BR0009861A - Derivados de avermectina - Google Patents

Derivados de avermectina

Info

Publication number
BR0009861A
BR0009861A BR0009861-2A BR0009861A BR0009861A BR 0009861 A BR0009861 A BR 0009861A BR 0009861 A BR0009861 A BR 0009861A BR 0009861 A BR0009861 A BR 0009861A
Authority
BR
Brazil
Prior art keywords
line
carbon atom
avermectin derivatives
double bond
avermectin
Prior art date
Application number
BR0009861-2A
Other languages
English (en)
Inventor
Satoshi Omura
Toshiaki Sunazuka
Andreas Turberg
Georg Von Samson-Himmelstjerna
Olaf Hansen
Achim Harder
Original Assignee
Kitasato Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kitasato Inst filed Critical Kitasato Inst
Publication of BR0009861A publication Critical patent/BR0009861A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção "DERIVADOS DE AVERMECTINA". Representados pela fórmula geral (I) ou seus sais: em que -X<sym>Y- designa -CH=CH-, -CH~ 2~-C(=O)-, -CH~ 2~-CH~ 2~- ou -CH~ 2~-CH(R^ 13^)-; por exemplo, 1) quando -X<sym>Y- representar -CH=CH-, R^ 1^ representa (R^ 11^) (R^ 12^)C (em que R^ 11^ representa um grupo alquila inferior substituído ou não substituído; um grupo formila; um grupo alcoxilcarbonila inferior, etc.; e R^ 12^ representa um átomo de hidrogênio ou um grupo alquila inferior); quando a união entre R^ 2^ c um átomo de carbono na posição 5 for uma união dupla, R^ 2^ representa um grupo hidroxila ou um grupo tri(alquila inferior)sililóxi; ou R^ 2^ forma um grupo carbonila ou um grupo hidroxima, juntamente com o átomo de carbono na posição 5; 2) quando -X<sym>Yrepresentar -CH~ 2~-C(=O)-, R^ 1^ representa (R^ 11a^) (R^ 12a^)C (em que R^ 11a^ representa um grupo alcoxicarbonila inferior ou COOCH~ 2~CH=CH~ 2~; e R^ 12^ representa um átomo de hidrogênio); e R^ 2^ representa um grupo hidroxila ou um grupo tri(alquila inferior)sililóxi.
BR0009861-2A 1999-02-09 2000-02-09 Derivados de avermectina BR0009861A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3105899 1999-02-09
JP24863399 1999-09-02
PCT/JP2000/000691 WO2000047597A1 (fr) 1999-02-09 2000-02-09 Derives de l'avermectine

Publications (1)

Publication Number Publication Date
BR0009861A true BR0009861A (pt) 2002-01-15

Family

ID=26369507

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009861-2A BR0009861A (pt) 1999-02-09 2000-02-09 Derivados de avermectina

Country Status (14)

Country Link
US (1) US6605595B1 (pt)
EP (2) EP2332949A1 (pt)
JP (1) JP4832645B2 (pt)
KR (1) KR20010101819A (pt)
CN (2) CN1202116C (pt)
AT (1) ATE556083T1 (pt)
AU (1) AU769612B2 (pt)
BR (1) BR0009861A (pt)
CA (1) CA2362253C (pt)
ES (1) ES2387384T3 (pt)
HK (1) HK1040083A1 (pt)
MX (1) MXPA01007963A (pt)
NZ (1) NZ514026A (pt)
WO (1) WO2000047597A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040087519A1 (en) * 2000-08-09 2004-05-06 Satoshi Omura Avermectin derivatives
CA2418968C (en) * 2000-08-09 2009-11-24 The Kitasato Institute Avermectin derivatives
EG23124A (en) 2001-02-27 2004-04-28 Syngenta Participations Ag Avermectins substituted in the 4-position having pesticidal properties
CR6574A (es) 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
AR036486A1 (es) * 2001-08-28 2004-09-15 Syngenta Participations Ag Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
PL370227A1 (en) * 2001-10-25 2005-05-16 Sankyo Lifetech Company, Limited Anthelmintic composition
TW200407330A (en) 2002-05-07 2004-05-16 Syngenta Participations Ag 4"-Deoxy-4"-(S)-amido avermectin derivatives
GB0302310D0 (en) * 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0302308D0 (en) * 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302309D0 (en) * 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin monosaccharide derivatives substituted in the 4 -position having pesticidal properties
GB0302547D0 (en) 2003-02-04 2003-03-12 Syngenta Participations Ag Avermectins and avermectin monosaccharide substituted in the 4'- and 4" position having pesticidal properties
US7396819B2 (en) * 2003-08-08 2008-07-08 Virbac Corporation Anthelmintic formulations
GB0320176D0 (en) 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
US7582612B2 (en) * 2004-03-12 2009-09-01 Hartz Mountain Corporation Multi-action anthelmintic formulations
CN103360444B (zh) * 2012-04-03 2016-05-11 浙江海正药业股份有限公司 抗寄生虫药赛拉菌素的合成新工艺
CN104231022B (zh) * 2013-06-14 2018-10-09 南开大学 一种大环内酯类化合物的制备及应用
CN103421065B (zh) * 2013-07-03 2016-05-18 大庆志飞生物化工有限公司 一类新型阿维菌素衍生物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4833168A (en) * 1986-10-03 1989-05-23 Merck & Co., Inc. Avermectin reformatsky adducts
US4895837A (en) * 1988-01-29 1990-01-23 Merck & Co., Inc. Avermectin derivatives
US4906619A (en) * 1988-07-22 1990-03-06 Merck & Co., Inc. Alkyl avermectin derivatives
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
JPH0325467A (ja) 1989-06-22 1991-02-04 Konica Corp カラー画像形成装置
JP2888586B2 (ja) 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
JPH0633273A (ja) 1992-07-16 1994-02-08 Asahi Chem Ind Co Ltd Ａｌｃの埋込金属部材用の防錆剤
GB9312154D0 (en) * 1993-06-12 1993-07-28 Pfizer Ltd Antiparasitic agents

Also Published As

Publication number Publication date
JP4832645B2 (ja) 2011-12-07
KR20010101819A (ko) 2001-11-14
CN1202116C (zh) 2005-05-18
EP1160252A4 (en) 2002-07-17
EP2332949A1 (en) 2011-06-15
CA2362253C (en) 2008-09-23
HK1040083A1 (zh) 2002-05-24
EP1160252A1 (en) 2001-12-05
AU769612B2 (en) 2004-01-29
AU2459000A (en) 2000-08-29
WO2000047597A1 (fr) 2000-08-17
CN1346362A (zh) 2002-04-24
ES2387384T3 (es) 2012-09-21
CN1637011A (zh) 2005-07-13
ATE556083T1 (de) 2012-05-15
CA2362253A1 (en) 2000-08-17
US6605595B1 (en) 2003-08-12
EP1160252B1 (en) 2012-05-02
MXPA01007963A (es) 2004-01-29
NZ514026A (en) 2001-09-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE(S).

B08J Incorrect entry in the gazette republished [chapter 8.10 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011. TEXTO CORRETO: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 11A ANUIDADE.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: CABEM SER ANULADOS OS DESPACHOS PUBLICADOS NA RPI 2138 DE 27/12/2011, RPI 2141 DE 17/01/2012 E RPI 2156 DE 02/05/2012.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART .8O COMBINADO COM ART. 13 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.