BR0109996A - Uso de agentes bradicardìacos no tratamento de doenças miocárdicas acompanhadas de hipertrofia, e novas combinações de drogas - Google Patents

Uso de agentes bradicardìacos no tratamento de doenças miocárdicas acompanhadas de hipertrofia, e novas combinações de drogas

Info

Publication number
BR0109996A
BR0109996A BR0109996-5A BR0109996A BR0109996A BR 0109996 A BR0109996 A BR 0109996A BR 0109996 A BR0109996 A BR 0109996A BR 0109996 A BR0109996 A BR 0109996A
Authority
BR
Brazil
Prior art keywords
hypertrophy
treatment
diseases accompanied
new drug
drug combinations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BR0109996-5A
Other languages
English (en)
Inventor
Juergen Daemmgen
Brian Guth
Randolph Seidler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BR0109996A publication Critical patent/BR0109996A/pt
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"USO DE AGENTES BRADICARDìACOS NO TRATAMENTO DE DOENçAS MIOCáRDICAS ACOMPANHADAS DE HIPERTROFIA, E NOVAS COMBINAçõES DE DROGAS". A presente invenção refere-se ao novo uso de substâncias bradicardíacas tais como um bloqueador de canais de Ca^ ++^, um bloqueador de beta-receptores ou um bloqueador de canais de i~ f~, os bloqueadores de canais de i~ f~ sendo preferidos, opcionalmente em combinação com uma substância cardioativa para induzir a regressão de doenças miocárdicas acompanhadas de hipertrofia, particularmente para o tratamento de cardiomiopatias hipertróficas idiopáticas (HCM) no homem e em animais domésticos.
BR0109996-5A 2000-04-13 2001-04-07 Uso de agentes bradicardìacos no tratamento de doenças miocárdicas acompanhadas de hipertrofia, e novas combinações de drogas Pending BR0109996A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10018401A DE10018401A1 (de) 2000-04-13 2000-04-13 Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
PCT/EP2001/004034 WO2001078699A2 (de) 2000-04-13 2001-04-07 Verwendung von bradycardica bei der behandlung von mit hypertrophie einhergehenden myocarderkrankungen und neue arzneimittelkombinationen

Publications (1)

Publication Number Publication Date
BR0109996A true BR0109996A (pt) 2003-05-27

Family

ID=7638652

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109996-5A Pending BR0109996A (pt) 2000-04-13 2001-04-07 Uso de agentes bradicardìacos no tratamento de doenças miocárdicas acompanhadas de hipertrofia, e novas combinações de drogas

Country Status (33)

Country Link
US (2) US7208508B2 (pt)
EP (2) EP1276476B1 (pt)
JP (1) JP3905386B2 (pt)
KR (1) KR20020089453A (pt)
CN (1) CN1245963C (pt)
AT (1) ATE330588T1 (pt)
AU (2) AU7048401A (pt)
BG (1) BG65816B1 (pt)
BR (1) BR0109996A (pt)
CA (2) CA2575059A1 (pt)
CY (1) CY1105081T1 (pt)
CZ (1) CZ300549B6 (pt)
DE (2) DE10018401A1 (pt)
DK (1) DK1276476T3 (pt)
EA (1) EA006977B1 (pt)
EE (1) EE05099B1 (pt)
ES (1) ES2266216T3 (pt)
HR (1) HRP20020815A2 (pt)
HU (1) HU228387B1 (pt)
IL (2) IL152103A0 (pt)
ME (1) MEP45908A (pt)
MX (1) MXPA02009935A (pt)
NO (1) NO330311B1 (pt)
NZ (1) NZ521934A (pt)
PL (1) PL215235B1 (pt)
PT (1) PT1276476E (pt)
RS (1) RS51478B (pt)
SI (1) SI1276476T1 (pt)
SK (1) SK286075B6 (pt)
TR (1) TR200202326T2 (pt)
UA (1) UA78679C2 (pt)
WO (1) WO2001078699A2 (pt)
ZA (1) ZA200208162B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10018401A1 (de) * 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
SI1362590T1 (en) * 2002-07-25 2004-04-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of cilobradine or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
US20040138306A1 (en) * 2002-07-25 2004-07-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
EP3045174A1 (en) * 2003-01-31 2016-07-20 Daiichi Sankyo Company, Limited Medicine for prevention of and treatment for arteriosclerosis and hypertension
ES2404939T3 (es) * 2005-06-27 2013-05-29 Daiichi Sankyo Company, Limited Preparación farmacéutica que contiene un antagonista del receptor de la angiotensina II y un bloqueador de los canales de calcio
US20090247572A1 (en) * 2005-08-23 2009-10-01 Koichi Wada Agent for treating atrial fibrillation
EP1762179A1 (en) 2005-09-07 2007-03-14 Boehringer Ingelheim Vetmedica Gmbh Method for improving diagnostic quality in echocardiography
FR2894825B1 (fr) * 2005-12-21 2010-12-03 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
TWI399223B (zh) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
EP1908469A1 (en) * 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
MX346039B (es) 2009-05-20 2017-03-03 Boehringer Ingelheim Vetmedica Gmbh Solucion farmaceutica bebible de telmisartan.
FR2961105B1 (fr) * 2010-06-15 2013-02-08 Servier Lab Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
KR101296743B1 (ko) * 2011-02-17 2013-08-20 한국과학기술연구원 심근 비대증 진단용 바이오마커 및 이를 이용한 심근 비대증 진단 방법
BR112014003117A2 (pt) 2011-08-12 2017-06-13 Boehringer Ingelheim Vetmedica Gmbh inibidores da corrente funny (if) para uso em um método de tratamento e prevenção de insuficiência cardíaca em felino
EP2953612A1 (en) 2013-02-11 2015-12-16 Boehringer Ingelheim Vetmedica GmbH Kit-of-parts
CA3067918A1 (en) 2017-07-07 2019-01-10 Boehringer Ingelheim Vetmedica Gmbh Angiotensin ii receptor antagonish for the prevention or treatment of hypertension in cats
KR102398532B1 (ko) 2020-07-20 2022-05-13 한림대학교 산학협력단 중증 지주막하출혈 진단용 조성물
KR102331806B1 (ko) 2020-07-20 2021-12-01 한림대학교 산학협력단 중증 지주막하출혈 진단용 바이오 마커

