UA89795C2 - Фармацевтическая композиция, которая содержит эстер темозоломида - Google Patents
Фармацевтическая композиция, которая содержит эстер темозоломидаInfo
- Publication number
- UA89795C2 UA89795C2 UAA200704418A UAA200704418A UA89795C2 UA 89795 C2 UA89795 C2 UA 89795C2 UA A200704418 A UAA200704418 A UA A200704418A UA A200704418 A UAA200704418 A UA A200704418A UA 89795 C2 UA89795 C2 UA 89795C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- pharmaceutical composition
- temozolomide
- pharmaceutical
- ester
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 5
- 229960004964 temozolomide Drugs 0.000 title 1
- -1 temozolomide ester Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000012059 conventional drug carrier Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003333 secondary alcohols Chemical class 0.000 abstract 1
- 150000003509 tertiary alcohols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Данное изобретение раскрывает соединения темозоломид-8-карбоксилата общей формулы И, способ их получения, фармацевтические композиции, которые содержат указанные соединения, и применение соединений и фармацевтических композиций для производства противоопухолевого лекарственного средства.Указанная фармацевтическая композиция содержит одно или более соединений темозоломид-8-карбоксилата общей формулы И, в качестве активного ингредиента, вместе с традиционными фармацевтическими носителями.Композиция также содержит один или более фармацевтически приемлемых материалов кислотной природы, необязательно содержит вторичный или третичный спирт или их эфирные производные.Указанная фармацевти�
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100720564A CN1752088A (zh) | 2004-09-22 | 2004-09-22 | 含有替莫唑胺酯的药用组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA89795C2 true UA89795C2 (ru) | 2010-03-10 |
Family
ID=36089840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200704418A UA89795C2 (ru) | 2004-09-22 | 2005-09-15 | Фармацевтическая композиция, которая содержит эстер темозоломида |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7579336B2 (ru) |
| EP (1) | EP1798234B1 (ru) |
| JP (2) | JP5620046B2 (ru) |
| KR (1) | KR101065984B1 (ru) |
| CN (1) | CN1752088A (ru) |
| AR (1) | AR050947A1 (ru) |
| AU (1) | AU2005287799B2 (ru) |
| BR (1) | BRPI0515555A (ru) |
| CA (1) | CA2580910C (ru) |
| DK (1) | DK1798234T3 (ru) |
| ES (1) | ES2389376T3 (ru) |
| HK (1) | HK1100440A1 (ru) |
| IL (1) | IL182027A (ru) |
| MX (1) | MX2007003366A (ru) |
| MY (1) | MY153713A (ru) |
| NZ (1) | NZ554609A (ru) |
| PL (1) | PL1798234T3 (ru) |
| RU (1) | RU2393160C2 (ru) |
| UA (1) | UA89795C2 (ru) |
| WO (1) | WO2006032190A1 (ru) |
| ZA (1) | ZA200702801B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1727340B (zh) * | 2004-07-29 | 2011-05-18 | 天津帝士力投资控股集团有限公司 | 一种替莫唑胺-8-羧酸酯及其组合物 |
| EP1808173A1 (en) * | 2006-01-12 | 2007-07-18 | Matthias Dormeyer | Use of CNS penetrating anticancer compounds for the treatment of protozan diseases |
| US8558511B2 (en) * | 2009-04-07 | 2013-10-15 | Battelle Memorial Institute | Method and apparatus for smart battery charging including a plurality of controllers each monitoring input variables |
| KR20140087846A (ko) * | 2012-12-31 | 2014-07-09 | 주식회사 삼양바이오팜 | 테모졸로미드를 포함하는 안정성이 개선된 약제학적 조성물 및 이의 제조방법 |
| RU2527258C1 (ru) * | 2013-02-19 | 2014-08-27 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | 6-ЗАМЕЩЕННЫЕ 3-АЗОЛИЛИМИДАЗО[1,2-b][1,2,4,5]ТЕТРАЗИНЫ, ПРОЯВЛЯЮЩИЕ ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ |
| US10709715B2 (en) * | 2017-12-03 | 2020-07-14 | Cipla Limited | Method of treating hypertension |
| CN114014862A (zh) * | 2021-06-28 | 2022-02-08 | 烟台大学 | 一种治疗脑胶质瘤的新化合物及其制备和应用 |
| CN115260107B (zh) * | 2022-06-23 | 2023-11-24 | 烟台邦杰生物科技有限公司 | 一种抗肿瘤药物前药、药物组合物及在肿瘤靶向治疗领域的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8616125D0 (en) | 1986-07-02 | 1986-08-06 | May & Baker Ltd | Compositions of matter |
| CN1244583C (zh) | 2002-09-29 | 2006-03-08 | 天津天士力集团有限公司 | 替莫唑胺－8－羧酸脂和－8－酰胺衍生物，它们的合成方法以及它们在制备抗癌制剂中的应用 |
| CN1742723A (zh) * | 2004-09-02 | 2006-03-08 | 天津倍方科技发展有限公司 | 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途 |
-
2004
- 2004-09-22 CN CNA2004100720564A patent/CN1752088A/zh active Pending
-
2005
- 2005-09-15 US US11/575,849 patent/US7579336B2/en not_active Expired - Fee Related
- 2005-09-15 NZ NZ554609A patent/NZ554609A/en not_active IP Right Cessation
- 2005-09-15 JP JP2007532748A patent/JP5620046B2/ja not_active Expired - Fee Related
