MX348078B - Metodos para disminuir la produccion de sebo en la piel. - Google Patents

Metodos para disminuir la produccion de sebo en la piel.

Info

Publication number
MX348078B
MX348078B MX2013006871A MX2013006871A MX348078B MX 348078 B MX348078 B MX 348078B MX 2013006871 A MX2013006871 A MX 2013006871A MX 2013006871 A MX2013006871 A MX 2013006871A MX 348078 B MX348078 B MX 348078B
Authority
MX
Mexico
Prior art keywords
skin
methods
sebum production
nitric oxide
decreasing sebum
Prior art date
Application number
MX2013006871A
Other languages
English (en)
Other versions
MX2013006871A (es
Inventor
Susanne Bauman
Nathan Stasko
Original Assignee
Novan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novan Inc filed Critical Novan Inc
Publication of MX2013006871A publication Critical patent/MX2013006871A/es
Publication of MX348078B publication Critical patent/MX348078B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proveen en la presente métodos de uso de óxido nítrico gaseoso y/o por lo menos una fuente de óxido nítrico para disminuir la producción de sebo en la piel de un sujeto; en algunas modalidades, la fuente de óxido nítrico incluye compuestos que liberan NO macromoleculares y/o de pequeña molécula.
MX2013006871A 2010-12-15 2011-12-15 Metodos para disminuir la produccion de sebo en la piel. MX348078B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42329210P 2010-12-15 2010-12-15
US201161504634P 2011-07-05 2011-07-05
US13/325,826 US8591876B2 (en) 2010-12-15 2011-12-14 Methods of decreasing sebum production in the skin
PCT/US2011/065043 WO2012082976A1 (en) 2010-12-15 2011-12-15 Methods of decreasing sebum production in the skin

Publications (2)

Publication Number Publication Date
MX2013006871A MX2013006871A (es) 2013-07-05
MX348078B true MX348078B (es) 2017-05-25

Family

ID=46234713

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006871A MX348078B (es) 2010-12-15 2011-12-15 Metodos para disminuir la produccion de sebo en la piel.

Country Status (11)

Country Link
US (2) US8591876B2 (es)
EP (2) EP2651381B1 (es)
JP (1) JP5980804B2 (es)
KR (1) KR101874141B1 (es)
CN (1) CN103379892B (es)
AU (1) AU2011343779B2 (es)
BR (1) BR112013014003B1 (es)
CA (1) CA2821962C (es)
ES (2) ES2664360T3 (es)
MX (1) MX348078B (es)
WO (1) WO2012082976A1 (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
PL1871433T3 (pl) 2005-03-24 2009-09-30 Nolabs Ab Zabieg kosmetyczny z tlenkiem azotu, urządzenie do wykonywania tego zabiegu i sposób jego wytwarzania
GB2463181B (en) 2007-05-14 2013-03-27 Univ New York State Res Found Induction of a physiological dispersion response in bacterial cells in a biofilm
ES2958410T3 (es) 2009-08-21 2024-02-08 Novan Inc Geles tópicos
US8591876B2 (en) * 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8668937B2 (en) 2011-03-17 2014-03-11 Transdermal Biotechnology, Inc. Topical nitric oxide systems and methods of use thereof
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
JP6277124B2 (ja) 2011-07-05 2018-02-07 ノヴァン，インコーポレイテッド 局所用組成物
WO2013029009A1 (en) 2011-08-24 2013-02-28 Novan, Inc. Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures
JP6265967B2 (ja) 2012-03-14 2018-01-24 ノヴァン，インコーポレイテッド 医薬組成物
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US9855211B2 (en) * 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9320706B2 (en) * 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9314417B2 (en) * 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9387159B2 (en) * 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9241899B2 (en) * 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9393264B2 (en) * 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US10206947B2 (en) 2013-08-08 2019-02-19 Novan, Inc. Topical compositions and methods of using the same
AU2014305778B2 (en) 2013-08-08 2019-11-21 Novan, Inc. Topical compositions and methods of using the same
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
AU2015287674B2 (en) 2014-07-11 2019-11-21 Novan, Inc. Topical antiviral compositions and methods of using the same
WO2016010988A1 (en) 2014-07-14 2016-01-21 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
EP3943160A1 (en) * 2015-07-02 2022-01-26 Aobiome LLC Ammonia oxidizing bacteria for treatment of acne
US10849864B2 (en) 2015-07-28 2020-12-01 Novan, Inc. Combinations and methods for the treatment and/or prevention of fungal infections
US10912743B2 (en) 2016-03-02 2021-02-09 Novan, Inc. Compositions for treating inflammation and methods of treating the same
KR102426006B1 (ko) 2016-04-13 2022-07-29 노반, 인크. 감염 치료용 조성물, 시스템, 키트, 및 방법
GB201614961D0 (en) * 2016-09-02 2016-10-19 Relaxsol Ltd Compounds and compositions for use
WO2018236803A1 (en) 2017-06-19 2018-12-27 Novan, Inc. TOPICAL COMPOSITIONS AND METHODS OF USE
WO2019114705A1 (zh) 2017-12-13 2019-06-20 上海小午医药科技有限公司 一种用于预防或治疗与egfr被抑制相关疾病的方法
US11285171B2 (en) 2018-03-01 2022-03-29 Novan, Inc. Nitric oxide releasing suppositories and methods of use thereof
CN114028568A (zh) 2018-04-16 2022-02-11 上海岸阔医药科技有限公司 预防或治疗肿瘤疗法副作用的方法
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance

Family Cites Families (407)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507466A (en) 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4631337A (en) 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4568737A (en) 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4737550A (en) 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4558120A (en) 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4587329A (en) 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4871779A (en) 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
US4694064A (en) 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
US4713975A (en) 1986-05-30 1987-12-22 The Dow Chemical Company Dense star polymers for calibrating/characterizing sub-micron apertures
US4857599A (en) 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
US5061487A (en) 1988-05-09 1991-10-29 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5035892A (en) 1988-05-09 1991-07-30 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US5045322A (en) 1988-05-09 1991-09-03 Dow Corning Corporation Antimicrobial superabsorbent sanitary napkin
US4990338A (en) 1988-05-09 1991-02-05 Dow Corning Corporation Antimicrobial superabsorbent compositions and methods
US4985023A (en) 1988-05-09 1991-01-15 Dow Corning Corporation Antimicrobial superabsorbent articles
US5079004A (en) 1990-08-06 1992-01-07 Dow Corning Corporation Antimicrobial superabsorbent compositions and method
US5380758A (en) 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
EP1023905B1 (en) 1991-11-14 2005-01-26 The Brigham And Women's Hospital, Inc. Pharmaceutical composition containing S-nitroso-immunoglobulins and use thereof
US6291424B1 (en) 1991-11-14 2001-09-18 Brigham And Women's Hospital Nitrosated and nitrosylated heme proteins
SE9200564L (sv) 1992-02-26 1993-03-15 Perstorp Ab Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5650447A (en) 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US5405919A (en) 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5891459A (en) 1993-06-11 1999-04-06 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
US5852058A (en) 1993-06-11 1998-12-22 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US5428070A (en) 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity
US5861168A (en) 1993-06-11 1999-01-19 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US6087479A (en) 1993-09-17 2000-07-11 Nitromed, Inc. Localized use of nitric oxide-adducts to prevent internal tissue damage
WO1995007691A1 (en) 1993-09-17 1995-03-23 Brigham And Women's Hospital Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces
US6255277B1 (en) 1993-09-17 2001-07-03 Brigham And Women's Hospital Localized use of nitric oxide-adducts to prevent internal tissue damage
US5840759A (en) 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
ATE194769T1 (de) 1993-10-08 2000-08-15 Us Health Verwendung von stickstoffoxid freisetzenden verbindungen als arzneimittel zur strahlungssensibilisation fur hypoxische zellen
DK0726768T3 (da) 1993-11-02 2000-10-02 Us Health Anvendelse af nitrogenoxidfrigørende forbindelser til fremstillingen af et medikament til beskyttelse i iskæmisk reperfusio
US5786332A (en) 1995-03-06 1998-07-28 Trega Biosciences, Inc. Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels
US5726156A (en) 1995-03-06 1998-03-10 Trega Biosciences, Inc. Cytokine regulatory agents and methods of use in pathologies and conditions associated with altered cytokine levels
US6008255A (en) 1994-01-21 1999-12-28 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
US5599984A (en) 1994-01-21 1997-02-04 The Picower Institute For Medical Research Guanylhydrazones and their use to treat inflammatory conditions
PL180769B1 (pl) 1994-02-21 2001-04-30 Univ Aberdeen Postać dawkowana do miejscowego leczenia stanów powodowanych przez drobnoustroje, sposób sterylizacji obiektów i kompozycja sterylizująca
US6709681B2 (en) 1995-02-17 2004-03-23 Aberdeen University Acidified nitrite as an antimicrobial agent
US5935924A (en) 1994-04-15 1999-08-10 Genentech, Inc. Treatment of congestive heart failure
AU2282395A (en) 1994-05-27 1995-12-21 Neptune Pharmaceutical Corporation Nitric oxide donor composition and method for treatment of anal disorders
US5504117A (en) 1994-05-27 1996-04-02 Neptune Pharmaceutical Corporation Pharmacologic preparation for the treatment of anal disorders
US6190704B1 (en) 1994-09-23 2001-02-20 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US6747062B2 (en) 1994-09-26 2004-06-08 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US5519020A (en) 1994-10-28 1996-05-21 The University Of Akron Polymeric wound healing accelerators
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
US5700830A (en) 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
US5810010A (en) 1995-01-03 1998-09-22 Anbar; Michael Detection of cancerous lesions by their effect on the periodic modulation of perfusion in the surrounding tissues
US5999843A (en) 1995-01-03 1999-12-07 Omnicorder Technologies, Inc. Detection of cancerous lesions by their effect on the spatial homogeneity of skin temperature
US6035225A (en) 1995-01-03 2000-03-07 Omnicorder Technologies Detection of cancerous lesions by measuring nitric oxide concentrations in tissue
US5961466A (en) 1995-01-03 1999-10-05 Omnicorder Technologies, Inc. Method of detection of cancerous lesions by their effect on the spatial distribution of modulation of temperature and homogeneity of tissue
JPH10511957A (ja) 1995-01-05 1998-11-17 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ミシガン 表面改質ナノ微粒子並びにその製造及び使用方法
US5665077A (en) 1995-04-24 1997-09-09 Nitrosci Pharmaceuticals Llc Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
DE69637676D1 (de) 1995-11-09 2008-10-23 Univ R Verwendung von lokal verabreichten Lysine zur VERBESSERUNG DER VASKULAREN FUNKTION
US5821261A (en) 1995-12-08 1998-10-13 Merck & Co., Inc. Substituted saturated aza heterocycles as inhibitors of nitric oxide synthase
US5994294A (en) 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US20020143007A1 (en) 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US20050065161A1 (en) 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US5932538A (en) 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US6323211B1 (en) 1996-02-02 2001-11-27 Nitromed, Inc. Compositions and methods for treating sexual dysfunctions
US6294517B1 (en) 1996-02-02 2001-09-25 Nitromed, Inc. Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
US20020061879A1 (en) 1996-02-02 2002-05-23 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
IT1282686B1 (it) 1996-02-26 1998-03-31 Nicox Sa Composti in grado di ridurre la tossicita' da farmaci
EP0907747A1 (en) 1996-03-15 1999-04-14 Yale University Methods and means of detecting nitric oxide synthase
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6232434B1 (en) 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US5770645A (en) 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
AU3986097A (en) 1996-08-27 1998-03-19 University Of Akron, The Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use
US20030093143A1 (en) 1999-03-01 2003-05-15 Yiju Zhao Medical device having surface depressions containing nitric oxide releasing compound
US5797887A (en) 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
CA2266908C (en) 1996-09-27 2010-07-20 Joseph E. Saavedra O2-arylated or o2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and o2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
