BR0215310A - Processo para a preparação de um derivado do ácido 2-(6-substituìdo)-1,3-dioxano-4-il) acético - Google Patents
Processo para a preparação de um derivado do ácido 2-(6-substituìdo)-1,3-dioxano-4-il) acéticoInfo
- Publication number
- BR0215310A BR0215310A BR0215310-6A BR0215310A BR0215310A BR 0215310 A BR0215310 A BR 0215310A BR 0215310 A BR0215310 A BR 0215310A BR 0215310 A BR0215310 A BR 0215310A
- Authority
- BR
- Brazil
- Prior art keywords
- dioxan
- substituted
- acetic acid
- acid derivative
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001242 acetic acid derivatives Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003444 phase transfer catalyst Substances 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- -1 2- (6-substituted-1,3-dioxan-4-yl) acetic acid Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Liquid Crystal Substances (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE UM DERIVADO DO áCIDO 2(6-SUBSTITUìDO)-1,3-DIOXANO-4-IL) ACéTICO". A invenção refere-se a um processo para a conversão do grupo X, de um derivado do ácido 2-(6-substituído-1,3-dioxano-4-il) acético, de acordo com a fórmula 2, em um grupo OY, na presença de um catalisador de transferência de fase e um agente oxilante, pela utilização, como um catalisador de transferência de fase, de um íon fosfónio quaternário e pela utilização, como um agente oxilante, de um íon OY. X representa um halogênio e R^ 1^, R^ 2^ e R^ 3^ são, cada um independentemente, um grupo C~ 1~-C~ 4~ alquila ou R^ 1^ e R^ 2^, juntos com o átomo-C a que eles são ligados, formam uma cicloalquila de 5 ou 6 membros; Y representa R^ A^-CO- ou R^ B^-SO~ 2-~, com R^ A^ e R^ B^ escolhidos do grupo alquila ou arila com 1 - 12 átomos de carbono.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01000794A EP1323717A1 (en) | 2001-12-27 | 2001-12-27 | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
| PCT/NL2002/000876 WO2003059901A1 (en) | 2001-12-27 | 2002-12-09 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0215310A true BR0215310A (pt) | 2004-12-21 |
Family
ID=8176121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0215310-6A BR0215310A (pt) | 2001-12-27 | 2002-12-09 | Processo para a preparação de um derivado do ácido 2-(6-substituìdo)-1,3-dioxano-4-il) acético |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7718812B2 (pt) |
| EP (2) | EP1323717A1 (pt) |
| JP (2) | JP2005519898A (pt) |
| KR (1) | KR100958367B1 (pt) |
| CN (1) | CN1286830C (pt) |
| AT (1) | ATE319701T1 (pt) |
| AU (1) | AU2002359093B2 (pt) |
| BR (1) | BR0215310A (pt) |
| CA (1) | CA2470647C (pt) |
| CO (1) | CO5590893A2 (pt) |
| DE (1) | DE60209798T2 (pt) |
| HK (1) | HK1069575A1 (pt) |
| HU (1) | HUP0402007A3 (pt) |
| IL (2) | IL162687A0 (pt) |
| IS (1) | IS2407B (pt) |
| MX (1) | MXPA04006306A (pt) |
| NO (1) | NO328643B1 (pt) |
| NZ (1) | NZ533445A (pt) |
| PL (1) | PL207129B1 (pt) |
| RU (1) | RU2301229C2 (pt) |
| UA (1) | UA77467C2 (pt) |
| WO (1) | WO2003059901A1 (pt) |
| ZA (1) | ZA200404482B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| EP1417180B1 (en) | 2001-07-13 | 2006-12-27 | AstraZeneca UK Limited | Preparation of aminopyrimidine compounds |
| EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| AU2003288443B2 (en) | 2002-12-16 | 2007-10-25 | Astrazeneka Uk Limited | Process for the preparation of pyrimidine compounds |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0324791D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
| GB0514078D0 (en) * | 2005-07-08 | 2005-08-17 | Astrazeneca Uk Ltd | Chemical process |
| TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
| GB2482525A (en) * | 2010-08-05 | 2012-02-08 | Phoenix Chemicals Ltd | A process for the production of acyloxymethyldioxanylacetic derivatives |
| CN105622566B (zh) * | 2014-11-19 | 2018-07-27 | 上海弈柯莱生物医药科技有限公司 | 一种3,5-二取代羟基-6-取代己酸酯衍生物的制备方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB885516A (en) | 1958-01-16 | 1961-12-28 | Arthur Henry Clarkson | Higher fatty acid esters of dextran |
| US3992432A (en) * | 1967-04-05 | 1976-11-16 | Continental Oil Company | Phase transfer catalysis of heterogeneous reactions by quaternary salts |
| JPS58164546A (ja) * | 1982-03-25 | 1983-09-29 | Sanki Kosan Kk | ｄｌ−マンデル酸ベンジルエステルの製造法 |
| GB9005966D0 (en) | 1990-03-16 | 1990-05-09 | May & Baker Ltd | New compositions of matter |
| JP3097143B2 (ja) | 1991-02-21 | 2000-10-10 | チッソ株式会社 | 生理活性物質合成用光学活性化合物の製造法および光学活性中間体化合物 |
