BR0316595A - Composto, método para a preparação de compostos, composição farmacêutica e usos do composto - Google Patents

Composto, método para a preparação de compostos, composição farmacêutica e usos do composto

Info

Publication number
BR0316595A
BR0316595A BR0316595-7A BR0316595A BR0316595A BR 0316595 A BR0316595 A BR 0316595A BR 0316595 A BR0316595 A BR 0316595A BR 0316595 A BR0316595 A BR 0316595A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
compounds
preparation
drugs
Prior art date
Application number
BR0316595-7A
Other languages
English (en)
Inventor
Shiping Xu
Xiaoguang Chen
Song Xu
Lanmin Li
Longfei Xie
Hongyan Li
Yan Li
Guifang Cheng
Original Assignee
Inst Materia Medica Cams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Materia Medica Cams filed Critical Inst Materia Medica Cams
Publication of BR0316595A publication Critical patent/BR0316595A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"COMPOSTO, MéTODO PARA A PREPARAçãO DE COMPOSTOS, COMPOSIçãO FARMACêUTICA E USOS DO COMPOSTO". A presente invenção refere-se a novos derivados de cumarinas suas carboxamidas, composições farmacêuticas contendo seu(s) uso(s) como fármacos para proteção dos rins, tármacos para tratamento de hipertenção, doenças cardio-cerebrovasculares, diabetes não dependente de insulina, tumores, lesões pré-cancerianas, e edemas.
BR0316595-7A 2002-12-05 2003-12-05 Composto, método para a preparação de compostos, composição farmacêutica e usos do composto BR0316595A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA021555257A CN1506359A (zh) 2002-12-05 2002-12-05 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
PCT/CN2003/001046 WO2004050082A1 (fr) 2002-12-05 2003-12-05 Nouveaux derives coumarine-amide et leur preparation, composition medicamenteuse associee et son utilisation

Publications (1)

Publication Number Publication Date
BR0316595A true BR0316595A (pt) 2005-10-04

Family

ID=32400079

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0316595-7A BR0316595A (pt) 2002-12-05 2003-12-05 Composto, método para a preparação de compostos, composição farmacêutica e usos do composto
BRPI0316595A BRPI0316595B1 (pt) 2002-12-05 2003-12-05 composto, método para a preparação de compostos, composição farmacêutica e usos de um composto

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0316595A BRPI0316595B1 (pt) 2002-12-05 2003-12-05 composto, método para a preparação de compostos, composição farmacêutica e usos de um composto

Country Status (11)