GB9622997D0 (en) 1996-11-05 1997-01-08 Univ St Andrews Nitric oxide donor drugs
US5958427A (en) 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
US5891472A (en) 1996-11-19 1999-04-06 Meri Charmyne Russell Treatment of equine laminitis
CA2276183C (en) 1996-12-31 2009-06-09 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
US6896899B2 (en) 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
WO1998031566A1 (en) 1997-01-17 1998-07-23 Cascade Engineering, Inc. Mat with integrally molded door
EP1001677A4 (en) 1997-02-04 2003-01-08 Gen Hospital Corp METHOD FOR TREATING EPIDERMAL OR DERMAL SKIN CONDITIONS
US6034752A (en) 1997-03-22 2000-03-07 Kent Displays Incorporated Display device reflecting visible and infrared radiation
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US6171232B1 (en) 1997-06-26 2001-01-09 Cordis Corporation Method for targeting in vivo nitric oxide release
US6232336B1 (en) 1997-07-03 2001-05-15 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
US6796966B2 (en) 1997-10-15 2004-09-28 Jeffrey E. Thomas Apparatus, and kits for preventing of alleviating vasoconstriction or vasospasm in a mammal
US6358536B1 (en) 1997-10-15 2002-03-19 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US5994444A (en) 1997-10-16 1999-11-30 Medtronic, Inc. Polymeric material that releases nitric oxide
CA2219867A1 (en) 1997-10-31 1999-04-30 Jiangping Wu The use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
AU1770299A (en) 1997-12-23 1999-07-19 Nycomed Imaging As Nitric oxide releasing chelating agents and their therapeutic use
GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1298338B1 (it) 1998-03-05 1999-12-20 Nicox Sa Composizioni farmaceutiche per l'ulcera
US6560478B1 (en) 1998-03-16 2003-05-06 The Research Foundation Of City University Of New York Method and system for examining biological materials using low power CW excitation Raman spectroscopy
US6151522A (en) 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
US5962520A (en) 1998-04-02 1999-10-05 The University Of Akron Hydrolytically unstable, biocompatible polymer
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US6207855B1 (en) 1998-06-23 2001-03-27 Duke University Medical Center Stable no-delivering compounds
US20020068365A1 (en) 1998-07-28 2002-06-06 Eric H. Kuhrts Controlled release nitric oxide producing agents
US6379691B1 (en) 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
US20040043068A1 (en) 1998-09-29 2004-03-04 Eugene Tedeschi Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6299980B1 (en) 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
CA2254645A1 (en) 1998-11-23 2000-05-23 Pulmonox Medical Corporation Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US20070275100A1 (en) 1998-11-23 2007-11-29 Miller Christopher C Use of gaseous nitric oxide as an anti-cancer agent
US20070086954A1 (en) 1998-11-23 2007-04-19 Miller Christopher C Method and apparatus for treatment of respiratory infections by nitric oxide inhalation
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
US7179475B1 (en) 1998-12-04 2007-02-20 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US6238683B1 (en) 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
GB9905425D0 (en) 1999-03-09 1999-05-05 Queen Mary & Westfield College Pharmaceutical composition
US20050142218A1 (en) 2000-03-09 2005-06-30 Queen Mary & Westfield College Pharmaceutical composition containing nitrate source and an acidifying agent for treating skin ischaemia
US6312663B1 (en) 1999-03-19 2001-11-06 Joseph V. Boykin, Jr. Prediction of diabetes impaired wound healing by urinary nitrate assay
US6562785B1 (en) 1999-03-23 2003-05-13 Howard M. Shapiro Method for overcoming bacterial antibiotic resistance
US7655423B2 (en) 1999-06-14 2010-02-02 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
JP2003532622A (ja) 1999-06-14 2003-11-05 ヘンリー フォード ヘルス システム 神経発生を誘導する一酸化窒素ドナー
US7135498B1 (en) 1999-06-14 2006-11-14 Henry Ford Health System Nitric oxide donors for inducing neurogenesis
US20010012851A1 (en) 1999-07-29 2001-08-09 Kristin M. Lundy Nitric oxide releasing oxindole prodrugs for anagesic, anti-inflammatory and disease-modifying use
US20020049157A1 (en) 1999-08-25 2002-04-25 Jiangping Wu Use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock
CA2353531A1 (en) 1999-09-02 2001-03-08 Rice University Nitric oxide-producing hydrogel materials
US7279176B1 (en) 1999-09-02 2007-10-09 Rice University Nitric oxide-producing hydrogel materials
US7052711B2 (en) 1999-09-02 2006-05-30 Rice University Nitric oxide-producing hydrogel materials
US6737447B1 (en) 1999-10-08 2004-05-18 The University Of Akron Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
ES2262555T3 (es) 1999-12-20 2006-12-01 Sa Majeste La Reine Du Chef Du Canada Agriculture Et Agroalimentaire Canada Procedimiento y composicion para el tratamiento y/o prevencion de infecciones por microorganismos resistentes a antibioticos.
US6492405B2 (en) 1999-12-30 2002-12-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nitric oxide donors and pharmaceutical compositions containing them
AU2001234538A1 (en) 2000-01-24 2001-07-31 Dzgenes, L.L.C. Nitric oxide synthase gene diagnostic polymorphisms
US6758214B2 (en) 2000-01-28 2004-07-06 Cyterra Corporation Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment
US6699846B2 (en) 2000-03-17 2004-03-02 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders
AU4757901A (en) 2000-03-20 2001-10-03 Novovascular Inc Matrices containing nitric oxide donors and reducing agents and their use
US20010038832A1 (en) 2000-04-11 2001-11-08 Benjamin Bonavida Nitric oxide and analogues thereof effectuate sensitization of neoplasm and immunologically undesired tissues to cytotoxicity
US6946484B2 (en) 2000-04-26 2005-09-20 Cellegy Pharmaceuticals, Inc. Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US20050142217A1 (en) 2000-04-26 2005-06-30 Adams Michael A. Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US7678391B2 (en) 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US20010053772A1 (en) 2000-04-28 2001-12-20 Benjamin Bonavida Aza analogues of alkyl lysophospholipids exert immunomodulatory effects
US6270779B1 (en) 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
AU2001264729A1 (en) 2000-05-22 2001-12-03 Nitromed, Inc. Thromboxane inhibitors, compositions and methods of use related applications
US6623728B2 (en) 2000-06-30 2003-09-23 Unilever Home & Personal Care Usa Division Of Conopco, Inc. Cosmetic skin care compositions and containing gum mastic
US6538033B2 (en) 2000-08-29 2003-03-25 Huntington Medical Research Institutes Nitric oxide donor compounds
GB0021317D0 (en) 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
JP4841066B2 (ja) 2000-09-01 2011-12-21 ライスユニバーシティ 酸化窒素生成ヒドロゲル物質
GB0022084D0 (en) 2000-09-08 2000-10-25 Univ Aberdeen Treatment of multiply antibiotic-resistant organisms
US6410622B1 (en) 2000-09-11 2002-06-25 Gregory W. Endres Method of preventing fouling organisms in marine environments and polymer-bound nitric oxide/nitric oxide-releasing compositions usable therefor
EP1333823B1 (en) 2000-10-16 2010-03-31 Duke University Therapeutic use of aerosolized s-nitrosoglutathione in cystic fibrosis
AU2002211776A1 (en) 2000-10-17 2002-04-29 Board Of Regents, The University Of Texas System A method to incorporate n-(4-hydroxyphenyl) retinamide in liposomes
US6359182B1 (en) 2000-10-26 2002-03-19 Duke University C-nitroso compounds and use thereof
