BR0008205A - Vetores e vacinas a base de adenovirus porcinos recombinados - Google Patents

Vetores e vacinas a base de adenovirus porcinos recombinados

Info

Publication number
BR0008205A
BR0008205A BR0008205-8A BR0008205A BR0008205A BR 0008205 A BR0008205 A BR 0008205A BR 0008205 A BR0008205 A BR 0008205A BR 0008205 A BR0008205 A BR 0008205A
Authority
BR
Brazil
Prior art keywords
adenovirus
porcine adenovirus
porcine
vivo
nucleotide sequence
Prior art date
Application number
BR0008205-8A
Other languages
English (en)
Inventor
Marc Eloit
Bernard Georges Klonjkowski
Original Assignee
Merial Sas
Envt Toulouse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas, Envt Toulouse filed Critical Merial Sas
Publication of BR0008205A publication Critical patent/BR0008205A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Patente de Invenção: "VETORES E VACINAS à BASE DE ADENOVìRUS PORCINOS RECOMBINADOS". Adenovírus porcino recombinado e replicante in vivo, caracterizado pelo fato de que ele compreende uma sequencia nucleotídica heteróloga inserida no genoma do adenovirus porcino em condições que permitem que esse último se replique in vivo e expresse a seq³ência nucleotídica heteróloga inserida, e pelo fato de que o genoma de adenovirus provém de um adenovírus de sorotipo 3 ou 5 (PAV-3 ou PAV-5). A inserção é notadamente em uma zona não essencial da região E3, de preferência com uma deleção dessa zona. Vacina recombinada porcina que compreende um tal adenovírus porcino. Vetor adenovírus porcino de sorotípo 3 ou 5, ao mesmo tempo replicante in vivo e deletado em uma região nao essencial de seu genoma. Fragmento de DNA que compreende a totalidade ou parte da seq³ência nucleotídica referenciada SEQ ID NO: S.
BR0008205-8A 1999-02-11 2000-02-08 Vetores e vacinas a base de adenovirus porcinos recombinados BR0008205A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9901813A FR2789695B1 (fr) 1999-02-11 1999-02-11 Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
PCT/FR2000/000294 WO2000047756A1 (fr) 1999-02-11 2000-02-08 Vecteurs et vaccins viraux a base d'adenovirus porcins recombines

Publications (1)

Publication Number Publication Date
BR0008205A true BR0008205A (pt) 2002-04-02

Family

ID=9542037

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008205-8A BR0008205A (pt) 1999-02-11 2000-02-08 Vetores e vacinas a base de adenovirus porcinos recombinados

Country Status (16)