Country Link
US (1) US8338401B2 (pt)
EP (2) EP1570846A4 (pt)
JP (1) JP4722487B2 (pt)
KR (2) KR20100087748A (pt)
CN (2) CN1506359A (pt)
AU (1) AU2003289641A1 (pt)
BR (2) BR0316595A (pt)
CA (1) CA2508573C (pt)
IL (1) IL168959A (pt)
RU (1) RU2361870C2 (pt)
WO (1) WO2004050082A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0319126D0 (en) * 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
JP5349800B2 (ja) * 2004-12-31 2013-11-20 エスケー ケミカルズ カンパニー リミテッド 肝線維症および肝硬変に対する阻害活性を示す新規ベンゾピラン誘導体とその医薬的用途
SI2562170T1 (sl) * 2006-02-21 2015-03-31 Toyama Chemical Co., Ltd. Postopek za izdelavo 3-(5-(4-(ciklopentiloksi)-2-hidroksibenzoil)-2-((3-okso-2-substituiran- 2,3-dihidro-1,2-benzizoksazol-6-il)metoksi)fenil)propionat estra in intermediata za ta postopek
CN1810795A (zh) * 2006-03-03 2006-08-02 中国科学院上海药物研究所 一类新的苯并吡喃化合物、其制备方法和用途
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
GB0607389D0 (en) * 2006-04-12 2006-05-24 Novartis Ag Organic compounds
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
JP5280357B2 (ja) * 2006-07-07 2013-09-04 スティーブン・ピー・ガベック Ｐｄｅ４の二環式ヘテロアリール阻害剤
KR20090114383A (ko) * 2007-02-02 2009-11-03 노파르티스 아게 크로멘 ｓ1ｐ1 수용체 길항제
WO2008128100A1 (en) * 2007-04-13 2008-10-23 The Regents Of The University Of California Small-molecule inhibitors of the androgen receptor
CN101368003B (zh) * 2007-08-15 2011-09-14 中国科学院理化技术研究所 吡唑啉吡啶并香豆素荧光染料衍生物及其合成方法和用途
KR101093930B1 (ko) * 2007-09-13 2011-12-13 경북대학교병원 스코파론의 신규 용도
WO2009100250A1 (en) 2008-02-05 2009-08-13 Fibrogen, Inc. Chromene derivatives and use thereof as hif hydroxylase activity inhibitors
CN101525497B (zh) * 2008-03-06 2012-07-04 中国科学院理化技术研究所 吡唑啉吡啶并苯并香豆素荧光染料衍生物及其合成方法和用途
KR101640512B1 (ko) * 2008-04-24 2016-07-18 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 안드로겐 수용체의 소분자 억제제
CN105037323A (zh) 2008-11-14 2015-11-11 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
CN103788044B (zh) * 2008-11-28 2016-09-14 中国医学科学院药物研究所 硝克柳胺化合物晶i型、其制法和其药物组合物与用途
CN103833713B (zh) * 2008-11-28 2016-02-03 中国医学科学院药物研究所 硝克柳胺化合物晶iii型、其制法和其药物组合物与用途
CN101780070B (zh) * 2009-01-16 2012-08-22 广州康臣药物研究有限公司 一种治疗糖尿病肾病的药物组合物及其制备方法
CN101643463B (zh) * 2009-09-03 2011-12-28 祁刚 6-甲基香豆素-7-磺酰脲类化合物及其合成方法
SG10201501272SA (en) * 2009-10-22 2015-04-29 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
BR112012009670A2 (pt) 2009-10-23 2016-05-17 Allergan Inc compostos de cumarina como moduladores de receptor com utilidade terapêutica
KR101133246B1 (ko) * 2010-02-24 2012-04-05 원광대학교산학협력단 신규한 코마린 유도체, 이의 제조방법 및 상기 코마린 유도체를 포함하는 형광 면역측정용 키트
CN102241891B (zh) * 2010-05-14 2013-08-21 中国科学院理化技术研究所 吡唑并吡啶类香豆素染料衍生物及其合成方法和用途
CN101985449B (zh) * 2010-09-28 2012-08-22 中山大学 一种香豆素衍生物及其制备方法和作为抗癌药物的用途
CN102584762A (zh) * 2012-01-10 2012-07-18 中国药科大学 东莨菪素衍生物、制备方法及其用途
CN102558125A (zh) * 2012-01-10 2012-07-11 中国药科大学 3-乙酰氨基-7-羟基-6-甲氧基香豆素衍生物、制备方法及其用途
WO2014028025A1 (en) * 2012-08-16 2014-02-20 University Of Southern California Compositions and methods for treating myotonic dystrophy type 1
RU2549357C2 (ru) * 2013-06-04 2015-04-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" Способ получения метил 1-[3-(циклогексилкарбамоил)-2-оксохроман-4-ил] циклопентакарбоксилата, проявляющего анальгетическую активность
CN103408530B (zh) * 2013-08-26 2015-05-27 中国人民解放军第三军医大学 具有生物活性的香豆素骨架多环化合物及制备方法和用途
