BG64155B1 - Псевдополиморфни форми на 2-[2-[4-[бис(4-флуорофенил) метил]-1-пиперазинил]етокси]оцетна киселина дихидрохлорид - Google Patents

Псевдополиморфни форми на 2-[2-[4-[бис(4-флуорофенил) метил]-1-пиперазинил]етокси]оцетна киселина дихидрохлорид Download PDF

Info

Publication number
BG64155B1
BG64155B1 BG104424A BG10442400A BG64155B1 BG 64155 B1 BG64155 B1 BG 64155B1 BG 104424 A BG104424 A BG 104424A BG 10442400 A BG10442400 A BG 10442400A BG 64155 B1 BG64155 B1 BG 64155B1
Authority
BG
Bulgaria
Prior art keywords
methyl
bis
piperazinyl
fluorophenyl
ethoxy
Prior art date
Application number
BG104424A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104424A (en
Inventor
Monique Berwaer
Guy Bodson
Michel Deleers
Charles Dogimont
Domenico Fanara
Jacques Timmermans
Original Assignee
Ucb S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S.A. filed Critical Ucb S.A.
Publication of BG104424A publication Critical patent/BG104424A/xx
Publication of BG64155B1 publication Critical patent/BG64155B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BG104424A 1997-11-26 2000-05-11 Псевдополиморфни форми на 2-[2-[4-[бис(4-флуорофенил) метил]-1-пиперазинил]етокси]оцетна киселина дихидрохлорид BG64155B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97870193A EP0919550A1 (en) 1997-11-26 1997-11-26 Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
PCT/BE1998/000184 WO1999028310A1 (en) 1997-11-26 1998-11-26 Pseudopolymorphic forms of 2-[2-[4-[bis (4-fluorophenyl) methyl]-1-piperazinyl] ethoxy]acetic acid dihydrochloride

Publications (2)

Publication Number Publication Date
BG104424A BG104424A (en) 2001-01-31
BG64155B1 true BG64155B1 (bg) 2004-02-27

Family

ID=8231072

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104424A BG64155B1 (bg) 1997-11-26 2000-05-11 Псевдополиморфни форми на 2-[2-[4-[бис(4-флуорофенил) метил]-1-пиперазинил]етокси]оцетна киселина дихидрохлорид

Country Status (39)

Country Link
US (2) US6262057B1 (no)
EP (2) EP0919550A1 (no)
JP (2) JP3996348B2 (no)
KR (1) KR100557711B1 (no)
CN (1) CN100406448C (no)
AR (1) AR017676A1 (no)
AT (1) ATE203237T1 (no)
AU (1) AU735819B2 (no)
BG (1) BG64155B1 (no)
BR (1) BR9815405A (no)
CA (1) CA2310318C (no)
CO (1) CO4980892A1 (no)
CZ (1) CZ295972B6 (no)
DE (1) DE69801163T2 (no)
DK (1) DK1034171T3 (no)
EG (1) EG23776A (no)
ES (1) ES2161552T3 (no)
GC (1) GC0000094A (no)
GR (1) GR3036702T3 (no)
HU (1) HUP0100343A3 (no)
ID (1) ID24964A (no)
IL (1) IL135544A (no)
MA (1) MA26569A1 (no)
MY (1) MY119653A (no)
NO (1) NO314692B1 (no)
NZ (1) NZ504461A (no)
PE (1) PE134899A1 (no)
PL (1) PL190871B1 (no)
PT (1) PT1034171E (no)
RS (1) RS49904B (no)
RU (1) RU2182575C2 (no)
SI (1) SI20325A (no)
SK (1) SK283237B6 (no)
TN (1) TNSN98214A1 (no)
TR (1) TR200001505T2 (no)
TW (1) TWI225053B (no)
UA (1) UA54568C2 (no)
WO (1) WO1999028310A1 (no)
ZA (1) ZA9810780B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002221854A1 (en) * 2000-12-15 2002-06-24 U C B, S.A. Use of cetirizine or efletirizine for preventing urticaria
EP1414460A1 (en) * 2001-07-26 2004-05-06 Ucb, S.A. Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor
US20050181032A1 (en) * 2002-06-25 2005-08-18 Acrux Dds Pty Ltd. Metastable pharmaceutical compositions
JP5160018B2 (ja) 2002-06-25 2013-03-13 アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド 非晶質医薬組成物を用いる経皮送達速度調節
WO2004105760A1 (en) * 2003-05-28 2004-12-09 Ucb Farchim, S.A. Use of efletirizine for treating persistent allergic rhinitis
WO2006050909A1 (en) * 2004-11-10 2006-05-18 Ucb Farchim Sa Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them
WO2008155777A2 (en) * 2007-06-18 2008-12-24 Cadila Healthcare Limited Process for preparing efletrizine
KR101006760B1 (ko) * 2008-07-17 2011-01-11 주식회사 진영테크 모터 순간 정전 복원 장치

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505116A (it) * 1966-11-21 1971-03-31 Crc Ricerca Chim Metodo per l'ottenimento di derivati della piperazina
SE409706B (sv) 1976-05-21 1979-09-03 Astra Pharma Prod Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat
ZA82752B (en) * 1981-02-06 1982-12-29 Ucb Sa 2-(4-(diphenylmethyl)-1-piperazinyl)-acetic acids and their amides
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
TW401300B (en) * 1992-12-25 2000-08-11 Senju Pharma Co Antiallergic composition for ophthalmic or nasal use
US5625358A (en) * 1993-09-13 1997-04-29 Analog Devices, Inc. Digital phase-locked loop utilizing a high order sigma-delta modulator
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.