Country Link
US (1) US7109025B1 (pt)
EP (1) EP1151121B1 (pt)
JP (1) JP2002537766A (pt)
KR (1) KR100818673B1 (pt)
CN (2) CN1869243B (pt)
AT (1) ATE316580T1 (pt)
AU (1) AU781195B2 (pt)
BR (1) BR0008205A (pt)
CA (1) CA2362454C (pt)
DE (1) DE60025701T2 (pt)
DK (1) DK1151121T3 (pt)
ES (1) ES2258970T3 (pt)
FR (1) FR2789695B1 (pt)
MX (1) MXPA01008069A (pt)
PL (1) PL205524B1 (pt)
WO (1) WO2000047756A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
JP4778620B2 (ja) * 1999-04-22 2011-09-21 ユナイテッド ステイツ デパートメント オブ アグリカルチャー 分離株ｊａ−１４２に基づく、豚繁殖・呼吸障害症候群ワクチン
CA2413265A1 (en) * 2000-05-03 2001-11-08 University Of Guelph Porcine adenovirus type 5 vector and vaccine
WO2002077210A2 (en) 2001-03-27 2002-10-03 University Of Saskatchewan Methods to culture circovirus
US7906311B2 (en) 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
KR20070028547A (ko) 2004-06-18 2007-03-12 리전츠 오브 더 유니버스티 오브 미네소타 바이러스에 감염되고 백신접종된 생물의 동정
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95778C2 (ru) 2005-06-24 2011-09-12 Риджентс Оф Зе Юниверсити Оф Миннесота Вирусы репродуктивно-респираторного синдрома свиней, их инфекционные клоны и мутанты и способы применения
KR101436794B1 (ko) * 2005-12-29 2014-09-04 베링거잉겔하임베트메디카인코퍼레이티드 다가 ｐｃｖ2 면역원성 조성물 및 이러한 조성물의 제조방법
ES2572736T3 (es) 2005-12-29 2016-06-02 Boehringer Ingelheim Vetmedica, Inc. Uso de una composición inmunógena para atenuar síntomas clínicos en cerdos
US20100129397A1 (en) 2006-12-11 2010-05-27 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
DK2094872T4 (da) * 2006-12-15 2020-05-18 Boehringer Ingelheim Animal Health Usa Inc Behandling af anti-PCV2-antistofseropositive svin med PCV2-antigen
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
AU2008347235A1 (en) * 2007-12-31 2009-07-16 Boehringer Ingelheim Vetmedica, Inc. PCV2 ORF2 virus like particle with foreign amino acid insertion
US20090317423A1 (en) * 2008-01-23 2009-12-24 Boehringer Ingelheim Vetmedica, Inc. Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
US8444989B1 (en) * 2008-04-18 2013-05-21 Boehringer Ingelheim Vetmedica Gmbh One dose vaccination against mycoplasma infections of pigs
CA2734390A1 (en) * 2008-08-25 2010-03-04 Boehringer Ingelheim Vetmedica, Inc. Vaccine against highly pathogenic porcine reproductive and respiratory syndrome (hp prrs)
AU2009100018B4 (en) * 2008-10-15 2009-09-03 Australasian Pork Research Institute Ltd A Method of vaccination
US20100150959A1 (en) * 2008-12-15 2010-06-17 Vectogen Pty Ltd. PCV 2-Based Methods and Compositions for the Treatment of Pigs
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
KR102183276B1 (ko) 2011-02-17 2020-11-26 베링거잉겔하임베트메디카게엠베하 신규 유럽형 ｐｒｒｓｖ 스트레인
KR101983980B1 (ko) 2011-02-17 2019-05-30 베링거잉겔하임베트메디카게엠베하 Ｐｒｒｓｖ의 상업적 규모의 제조 방법
EP2737058A1 (en) 2011-07-29 2014-06-04 Boehringer Ingelheim Vetmedica GmbH INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
CN102766604B (zh) * 2012-06-19 2013-06-05 河南农业大学 一种猪流感病毒毒株及其应用
CN105073130A (zh) 2013-03-15 2015-11-18 勃林格殷格翰动物保健公司 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法
US9649370B2 (en) 2013-05-08 2017-05-16 Protatek International, Inc. Vaccine for PCV2 and mycoplasma
CA2925281C (en) 2013-09-25 2022-05-03 Zoetis Services Llc Pcv2b divergent vaccine composition and methods of use
JP6778104B2 (ja) 2013-10-02 2020-10-28 ベーリンガー・インゲルハイム・アニマル・ヘルス・ユーエスエー・インコーポレイテッドＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ａｎｉｍａｌ Ｈｅａｌｔｈ Ｕｓａ Ｉｎｃ． Ｐｃｖ２ ｏｒｆ２タンパク質変種および前記を含むウイルス様粒子
CN105273067A (zh) * 2015-03-13 2016-01-27 中国疾病预防控制中心病毒病预防控制所 一种编码MERS-CoV棘突蛋白的重组41型腺病毒载体疫苗
US9944904B2 (en) 2015-05-14 2018-04-17 Merial Inc. Method for porcine circovirus production and PCV2 vaccines
CN105368796A (zh) * 2015-09-09 2016-03-02 河南农业大学 一种表达ppv vp2基因和猪il-18基因的重组猪伪狂犬病毒株
EP3534945A1 (en) * 2016-11-03 2019-09-11 Boehringer Ingelheim Vetmedica GmbH Vaccine against porcine parvovirus
CN109206491A (zh) * 2017-07-07 2019-01-15 浙江海隆生物科技有限公司 猪伪狂犬病毒gD蛋白的制备方法及猪伪狂犬病毒亚单位疫苗和应用
CN110038124B (zh) * 2019-05-13 2023-04-14 天康生物股份有限公司 猪瘟-猪传染性胸膜肺炎二联亚单位的疫苗及其制备方法和应用
CN112834744A (zh) * 2020-12-31 2021-05-25 天津瑞普生物技术股份有限公司 一种猪群体内腺病毒3型中和抗体阳性率的elisa试剂盒及其检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1154718A (zh) * 1994-07-29 1997-07-16 美国氰胺公司 与主要组织相容性复合体i类重链表达负调节有关的人巨细胞病毒基因区域的鉴定
ES2105984B1 (es) * 1995-11-30 1998-04-16 Iberica Cyanamid Adenovirus recombinantes que expresan antigenos del virus de la gastroenteritis porcina transmisible (vgpt) y su empleo en la formacion de vacunas.
AUPO856097A0 (en) * 1997-08-14 1997-09-04 Commonwealth Scientific And Industrial Research Organisation Vector
US6492343B1 (en) * 1998-04-15 2002-12-10 University Of Saskatchewan Porcine adenovirus type 3 genome

Also Published As

Publication number Publication date
FR2789695B1 (fr) 2003-03-07
MXPA01008069A (es) 2003-09-10
ATE316580T1 (de) 2006-02-15
EP1151121A1 (fr) 2001-11-07
DE60025701T2 (de) 2006-10-19
CN1343257A (zh) 2002-04-03
CN1869243B (zh) 2016-01-20
KR100818673B1 (ko) 2008-04-01
AU781195B2 (en) 2005-05-12
JP2002537766A (ja) 2002-11-12
AU2553700A (en) 2000-08-29
ES2258970T3 (es) 2006-09-16
WO2000047756A1 (fr) 2000-08-17
DK1151121T3 (da) 2006-05-29
PL205524B1 (pl) 2010-04-30
PL350182A1 (en) 2002-11-18
CA2362454C (en) 2011-12-20
FR2789695A1 (fr) 2000-08-18
KR20020013502A (ko) 2002-02-20
CA2362454A1 (en) 2000-08-17
CN1869243A (zh) 2006-11-29
DE60025701D1 (de) 2006-04-13
CN1262664C (zh) 2006-07-05
EP1151121B1 (fr) 2006-01-25
US7109025B1 (en) 2006-09-19

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15V Prolongation of time limit allowed

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B12B Appeal against refusal [chapter 12.2 patent gazette]