BG64195B1 - Производни на 4-аминотиазол, тяхното получаване и използване като инхибитори на циклинзависими кинази - Google Patents
Производни на 4-аминотиазол, тяхното получаване и използване като инхибитори на циклинзависими кинази Download PDFInfo
- Publication number
- BG64195B1 BG64195B1 BG104478A BG10447800A BG64195B1 BG 64195 B1 BG64195 B1 BG 64195B1 BG 104478 A BG104478 A BG 104478A BG 10447800 A BG10447800 A BG 10447800A BG 64195 B1 BG64195 B1 BG 64195B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- phenyl
- amino
- substituted
- fused
- nmr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6363497P | 1997-10-27 | 1997-10-27 | |
| US6366697P | 1997-10-28 | 1997-10-28 | |
| PCT/US1998/022809 WO1999021845A2 (en) | 1997-10-27 | 1998-10-27 | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG104478A BG104478A (en) | 2001-02-28 |
| BG64195B1 true BG64195B1 (bg) | 2004-04-30 |
Family
ID=26743609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104478A BG64195B1 (bg) | 1997-10-27 | 2000-05-26 | Производни на 4-аминотиазол, тяхното получаване и използване като инхибитори на циклинзависими кинази |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6569878B1 (is) |
| EP (1) | EP1056732B1 (is) |
| JP (1) | JP2004500304A (is) |
| KR (1) | KR20010082501A (is) |
| CN (1) | CN1158269C (is) |
| AP (1) | AP1445A (is) |
| AT (2) | ATE315553T1 (is) |
| AU (1) | AU738792B2 (is) |
| BG (1) | BG64195B1 (is) |
| BR (1) | BR9815200A (is) |
| CA (1) | CA2306082A1 (is) |
| DE (2) | DE69835241T2 (is) |
| EA (1) | EA003527B1 (is) |
| EE (1) | EE200000289A (is) |
| ES (2) | ES2267873T3 (is) |
| GE (1) | GEP20032896B (is) |
| HR (1) | HRP20000222A2 (is) |
| HU (1) | HUP0004512A3 (is) |
| ID (1) | ID24372A (is) |
| IL (1) | IL135574A0 (is) |
| IS (1) | IS5462A (is) |
| LT (1) | LT4855B (is) |
| LV (1) | LV12592B (is) |
| NO (1) | NO20001955L (is) |
| NZ (1) | NZ503788A (is) |
| OA (1) | OA11352A (is) |
| PL (1) | PL342447A1 (is) |
| RO (1) | RO119463B1 (is) |
| SI (1) | SI20324A (is) |
| SK (1) | SK5212000A3 (is) |
| TR (1) | TR200001081T2 (is) |
| UA (1) | UA66810C2 (is) |
| WO (1) | WO1999021845A2 (is) |
| YU (1) | YU22400A (is) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9815200A (pt) * | 1997-10-27 | 2001-10-16 | Agouron Pharma | Composto, composição farmacêutica e método de tratamento de uma doença ou distúrbio mediado pela inibição de cdk4 ou um complexo de cdk4/ciclina |
| UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| US6673799B1 (en) * | 1998-09-22 | 2004-01-06 | Yamanouchi Pharmaceutical Co. Ltd. | Cyanophenyl derivative |
| US6214852B1 (en) | 1998-10-21 | 2001-04-10 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US6414156B2 (en) | 1998-10-21 | 2002-07-02 | Bristol-Myers Squibb Company | Process for preparing azacycloalkanoylaminothiazoles |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| AU779089B2 (en) * | 1999-04-15 | 2005-01-06 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | Cyclic protein tyrosine kinase inhibitors |
| UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US7141581B2 (en) | 1999-07-02 | 2006-11-28 | Agouron Pharmaceuticals, Inc. | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use |
| US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| US6515004B1 (en) | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US6392053B2 (en) | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| WO2001056567A1 (en) * | 2000-02-04 | 2001-08-09 | Novo Nordisk A/S | 2,4-diaminothiazole derivatives and their use as glycogen synthase kinase-3 (gsk-3) inhibitors |
| WO2001079198A1 (en) | 2000-04-18 | 2001-10-25 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinase |
| KR100423899B1 (ko) * | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| AU2001277285A1 (en) | 2000-08-09 | 2002-02-18 | Agouron Pharmaceuticals, Inc. | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases |
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| CN106854200B (zh) * | 2015-12-08 | 2019-05-21 | 上海复星星泰医药科技有限公司 | 色瑞替尼及其中间体的制备方法 |
| WO2018089902A1 (en) * | 2016-11-13 | 2018-05-17 | Apogee Biotechnology Corporation | Diaminothiazole compounds, compositions and methods of use |
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| WO2018136766A1 (en) | 2017-01-19 | 2018-07-26 | Temple University-Of The Commonwealth System Of Higher Education | Novel bridged bicycloalkyl-substituted aminothizoles and their methods of use |
| US11759450B2 (en) | 2018-02-06 | 2023-09-19 | The Board Of Trustees Of The University Of Illinois | Substituted benzothiophene analogs as selective estrogen receptor degraders |
| TWI770624B (zh) | 2018-06-15 | 2022-07-11 | 漢達生技醫藥股份有限公司 | 尼洛替尼十二烷基硫酸鹽在製備用於治療慢性骨髓性白血病之劑型的用途 |
| CN109897014A (zh) * | 2019-04-17 | 2019-06-18 | 成都睿智化学研究有限公司 | 一种1-（取代苯基）-4-甲基哌嗪的工艺制备方法 |
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1998
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- 1998-10-27 CN CNB988104741A patent/CN1158269C/zh not_active Expired - Fee Related
- 1998-10-27 PL PL98342447A patent/PL342447A1/xx not_active Application Discontinuation
- 1998-10-27 EP EP98957393A patent/EP1056732B1/en not_active Expired - Lifetime
- 1998-10-27 CA CA002306082A patent/CA2306082A1/en not_active Abandoned
- 1998-10-27 YU YU22400A patent/YU22400A/sh unknown
- 1998-10-27 DE DE69835241T patent/DE69835241T2/de not_active Expired - Fee Related
- 1998-10-27 AU AU13664/99A patent/AU738792B2/en not_active Ceased
- 1998-10-27 RO ROA200000423A patent/RO119463B1/ro unknown
- 1998-10-27 EE EEP200000289A patent/EE200000289A/xx unknown
- 1998-10-27 NZ NZ503788A patent/NZ503788A/xx unknown
- 1998-10-27 AP APAP/P/2000/001795A patent/AP1445A/en active
- 1998-10-27 AT AT98957393T patent/ATE315553T1/de not_active IP Right Cessation
- 1998-10-27 AT AT02001881T patent/ATE332896T1/de not_active IP Right Cessation
- 1998-10-27 EA EA200000464A patent/EA003527B1/ru not_active IP Right Cessation
- 1998-10-27 GE GEAP19985301A patent/GEP20032896B/en unknown
- 1998-10-27 ES ES02001881T patent/ES2267873T3/es not_active Expired - Lifetime
- 1998-10-27 TR TR2000/01081T patent/TR200001081T2/xx unknown
- 1998-10-27 IL IL13557498A patent/IL135574A0/xx unknown
- 1998-10-27 UA UA2000042107A patent/UA66810C2/uk unknown
- 1998-10-27 DE DE69833223T patent/DE69833223T2/de not_active Expired - Fee Related
- 1998-10-27 US US09/179,744 patent/US6569878B1/en not_active Expired - Fee Related
- 1998-10-27 ID IDW20000740A patent/ID24372A/id unknown
- 1998-10-27 ES ES98957393T patent/ES2256968T3/es not_active Expired - Lifetime
- 1998-10-27 SI SI9820068A patent/SI20324A/sl unknown
- 1998-10-27 KR KR1020007004392A patent/KR20010082501A/ko not_active Application Discontinuation
- 1998-10-27 WO PCT/US1998/022809 patent/WO1999021845A2/en active IP Right Grant
- 1998-10-27 JP JP2000517957A patent/JP2004500304A/ja active Pending
- 1998-10-27 HU HU0004512A patent/HUP0004512A3/hu unknown
- 1998-10-27 SK SK521-2000A patent/SK5212000A3/sk unknown
-
2000
- 2000-04-14 LT LT2000033A patent/LT4855B/lt not_active IP Right Cessation
- 2000-04-14 NO NO20001955A patent/NO20001955L/no not_active Application Discontinuation
- 2000-04-17 HR HR20000222A patent/HRP20000222A2/hr not_active Application Discontinuation
- 2000-04-19 IS IS5462A patent/IS5462A/is unknown
- 2000-04-25 OA OA1200000120A patent/OA11352A/en unknown
- 2000-05-03 LV LVP-00-51A patent/LV12592B/en unknown
- 2000-05-26 BG BG104478A patent/BG64195B1/bg unknown
-
2003
- 2003-03-13 US US10/388,851 patent/US20030220326A1/en not_active Abandoned
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