Also Published As

Publication number Publication date
EP1034171A1 (en) 2000-09-13
EP1034171B1 (en) 2001-07-18
BG104424A (en) 2001-01-31
NO314692B1 (no) 2003-05-05
IL135544A0 (en) 2001-05-20
KR20010032420A (ko) 2001-04-16
SI20325A (sl) 2001-02-28
GC0000094A (en) 2005-06-29
NZ504461A (en) 2001-06-29
NO20002631L (no) 2000-05-23
AU735819B2 (en) 2001-07-19
MA26569A1 (fr) 2004-12-20
EP0919550A1 (en) 1999-06-02
NO20002631D0 (no) 2000-05-23
PT1034171E (pt) 2001-11-30
RS49904B (sr) 2008-08-07
RU2182575C2 (ru) 2002-05-20
DE69801163T2 (de) 2002-03-28
ES2161552T3 (es) 2001-12-01
JP2001524548A (ja) 2001-12-04
CA2310318C (en) 2003-10-21
ZA9810780B (en) 1999-05-31
DK1034171T3 (da) 2001-11-05
PE134899A1 (es) 2000-01-11
AR017676A1 (es) 2001-09-12
PL340724A1 (en) 2001-02-26
SK5942000A3 (en) 2000-10-09
UA54568C2 (uk) 2003-03-17
JP2007224042A (ja) 2007-09-06
HUP0100343A3 (en) 2001-09-28
TWI225053B (en) 2004-12-11
CN1279676A (zh) 2001-01-10
PL190871B1 (pl) 2006-02-28
GR3036702T3 (en) 2001-12-31
CO4980892A1 (es) 2000-11-27
ID24964A (id) 2000-08-31
US6262057B1 (en) 2001-07-17
CZ295972B6 (cs) 2005-12-14
KR100557711B1 (ko) 2006-03-07
US6335331B2 (en) 2002-01-01
DE69801163D1 (en) 2001-08-23
TNSN98214A1 (fr) 2005-03-15
JP3996348B2 (ja) 2007-10-24
EG23776A (en) 2007-08-08
CA2310318A1 (en) 1999-06-10
TR200001505T2 (tr) 2000-09-21
IL135544A (en) 2004-02-08
MY119653A (en) 2005-06-30
CZ20001787A3 (cs) 2000-09-13
HUP0100343A2 (hu) 2001-07-30
YU31600A (sh) 2002-03-18
CN100406448C (zh) 2008-07-30
SK283237B6 (sk) 2003-04-01
BR9815405A (pt) 2000-10-10
AU1327799A (en) 1999-06-16
US20010021712A1 (en) 2001-09-13
WO1999028310A1 (en) 1999-06-10
ATE203237T1 (de) 2001-08-15

Similar Documents

Publication Publication Date Title
EP2897943B1 (en) Crystalline form of vortioxetine hydrobromide
EP3022209B1 (en) Dolutegravir potassium salt
MX2007000911A (es) Nevibolol y sus sales farmaceuticamente aceptables, proceso para su preparacion y composiciones farmaceuticas de nevibolol.
JP2007224042A (ja) ２−〔２−〔４−〔ビス（４−フルオロフェニル）メチル〕−１−ピペラジニル〕エトキシ〕酢酸ジヒドロクロリドの偽多形
US20090247542A1 (en) Syntheses and preparations of polymorphs of crystalline aripiprazole
WO2022217008A1 (en) Solid state forms of zavegepant and process for preparation thereof
EP3936506A1 (en) Crystal form of acid addition salt of puropyrimidine compound
JP6907439B2 (ja) チエノピリミジン化合物の塩酸塩の結晶形
EA020944B1 (ru) Кристаллическая форма i соли розувастатина цинка
JP2007502802A (ja) ビフェプルノックスメシラートの安定な多形体
EP3656767A1 (en) Beraprost-314d monohydrate crystals and methods for preparation thereof
MXPA00004826A (en) Pseudopolymorphic forms of 2-[2-[4-[bis (4-fluorophenyl) methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride
TW202413369A (zh) 呋喃嘧啶化合物酸加成鹽之晶形及藥物組成物
NZ743660A (en) Crystalline forms of hydrochloride salts of thienopyrimidine compound
WO2010107329A2 (en) Aripiprazole salts