HUP0402007A2 - Eljárás 2-(6-szubsztituált-1,3-dioxan-4-il)-ecetsav-származékok előállítására - Google Patents

Eljárás 2-(6-szubsztituált-1,3-dioxan-4-il)-ecetsav-származékok előállítására

Info

Publication number
HUP0402007A2
HUP0402007A2 HU0402007A HUP0402007A HUP0402007A2 HU P0402007 A2 HUP0402007 A2 HU P0402007A2 HU 0402007 A HU0402007 A HU 0402007A HU P0402007 A HUP0402007 A HU P0402007A HU P0402007 A2 HUP0402007 A2 HU P0402007A2
Authority
HU
Hungary
Prior art keywords
formula
general formula
substituted
acetic acid
preparation
Prior art date
Application number
HU0402007A
Other languages
English (en)
Inventor
Robert Patrick Hof
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of HUP0402007A2 publication Critical patent/HUP0402007A2/hu
Publication of HUP0402007A3 publication Critical patent/HUP0402007A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

(57) A találmány tárgya eljárás (1) általános képletű 2-(6-szubsztituált-1,3-dioxan-4-il)-ecetsav-származékok - a képletben R1,R2 és R3 azonos vagy eltérő 1-4 szénatomos alkilcsoportot jelent, vagyR1 és R2 a közbezárt szénatommal együtt öt- vagy hattagúcikloalkilcsoportot alkot, és Y RA-CO- vagy RB-SO2- általános képletűcsoportot jelent, amelyekben RA és RB egymástól függetlenül 1-12szénatomos alkil- vagy arilcsoportot képvisel - előállítására amegfelelő (2) általános képletű 2-(6-szubsztituált-1,3-dioxan-4-il)-ecetsav-származékok - a képletben R1, R2 és R3 jelentése a fenti, és Xhalogénatomot jelent - és oxilezőszerek fázisátvivő katalizátorjelenlétében végrehajtott reagáltatása útján. A találmány értelmébenfázisátvivő katalizátorként (3) általános képletű kvaternerfoszfónium-iont - a képletben R4, R5, R6 és R7 egymástól függetlenül1-12 szénatomos alkil-, cikIoalkil-, aralkil- vagy arilcsoportotjelent -, oxilezőszerként pedig (4) általános képletű iont - aképletben Y jelentése a fenti - használnak. Ó
HU0402007A 2001-12-27 2002-12-09 Process for the preparation of-2(6-substituted-1,3-dioxane-4-yl)acetic acid derivates HUP0402007A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01000794A EP1323717A1 (en) 2001-12-27 2001-12-27 Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
PCT/NL2002/000876 WO2003059901A1 (en) 2001-12-27 2002-12-09 Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivates

Publications (2)

Publication Number Publication Date
HUP0402007A2 true HUP0402007A2 (hu) 2005-02-28
HUP0402007A3 HUP0402007A3 (en) 2007-02-28

Family

ID=8176121

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402007A HUP0402007A3 (en) 2001-12-27 2002-12-09 Process for the preparation of-2(6-substituted-1,3-dioxane-4-yl)acetic acid derivates

Country Status (23)