US7049308B2 (en) 2000-10-26 2006-05-23 Duke University C-nitroso compounds and use thereof
KR100383149B1 (ko) 2000-12-12 2003-05-12 한국생명공학연구원 디테르펜계 화합물을 염증질환, 면역질환 및 암 치료제로사용하는 신규한 용도
DE10063937A1 (de) 2000-12-20 2002-07-18 Bayer Ag Verfahren zur Herstellung von Trimethylolverbindungen und Ameisensäure
US6780849B2 (en) 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US7329412B2 (en) 2000-12-22 2008-02-12 The Trustees Of Columbia University In The City Of New York Antimicrobial medical devices containing chlorhexidine free base and salt
US6432077B1 (en) 2000-12-26 2002-08-13 Sensormedics Corporation Device and method for treatment of surface infections with nitric oxide
US7122018B2 (en) 2000-12-26 2006-10-17 Sensormedics Corporation Device and method for treatment of wounds with nitric oxide
US20040009238A1 (en) 2002-07-09 2004-01-15 Chris Miller Exogenenous nitric oxide gas (gNO) therapy in wound healing
DE60229108D1 (de) 2001-01-16 2008-11-13 Univ Michigan Biokatalytische und biomimetische erzeugung von stickoxid in situ an substrat/blut-grenzflächen
US7128904B2 (en) 2001-01-16 2006-10-31 The Regents Of The University Of Michigan Material containing metal ion ligand complex producing nitric oxide in contact with blood
US7335383B2 (en) 2001-01-16 2008-02-26 The Regents Of The University Of Michigan Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
US6706274B2 (en) 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
ITMI20010426A1 (it) 2001-03-01 2002-09-01 Consiglio Nazionale Ricerche Donatori di ossido di azoto basati su centri metallici
US7012098B2 (en) 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
US20020138051A1 (en) 2001-03-26 2002-09-26 Hole Douglas R. System and method for the prevention and treatment of animal wound infections using nitric oxide
US6710037B2 (en) 2001-05-01 2004-03-23 Schering Corporation Method of treating androgen-dependent disorders
US7122027B2 (en) 2001-05-25 2006-10-17 Medtronic, Inc. Implantable medical device with controllable gaseous agent release system
ES2180446B1 (es) 2001-07-02 2004-01-16 Esteve Labor Dr Empleo de derivados de acidos 2,5-dihidroxibencenosulfonicos en la elaboracion de un medicamento para potenciar el efecto de otros farmacos en el tratamiento de la disfuncion erectil.
US7122529B2 (en) 2001-07-12 2006-10-17 The Johns Hopkins University Compounds that release nitric oxide at controlled rates upon photolysis
GB0119011D0 (en) 2001-08-03 2001-09-26 Univ Aberdeen Treatment of nail infections
CA2459647A1 (en) 2001-08-20 2003-02-27 University Of Virginia Patent Foundation Use of s-nitrosothiol signaling to treat disordered control of breathing
US6841166B1 (en) 2001-08-21 2005-01-11 The Regents Of The University Of Michigan Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives
US7135189B2 (en) 2001-08-23 2006-11-14 Boston Scientific Scimed, Inc. Compositions and techniques for localized therapy
AU2002336401A1 (en) 2001-09-05 2003-03-18 Cyterra Corporation Nitric oxide generation
AU2002336761A1 (en) 2001-09-26 2003-04-07 The Government Of The United States Of America, Represented By The Secretary, Department Of Health A Nitric oxide-releasing coated medical devices and method of preparing same
US6703046B2 (en) 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
EP1300083A1 (en) 2001-10-04 2003-04-09 Societe Des Produits Nestle S.A. Milk-based snack
GB0125222D0 (en) 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
US6627602B2 (en) 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
US20040110691A1 (en) 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
US6472390B1 (en) 2001-11-13 2002-10-29 Duke University Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
CN1612804A (zh) 2001-12-03 2005-05-04 C·R·巴德公司 抗微生物医用器材、抗微生物聚合物涂层及其制备方法
WO2003059339A1 (en) 2002-01-15 2003-07-24 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US6474508B1 (en) 2002-01-24 2002-11-05 Saint-Gobain Calmar Inc. Unit dose tube and cap assembly
AU2003230715A1 (en) 2002-03-21 2003-10-08 The University Of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors
US20030219854A1 (en) 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
JP2005537223A (ja) 2002-04-05 2005-12-08 ニトロメッド，インク． 酸化窒素供与体、組成物および使用法
AU2003237128A1 (en) 2002-05-03 2003-11-17 Duke University Carbon nanotubules for storage of nitric oxide
CA2485167A1 (en) 2002-05-07 2003-11-20 The Government Of The United States Of America Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
EP1507541A4 (en) 2002-05-13 2009-06-03 Dartmouth College HEMMER AND APPLICATION METHOD THEREFOR
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
PL375161A1 (en) 2002-06-21 2005-11-28 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
US20070065473A1 (en) * 2002-07-09 2007-03-22 Miller Christopher C Nitric oxide gas (gO) as a cosmetic and wound healing agent
US6949530B2 (en) 2002-07-18 2005-09-27 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
US7199154B2 (en) 2002-07-26 2007-04-03 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
AU2003281815A1 (en) 2002-08-02 2004-02-23 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Hu Cross-linked nitric oxide-releasing polyamine coated substrates, compositions comprising same and method of making same
US20020182162A1 (en) 2002-08-07 2002-12-05 Mohsen Shahinpoor Nitric oxide (NO) donor+cGMP-PDE5 inhibitor as a topical drug for enhanced hair growth
US20040076582A1 (en) 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US20050080024A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives for the treatment of cardiovascular disorders
US20040033480A1 (en) 2002-08-15 2004-02-19 Wong Norman C.W. Use of resveratrol to regulate expression of apolipoprotein A1
US20050080021A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders
US6951902B2 (en) 2002-08-16 2005-10-04 Michigan Biotechnology Institute Two dimensional polymer that generates nitric oxide
US20030039697A1 (en) 2002-09-12 2003-02-27 Yi-Ju Zhao Matrices containing nitric oxide donors and reducing agents and their use
CA2503063A1 (en) 2002-10-22 2004-05-06 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Nitric oxide releasing selective cyclooxygenase-2 inhibitors
US20080317679A1 (en) 2002-10-25 2008-12-25 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
WO2005107770A1 (en) 2004-04-28 2005-11-17 Brigham Young University Use of equol for treating skin diseases
JP4733393B2 (ja) 2002-11-18 2011-07-27 ポラリス・グループ インビボでウイルス複製を阻害する方法
WO2004060283A2 (en) 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
WO2004064767A2 (en) 2003-01-23 2004-08-05 Kahn Nighat N Nitric oxide inducing agents
FR2850579B1 (fr) * 2003-02-03 2006-08-18 Oreal Utilisation de mono-ou di-esters d'acide cinnamique ou de l'un de ses derives et de vitamine c, comme donneur de no
FR2850578B1 (fr) * 2003-02-03 2006-07-28 Oreal Utilisation de n-arylmethylene ethylenediaminetriacetates, n-arylmethyleneiminodiacetates ou n,n'-diarylmethylene ethylenediamineacetates comme donneurs de no
JP4425921B2 (ja) 2003-03-05 2010-03-03 メルク フロスト カンパニー シクロオキシゲナーゼ−２インヒビターとして作用するジアリール２−（５ｈ）−フラノンの酸化窒素放出プロドラッグ
EP1603933A2 (en) 2003-03-13 2005-12-14 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
SE0300971D0 (sv) 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US20050079132A1 (en) 2003-04-08 2005-04-14 Xingwu Wang Medical device with low magnetic susceptibility
US20040254419A1 (en) 2003-04-08 2004-12-16 Xingwu Wang Therapeutic assembly
US7972137B2 (en) 2003-06-30 2011-07-05 Rosen Gerald M Anti-microbial dental formulations for the prevention and treatment of oral mucosal disease
