BR0005703A - Compostos de sulfamoil-heteroarilpirazole com agentes anti-inflamatórios/analgésicos - Google Patents

Compostos de sulfamoil-heteroarilpirazole com agentes anti-inflamatórios/analgésicos

Info

Publication number
BR0005703A
BR0005703A BR0005703-7A BR0005703A BR0005703A BR 0005703 A BR0005703 A BR 0005703A BR 0005703 A BR0005703 A BR 0005703A BR 0005703 A BR0005703 A BR 0005703A
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BR
Brazil
Prior art keywords
compounds
halogen
inflammatory
analgesic agents
optionally substituted
Prior art date
Application number
BR0005703-7A
Other languages
English (en)
Inventor
Kazuo Ando
Kiyoshi Kawamura
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0005703A publication Critical patent/BR0005703A/pt

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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS DE SULFAMOIL-HETEROARILPIRAZOLE COMO AGENTES ANTI-INFLAMATóRIOS/ANALGéSICOS"<D>. A presente invenção relaciona-se com um composto da fórmula: ou um sal farmaceuticamente aceitável deste, em que A e R¹ são cada um deles um heteroarila de 5 a 6 membros opcionalmente substituído, em que o heteroarila está opcionalmente fusionado a um anel carbocíclico ou a um heteroarila de 5 a 6 membros; R² é NH~ 2~; R³ e R^ 4^ são cada um deles hidrogénio, halogéneo, alquila(C~ 1~-C~ 4~) opcionalmente substituído com halogéneo e semelhantes; e X¹ a X^ 4^ são cada um deles hidrogénio, halogéneo, hidroxila, alquila(C~ 1~-C~ 4~) opcionalmente substituído com halogéneo e semelhantes. Estes compostos possuem actividade inibidora da COX-2 e são, consequentemente, proveitosos para tratar ou prevenir inflamações ou outras doenças relacionadas com a COX-2.
BR0005703-7A 1999-12-03 2000-12-04 Compostos de sulfamoil-heteroarilpirazole com agentes anti-inflamatórios/analgésicos BR0005703A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16888999P 1999-12-03 1999-12-03

Publications (1)

Publication Number Publication Date
BR0005703A true BR0005703A (pt) 2001-07-31

Family

ID=22613376

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0005703-7A BR0005703A (pt) 1999-12-03 2000-12-04 Compostos de sulfamoil-heteroarilpirazole com agentes anti-inflamatórios/analgésicos

Country Status (11)

Country Link
US (2) US6603008B1 (pt)
EP (1) EP1104760B1 (pt)
JP (2) JP3338027B2 (pt)
AT (1) ATE234299T1 (pt)
BR (1) BR0005703A (pt)
CA (1) CA2327385A1 (pt)
DE (1) DE60001623T2 (pt)
DK (1) DK1104760T3 (pt)
ES (1) ES2193921T3 (pt)
MX (1) MXPA00011844A (pt)
PT (1) PT1104760E (pt)

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