Country Link
US (1) US7718812B2 (hu)
EP (2) EP1323717A1 (hu)
JP (2) JP2005519898A (hu)
KR (1) KR100958367B1 (hu)
CN (1) CN1286830C (hu)
AT (1) ATE319701T1 (hu)
AU (1) AU2002359093B2 (hu)
BR (1) BR0215310A (hu)
CA (1) CA2470647C (hu)
CO (1) CO5590893A2 (hu)
DE (1) DE60209798T2 (hu)
HK (1) HK1069575A1 (hu)
HU (1) HUP0402007A3 (hu)
IL (2) IL162687A0 (hu)
IS (1) IS2407B (hu)
MX (1) MXPA04006306A (hu)
NO (1) NO328643B1 (hu)
NZ (1) NZ533445A (hu)
PL (1) PL207129B1 (hu)
RU (1) RU2301229C2 (hu)
UA (1) UA77467C2 (hu)
WO (1) WO2003059901A1 (hu)
ZA (1) ZA200404482B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
AU2002318041B2 (en) 2001-07-13 2008-01-03 Astrazeneca Uk Limited Preparation of aminopyrimidine compounds
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
ATE448209T1 (de) 2002-12-16 2009-11-15 Astrazeneca Uk Ltd Verfahren zur herstellung von pyrimidinverbindungen
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
GB2482525A (en) * 2010-08-05 2012-02-08 Phoenix Chemicals Ltd A process for the production of acyloxymethyldioxanylacetic derivatives
CN105622566B (zh) * 2014-11-19 2018-07-27 上海弈柯莱生物医药科技有限公司 一种3,5-二取代羟基-6-取代己酸酯衍生物的制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885516A (en) 1958-01-16 1961-12-28 Arthur Henry Clarkson Higher fatty acid esters of dextran
US3992432A (en) 1967-04-05 1976-11-16 Continental Oil Company Phase transfer catalysis of heterogeneous reactions by quaternary salts
JPS58164546A (ja) 1982-03-25 1983-09-29 Sanki Kosan Kk ｄｌ−マンデル酸ベンジルエステルの製造法
GB9005966D0 (en) 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
JP3097143B2 (ja) 1991-02-21 2000-10-10 チッソ株式会社 生理活性物質合成用光学活性化合物の製造法および光学活性中間体化合物
JP3120292B2 (ja) 1991-10-18 2000-12-25 イハラケミカル工業株式会社 脂肪族カルボン酸ハロメチルエステル類の製造法
WO1993008823A1 (en) 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5278313A (en) 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
JP3071340B2 (ja) 1993-06-02 2000-07-31 セントラル硝子株式会社 ２−クロロ−ピリジンメタノールの製造方法
US6278001B1 (en) 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
FR2741620B1 (fr) 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
JPH10158199A (ja) 1996-10-02 1998-06-16 Dai Ichi Seiyaku Co Ltd カルボン酸化合物のエステル化法
US6472544B1 (en) * 1998-08-05 2002-10-29 Kaneka Corporation Process for the preparation of optically active 2-[6-hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
HU227840B1 (en) 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
WO2001072706A1 (en) 2000-03-28 2001-10-04 Biocon India Limited Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
AU2002318041B2 (en) 2001-07-13 2008-01-03 Astrazeneca Uk Limited Preparation of aminopyrimidine compounds
NZ534688A (en) 2002-02-25 2005-04-29 Biocon Ltd Novel boronate esters
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
ATE448209T1 (de) 2002-12-16 2009-11-15 Astrazeneca Uk Ltd Verfahren zur herstellung von pyrimidinverbindungen
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
WO2004113314A1 (en) 2003-06-23 2004-12-29 Biocon Limited Novel boronate esters
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
JP4266879B2 (ja) 2004-05-12 2009-05-20 大阪瓦斯株式会社 ガス化炉及び複合リサイクル装置
US9626437B2 (en) * 2004-06-10 2017-04-18 International Business Machines Corporation Search scheduling and delivery tool for scheduling a search using a search framework profile
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
MXPA04006306A (es) 2005-03-31
ZA200404482B (en) 2005-09-26
PL207129B1 (pl) 2010-11-30
DE60209798D1 (de) 2006-05-04
IS2407B (is) 2008-09-15
CA2470647C (en) 2010-10-19
EP1461331B1 (en) 2006-03-08
UA77467C2 (en) 2006-12-15
CN1608058A (zh) 2005-04-20
IL162687A (en) 2007-10-31
WO2003059901A1 (en) 2003-07-24
DE60209798T2 (de) 2006-11-02
BR0215310A (pt) 2004-12-21
NO328643B1 (no) 2010-04-19
RU2004118057A (ru) 2006-02-27
RU2301229C2 (ru) 2007-06-20
JP2005519898A (ja) 2005-07-07
CN1286830C (zh) 2006-11-29
HK1069575A1 (en) 2005-05-27
HUP0402007A3 (en) 2007-02-28
IL162687A0 (en) 2005-11-20
US7718812B2 (en) 2010-05-18
ATE319701T1 (de) 2006-03-15
AU2002359093A1 (en) 2003-07-30
JP2010132690A (ja) 2010-06-17
IS7332A (is) 2004-06-22
CO5590893A2 (es) 2005-12-30
EP1323717A1 (en) 2003-07-02
KR100958367B1 (ko) 2010-05-17
EP1461331B9 (en) 2006-06-28
AU2002359093B2 (en) 2008-11-13
CA2470647A1 (en) 2003-07-24
PL370223A1 (en) 2005-05-16
KR20040075910A (ko) 2004-08-30
EP1461331A1 (en) 2004-09-29
US20050090674A1 (en) 2005-04-28
NO20043159L (no) 2004-07-23
NZ533445A (en) 2006-02-24

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees