BG64317B1 - Глюкокортикоид-селективни противовъзпалителни средства - Google Patents

Глюкокортикоид-селективни противовъзпалителни средства Download PDF

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Publication number
BG64317B1
BG64317B1 BG104719A BG10471900A BG64317B1 BG 64317 B1 BG64317 B1 BG 64317B1 BG 104719 A BG104719 A BG 104719A BG 10471900 A BG10471900 A BG 10471900A BG 64317 B1 BG64317 B1 BG 64317B1
Authority
BG
Bulgaria
Prior art keywords
dihydro
trimethyl
quinoline
methoxy
benzopyrano
Prior art date
Application number
BG104719A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104719A (en
Inventor
Michael J. Coughlan
Steven W. Elmore
Michael E. Kort
Philip R. Kym
Jimmie L. Moore
John K. Pratt
Alan X. Wang
James P. Edwards
Todd K. Jones
Original Assignee
Abbott Laboratories
Ligand Pharmaceuticals,Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories, Ligand Pharmaceuticals,Inc filed Critical Abbott Laboratories
Publication of BG104719A publication Critical patent/BG104719A/xx
Publication of BG64317B1 publication Critical patent/BG64317B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
BG104719A 1998-02-13 2000-08-28 Глюкокортикоид-селективни противовъзпалителни средства BG64317B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2394798A 1998-02-13 1998-02-13
US24783199A 1999-02-10 1999-02-10
PCT/US1999/003127 WO1999041256A1 (fr) 1998-02-13 1999-02-12 Agents anti-inflammatoires presentant une selectivite pour les glucocorticoides

Publications (2)

Publication Number Publication Date
BG104719A BG104719A (en) 2001-05-31
BG64317B1 true BG64317B1 (bg) 2004-09-30

Family

ID=26697833

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104719A BG64317B1 (bg) 1998-02-13 2000-08-28 Глюкокортикоид-селективни противовъзпалителни средства

Country Status (21)