| JP3120292B2 (ja) * | 1991-10-18 | 2000-12-25 | イハラケミカル工業株式会社 | 脂肪族カルボン酸ハロメチルエステル類の製造法 |
| WO1993008823A1 (en) | 1991-11-06 | 1993-05-13 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
| US5278313A (en) * | 1992-03-27 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors |
| JP3071340B2 (ja) | 1993-06-02 | 2000-07-31 | セントラル硝子株式会社 | ２−クロロ−ピリジンメタノールの製造方法 |
| US6278001B1 (en) * | 1995-11-28 | 2001-08-21 | L'oréal | Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping |
| FR2741620B1 (fr) | 1995-11-28 | 1997-12-26 | Oreal | Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline |
| JPH10158199A (ja) * | 1996-10-02 | 1998-06-16 | Dai Ichi Seiyaku Co Ltd | カルボン酸化合物のエステル化法 |
| CA2305564C (en) | 1998-08-05 | 2008-06-17 | Kaneka Corporation | Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives |
| GB9903472D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| HU227840B1 (en) | 1999-05-06 | 2012-05-02 | Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag | Intermediates of atorvastatin synthesis and process for producing them |
| AU2000254249A1 (en) | 2000-03-28 | 2001-10-08 | Biocon India Limited | Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1- |
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| EP1417180B1 (en) | 2001-07-13 | 2006-12-27 | AstraZeneca UK Limited | Preparation of aminopyrimidine compounds |
| DE60233899D1 (de) * | 2002-02-25 | 2009-11-12 | Biocon Ltd | Neue boronatester |
| EP1375493A1 (en) | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| AU2003288443B2 (en) | 2002-12-16 | 2007-10-25 | Astrazeneka Uk Limited | Process for the preparation of pyrimidine compounds |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| WO2004113314A1 (en) | 2003-06-23 | 2004-12-29 | Biocon Limited | Novel boronate esters |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| GB0321827D0 (en) | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| JP4266879B2 (ja) | 2004-05-12 | 2009-05-20 | 大阪瓦斯株式会社 | ガス化炉及び複合リサイクル装置 |
| US9626437B2 (en) * | 2004-06-10 | 2017-04-18 | International Business Machines Corporation | Search scheduling and delivery tool for scheduling a search using a search framework profile |
| GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
-
2001
- 2001-12-27 EP EP01000794A patent/EP1323717A1/en not_active Withdrawn
-
2002
- 2002-09-12 UA UA20040604878A patent/UA77467C2/uk unknown
- 2002-12-09 JP JP2003560004A patent/JP2005519898A/ja active Pending
- 2002-12-09 EP EP02793596A patent/EP1461331B9/en not_active Expired - Lifetime
- 2002-12-09 IL IL16268702A patent/IL162687A0/xx active IP Right Grant
- 2002-12-09 NZ NZ533445A patent/NZ533445A/en not_active IP Right Cessation
- 2002-12-09 RU RU2004118057/04A patent/RU2301229C2/ru not_active IP Right Cessation
- 2002-12-09 CA CA2470647A patent/CA2470647C/en not_active Expired - Fee Related
- 2002-12-09 AU AU2002359093A patent/AU2002359093B2/en not_active Ceased
- 2002-12-09 PL PL370223A patent/PL207129B1/pl not_active IP Right Cessation
- 2002-12-09 US US10/501,250 patent/US7718812B2/en not_active Expired - Lifetime
- 2002-12-09 WO PCT/NL2002/000876 patent/WO2003059901A1/en active IP Right Grant
- 2002-12-09 MX MXPA04006306A patent/MXPA04006306A/es active IP Right Grant
- 2002-12-09 HU HU0402007A patent/HUP0402007A3/hu unknown
- 2002-12-09 KR KR1020047010040A patent/KR100958367B1/ko not_active IP Right Cessation
- 2002-12-09 CN CNB028262018A patent/CN1286830C/zh not_active Expired - Lifetime
- 2002-12-09 BR BR0215310-6A patent/BR0215310A/pt not_active Application Discontinuation
- 2002-12-09 DE DE60209798T patent/DE60209798T2/de not_active Expired - Lifetime
- 2002-12-09 AT AT02793596T patent/ATE319701T1/de not_active IP Right Cessation
-
2004
- 2004-06-07 ZA ZA200404482A patent/ZA200404482B/en unknown
- 2004-06-22 CO CO04058284A patent/CO5590893A2/es not_active Application Discontinuation
- 2004-06-22 IS IS7332A patent/IS2407B/is unknown
- 2004-06-22 IL IL162687A patent/IL162687A/en not_active IP Right Cessation
- 2004-07-23 NO NO20043159A patent/NO328643B1/no not_active IP Right Cessation
-
2005
- 2005-03-10 HK HK05102090A patent/HK1069575A1/xx not_active IP Right Cessation
-
2010
- 2010-02-09 JP JP2010026513A patent/JP2010132690A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART. 8O COMBINADO COM ART. 13 E ART. 25 DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |