BR0308231A - Composições farmacêuticas em grânulos de liberação imediata e um processo contìnuo para a obtenção das mesmas - Google Patents

Composições farmacêuticas em grânulos de liberação imediata e um processo contìnuo para a obtenção das mesmas

Info

Publication number
BR0308231A
BR0308231A BR0308231-8A BR0308231A BR0308231A BR 0308231 A BR0308231 A BR 0308231A BR 0308231 A BR0308231 A BR 0308231A BR 0308231 A BR0308231 A BR 0308231A
Authority
BR
Brazil
Prior art keywords
immediate release
pharmaceutical compositions
continuous process
weight
release granules
Prior art date
Application number
BR0308231-8A
Other languages
English (en)
Inventor
Jean-Paul Remon
Kris Vervaet
Original Assignee
Univ Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Gent filed Critical Univ Gent
Publication of BR0308231A publication Critical patent/BR0308231A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSIçõES FARMACêUTICAS EM GRâNULOS DE LIBERAçãO IMEDIATA E UM PROCESSO CONTìNUO PARA A OBTENçãO DAS MESMAS". A presente invenção refere-se a uma composição farmacêutica em grânulos de liberação imediata que compreende (I) pelo menos uma droga que pode ser classificada como classe II ou Classe IV do Biopharmaceutical Classification System, em que a dita droga constitui pelo menos aproximadamente 0,5 % em peso e até aproximadamente 20 % em peso da composição, a dita composição compreendendo ainda (ii) um primeiro excipiente selecionado do grupo que consiste em: mesclas de uma celulose microcristalina e um polímero inflável em quantidades respectivas tal que a proporção em peso do dito polímero para a celulose microcristalina na mescla seja acima de aproximadamente 2 : 100 e até aproximadamente 30 : 100, - um ou mais compostos que contêm dextrina selecionados do grupo que consiste em maltodextrinas, ciclodextrinas e derivado das mesmas e - misturas dos ditos compostos que contêm dextrina e das ditas mesclas e (iii) uma quantidade para umidificação de um segundo excipiente que é um composto para umidificação não-aquoso ou um composto que pode ser fundido e que compreende uma fração sólida e opcionalmente uma fração líquida.
BR0308231-8A 2002-03-06 2003-03-05 Composições farmacêuticas em grânulos de liberação imediata e um processo contìnuo para a obtenção das mesmas BR0308231A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0205253.8A GB0205253D0 (en) 2002-03-06 2002-03-06 Immediate release pharmaceutical granule compositions and a continuous process for making them
PCT/BE2003/000040 WO2003074031A1 (en) 2002-03-06 2003-03-05 Immediate release pharmaceutical granule compositions and a continuous process for making them

Publications (1)

Publication Number Publication Date
BR0308231A true BR0308231A (pt) 2004-12-28

Family

ID=9932403

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308231-8A BR0308231A (pt) 2002-03-06 2003-03-05 Composições farmacêuticas em grânulos de liberação imediata e um processo contìnuo para a obtenção das mesmas

Country Status (22)

Country Link
US (4) US20050058705A1 (pt)
EP (1) EP1480622B1 (pt)
KR (1) KR20040091099A (pt)
CN (1) CN1638738B (pt)
AR (1) AR038880A1 (pt)
AT (1) ATE418327T1 (pt)
AU (1) AU2003215449B2 (pt)
BR (1) BR0308231A (pt)
CA (1) CA2477890C (pt)
DE (1) DE60325461D1 (pt)
DK (1) DK1480622T3 (pt)
ES (1) ES2318147T3 (pt)
GB (1) GB0205253D0 (pt)
HK (1) HK1078006A1 (pt)
MX (1) MXPA04008543A (pt)
MY (1) MY138752A (pt)
PL (1) PL208133B1 (pt)
PT (1) PT1480622E (pt)
SA (1) SA03240089B1 (pt)
TW (1) TWI296198B (pt)
WO (1) WO2003074031A1 (pt)
ZA (1) ZA200407998B (pt)

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Also Published As

Publication number Publication date
ES2318147T3 (es) 2009-05-01
US20050058705A1 (en) 2005-03-17
TW200305446A (en) 2003-11-01
AU2003215449A1 (en) 2003-09-16
EP1480622A1 (en) 2004-12-01
US20110027377A1 (en) 2011-02-03
TWI296198B (en) 2008-05-01
AU2003215449B2 (en) 2007-07-26
KR20040091099A (ko) 2004-10-27
CA2477890C (en) 2011-05-10
US20110008454A1 (en) 2011-01-13
GB0205253D0 (en) 2002-04-17
SA03240089B1 (ar) 2008-07-12
PL372579A1 (en) 2005-07-25
PT1480622E (pt) 2009-03-06
CN1638738A (zh) 2005-07-13
MXPA04008543A (es) 2004-12-06
CN1638738B (zh) 2012-06-06
CA2477890A1 (en) 2003-09-12
DK1480622T3 (da) 2009-02-16
US20070009592A1 (en) 2007-01-11
ZA200407998B (en) 2006-06-28
ATE418327T1 (de) 2009-01-15
US8337897B2 (en) 2012-12-25
WO2003074031A1 (en) 2003-09-12
HK1078006A1 (en) 2006-03-03
EP1480622B1 (en) 2008-12-24
AR038880A1 (es) 2005-02-02
US8349366B2 (en) 2013-01-08
PL208133B1 (pl) 2011-03-31
MY138752A (en) 2009-07-31
DE60325461D1 (de) 2009-02-05

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA.INT.CI. A61K 9/16, A61P 11/00, A61P 29/00

Ipc: A61K 9/16 (2011.01), A61P 11/00 (2011.01), A61P 29

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time