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759125A (fr) 1969-11-19 1971-05-18 Boehringer Sohn Ingelheim Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
DE3541811A1 (de) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) * 1987-10-30 1989-05-11 Thomae Gmbh Dr K Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
DE3805635A1 (de) 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
US5308853A (en) * 1991-12-20 1994-05-03 Warner-Lambert Company Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties
RU2078536C1 (ru) * 1993-09-02 1997-05-10 Украинский научно-исследовательский институт кардиологии им.акад.Н.Д.Стражеско Способ определения клинической эффективности применения верапамила и дилтиазема у больных гипертрофической кардиомиопатией
PL313621A1 (en) * 1993-09-24 1996-07-08 Procter & Gamble Novel 14-aminosteroid compounds containing desoxy oxygen-substituted sugar
US5595987A (en) * 1994-07-22 1997-01-21 The Trustees Of Columbia University In The City Of New York Method of slowing ventricular arrhythmias using zatebradine
US6083991A (en) * 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
DE19741635A1 (de) * 1997-09-22 1999-03-25 Hoechst Marion Roussel De Gmbh Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
ID27664A (id) 1998-07-10 2001-04-19 Novartis Ag Kombinasi antihipersensitif dari valsartan dan penghalang saluran kalsium
DE10018401A1 (de) 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
US20040138306A1 (en) * 2002-07-25 2004-07-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
CA2435526A1 (en) 2002-07-25 2004-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of cyclic amine derivatives or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
EP1762179A1 (en) * 2005-09-07 2007-03-14 Boehringer Ingelheim Vetmedica Gmbh Method for improving diagnostic quality in echocardiography

Also Published As

Publication number Publication date
EA200201053A1 (ru) 2003-02-27
EP1276476A2 (de) 2003-01-22
DE50110262D1 (de) 2006-08-03
EP1666042A2 (de) 2006-06-07
AU2001270484B2 (en) 2007-01-25
EP1276476B1 (de) 2006-06-21
CA2575059A1 (en) 2001-10-25
NZ521934A (en) 2007-05-31
MEP45908A (en) 2011-02-10
CN1245963C (zh) 2006-03-22
HUP0300917A2 (hu) 2003-08-28
EP1666042A3 (de) 2006-06-21
US20040014795A1 (en) 2004-01-22
US7208508B2 (en) 2007-04-24
EA006977B1 (ru) 2006-06-30
ES2266216T3 (es) 2007-03-01
CZ300549B6 (cs) 2009-06-10
PL215235B1 (pl) 2013-11-29
HU228387B1 (en) 2013-03-28
IL152103A0 (en) 2003-07-31
WO2001078699A3 (de) 2002-06-20
CZ20023752A3 (cs) 2003-03-12
NO330311B1 (no) 2011-03-28
PL357827A1 (en) 2004-07-26
HUP0300917A3 (en) 2009-04-28
CY1105081T1 (el) 2009-11-04
EE05099B1 (et) 2008-12-15
ATE330588T1 (de) 2006-07-15
SK286075B6 (sk) 2008-03-05
DE10018401A1 (de) 2001-10-25
EE200200590A (et) 2004-04-15
WO2001078699A2 (de) 2001-10-25
HRP20020815A2 (en) 2004-12-31
BG65816B1 (bg) 2010-01-29
IL152103A (en) 2008-07-08
RS51478B (sr) 2011-04-30
ZA200208162B (en) 2003-10-17
NO20024924D0 (no) 2002-10-11
UA78679C2 (en) 2007-04-25
CA2404120C (en) 2008-01-22
PT1276476E (pt) 2006-09-29
TR200202326T2 (tr) 2003-03-21
JP3905386B2 (ja) 2007-04-18
KR20020089453A (ko) 2002-11-29
JP2003535050A (ja) 2003-11-25
CN1422153A (zh) 2003-06-04
US20070155679A1 (en) 2007-07-05
SK14582002A3 (sk) 2003-03-04
CA2404120A1 (en) 2001-10-25
AU7048401A (en) 2001-10-30
DK1276476T3 (da) 2006-08-14
NO20024924L (no) 2002-10-11
MXPA02009935A (es) 2003-02-12
BG107103A (bg) 2003-04-30
YU76902A (sh) 2006-05-25
SI1276476T1 (sl) 2006-10-31

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]