WO2005003032A1 (en) 2003-07-03 2005-01-13 The University Court Of The University Of St Andrews Zeolites for delivery of nitric oxide
US7234079B2 (en) 2003-07-11 2007-06-19 Agency For Science, Technology & Research Method and system for enabling recovery of data stored in a computer network; a method and a system for recovering data stored in a computer network
US20050054714A1 (en) 2003-07-17 2005-03-10 Benito Munoz Nitric oxide releasing drugs for Alzheimer's disease
EP1648527A4 (en) 2003-07-25 2008-04-23 Univ Akron STABILIZATION AND IONIC RELEASE OF NITRIC OXIDE RELEASE
US7364585B2 (en) 2003-08-11 2008-04-29 Boston Scientific Scimed, Inc. Medical devices comprising drug-loaded capsules for localized drug delivery
US7314857B2 (en) 2003-08-25 2008-01-01 Kane Biotech Inc. Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
AU2004270162B2 (en) 2003-08-28 2010-05-13 Nicox S.A. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use
EP1667646A4 (en) 2003-09-26 2007-07-04 David R Whitlock METHOD FOR USE OF AMMONIA-OXIDATING BACTERIA
WO2005030135A2 (en) 2003-09-26 2005-04-07 Nitromed, Inc. Nitrosated glutamic acid compounds, compositions and methods of use
US7485324B2 (en) 2003-09-29 2009-02-03 Pulmonox Technologies Corporation Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms
US20050074506A1 (en) 2003-10-02 2005-04-07 Brainsgate Ltd. Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
WO2005037339A1 (en) 2003-10-14 2005-04-28 Cube Medical A/S A balloon for use in angioplasty
US20070059351A1 (en) 2003-10-17 2007-03-15 Murrell George A C Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods
US20050171199A1 (en) 2003-10-17 2005-08-04 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
US20070053966A1 (en) 2003-10-17 2007-03-08 Robert Ang Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue
US20060286159A1 (en) 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of persistent active tendinopathy using transdermal glyceryl trinitrate providing durability of effect
US20060286158A1 (en) 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
AU2004296174A1 (en) 2003-12-15 2005-06-23 Nitricare Hb Device and method for administering therapeutic agents
WO2005067986A1 (en) 2004-01-07 2005-07-28 Noxilizer, Inc. Sterilization system and device
US8017074B2 (en) 2004-01-07 2011-09-13 Noxilizer, Inc. Sterilization system and device
CN101420989B (zh) 2004-01-22 2011-04-06 阿克伦大学 用于医疗器械和治疗的聚合物no供体前药纳米纤维涂层
AU2005207037A1 (en) 2004-01-22 2005-08-04 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
EP1711459A4 (en) 2004-01-27 2008-01-02 Merck Frosst Company NITRIC OXIDE-FREE DIARYL-2- (5H) -FURANONES PROMOTERS AS INHIBITORS OF CYCLOOXYGENASE-2
CA2554333A1 (en) 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
US20050165452A1 (en) 2004-01-28 2005-07-28 Medtronic, Inc. Antithrombogenic medical device
US7569559B2 (en) 2004-02-09 2009-08-04 Noxilizer, Inc. Nitric oxide-releasing molecules
US7829553B2 (en) 2004-02-09 2010-11-09 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
EP1718656A2 (en) 2004-02-10 2006-11-08 Purdue Research Foundation Crowned dithiocarbamate metal complexes and methods for their use
AU2005216192B2 (en) 2004-02-23 2010-11-04 Strategic Science & Technologies, Llc Topical delivery of a nitric oxide donor to improve body and skin appearance
CA2561141A1 (en) 2004-03-31 2005-11-17 Nitromed, Inc. Methods for treating blood disorders with nitric oxide donor compounds
CA2563670C (en) 2004-04-19 2014-09-16 Strategic Science & Technologies, Llc Transdermal delivery of beneficial substances effected by a hostile biophysical environment
WO2005115440A2 (en) 2004-04-29 2005-12-08 Kahn Nighat N Compositions and method for modulating insulin-activated nitric oxide synthase
WO2005112954A1 (en) 2004-05-14 2005-12-01 William Marsh Rice University Nitric oxide releasing compositions and associated methods
US8791073B2 (en) 2004-05-14 2014-07-29 William Marsh Rice University Peptide-modified polyurethane compositions and associated methods
US7582623B2 (en) 2004-05-20 2009-09-01 The Regents Of The University Of California Photoactive metal nitrosyls for blood pressure regulation and cancer therapy
WO2005120493A1 (en) 2004-06-10 2005-12-22 Tohoku University Anticancer effect enhancer
US20060008529A1 (en) 2004-07-12 2006-01-12 Meyerhoff Mark E Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers
US20060039950A1 (en) 2004-08-23 2006-02-23 Zhengrong Zhou Multi-functional biocompatible coatings for intravascular devices
EP1794195B1 (en) 2004-09-27 2014-12-17 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US20070154570A1 (en) 2004-09-29 2007-07-05 Miller Christopher C Use of nitric oxide in the treatment and disinfection of biofilms
US8067464B2 (en) 2004-10-04 2011-11-29 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
FR2877004B1 (fr) 2004-10-21 2007-03-09 Oreal Esters et amides silaniques d'acide 2-oxothiazolidine-4- carboxylique et leurs utilisations cosmetiques.
JP2008520578A (ja) 2004-11-15 2008-06-19 ニトロメッド インコーポレーティッド 複素環式の酸化窒素供与体基を含む利尿化合物、組成物および使用方法
CN101065084A (zh) 2004-11-29 2007-10-31 阿克伦大学 局部的一氧化氮供体器械
EP1681068A1 (en) 2004-12-16 2006-07-19 NOLabs AB Anti-pathogen and anti-cancer filtering device and method comprising nitric oxide
WO2006064056A2 (en) 2004-12-16 2006-06-22 Nolabs Ab Anti-pathogen and anti-cancer filtering device and method comprising nitric oxide
CA2592407A1 (en) 2004-12-24 2006-06-29 The University Of Queensland Methods of treating pain
KR20080016527A (ko) 2005-01-31 2008-02-21 밀란 래보러토리즈, 인크. 하이드록시화된 네비볼롤을 함유하는 약학적 조성물
WO2006084911A2 (en) 2005-02-11 2006-08-17 Nolabs Ab Improved device for application of medicaments, manufacturing method therefor, and method of treatment
WO2006084910A2 (en) 2005-02-11 2006-08-17 Nolabs Ab Device and method for treatment of dermatomycosis, and in particular onychomycosis
EP1690558A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of diabetic disorders
EP1690557A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of rectal disorders, and manufacturing process for the same
EP1757278A1 (en) 2005-08-23 2007-02-28 NOLabs AB Device, system, and method comprising microencapsulated liquid for release of nitric oxide from a polymer
EP1690554A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of infections, including dermatophytosis and onychomycosis
EP1690532A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for gastric treatment and manufacturing process for the same
CA2594407C (en) 2005-02-11 2014-06-10 Nolabs Ab Device method, and use for treatment of neuropathy involving nitric oxide
EP1700611A1 (en) 2005-02-11 2006-09-13 NOLabs AB Device for treatment of disorders in the oral cavity, and manufacturing process for the same
WO2007086884A2 (en) 2005-02-16 2007-08-02 Nitromed, Inc. Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use
CA2597460A1 (en) 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
US8119840B2 (en) 2005-03-04 2012-02-21 The University Of Akron Ethambutol based nitric oxide donors
JP2008533031A (ja) 2005-03-09 2008-08-21 ニトロメッド インコーポレーティッド アンギオテンシンｉｉアンタゴニストの有機酸化窒素増強塩、組成物および使用法
GB0505035D0 (en) 2005-03-11 2005-04-20 Insense Ltd Improvements relating to skin dressings
WO2006097348A1 (en) 2005-03-15 2006-09-21 L'oreal Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
EP1704877A1 (en) 2005-03-24 2006-09-27 NOLabs AB A wound care device comprising a nitric oxide eluting polymer
