BR0109861A - Inibidores macrocìclicos de protease ns3-serina do vìrus da hepatite c compreendendo porções n-cìclicas p2 - Google Patents

Inibidores macrocìclicos de protease ns3-serina do vìrus da hepatite c compreendendo porções n-cìclicas p2

Info

Publication number
BR0109861A
BR0109861A BR0109861-6A BR0109861A BR0109861A BR 0109861 A BR0109861 A BR 0109861A BR 0109861 A BR0109861 A BR 0109861A BR 0109861 A BR0109861 A BR 0109861A
Authority
BR
Brazil
Prior art keywords
cyclic moieties
virus protease
hepatitis
serine inhibitors
serine
Prior art date
Application number
BR0109861-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Kevin X Chen
Ashok Arasappan
Srikanth Venkatraman
Tejal N Parekh
Haining Gu
F George Njoroge
Viyyoor M Girijavallabhan
Ashit Ganguly
Anil Saksena
Edwin Jao
Nanhua H Yao
Andrew J Prongay
Vincent S Madison
Bancha Vibulbhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR0109861A publication Critical patent/BR0109861A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR0109861-6A 2000-04-05 2001-04-03 Inibidores macrocìclicos de protease ns3-serina do vìrus da hepatite c compreendendo porções n-cìclicas p2 BR0109861A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19460700P 2000-04-05 2000-04-05
PCT/US2001/010869 WO2001077113A2 (en) 2000-04-05 2001-04-03 Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties

Publications (1)

Publication Number Publication Date
BR0109861A true BR0109861A (pt) 2003-06-10

Family

ID=22718227

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109861-6A BR0109861A (pt) 2000-04-05 2001-04-03 Inibidores macrocìclicos de protease ns3-serina do vìrus da hepatite c compreendendo porções n-cìclicas p2

Country Status (26)

Country Link
US (1) US6846802B2 (https=)
EP (1) EP1268525B1 (https=)
JP (1) JP4748911B2 (https=)
KR (1) KR20030036152A (https=)
CN (1) CN1441806A (https=)
AR (1) AR029903A1 (https=)
AT (1) ATE419270T1 (https=)
AU (1) AU2001253124A1 (https=)
BR (1) BR0109861A (https=)
CA (1) CA2405521C (https=)
CZ (1) CZ20023321A3 (https=)
DE (1) DE60137207D1 (https=)
EC (1) ECSP014009A (https=)
ES (1) ES2317900T3 (https=)
HK (1) HK1047947A1 (https=)
HU (1) HUP0400456A3 (https=)
IL (1) IL151934A0 (https=)
MX (1) MXPA02009920A (https=)
NO (1) NO20024797L (https=)
NZ (1) NZ521455A (https=)
PE (1) PE20020188A1 (https=)
PL (1) PL359359A1 (https=)
RU (1) RU2002129564A (https=)
SK (1) SK14192002A3 (https=)
WO (1) WO2001077113A2 (https=)
ZA (1) ZA200207845B (https=)

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* Cited by examiner, † Cited by third party
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