E. Meyerhoff Biocatalytic and biomimetic generation of nitric oxide in situ at substrate/blood interfaces
US6706274B2 (en) 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
ITMI20010426A1 (it) 2001-03-01 2002-09-01 Consiglio Nazionale Ricerche Donatori di ossido di azoto basati su centri metallici
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20020138051A1 (en) 2001-03-26 2002-09-26 Hole Douglas R. System and method for the prevention and treatment of animal wound infections using nitric oxide
US6710037B2 (en) 2001-05-01 2004-03-23 Schering Corporation Method of treating androgen-dependent disorders
WO2002096387A1 (en) 2001-05-25 2002-12-05 Medtronic, Inc. Implantable medical device with controllable gaseous agent release system
ES2180446B1 (es) 2001-07-02 2004-01-16 Esteve Labor Dr Empleo de derivados de acidos 2,5-dihidroxibencenosulfonicos en la elaboracion de un medicamento para potenciar el efecto de otros farmacos en el tratamiento de la disfuncion erectil.
WO2003006427A1 (en) 2001-07-12 2003-01-23 Johns Hopkins University Compounds that release nitric oxide at controlled rates upon photolysis
GB0119011D0 (en) 2001-08-03 2001-09-26 Univ Aberdeen Treatment of nail infections
US7432301B2 (en) 2001-08-20 2008-10-07 University Of Virginia Patent Foundation Use of S-nitrosothiol signaling to treat disordered control of breathing
US6841166B1 (en) 2001-08-21 2005-01-11 The Regents Of The University Of Michigan Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives
US7135189B2 (en) 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
WO2003020211A2 (en) 2001-09-05 2003-03-13 Cyterra Corporation Nitric oxide generation
AU2002336761A1 (en) 2001-09-26 2003-04-07 The Government Of The United States Of America, Represented By The Secretary, Department Of Health A Nitric oxide-releasing coated medical devices and method of preparing same
EP1300083A1 (en) 2001-10-04 2003-04-09 Societe Des Produits Nestle S.A. Milk-based snack
US6703046B2 (en) 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
GB0125222D0 (en) 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US6472390B1 (en) 2001-11-13 2002-10-29 Duke University Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
US6627602B2 (en) 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
US20040110691A1 (en) 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
MXPA04005332A (es) 2001-12-03 2005-05-16 Bard Inc C R Dispositivo medico resistente a microbios, revestimiento polimerico resistente a microbios y metodos para producir los mismos.
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
US6474508B1 (en) 2002-01-24 2002-11-05 Saint-Gobain Calmar Inc. Unit dose tube and cap assembly
US20030219854A1 (en) 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
CA2480033C (en) 2002-03-21 2011-05-10 The University Of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors
AU2003223491A1 (en) 2002-04-05 2003-10-27 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
EP1501563A1 (en) 2002-05-03 2005-02-02 Duke University Medical Center Carbon nanotubules for storage of nitric oxide
EP1507526A2 (en) 2002-05-07 2005-02-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
CA2485565A1 (en) 2002-05-13 2004-08-05 Trustees Of Dartmouth College Inhibitors and methods of use thereof
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
AU2003279236B8 (en) 2002-06-21 2009-02-19 Beth Israel Deaconess Medical Center, Inc. Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
US20070065473A1 (en) * 2002-07-09 2007-03-22 Miller Christopher C Nitric oxide gas (gO) as a cosmetic and wound healing agent
US6949530B2 (en) 2002-07-18 2005-09-27 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
CA2493082A1 (en) 2002-07-26 2004-02-05 Merck Frosst Canada & Co. Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
JP2005534485A (ja) 2002-08-02 2005-11-17 アメリカ合衆国 架橋した一酸化窒素−放出ポリアミン被覆基質、それを含む組成物及びその製造方法
US20020182162A1 (en) 2002-08-07 2002-12-05 Mohsen Shahinpoor Nitric oxide (NO) donor+cGMP-PDE5 inhibitor as a topical drug for enhanced hair growth
US20040076582A1 (en) 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US20050080021A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders
US20040033480A1 (en) 2002-08-15 2004-02-19 Wong Norman C.W. Use of resveratrol to regulate expression of apolipoprotein A1
US20050080024A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives for the treatment of cardiovascular disorders
US6951902B2 (en) 2002-08-16 2005-10-04 Michigan Biotechnology Institute Two dimensional polymer that generates nitric oxide
US20030039697A1 (en) 2002-09-12 2003-02-27 Yi-Ju Zhao Matrices containing nitric oxide donors and reducing agents and their use
AU2003278039A1 (en) 2002-10-22 2004-05-13 Merck Frosst Canada And Co. Nitric oxide releasing selective cyclooxygenase-2 inhibitors
US20080317679A1 (en) 2002-10-25 2008-12-25 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
ES2477118T3 (es) 2002-11-18 2014-07-15 Polaris Group Método para inhibir la replicaci�n viral in vivo
WO2004060283A2 (en) 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
WO2004064767A2 (en) 2003-01-23 2004-08-05 Kahn Nighat N Nitric oxide inducing agents
FR2850579B1 (fr) * 2003-02-03 2006-08-18 Oreal Utilisation de mono-ou di-esters d'acide cinnamique ou de l'un de ses derives et de vitamine c, comme donneur de no
FR2850578B1 (fr) * 2003-02-03 2006-07-28 Oreal Utilisation de n-arylmethylene ethylenediaminetriacetates, n-arylmethyleneiminodiacetates ou n,n'-diarylmethylene ethylenediamineacetates comme donneurs de no
DE602004021238D1 (de) 2003-03-05 2009-07-09 Merck Frosst Company Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2
CA2518506A1 (en) 2003-03-13 2004-11-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
SE0300971D0 (sv) 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US20040254419A1 (en) 2003-04-08 2004-12-16 Xingwu Wang Therapeutic assembly
US20050079132A1 (en) 2003-04-08 2005-04-14 Xingwu Wang Medical device with low magnetic susceptibility
US7972137B2 (en) 2003-06-30 2011-07-05 Rosen Gerald M Anti-microbial dental formulations for the prevention and treatment of oral mucosal disease
CN101912412B (zh) 2003-07-03 2013-06-05 圣安德鲁斯大学董事会 用于传递一氧化氮的沸石
US7234079B2 (en) 2003-07-11 2007-06-19 Agency For Science, Technology & Research Method and system for enabling recovery of data stored in a computer network; a method and a system for recovering data stored in a computer network
US20050054714A1 (en) 2003-07-17 2005-03-10 Benito Munoz Nitric oxide releasing drugs for Alzheimer's disease
WO2005011575A2 (en) 2003-07-25 2005-02-10 The University Of Akron Stabilization and ionic triggering of nitric oxide release
US7364585B2 (en) 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
US7314857B2 (en) 2003-08-25 2008-01-01 Kane Biotech Inc. Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
CA2536975A1 (en) 2003-08-28 2005-03-17 Nitromed, Inc. Nitrosated and nitrosylated diuretic compounds, compositions and methods of use
CA2539974A1 (en) 2003-09-26 2005-04-07 David R. Whitlock Methods of using ammonia oxidizing bacteria
CA2539973A1 (en) 2003-09-26 2005-04-07 Nitromed, Inc. Nitrosated glutamic acid compounds, compositions and methods of use
US7485324B2 (en) 2003-09-29 2009-02-03 Pulmonox Technologies Corporation Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms
US20050074506A1 (en) 2003-10-02 2005-04-07 Brainsgate Ltd. Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
US20070255206A1 (en) 2003-10-14 2007-11-01 Reneker Darrell H Balloon for Use in Angioplasty
US20060286158A1 (en) 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
US20070053966A1 (en) 2003-10-17 2007-03-08 Robert Ang Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue
US20050171199A1 (en) 2003-10-17 2005-08-04 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
US20060286159A1 (en) 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of persistent active tendinopathy using transdermal glyceryl trinitrate providing durability of effect
US20070059351A1 (en) 2003-10-17 2007-03-15 Murrell George A C Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods
JP2007534361A (ja) 2003-12-15 2007-11-29 ニトリカーレ・ハンデルスボラーグ 治療薬を投与する装置および方法
EP1701747B1 (en) 2004-01-07 2014-03-12 Noxilizer, Inc. Sterilisation method
US8017074B2 (en) 2004-01-07 2011-09-13 Noxilizer, Inc. Sterilization system and device
AU2005207039A1 (en) 2004-01-22 2005-08-04 Reneker, Darrell Polymer NO donor predrug nanofiber coating for medical devices and therapy
US20090131342A1 (en) 2004-01-22 2009-05-21 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
CA2554334A1 (en) 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
AU2005206229A1 (en) 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
US20050165452A1 (en) 2004-01-28 2005-07-28 Medtronic, Inc. Antithrombogenic medical device
CA2555591C (en) 2004-02-09 2011-01-04 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
US7569559B2 (en) 2004-02-09 2009-08-04 Noxilizer, Inc. Nitric oxide-releasing molecules
EP1718656A2 (en) 2004-02-10 2006-11-08 Purdue Research Foundation Crowned dithiocarbamate metal complexes and methods for their use
JP5376761B2 (ja) 2004-02-23 2013-12-25 ストラテジック サイエンス アンド テクノロジーズ， エルエルシー 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達
WO2005107384A2 (en) 2004-03-31 2005-11-17 Nitromed, Inc. Methods for treating blood disorders with nitric oxide donor compounds
WO2005102282A1 (en) 2004-04-19 2005-11-03 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment
CA2564399A1 (en) 2004-04-28 2005-11-17 Brigham Young University Use of equol for treating skin diseases
WO2005115440A2 (en) 2004-04-29 2005-12-08 Kahn Nighat N Compositions and method for modulating insulin-activated nitric oxide synthase
WO2005112954A1 (en) 2004-05-14 2005-12-01 William Marsh Rice University Nitric oxide releasing compositions and associated methods
WO2005112974A2 (en) 2004-05-14 2005-12-01 William Marsh Rice University Peptide-modified polyurethane compositions and associated methods
US7582623B2 (en) 2004-05-20 2009-09-01 The Regents Of The University Of California Photoactive metal nitrosyls for blood pressure regulation and cancer therapy
DE602005018222D1 (pt) 2004-06-10 2010-01-21 Nippon Kayaku Kk
US20060008529A1 (en) 2004-07-12 2006-01-12 Meyerhoff Mark E Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers
US20060039950A1 (en) 2004-08-23 2006-02-23 Zhengrong Zhou Multi-functional biocompatible coatings for intravascular devices
US7968664B2 (en) 2004-09-27 2011-06-28 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US20070154570A1 (en) 2004-09-29 2007-07-05 Miller Christopher C Use of nitric oxide in the treatment and disinfection of biofilms
US8067464B2 (en) 2004-10-04 2011-11-29 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
FR2877004B1 (fr) 2004-10-21 2007-03-09 Oreal Esters et amides silaniques d'acide 2-oxothiazolidine-4- carboxylique et leurs utilisations cosmetiques.
CA2574535A1 (en) 2004-11-15 2006-05-26 Nitromed, Inc. Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use
WO2006058318A2 (en) 2004-11-29 2006-06-01 The University Of Akron Topical nitric oxide donor devices
WO2006064056A2 (en) 2004-12-16 2006-06-22 Nolabs Ab Anti-pathogen and anti-cancer filtering device and method comprising nitric oxide
EP1681068A1 (en) 2004-12-16 2006-07-19 NOLabs AB Anti-pathogen and anti-cancer filtering device and method comprising nitric oxide
WO2006066362A1 (en) 2004-12-24 2006-06-29 The University Of Queensland Methods of treating pain
JP2008528626A (ja) 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
EP1757278A1 (en) 2005-08-23 2007-02-28 NOLabs AB Device, system, and method comprising microencapsulated liquid for release of nitric oxide from a polymer
BRPI0606829A2 (pt) 2005-02-11 2009-07-21 Nolabs Ab dispositivo configurado, processo para fabricação de dispositivo configurado, usos de polìmero eluente de óxido nìtrico(no), método de tratamento e uso de óxido nìtrico(no)
DK1846058T3 (da) 2005-02-11 2009-11-23 Nolabs Ab Indretning, fremgangsmåde og anvendelse til behandling af neuropati med nitrogenoxid
EP1690532A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for gastric treatment and manufacturing process for the same
EP1707224A1 (en) 2005-02-11 2006-10-04 NOLabs AB Pharmaceutical mixture with nitric oxide booster, device for applying the mixture and manufacturing method therefor
EP1846009A2 (en) 2005-02-11 2007-10-24 NOLabs AB Improved device for application of medicaments, manufacturing method therefor, and method of treatment
EP1690558A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of diabetic disorders
EP1700611A1 (en) 2005-02-11 2006-09-13 NOLabs AB Device for treatment of disorders in the oral cavity, and manufacturing process for the same
EP1690557A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of rectal disorders, and manufacturing process for the same
AU2006336387A1 (en) 2005-02-16 2007-08-02 Nicox S.A. Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use
JP2008531579A (ja) 2005-02-24 2008-08-14 ニトロメッド インコーポレーティッド 酸化窒素増強利尿化合物、組成物および使用方法
US8119840B2 (en) 2005-03-04 2012-02-21 The University Of Akron Ethambutol based nitric oxide donors
CA2597444A1 (en) 2005-03-09 2006-09-21 Nitromed, Inc. Organic nitric oxide enhancing salts of angiotensin ii antagonists, compositions and methods of use
GB0505035D0 (en) 2005-03-11 2005-04-20 Insense Ltd Improvements relating to skin dressings
WO2006097348A1 (en) 2005-03-15 2006-09-21 L'oreal Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
EP1871433B1 (en) 2005-03-24 2009-04-22 NOLabs AB Cosmetic treatment with nitric oxide, device for performing said treatment and manufacturing method therefor
EP1704876A1 (en) * 2005-03-24 2006-09-27 NOLabs AB Cosmetic treatment, device for performing said treatment and manufacturing method thereof
EP1704879A1 (en) 2005-03-24 2006-09-27 NOLabs AB Intravascular, interstitial or intraorgan medical device comprising a nitric oxide eluting polymer
WO2006100155A1 (en) 2005-03-24 2006-09-28 Nolabs Ab Device for wound care, and manufacturing method thereof, involving the use of nitric oxide
EP1704877A1 (en) 2005-03-24 2006-09-27 NOLabs AB A wound care device comprising a nitric oxide eluting polymer
KR20080003320A (ko) 2005-03-24 2008-01-07 노랩스 에이비 산화질소를 포함하는 혈관내, 간질 또는 장기내 의료 접근기기 및 제조 방법
JP2008545655A (ja) 2005-05-16 2008-12-18 ザ ガバナーズ オブ ザ ユニバーシティ オブ アルバータ 一酸化窒素供与体ジアゼン−１−イウム−１，２−ジオラート部分を有する新規非ステロイド系抗炎症薬
WO2006122573A1 (en) 2005-05-17 2006-11-23 Syntach Ag A device a kit for treatment of disorders in the heart rhythm regulation system
WO2006127591A2 (en) 2005-05-23 2006-11-30 Nitromed, Inc. Organic nitric oxide enhancing salts of nonsteroidal antiinflammatory compounds, compositions and methods of use
DK2351828T3 (en) 2005-05-24 2018-01-22 Univ Nanyang Tech Methods and compositions for regulating biofilm development
EP2669269B1 (en) 2005-05-27 2019-05-22 The University of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
EP1731176A1 (en) 2005-06-01 2006-12-13 NOLabs AB Pre-treatment device comprising nitric oxide
WO2006128742A2 (en) 2005-06-01 2006-12-07 Nolabs Ab Treatment and pre-treatment device, and manufacturing method therefor, involving nitric oxide
WO2006128743A1 (en) 2005-06-01 2006-12-07 Nolabs Ab Feedstuff
EP1728438A1 (en) 2005-06-01 2006-12-06 NOLabs AB Feedstuff
WO2006130982A1 (en) 2005-06-09 2006-12-14 University Of Manitoba Compositions and methods for enhancing nitric oxide delivery
US20080241208A1 (en) 2005-06-30 2008-10-02 Charles Shanley Methods, Compositions and Devices For Promoting Anglogenesis
US20090118819A1 (en) 2005-06-30 2009-05-07 Mc3, Inc. Nitric Oxide Coatings for Medical Devices
US20080139450A1 (en) 2005-07-01 2008-06-12 Srinivasa Madhyastha Antimicrobial Compositions and Uses Thereof
US8906364B2 (en) 2005-07-01 2014-12-09 Kane Biotech Inc. Antimicrobial compositions and uses thereof
BRPI0503201B8 (pt) 2005-07-28 2021-05-25 Sci Tech Produtos Medicos Ltda stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis
EP1915157A4 (en) 2005-08-02 2010-09-01 Nicox Sa NICKEL OXYGENIZING ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND USE PROCESSES
WO2007024501A2 (en) 2005-08-25 2007-03-01 Medtronic Vascular, Inc. Nitric oxide-releasing biodegradable polymers useful as medical devices and coatings therefore
WO2007022991A1 (en) 2005-08-26 2007-03-01 Nestec S.A. Compositions and methods for improving functional vascular integrity, cellular survival and reducing apoptosis in ischemia or after ischemic episode in the brain
US20070048344A1 (en) 2005-08-31 2007-03-01 Ali Yahiaoui Antimicrobial composition
US20070053952A1 (en) 2005-09-07 2007-03-08 Medtronic Vascular, Inc. Nitric oxide-releasing polymers derived from modified polymers
EP1764119A1 (en) 2005-09-09 2007-03-21 NOLabs AB Implants with improved osteointegration
US20090010989A1 (en) 2005-09-12 2009-01-08 N0Labs Ab Coating For Implants and Implants With Improved Osteointegration, and Manufacturing Method
KR20080059564A (ko) 2005-10-11 2008-06-30 바이엘 컨수머 케어 악티엔게젤샤프트 금속 맛을 차폐한 철 및 구리 염의 혼합물
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
US7531164B2 (en) 2005-10-21 2009-05-12 Duke University Preventing bacterial or viral infectivity and composition containing infection preventing additive
WO2007053578A2 (en) 2005-10-31 2007-05-10 Amulet Pharmaceuticals, Inc. Multi-phasic nitric oxide and drug co-eluting stent coatings
US7928079B2 (en) 2005-10-31 2011-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
EP1790335A1 (en) 2005-11-14 2007-05-30 NOLabs AB Composition and its use for the manufacture of a medicament for treating, prophylactically treating, preventing cancer and/or infections in the urinary tract
US7838023B2 (en) 2005-11-16 2010-11-23 Nitromed, Inc. Furoxan compounds, compositions and methods of use
US20070116785A1 (en) 2005-11-18 2007-05-24 Miller Christopher C Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant
US20090287072A1 (en) 2005-12-02 2009-11-19 The Regents Of The University Of Michigan Polymer compositions, coatings and devices, and methods of making and using the same
CA2632683A1 (en) 2005-12-06 2007-06-14 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
US20070243262A1 (en) 2005-12-21 2007-10-18 Hurley Kevin P Stable S-nitrosothiol formulations
US9801902B2 (en) 2006-01-17 2017-10-31 The University Of Akron Debridement method using topical nitric oxide donor devices and compositions
EP1979487A4 (en) 2006-01-26 2010-05-05 Bebaas Inc COBALAMINE COMPOSITIONS FOR THE TREATMENT OF CANCER
US8247460B2 (en) 2006-02-03 2012-08-21 Giulio Cossu Method of treatment for muscular dystrophy
PL1978947T3 (pl) 2006-02-03 2015-03-31 Nicox Science Ireland Nitrooksypochodne do zastosowania w leczeniu dystrofii mięśniowych
US20070202155A1 (en) 2006-02-03 2007-08-30 Cure Therapeutics, Inc. Low dose no donor-containing transdermal patch
US20070203242A1 (en) 2006-02-27 2007-08-30 Calwood Nutritionals, Inc. Method for treating gastric reflux
US20070219208A1 (en) 2006-02-27 2007-09-20 Balaraman Kalyanaraman Methods for Treating Cancer
US7645748B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
US7645749B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
CA2650383A1 (en) 2006-04-24 2007-11-08 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health & Human Services Diazeniumdiolated non-steroidal anti-inflammatory drugs, compositions thereof, and related methods
US8241619B2 (en) 2006-05-15 2012-08-14 Medtronic Vascular, Inc. Hindered amine nitric oxide donating polymers for coating medical devices
US20080171351A1 (en) 2006-05-22 2008-07-17 University Of Notre Dame Du Lac Probes for anionic cell surface detection
CA2655693A1 (en) 2006-06-16 2007-12-27 Alltech, Inc. Reduction of antibiotic resistance in bacteria
WO2007149520A2 (en) 2006-06-21 2007-12-27 Albert Einstein College Of Medicine Of Yeshiva University Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
WO2008012845A1 (en) 2006-07-26 2008-01-31 Stmicroelectronics S.R.L. Use of nitroaniline derivatives for the production of nitric oxide
US20080025972A1 (en) 2006-07-26 2008-01-31 Duke University Treating sex steriod responsive disorders
GB0616350D0 (en) 2006-08-17 2006-09-27 Univ St Andrews Adsorption and release of nitric oxide in metal organic frameworks
EP1895012A1 (en) 2006-08-30 2008-03-05 Universitätsklinikum Freiburg Method for inducing tumor apoptosis by increasing nitric oxide levels
GB0618711D0 (en) 2006-09-22 2006-11-01 Univ Exeter Agricultural treatment
US20080076721A1 (en) 2006-09-25 2008-03-27 Sal Abraham Use of branched chain fatty acid amino acid salts and compositions thereof
WO2008058333A1 (en) 2006-11-15 2008-05-22 Arthritis Relief Plus Ltd Topical formulation and uses thereof
GB0623531D0 (en) 2006-11-25 2007-01-03 Univ St Andrews Nitric oxide storage and production
US8642093B2 (en) 2007-10-30 2014-02-04 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US20090112197A1 (en) 2007-10-30 2009-04-30 Searete Llc Devices configured to facilitate release of nitric oxide
US8221690B2 (en) 2007-10-30 2012-07-17 The Invention Science Fund I, Llc Systems and devices that utilize photolyzable nitric oxide donors
US7862598B2 (en) 2007-10-30 2011-01-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US20090110933A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices related to nitric oxide releasing materials
US20080175881A1 (en) 2007-01-18 2008-07-24 Boston Scientific Scimed, Inc. Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
US8389482B2 (en) 2007-01-30 2013-03-05 New York University Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
ES2604562T3 (es) 2007-02-05 2017-03-07 Nicox Science Ireland Compuestos donantes de óxido nítrico
US20080193385A1 (en) 2007-02-08 2008-08-14 Todd Maibach Compositions and methods for treating neuropathy
US20080193566A1 (en) 2007-02-09 2008-08-14 Miller Christopher C Use of high dose concentrations of gaseous nitric oxide
US20100087370A1 (en) 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US7811600B2 (en) 2007-03-08 2010-10-12 Medtronic Vascular, Inc. Nitric oxide donating medical devices and methods of making same
US7851465B2 (en) 2007-03-09 2010-12-14 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
RU2009139781A (ru) 2007-03-27 2011-05-10 Нолабс Аб (Se) Устройство для доставки оксида азота для местного воздействия на кожу
WO2008130567A1 (en) 2007-04-20 2008-10-30 Duke University Stable neutral nitric oxide source
US20100255062A1 (en) 2007-06-01 2010-10-07 Amulet Pharmaceuticals, Inc. Compounds, polymers and methods for treating gastrointestinal dysfunction
US20100247680A1 (en) 2007-06-15 2010-09-30 Csaba Szabo Compositions and Methods to Modulate Angiogenesis
US8273828B2 (en) 2007-07-24 2012-09-25 Medtronic Vascular, Inc. Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
US9063160B2 (en) 2007-07-26 2015-06-23 Duke University Method for liberating and detecting nitric oxide from nitrosothiols and iron nitrosyls in blood
GB0715554D0 (en) 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
GB0715556D0 (en) 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
CA2599082A1 (en) 2007-08-27 2009-02-27 Ping I. Lee Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds
US20090088411A1 (en) 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
WO2009036571A1 (en) 2007-09-21 2009-03-26 Enox Biopharma, Inc. Antimicrobial gas-releasing ear drainage tubes
EP2209472A1 (en) 2007-10-12 2010-07-28 The University of North Carolina at Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
US8877508B2 (en) 2007-10-30 2014-11-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US7897399B2 (en) 2007-10-30 2011-03-01 The Invention Science Fund I, Llc Nitric oxide sensors and systems
US8349262B2 (en) 2007-10-30 2013-01-08 The Invention Science Fund I, Llc Nitric oxide permeable housings
US20090112055A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Sleeves configured to facilitate release of nitric oxide
US20090112193A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices that utilize photolyzable nitric oxide donors
WO2009064861A2 (en) 2007-11-13 2009-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing diazeniumdiolated polymers, compositions, medical devices, and uses thereof
WO2009073643A2 (en) 2007-12-03 2009-06-11 Cleveland State University Nitric oxide release coatings incorporating nitric oxide synthase enzyme
BRPI0705396B1 (pt) 2007-12-12 2021-10-05 Universidade Estadual De Campinas - Unicamp Compostos derivados ftalimídicos
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
US20090196930A1 (en) 2007-12-27 2009-08-06 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof
WO2009088433A1 (en) 2008-01-04 2009-07-16 Nestec S.A. Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing congnitive and related functions
AU2009212693B2 (en) 2008-01-31 2014-05-01 Vanderbilt University Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage
US8720436B2 (en) 2008-01-31 2014-05-13 Genosys, Inc. Nitric oxide gel apparatus and method
EP2238143B1 (en) 2008-02-07 2012-08-15 Nicox S.A. Nitric oxide donor compounds
US20090222088A1 (en) 2008-02-29 2009-09-03 Medtronic Vascular, Inc. Secondary Amine Containing Nitric Oxide Releasing Polymer Composition
US20090232863A1 (en) 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers
US20090232868A1 (en) 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Nitric Oxide Releasing Polymer Composition
WO2009124379A1 (en) 2008-04-09 2009-10-15 Enox Biopharma, Inc. Biofilm-inhibiting catheters and tubings
BRPI0907260A2 (pt) 2008-04-21 2015-07-14 3M Innovative Properties Co "métodos, dispositivos e composições que liberam óxido nítrico"
US20110106000A1 (en) 2008-06-24 2011-05-05 Micropharma Limited Nitric Oxide Compositions and Devices and Methods for Cosmesis
US8852640B2 (en) 2008-07-03 2014-10-07 Ecole Polytechnique Federale De Lausanne (Epfl) Micelles for delivery of nitric oxide
US20100040703A1 (en) 2008-08-13 2010-02-18 Chris Miller Use of nitric oxide
WO2010033242A2 (en) 2008-09-19 2010-03-25 Northwestern University Biodegradable nitric oxide generating polymers and related biomedical devices
US7807716B2 (en) 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
US20100086530A1 (en) 2008-10-06 2010-04-08 Martinov Norman P Cancer-tumor necrosis by artery nutrient-oxygen blocking
CA2740421C (en) 2008-10-15 2018-08-28 The University Of Memphis Research Foundation Method and device for detection of bioavailable drug concentration in a fluid sample
EP2334279A4 (en) 2008-10-16 2013-03-20 Novan Inc STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS
WO2010048724A1 (en) 2008-10-30 2010-05-06 Chris Miller Nitric oxide-releasing dressings
WO2010051378A1 (en) 2008-10-31 2010-05-06 Noxilizer, Inc. Powder sterilization
US8158187B2 (en) 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
US20100197702A1 (en) 2009-02-04 2010-08-05 Hellberg Mark R Ophthalmic composition with nitric oxide donor compound and method of forming and using same
WO2010096320A2 (en) 2009-02-18 2010-08-26 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
US8062653B2 (en) 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
US9216198B2 (en) 2009-03-30 2015-12-22 The Board Of Regents, The University Of Texas System Compositions and medical devices for controlled release of nitric oxide and methods of production thereof
US8236341B2 (en) 2009-04-02 2012-08-07 Medtronic Vascular, Inc. Poly(tetrafluoroethylene) polymer with nitric oxide donating surface
US8709465B2 (en) 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
US20100286272A1 (en) 2009-05-08 2010-11-11 Perricone Nicholas V Methods Of Use Of Nitroalkene Compositions In Dermatologic Applications