WO2016072946A1 (en) * 2014-11-05 2016-05-12 Ni̇dai̇ Özeş Osman Chromene-2 derivatives and use thereof in the treatment of fibrosis
CN105601624B (zh) * 2016-02-17 2018-05-22 南京双科医药开发有限公司 一种1,2,4-三嗪-香豆素型化合物及其制法和用途
WO2018144620A1 (en) 2017-02-03 2018-08-09 Shire Human Genetic Therapies, Inc. Anti-fibrotic compounds
CN107868069A (zh) * 2017-10-31 2018-04-03 山东新华制药股份有限公司 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺
CN108218854B (zh) * 2017-12-29 2020-04-10 厦门大学 苯丙吡喃-2-酮类化合物作为jmjd6抑制剂及用途
CN109232517B (zh) * 2018-10-16 2020-06-12 郑州大学第一附属医院 一组磺酰香豆素类衍生物及其在制备抗肿瘤药物中的应用
WO2020130120A1 (ja) * 2018-12-20 2020-06-25 学校法人京都薬科大学 癌転移抑制剤
CN110156761B (zh) * 2019-06-18 2022-08-09 郑州大学 含香豆素-联苯骨架化合物、制备方法及其应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683720A (en) * 1949-12-15 1954-07-13 Endo Products Inc Process for the preparation of 6-nitro-coumarin-3-carboxylic acid
FR7513M (pt) * 1967-11-20 1969-12-15
GB1388590A (en) * 1972-09-06 1975-03-26 Hickson & Welch Ltd 3-oxadiazolyl-coumarins and their use as brightening agents
EP0403535A1 (en) * 1988-03-01 1990-12-27 The Upjohn Company Coumarins to inhibit reverse transcriptase in humans
JP2802097B2 (ja) 1989-05-31 1998-09-21 財団法人微生物化学研究会 新規な制癌抗生物質ｍｉ４３―３７ｆ１１及びその製造法
HUT63843A (en) * 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
JPH06145164A (ja) * 1992-11-04 1994-05-24 Mitsui Toatsu Chem Inc 紫外線吸収剤およびそれに適したベンゾピラン誘導体ならびに該紫外線吸収剤を含有してなる熱可塑性樹脂組成物および成形体
JP3556970B2 (ja) * 1993-07-22 2004-08-25 三井化学株式会社 ベンゾピラン化合物及びその用途
JP3603327B2 (ja) 1994-04-12 2004-12-22 大日本インキ化学工業株式会社 糖尿病治療剤
US6090958A (en) * 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5716982A (en) * 1995-06-07 1998-02-10 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Retinoids and methods of use of same
DK0869785T3 (da) 1995-11-17 2002-12-16 Upjohn Co 4-Hydroxycoumarin-3-carboxyamider til behandling af ikke-insulinafhængig diabetes mellitus
JP3885900B2 (ja) * 1996-03-22 2007-02-28 大日本インキ化学工業株式会社 ベンゾピラン誘導体及びそれを有効成分とする心臓疾患治療剤
IT1289238B1 (it) 1996-12-10 1998-09-29 Bio S S P A Ora Bio S S R L Composizioni farmaceutiche per il trattamento di infezioni virali comprendenti una 4 arilcumarina
US5773647A (en) * 1997-02-07 1998-06-30 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CA2319672C (en) * 1997-02-07 2011-01-04 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
FR2763944B1 (fr) * 1997-06-03 2000-12-15 Centre Nat Rech Scient Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases
CN1108297C (zh) * 1997-07-31 2003-05-14 中国医学科学院药物研究所 维甲酰香豆素类化合物及其制备方法和含该化合物的药物组合物
GB9722600D0 (en) 1997-10-24 1997-12-24 Bio Monde Holdings Internation Pharmaceutical compositon
JP2000218940A (ja) * 1999-02-02 2000-08-08 Mitsui Chemicals Inc 光記録媒体
DE60027907T2 (de) 1999-09-14 2007-01-04 Biogen Idec Ma Inc., Cambridge Therapien für chronische niereninsuffizienz unter verwendung von ein oder mehreren integrinantagonist(en)
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FI20001593A (fi) 2000-07-03 2002-01-04 Orion Yhtymo Oyj Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
JP4933730B2 (ja) * 2001-05-04 2012-05-16 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用法
JP4986423B2 (ja) 2005-08-03 2012-07-25 日東電工株式会社 剥離処理基材及びその製造方法