WO2006100155A1 (en) 2005-03-24 2006-09-28 Nolabs Ab Device for wound care, and manufacturing method thereof, involving the use of nitric oxide
EP1866004A2 (en) 2005-03-24 2007-12-19 NOLabs AB Intravascular, interstitial or intraorgan medical access device, and manufacturing method thereof, involving nitric oxide
EP1704879A1 (en) 2005-03-24 2006-09-27 NOLabs AB Intravascular, interstitial or intraorgan medical device comprising a nitric oxide eluting polymer
EP1704876A1 (en) 2005-03-24 2006-09-27 NOLabs AB Cosmetic treatment, device for performing said treatment and manufacturing method thereof
PL1871433T3 (pl) 2005-03-24 2009-09-30 Nolabs Ab Zabieg kosmetyczny z tlenkiem azotu, urządzenie do wykonywania tego zabiegu i sposób jego wytwarzania
EP1885375A4 (en) 2005-05-16 2010-12-01 Univ Alberta NEW NSAID WITH STICK OXIDE DISPENSER DIAZEN-1-IUM-1,2-DIOLATE PART
JP4786710B2 (ja) 2005-05-17 2011-10-05 シンタク アーゲー 心拍調節系における障害の治療のための用具及びキット
WO2006127591A2 (en) 2005-05-23 2006-11-30 Nitromed, Inc. Organic nitric oxide enhancing salts of nonsteroidal antiinflammatory compounds, compositions and methods of use
TW200716741A (en) 2005-05-24 2007-05-01 Environmental Biotechnology Crc Pty Ltd Methods and compositions for regulating biofilm development
ES2731298T3 (es) * 2005-05-27 2019-11-14 Univ North Carolina Chapel Hill Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas
EP1731176A1 (en) 2005-06-01 2006-12-13 NOLabs AB Pre-treatment device comprising nitric oxide
WO2006128743A1 (en) 2005-06-01 2006-12-07 Nolabs Ab Feedstuff
US20100016790A1 (en) 2005-06-01 2010-01-21 Tor Peters Treatment And Pre-Treatment Device, And Manufacturing Method Therefor, Involving Nitric Oxide
EP1728438A1 (en) 2005-06-01 2006-12-06 NOLabs AB Feedstuff
US8106080B2 (en) 2005-06-09 2012-01-31 Gu-Qi Wang Compositions and methods for enhancing nitric oxide delivery
WO2007005910A2 (en) 2005-06-30 2007-01-11 Mc3, Inc. Nitric oxide coatings for medical devices
WO2007005758A2 (en) 2005-06-30 2007-01-11 Mc3, Inc. Methods , compositions and devices for promoting angiogenesis
US20080139450A1 (en) 2005-07-01 2008-06-12 Srinivasa Madhyastha Antimicrobial Compositions and Uses Thereof
US8906364B2 (en) 2005-07-01 2014-12-09 Kane Biotech Inc. Antimicrobial compositions and uses thereof
BRPI0503201B8 (pt) 2005-07-28 2021-05-25 Sci Tech Produtos Medicos Ltda stents revestidos com blendas poliméricas hidrofílicas, eluidoras de óxido nítrico e s-nitrosotióis
WO2007016677A2 (en) 2005-08-02 2007-02-08 Nitromed, Inc. Nitric oxide enhancing antimicrobial compounds, compositions and methods of use
JP2009505727A (ja) 2005-08-25 2009-02-12 メドトロニック ヴァスキュラー インコーポレイテッド 医療機器及びそのコーティングとして有益な一酸化窒素放出生分解性ポリマー
EP1919304B1 (en) 2005-08-26 2011-05-25 Nestec S.A. Compositions and methods for improving functional vascular integrity, cellular survival and reducing apoptosis after an ischemic episode in the brain
US20070048344A1 (en) 2005-08-31 2007-03-01 Ali Yahiaoui Antimicrobial composition
US20070053952A1 (en) 2005-09-07 2007-03-08 Medtronic Vascular, Inc. Nitric oxide-releasing polymers derived from modified polymers
EP1764119A1 (en) 2005-09-09 2007-03-21 NOLabs AB Implants with improved osteointegration
US20090010989A1 (en) 2005-09-12 2009-01-08 N0Labs Ab Coating For Implants and Implants With Improved Osteointegration, and Manufacturing Method
ES2380952T3 (es) 2005-10-11 2012-05-21 Bayer Consumer Care Ag Mezcla de sales de hierro y cobre que enmascaran el sabor metálico.
US20070088345A1 (en) 2005-10-13 2007-04-19 Ust Inc. Applications of HIFU and chemotherapy
US7531164B2 (en) 2005-10-21 2009-05-12 Duke University Preventing bacterial or viral infectivity and composition containing infection preventing additive
EP1942942A2 (en) 2005-10-31 2008-07-16 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
WO2007053578A2 (en) 2005-10-31 2007-05-10 Amulet Pharmaceuticals, Inc. Multi-phasic nitric oxide and drug co-eluting stent coatings
EP1790335A1 (en) 2005-11-14 2007-05-30 NOLabs AB Composition and its use for the manufacture of a medicament for treating, prophylactically treating, preventing cancer and/or infections in the urinary tract
WO2007059311A2 (en) 2005-11-16 2007-05-24 Nitromed, Inc. Furoxan compounds, compositions and methods of use
WO2007057763A2 (en) 2005-11-18 2007-05-24 Pulmonox Technologies Corporation Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant
US20090287072A1 (en) 2005-12-02 2009-11-19 The Regents Of The University Of Michigan Polymer compositions, coatings and devices, and methods of making and using the same
EP1968615A4 (en) 2005-12-06 2010-08-04 Amulet Pharmaceuticals Inc POLYMERS RELEASING NITRIC OXIDE
WO2007076053A2 (en) 2005-12-21 2007-07-05 Nitrox, Llc Stable s-nitrosothiol formulations
US9801902B2 (en) 2006-01-17 2017-10-31 The University Of Akron Debridement method using topical nitric oxide donor devices and compositions
WO2007087631A2 (en) 2006-01-26 2007-08-02 Bebaas, Inc. Cobalamin compositions for the treatment of cancer
US20070202155A1 (en) 2006-02-03 2007-08-30 Cure Therapeutics, Inc. Low dose no donor-containing transdermal patch
AU2007211508B2 (en) 2006-02-03 2012-08-23 Nicox Science Ireland Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
EP1983975B1 (en) 2006-02-03 2015-07-29 Giulio Cossu Method of treatment for muscular dystrophy
US20070203242A1 (en) 2006-02-27 2007-08-30 Calwood Nutritionals, Inc. Method for treating gastric reflux
US20070219208A1 (en) 2006-02-27 2007-09-20 Balaraman Kalyanaraman Methods for Treating Cancer
US7645748B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
US7645749B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol nitroderivatives and use thereof
AU2007244903B2 (en) 2006-04-24 2012-02-02 The Government Of The United States Of America As Represented By The Secretary Department Of Health And Human Services Diazeniumdiolated non-steroidal anti-inflammatory drugs, compositions thereof, and related methods
US8241619B2 (en) 2006-05-15 2012-08-14 Medtronic Vascular, Inc. Hindered amine nitric oxide donating polymers for coating medical devices
US20080171351A1 (en) 2006-05-22 2008-07-17 University Of Notre Dame Du Lac Probes for anionic cell surface detection
CA2655693A1 (en) 2006-06-16 2007-12-27 Alltech, Inc. Reduction of antibiotic resistance in bacteria
US8333997B2 (en) 2006-06-21 2012-12-18 Albert Einstein College Of Medicine Of Yeshiva University Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
EP2051935B1 (en) 2006-07-26 2016-09-07 STMicroelectronics Srl Use of nitroaniline derivatives for the production of nitric oxide
US20080025972A1 (en) 2006-07-26 2008-01-31 Duke University Treating sex steriod responsive disorders
GB0616350D0 (en) 2006-08-17 2006-09-27 Univ St Andrews Adsorption and release of nitric oxide in metal organic frameworks
EP1895012A1 (en) 2006-08-30 2008-03-05 Universitätsklinikum Freiburg Method for inducing tumor apoptosis by increasing nitric oxide levels
GB0618711D0 (en) 2006-09-22 2006-11-01 Univ Exeter Agricultural treatment
US20080076721A1 (en) 2006-09-25 2008-03-27 Sal Abraham Use of branched chain fatty acid amino acid salts and compositions thereof
CA2669918C (en) 2006-11-15 2020-03-10 Arthritis Relief Plus Ltd Topical formulation comprising comfrey and tannic acid, and uses thereof
GB0623531D0 (en) 2006-11-25 2007-01-03 Univ St Andrews Nitric oxide storage and production
US8221690B2 (en) 2007-10-30 2012-07-17 The Invention Science Fund I, Llc Systems and devices that utilize photolyzable nitric oxide donors
