BR0114851A - Derivados de cianopirrolidina - Google Patents

Derivados de cianopirrolidina

Info

Publication number
BR0114851A
BR0114851A BR0114851-6A BR0114851A BR0114851A BR 0114851 A BR0114851 A BR 0114851A BR 0114851 A BR0114851 A BR 0114851A BR 0114851 A BR0114851 A BR 0114851A
Authority
BR
Brazil
Prior art keywords
carbon atoms
group
atom
alkyl group
hydrogen atom
Prior art date
Application number
BR0114851-6A
Other languages
English (en)
Inventor
Hiroshi Fukushima
Akira Hiratate
Masato Takahashi
Kazuya Kameo
Original Assignee
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd
Publication of BR0114851A publication Critical patent/BR0114851A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE CIANOPIRROLIDINA". Derivado de cianopirrolidina representado pela Fórmula (1): [em que R^ 1^ é um átomo de halogênio, um grupo hidroxila, um grupo alcóxi tendo de 1 a 5 átomos de carbono ou um grupo alquila tendo de 1 a 5 átomos de carbono, R^ 2^ é um átomo de hidrogênio, um átomo de halogênio, um grupo hidroxila, um grupo alcóxi tendo de 1 a 5 átomos de carbono ou um grupo alquila tendo de 1 a 5 átomos de carbono ou R^ 1^ e R^ 2^ juntos formam um oxo, um grupo hidroximino, um grupo alcoximino tendo de 1 a 5 átomos de carbono ou um grupo alquilideno tendo de 1 a 5 átomos de carbono, R^ 3^ e R^ 4^ são, cada um, um átomo de hidrogênio, um átomo de halogênio, um grupo hidroxila, um grupo alcóxi tendo de 1 a 5 átomos de carbono ou um grupo alquila tendo de 1 a 5 átomos de carbono ou R^ 3^ e R^ 4^ juntos formam um oxo, um grupo hidroximino, um grupo alcoximino tendo de 1 a 5 átomos de carbono ou um grupo alquilideno tendo de 1 a 5 átomos de carbono, X é um átomo de oxigênio ou um átomo de enxofre, Y é -CR^ 5^R^ 6^- [em que R^ 5^ e R^ 6^ são os mesmos ou diferentes e, cada um, um átomo de hidrogênio; um átomo de halogênio; um grupo alquila tendo de 1 a 10 átomos de carbono ou um grupo alquenila tendo de 2 a 10 átomos de carbono), ou -CR^ 7^R^ 6^-CR^ 9^R^ 10^- (em que R^ 7^, R^ 8^, R^ 9^ e R^ 10^ são os mesmos ou diferentes e, cada um, um átomo de hidrogênio; um átomo de halogênio; ou um grupo alquila opcionalmente substituído tendo de 1 a 10 átomos de carbono ou R^ 7^ e R^ 9^ junto com o átomo de carbono ao qual eles são presos formam um grupo cicloalquila tendo de 3 a 8 átomos de carbono opcionalmente substituído, um grupo cicloalquenila tendo de 4 a 8 átomos de carbono, um grupo bicicloalquila tendo de 5 a 10 átomos de carbono ou um grupo bicicloalquenila tendo de 5 a 10 átomos de carbono) e Z é um átomo de hidrogênio ou um grupo alquila opcionalmente tendo de 1 a 10 átomos de carbono ou Y e Z junto com o átomo de nitrogênio ao qual eles são presos formam um grupo amino cíclico opcionalmente substituído tendo de 2 a 10 átomos de carbono] ou um sal farmaceuticamente aceitável do mesmo.
BR0114851-6A 2000-11-10 2001-11-09 Derivados de cianopirrolidina BR0114851A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000344036 2000-11-10
JP2001215766 2001-07-16
PCT/JP2001/009818 WO2002038541A1 (fr) 2000-11-10 2001-11-09 Derives de cyanopyrrolidine

Publications (1)

Publication Number Publication Date
BR0114851A true BR0114851A (pt) 2003-09-16

Family

ID=26603777

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114851-6A BR0114851A (pt) 2000-11-10 2001-11-09 Derivados de cianopirrolidina

Country Status (23)

Country Link
US (3) US20040072892A1 (pt)
EP (2) EP1333025A4 (pt)
JP (1) JP3987890B2 (pt)
KR (3) KR100680079B1 (pt)
CN (1) CN1298703C (pt)
AU (2) AU2002212745B2 (pt)
BG (1) BG107799A (pt)
BR (1) BR0114851A (pt)
CA (1) CA2428271C (pt)
CZ (1) CZ20031250A3 (pt)
EA (2) EA006204B1 (pt)
EE (1) EE200300175A (pt)
HK (1) HK1061688A1 (pt)
HR (2) HRP20030366A2 (pt)
HU (1) HUP0302248A2 (pt)
IL (2) IL155776A0 (pt)
MX (1) MXPA03004114A (pt)
NO (2) NO20031949L (pt)
NZ (1) NZ525705A (pt)
PL (1) PL361463A1 (pt)
SK (1) SK5632003A3 (pt)
TW (1) TWI243162B (pt)
WO (1) WO2002038541A1 (pt)

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