Country Link
EP (1) EP1053239B1 (fr)
JP (1) JP2002503665A (fr)
KR (1) KR20010040935A (fr)
CN (1) CN1119348C (fr)
AT (1) ATE230749T1 (fr)
AU (1) AU766441B2 (fr)
BG (1) BG64317B1 (fr)
BR (1) BR9907788A (fr)
CA (1) CA2320943A1 (fr)
DE (1) DE69904804T2 (fr)
DK (1) DK1053239T3 (fr)
ES (1) ES2192035T3 (fr)
HK (1) HK1033308A1 (fr)
HU (1) HUP0100460A3 (fr)
IL (1) IL137508A0 (fr)
NO (1) NO20004053L (fr)
NZ (1) NZ506013A (fr)
PL (1) PL193323B1 (fr)
SK (1) SK284689B6 (fr)
TR (1) TR200003094T2 (fr)
WO (1) WO1999041256A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506766B1 (en) * 1998-02-13 2003-01-14 Abbott Laboratories Glucocortiocoid-selective antinflammatory agents
CO5180649A1 (es) * 1999-09-01 2002-07-30 Abbott Lab Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes
US6436986B1 (en) 1999-09-01 2002-08-20 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
US6593480B2 (en) * 1999-09-01 2003-07-15 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
US6329534B1 (en) 1999-09-01 2001-12-11 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
ATE303369T1 (de) 2000-10-30 2005-09-15 Pfizer Prod Inc Glucocorticoid rezeptor modulatoren
WO2003002548A1 (fr) * 2001-06-29 2003-01-09 Abbott Laboratories Elaboration d'agents recepteurs de glucocorticoides chiraux
US6608216B2 (en) 2001-06-29 2003-08-19 Abbott Laboratories Process for the preparation of chiral glucocorticoid receptor agents
US6518430B1 (en) 2001-09-21 2003-02-11 Abbott Laboratories Process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-F]quinolines and derivatives thereof
ATE346058T1 (de) 2002-01-14 2006-12-15 Boehringer Ingelheim Pharma Glucocorticoid mimetika, verfahren zu ihrer herstellung, pharmazeutische formulierungen sie enthaltend und verwendungen davon
CA2477764A1 (fr) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Mimetiques du glucocorticoide, procedes de fabrication de ces mimetiques, compositions pharmaceutiques et leurs utilisations
MXPA04009329A (es) 2002-03-26 2005-01-25 Boehringer Ingelheim Pharma Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y usos de los mismos.
DE60335869D1 (de) 2002-04-11 2011-03-10 Merck Sharp & Dohme 1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE60322713D1 (de) 2002-08-21 2008-09-18 Boehringer Ingelheim Pharma Substituierte dihydrochinoline als glucocorticoid-mmimetika,verfahren zu deren herstellung, pharmazeutische zubereitungen und deren verwendung
AU2003258047A1 (en) 2002-10-11 2004-05-04 Ligand Pharmaceuticals Incorporated 5-(1',1'-CYCLOALKYL/ALKENYL)METHYLIDENE 1,2-DIHYDRO-5H-CHROMENO(3,4-f)QUINOLINES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS
CL2003001544A1 (es) 2002-10-11 2005-01-07 Ligand Pharm Inc Compuestos derivados de 5-cicloalquenil-5h-cromeno[3,4-f]quinolina de formula i, moduladores selectivos del receptor de progesterona; composicion farmaceutica; y su uso en el tratamiento de sangrado uterino disfuncional, dismenorrea, endometriosis, l
DE20301728U1 (de) * 2002-10-11 2004-03-11 Ligand Pharmaceuticals, Inc., San Diego 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
JP4373926B2 (ja) 2003-01-03 2009-11-25 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド １−プロパノール及び１−プロピルアミン誘導体ならびにグルココルチコイドリガンドとしての使用
US20070088042A1 (en) 2004-09-09 2007-04-19 Meissner Robert S Fluorinated 4-azasteroid derivatives as androgen receptor modulators
US7235662B2 (en) 2003-06-11 2007-06-26 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7507843B2 (en) 2003-10-16 2009-03-24 Boehringer Ingelheim Pharmaceuticals, Inc. Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
JP2008525525A (ja) 2004-12-27 2008-07-17 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメティクス、その製法、医薬組成物及び使用
KR101390094B1 (ko) * 2005-09-14 2014-04-28 산텐 세이야꾸 가부시키가이샤 글루코코르티코이드 수용체 결합 활성을 갖는 신규1,2-디히드로퀴놀린 유도체
MX2011013679A (es) 2009-06-16 2012-01-20 Schering Corp Esteroides de heteroarilo [3.2-c] novedosos como agonistas de receptor de glucocorticoide composiciones y uso de los mismos.
CA2769563A1 (fr) 2009-07-31 2011-02-10 Cadila Healthcare Limited Nouveaux composes comme modulateurs de recepteurs glucocorticoides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE252560T1 (de) * 1994-12-22 2003-11-15 Ligand Pharm Inc Steroidrezeptor-modulator verbindungen und methoden

Also Published As

Publication number Publication date
HUP0100460A3 (en) 2003-03-28
BG104719A (en) 2001-05-31
SK284689B6 (sk) 2005-09-08
HUP0100460A2 (hu) 2001-09-28
NO20004053L (no) 2000-09-11
AU766441B2 (en) 2003-10-16
DE69904804T2 (de) 2003-11-06
NO20004053D0 (no) 2000-08-11
SK11972000A3 (sk) 2001-08-06
WO1999041256A1 (fr) 1999-08-19
JP2002503665A (ja) 2002-02-05
TR200003094T2 (tr) 2001-01-22
ES2192035T3 (es) 2003-09-16
DK1053239T3 (da) 2003-04-22
DE69904804D1 (de) 2003-02-13
CN1119348C (zh) 2003-08-27
KR20010040935A (ko) 2001-05-15
IL137508A0 (en) 2001-07-24
CA2320943A1 (fr) 1999-09-19
NZ506013A (en) 2003-03-28
EP1053239A1 (fr) 2000-11-22
BR9907788A (pt) 2001-10-30
HK1033308A1 (en) 2001-08-24
EP1053239B1 (fr) 2003-01-08
PL343018A1 (en) 2001-07-30
PL193323B1 (pl) 2007-02-28
ATE230749T1 (de) 2003-01-15
AU2677399A (en) 1999-08-30
CN1296486A (zh) 2001-05-23

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