- 2005-09-15 KR KR1020077009054A patent/KR101065984B1/ko not_active IP Right Cessation
- 2005-09-15 PL PL05785075T patent/PL1798234T3/pl unknown
- 2005-09-15 ES ES05785075T patent/ES2389376T3/es active Active
- 2005-09-15 UA UAA200704418A patent/UA89795C2/ru unknown
- 2005-09-15 BR BRPI0515555-0A patent/BRPI0515555A/pt not_active IP Right Cessation
- 2005-09-15 CA CA2580910A patent/CA2580910C/en not_active Expired - Fee Related
- 2005-09-15 WO PCT/CN2005/001477 patent/WO2006032190A1/zh active Application Filing
- 2005-09-15 MX MX2007003366A patent/MX2007003366A/es active IP Right Grant
- 2005-09-15 EP EP05785075A patent/EP1798234B1/en not_active Not-in-force
- 2005-09-15 AU AU2005287799A patent/AU2005287799B2/en not_active Ceased
- 2005-09-15 DK DK05785075.2T patent/DK1798234T3/da active
- 2005-09-15 RU RU2007114948/04A patent/RU2393160C2/ru not_active IP Right Cessation
- 2005-09-21 AR ARP050103949A patent/AR050947A1/es not_active Application Discontinuation
- 2005-09-22 MY MYPI20054428A patent/MY153713A/en unknown
-
2007
- 2007-03-19 IL IL182027A patent/IL182027A/en not_active IP Right Cessation
- 2007-04-03 ZA ZA200702801A patent/ZA200702801B/xx unknown
- 2007-07-31 HK HK07108352.8A patent/HK1100440A1/xx not_active IP Right Cessation
-
2012
- 2012-09-24 JP JP2012209183A patent/JP2013028630A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1798234A4 (en) | 2009-04-29 |
| KR20070062569A (ko) | 2007-06-15 |
| JP5620046B2 (ja) | 2014-11-05 |
| CA2580910A1 (en) | 2006-03-30 |
| IL182027A (en) | 2014-05-28 |
| RU2393160C2 (ru) | 2010-06-27 |
| US7579336B2 (en) | 2009-08-25 |
| AU2005287799B2 (en) | 2009-03-26 |
| CA2580910C (en) | 2011-10-25 |
| US20080044457A1 (en) | 2008-02-21 |
| NZ554609A (en) | 2010-06-25 |
| DK1798234T3 (da) | 2012-08-27 |
| BRPI0515555A (pt) | 2008-07-29 |
| JP2008513523A (ja) | 2008-05-01 |
| AU2005287799A1 (en) | 2006-03-30 |
| WO2006032190A1 (fr) | 2006-03-30 |
| EP1798234B1 (en) | 2012-06-13 |
| MX2007003366A (es) | 2008-03-05 |
| KR101065984B1 (ko) | 2011-09-19 |
| AR050947A1 (es) | 2006-12-06 |
| EP1798234A1 (en) | 2007-06-20 |
| PL1798234T3 (pl) | 2012-11-30 |
| ES2389376T3 (es) | 2012-10-25 |
| HK1100440A1 (en) | 2007-09-21 |
| CN1752088A (zh) | 2006-03-29 |
| MY153713A (en) | 2015-03-13 |
| RU2007114948A (ru) | 2008-10-27 |
| ZA200702801B (en) | 2008-08-27 |
| IL182027A0 (en) | 2007-07-24 |
| JP2013028630A (ja) | 2013-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018253620A1 (en) | Injectable botulinum toxin formulations | |
| UA89795C2 (ru) | Фармацевтическая композиция, которая содержит эстер темозоломида | |
| AU2002218167A1 (en) | N-phenyl-2-pyrimidine-amine derivatives | |
| WO2007145991A3 (en) | Anti-inflammatory and analgesic compositions and related methods | |
| AR048336A1 (es) | Hidrocloruro de (4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il)-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona como un inhibidor de la triptasa de mastocitos | |
| UA86614C2 (ru) | Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата | |
| BRPI0508579A (pt) | composto, composição farmacêutica, e, uso de um composto | |
| WO2006099169A3 (en) | Novel liposome compositions | |
| SG158870A1 (en) | Bendamustine pharmaceutical compositions for lyophilisation | |
| HK1102991A1 (en) | Pharmaceutical formulation of decitabine | |
| MY143795A (en) | Tetrahydropyridoindole derivatives | |
| WO2010103544A3 (en) | A novel sustained release composition of compounds selected from the class of centrally acting muscle relaxants | |
| UA110013C2 (uk) | Застосування композиції для лікування шарко-марі-тута і пов'язаних з нею розладів | |
| TW200606164A (en) | New compounds | |
| NO20043367L (no) | Oralt farmasoytisk preparat | |
| WO2009109618A3 (en) | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 | |
| WO2009109616A3 (en) | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cxrl and p40 | |
| TW200510392A (en) | Chemical compounds | |
| TW200800984A (en) | New compounds | |
| TW200505452A (en) | Chemical compounds | |
| TW200640465A (en) | New pharmaceutically active compounds for the treatment of respiratory diseases | |
| UY30847A1 (es) | Uso de derivados de mononitrato de dianhidrohexita como agentes para el tratamiento de trastornos intestinales | |
| WO2010044097A3 (en) | Novel dosage form of paliperidone and process for preparing the same | |
| ATE429435T1 (de) | 7h-pyrrolopyrimidinderivate | |
| SE0000303D0 (sv) | Novel compounds |