US20090110933A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices related to nitric oxide releasing materials
US20090112197A1 (en) 2007-10-30 2009-04-30 Searete Llc Devices configured to facilitate release of nitric oxide
US7862598B2 (en) 2007-10-30 2011-01-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US8642093B2 (en) 2007-10-30 2014-02-04 The Invention Science Fund I, Llc Methods and systems for use of photolyzable nitric oxide donors
US20080175881A1 (en) 2007-01-18 2008-07-24 Boston Scientific Scimed, Inc. Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
US8389482B2 (en) 2007-01-30 2013-03-05 New York University Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
ES2604562T3 (es) 2007-02-05 2017-03-07 Nicox Science Ireland Compuestos donantes de óxido nítrico
US20080193385A1 (en) 2007-02-08 2008-08-14 Todd Maibach Compositions and methods for treating neuropathy
US20080193566A1 (en) 2007-02-09 2008-08-14 Miller Christopher C Use of high dose concentrations of gaseous nitric oxide
WO2008100591A2 (en) 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US7811600B2 (en) 2007-03-08 2010-10-12 Medtronic Vascular, Inc. Nitric oxide donating medical devices and methods of making same
MX2009009645A (es) 2007-03-09 2009-11-19 Univ Michigan Composiciones y metodos relacionados con nuevos compuestos y objetivos de los mismos.
RU2009139781A (ru) 2007-03-27 2011-05-10 Нолабс Аб (Se) Устройство для доставки оксида азота для местного воздействия на кожу
US8598368B2 (en) 2007-04-20 2013-12-03 Duke University Stable neutral nitric oxide source
US20100255062A1 (en) 2007-06-01 2010-10-07 Amulet Pharmaceuticals, Inc. Compounds, polymers and methods for treating gastrointestinal dysfunction
EP2155213A1 (en) 2007-06-15 2010-02-24 Ikaria, Inc. Compositions comprising sulfide alone or in combination with nitric oxide and their use to
US8273828B2 (en) 2007-07-24 2012-09-25 Medtronic Vascular, Inc. Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
EP2170157B1 (en) 2007-07-26 2016-09-07 Duke University Measuring amount of bound and combined nitric oxide in blood
GB0715554D0 (en) 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
GB0715556D0 (en) 2007-08-09 2007-09-19 Insense Ltd Improvements relating to skin dressings
CA2599082A1 (en) 2007-08-27 2009-02-27 Ping I. Lee Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds
US20090088411A1 (en) 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
CN101835502A (zh) 2007-09-21 2010-09-15 伊诺克斯生物制药公司 释放抗微生物气体的耳引流管
US8399005B2 (en) 2007-10-12 2013-03-19 University Of North Carolina At Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
US20090112055A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Sleeves configured to facilitate release of nitric oxide
US8877508B2 (en) 2007-10-30 2014-11-04 The Invention Science Fund I, Llc Devices and systems that deliver nitric oxide
US8349262B2 (en) 2007-10-30 2013-01-08 The Invention Science Fund I, Llc Nitric oxide permeable housings
US7897399B2 (en) 2007-10-30 2011-03-01 The Invention Science Fund I, Llc Nitric oxide sensors and systems
US20090112193A1 (en) 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and devices that utilize photolyzable nitric oxide donors
WO2009064861A2 (en) 2007-11-13 2009-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing diazeniumdiolated polymers, compositions, medical devices, and uses thereof
WO2009073643A2 (en) 2007-12-03 2009-06-11 Cleveland State University Nitric oxide release coatings incorporating nitric oxide synthase enzyme
BRPI0705396B1 (pt) 2007-12-12 2021-10-05 Universidade Estadual De Campinas - Unicamp Compostos derivados ftalimídicos
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
JP2011507968A (ja) 2007-12-27 2011-03-10 エイヤーズ ファーマシューティカルズ、インク． エアロゾル化ニトライトおよび一酸化窒素供与性化合物ならびにそれらの使用
CN105267969A (zh) 2008-01-04 2016-01-27 雀巢产品技术援助有限公司 包含不饱和脂肪酸和一氧化氮释放化合物的组合物及其用于增强认知和相关功能的用途
US8720436B2 (en) 2008-01-31 2014-05-13 Genosys, Inc. Nitric oxide gel apparatus and method
SG196863A1 (en) 2008-01-31 2014-02-13 Univ Vanderbilt Methods and compositions for treatment for coronary and arterial aneurysmal subarachnoid hemorrhage
JP5441928B2 (ja) 2008-02-07 2014-03-12 ニコックス エス エイ 一酸化窒素供与化合物
US20090222088A1 (en) 2008-02-29 2009-09-03 Medtronic Vascular, Inc. Secondary Amine Containing Nitric Oxide Releasing Polymer Composition
US20090232863A1 (en) 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers
US20090232868A1 (en) 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Nitric Oxide Releasing Polymer Composition
WO2009124379A1 (en) 2008-04-09 2009-10-15 Enox Biopharma, Inc. Biofilm-inhibiting catheters and tubings
BRPI0907260A2 (pt) 2008-04-21 2015-07-14 3M Innovative Properties Co "métodos, dispositivos e composições que liberam óxido nítrico"
CA2728789A1 (en) 2008-06-24 2009-12-30 Micropharma Limited Nitric oxide compositions and devices and methods for cosmesis
US8852640B2 (en) 2008-07-03 2014-10-07 Ecole Polytechnique Federale De Lausanne (Epfl) Micelles for delivery of nitric oxide
WO2010017633A1 (en) 2008-08-13 2010-02-18 Chris Miller Use of nitric oxide
EP2331606B1 (en) 2008-09-19 2016-11-02 Northwestern University Biodegradable nitric oxide generating polymers and related biomedical devices
US7807716B2 (en) 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
US20100086530A1 (en) 2008-10-06 2010-04-08 Martinov Norman P Cancer-tumor necrosis by artery nutrient-oxygen blocking
EP2349442B1 (en) 2008-10-15 2023-07-26 University of Tennessee Research Foundation Method and device for detection of bioavailable drug concentration in a fluid sample
EP2334279A4 (en) 2008-10-16 2013-03-20 Novan Inc STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS
CA2740135A1 (en) 2008-10-30 2010-05-06 Chris Miller Wound dressings comprising a nitric oxide gas producing component and an oxygen releasing component
US20100166603A1 (en) 2008-10-31 2010-07-01 Noxilizer, Inc. Powder Sterilization
US8158187B2 (en) 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
US20100197702A1 (en) 2009-02-04 2010-08-05 Hellberg Mark R Ophthalmic composition with nitric oxide donor compound and method of forming and using same
US8062653B2 (en) 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
WO2010096320A2 (en) 2009-02-18 2010-08-26 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
US9278113B2 (en) 2009-03-30 2016-03-08 The Board Of Regents, The University Of Texas System Titanium dioxide nanotubes for production and delivery of nitric oxide and methods for production thereof
US8236341B2 (en) 2009-04-02 2012-08-07 Medtronic Vascular, Inc. Poly(tetrafluoroethylene) polymer with nitric oxide donating surface
US8709465B2 (en) 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
US20100286272A1 (en) 2009-05-08 2010-11-11 Perricone Nicholas V Methods Of Use Of Nitroalkene Compositions In Dermatologic Applications
JP5878866B2 (ja) 2009-06-22 2016-03-08 ゲノ エルエルシー 一酸化窒素治療
ES2958410T3 (es) 2009-08-21 2024-02-08 Novan Inc Geles tópicos
US20110059189A1 (en) 2009-09-08 2011-03-10 Cisne Enterprises Inc. Method and composition for treating cancer, effecting apoptosis and treating retroviral infections
EP2488591A1 (en) 2009-10-13 2012-08-22 Novan, Inc. Nitric oxide-releasing coatings
US8591876B2 (en) * 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
JP6277124B2 (ja) * 2011-07-05 2018-02-07 ノヴァン，インコーポレイテッド 局所用組成物
WO2013138073A1 (en) * 2012-03-13 2013-09-19 Novan, Inc. Methods of modulating steroid hormone activity