Also Published As

Publication number Publication date
JP4722487B2 (ja) 2011-07-13
JP2006512328A (ja) 2006-04-13
US20060148834A1 (en) 2006-07-06
IL168959A (en) 2013-08-29
CN100488504C (zh) 2009-05-20
US8338401B2 (en) 2012-12-25
EP2295053B8 (en) 2018-03-28
CN1829506A (zh) 2006-09-06
KR20100087748A (ko) 2010-08-05
WO2004050082A1 (fr) 2004-06-17
EP2295053A1 (en) 2011-03-16
CN1506359A (zh) 2004-06-23
RU2361870C2 (ru) 2009-07-20
RU2005121137A (ru) 2006-01-20
EP1570846A4 (en) 2008-02-20
BRPI0316595B1 (pt) 2018-12-26
EP2295053B1 (en) 2016-10-19
CA2508573C (en) 2012-09-11
KR101000395B1 (ko) 2010-12-13
AU2003289641A1 (en) 2004-06-23
EP1570846A1 (en) 2005-09-07
KR20050084184A (ko) 2005-08-26
CA2508573A1 (en) 2004-06-17

Similar Documents

Publication Publication Date Title
BR0316595A (pt) Composto, método para a preparação de compostos, composição farmacêutica e usos do composto
BRPI0414514A (pt) uso de um composto, composto, e, composições farmacêuticas
BRPI0410760A (pt) compostos, processo para fabricação dos mesmos, composições farmacêuticas e uso deste compostos
BR0310077A (pt) Novos compostos e sua utilização
BRPI0415825A (pt) novos derivados de tetrahidroespiro{piperidino-2,7'-pirrol[3,2b]piridina } e novos derivados de indol úteis no tratamento de distúrbios relacionados ao receptor 5-ht6
BR0108678A (pt) Novos compostos
MY149181A (en) Isoxazoline derivative and preparation process thereof
BRPI0413232B8 (pt) composto tendo atividade inibitória contra transportador dependente de sódio, composição farmacêutica compreendendo o composto, uso do composto na preparação de um medicamento e processo para a preparação do composto
BR9807824A (pt) Derivados de n-hidróxi-beta-sulfonil-propionamida e seu uso como inibidores de metaloproteinases de matriz
DK1086124T3 (da) Nye cyclosporiner
BRPI0418099A (pt) compostos, composição farmacêutica, e uso de um composto
BRPI0511466A (pt) agonistas peptìdicos do receptor de vasopressina
BR0315580A (pt) Derivados de metileno uréia
WO2007054257A3 (en) Indene derivatives, their preparation and use as medicaments
BRPI0510719A (pt) derivados de naftalimida, composição farmacêutica, uso e método de preparação dos mesmos
BRPI0417833A (pt) novos derivados de benzofurano, os quais podem ser usados na profilaxia ou tratamento de distúrbios relacionados com o receptor 5-ht6
ES2193875A1 (es) Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos.
EA201070747A1 (ru) Фармацевтический препарат, содержащий толперизон
BR0316950A (pt) Derivados de indazol como antagonistas de crf
AR039190A1 (es) Derivados de benzofurano, composicion farmaceutica y medicamento que comprende el compuesto
BRPI0515897A (pt) composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto
BR0315320A (pt) Composto ou sais farmaceuticamente aceitáveis dos mesmos, uso de um composto, composição farmacêutica, e, métodos para a terapia de dor em um animal de sangue quente e para produzir um composto
BR0315995A (pt) Composto, uso de um composto composição farmacêutica, métodos para a terapia da dor, de distúrbios gastrointestinais, e da ansiedade em um animal de sangue quente, e, processo para preparar um composto
UA89795C2 (ru) Фармацевтическая композиция, которая содержит эстер темозоломида
BRPI0519152A2 (pt) composto ou um sal ou derivado Éster farmaceuticamente aceitÁvel do mesmo, formulaÇço farmacÊutica, formulaÇÕes para tratar osteoporose e psorÍase, uso de um composto ou de um sal farmaceuticamente aceitÁvel do mesmo, e, composiÇço farmacÊutica

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.