EP2445508B1 (en) 2009-06-22 2018-11-14 VERO Biotech LLC Nitric oxide therapies
BR112012003792B1 (pt) * 2009-08-21 2020-05-19 Novan Inc composição tópica, e, uso da composição tópica
US20110059189A1 (en) 2009-09-08 2011-03-10 Cisne Enterprises Inc. Method and composition for treating cancer, effecting apoptosis and treating retroviral infections
EP2488591A1 (en) 2009-10-13 2012-08-22 Novan, Inc. Nitric oxide-releasing coatings
US8591876B2 (en) * 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
ES2804263T3 (es) * 2011-07-05 2021-02-05 Novan Inc Composiciones tópicas
WO2013138073A1 (en) * 2012-03-13 2013-09-19 Novan, Inc. Methods of modulating steroid hormone activity

Also Published As

Publication number Publication date
JP5980804B2 (ja) 2016-08-31
MX2013006871A (es) 2013-07-05
CN103379892B (zh) 2017-04-19
US20140057001A1 (en) 2014-02-27
EP3085354A1 (en) 2016-10-26
EP2651381A1 (en) 2013-10-23
AU2011343779B2 (en) 2016-09-15
WO2012082976A1 (en) 2012-06-21
AU2011343779A1 (en) 2013-08-01
US20120156163A1 (en) 2012-06-21
ES2664360T3 (es) 2018-04-19
ES2589682T3 (es) 2016-11-15
BR112013014003B1 (pt) 2020-12-29
CA2821962C (en) 2020-10-27
CA2821962A1 (en) 2012-06-21
EP2651381B1 (en) 2016-06-08
EP2651381A4 (en) 2014-05-28
KR101874141B1 (ko) 2018-07-03
EP3085354B1 (en) 2018-02-14
US8591876B2 (en) 2013-11-26
JP2013545813A (ja) 2013-12-26
MX348078B (es) 2017-05-25
KR20130125790A (ko) 2013-11-19
CN103379892A (zh) 2013-10-30

Similar Documents

Publication Publication Date Title
BR112013014003A2 (pt) Métodos de redução de produção de sebo na pele
BR112015015031A2 (pt) processo de glicoconjugação
BR112016005816A2 (pt) Combinação de anticorpos anti-lag-3 e anticorpos anti-pd-1 para tratar tumores
MX2021001659A (es) Esteroides neuroactivos, composiciones, y usos de los mismos.
BR112014005978A2 (pt) métodos e composições para controle de erva daninha
BR112016012870A2 (pt) ?métodos e composições para melhorar a produção de alface
BR112013004012A2 (pt) anticorpos para o receptor de fator de crescimento epidérmico 3 (her3).
UY34701A (es) Formas sólidas de un profármaco de nucleótidos de tiofosforamidato
BRPI1011617A2 (pt) composição, e, métodos para aprimorar a eficácia de um regulador de crescimento de planta, e para regular crescimento de planta
BR112015026660A2 (pt) ligas metálicas aperfeiçoadas para dispositivos médicos
CR20180503A (es) Composiciones y métodos para programar células terapéuticas utilizando nanoportadores de ácidos nucleicos dirigidos
BR112015005369A2 (pt) inibidores de usp30 e métodos para sua utilização
BR112014026661A2 (pt) método in vitro para diagnóstico e vigilância do câncer
BR112015023987A2 (pt) creme dental de duas fases
BR112014032892A2 (pt) processo de amplificação por rcp e de detecção de pelo menos uma sequência-alvo nucleotídica, dispositivo de amplificação e de detecção rápida de pelo menos uma sequência-alvo nucleotídica e estojo de amplificação por rcp e de detecção de pelo menos uma sequência nucleotídica-alvo
BR112015005653A8 (pt) estimulação de desenvolvimento de folículo ovariano e maturação de oócitos
BR112014015661A2 (pt) método para avaliar cosmético
BR112012020491A2 (pt) processo para a preparação de forma alfa de mesilato de imatinib.
AU346985S (en) An instrument panel for an automobile
BR112014026568A2 (pt) método e aparelho para projeto de componentes de oleoduto
AU351119S (en) Instrument panel for automobile
BR112012029546B8 (pt) processo para geração de um patch ou curativo com pele
BR112015031772A2 (pt) composições e métodos para o tratamento da pele
BR112015029954A2 (pt) composição e processo para tratar as fibras queratínicas
BR112015002688A2 (pt) uso de uma fonte de uridina na fabricação de uma composição para aumentar, controlar e/ou manter concentrações plasmáticas de uridina de jejum em uma faixa de 4 a 8µm em um indivíduo em necessidade do mesmo

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/12/2011, OBSERVADAS AS CONDICOES LEGAIS.