Also Published As

Publication number Publication date
EP2651381A1 (en) 2013-10-23
EP2651381A4 (en) 2014-05-28
KR101874141B1 (ko) 2018-07-03
ES2664360T3 (es) 2018-04-19
MX2013006871A (es) 2013-07-05
BR112013014003A2 (pt) 2020-06-16
EP2651381B1 (en) 2016-06-08
CA2821962A1 (en) 2012-06-21
BR112013014003B1 (pt) 2020-12-29
EP3085354A1 (en) 2016-10-26
AU2011343779A1 (en) 2013-08-01
JP2013545813A (ja) 2013-12-26
AU2011343779B2 (en) 2016-09-15
CA2821962C (en) 2020-10-27
CN103379892B (zh) 2017-04-19
ES2589682T3 (es) 2016-11-15
JP5980804B2 (ja) 2016-08-31
WO2012082976A1 (en) 2012-06-21
US8591876B2 (en) 2013-11-26
US20140057001A1 (en) 2014-02-27
US20120156163A1 (en) 2012-06-21
KR20130125790A (ko) 2013-11-19
CN103379892A (zh) 2013-10-30
EP3085354B1 (en) 2018-02-14

Similar Documents

Publication Publication Date Title
MX2013006871A (es) Metodos para disminuir la produccion de sebo en la piel.
CA140658S (en) Aerosol with cap
EP2827842A4 (en) CYCLODEXTRIN MICROEMULSIONS AND DERMATOLOGICAL USES THEREOF
SG10201804869UA (en) Purification of biological molecules
AU338378S (en) Portable information terminal
AU337803S (en) Portable information terminal
AU338379S (en) Portable information terminal
AU337802S (en) Portable information terminal
CA151549S (en) Spacer for an asthma inhaler
CA140657S (en) Aerosol cap
AU337790S (en) Portable information terminal
WO2012080929A3 (fr) Utilisation de l'ide comme biomarqueur d'un etat du cuir chevelu
AU337801S (en) Portable information terminal
IT1405689B1 (it) Nuovo ceppo di clostridium beijerinckii e relativi impieghi nella produzione di biobutanolo per via fermentativa
IN2014DN09585A (es)
BR112014009383A2 (pt) catalisador de metanação de dióxido de carbono, preparação e uso do mesmo
GB201309927D0 (en) Caspofungin analog, and preparation method and applications thereof
AU337793S (en) Portable information terminal
IN2015DN00962A (es)
CA144202S (en) Hammer strap to draw bar adapter
IL231589A0 (en) A preparation for application to the skin and its use
CA142814S (en) Medical patch
GB201403485D0 (en) Improvements in and relating to medical, handheld instruments
PL399298A1 (pl) Kompozycja farmaceutyczna do stosowania miejscowego zawierajaca acyklowir oraz sposób jej wytwarzania
UA52805U (en) Nasal splint

Legal Events

Date Code Title Description
FG Grant or registration