BG63770B1 - Микрогранули със забавено освобождаване, съдържащи дилтиазем като активен компонент - Google Patents

Микрогранули със забавено освобождаване, съдържащи дилтиазем като активен компонент Download PDF

Info

Publication number
BG63770B1
BG63770B1 BG102555A BG10255598A BG63770B1 BG 63770 B1 BG63770 B1 BG 63770B1 BG 102555 A BG102555 A BG 102555A BG 10255598 A BG10255598 A BG 10255598A BG 63770 B1 BG63770 B1 BG 63770B1
Authority
BG
Bulgaria
Prior art keywords
microgranules
yed
layer
diltiazem
active
Prior art date
Application number
BG102555A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102555A (en
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Original Assignee
Laboratoires Des Produits Ethiques Ethypharm S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9485856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63770(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratoires Des Produits Ethiques Ethypharm S.A. filed Critical Laboratoires Des Produits Ethiques Ethypharm S.A.
Publication of BG102555A publication Critical patent/BG102555A/xx
Publication of BG63770B1 publication Critical patent/BG63770B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BG102555A 1995-12-22 1998-06-18 Микрогранули със забавено освобождаване, съдържащи дилтиазем като активен компонент BG63770B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515361A FR2742660B1 (fr) 1995-12-22 1995-12-22 Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
PCT/FR1996/002040 WO1997023219A1 (fr) 1995-12-22 1996-12-23 Microgranules a liberation prolongee contenant du diltiazem comme principe actif

Publications (2)

Publication Number Publication Date
BG102555A BG102555A (en) 1999-02-26
BG63770B1 true BG63770B1 (bg) 2002-12-29

Family

ID=9485856

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102555A BG63770B1 (bg) 1995-12-22 1998-06-18 Микрогранули със забавено освобождаване, съдържащи дилтиазем като активен компонент

Country Status (27)

Country Link
US (3) US6228395B1 (de)
EP (1) EP0868184B1 (de)
JP (1) JP2000506500A (de)
KR (1) KR100354054B1 (de)
CN (1) CN1145488C (de)
AR (1) AR004410A1 (de)
AT (1) ATE238798T1 (de)
AU (1) AU721949B2 (de)
BG (1) BG63770B1 (de)
BR (1) BR9612225A (de)
CA (1) CA2242224C (de)
DE (1) DE69627880T2 (de)
DK (1) DK0868184T3 (de)
EA (1) EA001721B1 (de)
EE (1) EE04045B1 (de)
ES (1) ES2198505T3 (de)
FR (1) FR2742660B1 (de)
GE (1) GEP20022629B (de)
HK (1) HK1018400A1 (de)
HU (1) HU224214B1 (de)
IL (1) IL125047A (de)
NO (1) NO324680B1 (de)
NZ (1) NZ324739A (de)
PL (1) PL186621B1 (de)
PT (1) PT868184E (de)
WO (1) WO1997023219A1 (de)
ZA (1) ZA9610776B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2742660B1 (fr) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
US6162463A (en) * 1997-05-01 2000-12-19 Dov Pharmaceutical Inc Extended release formulation of diltiazem hydrochloride
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
EP1064937A1 (de) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmazeutische Zusammensetzungen mit kontrollierten Freigabe enthaltend ein Hypnotikum mit kurzer Wirkung oder deren Salze
EP1064938A1 (de) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmazeutische Dosierungsformen zur kontrollierte Wirkstoffabgabe mit mindenstens ein pulsierendem Zeitverlauf
US7179483B2 (en) 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
FR2831546B1 (fr) * 2001-10-31 2007-03-23 Atofina Materiau polymere thermoplastique pour supports d'enregistrement d'informations audio et/ou optiques
CN1874764B (zh) * 2003-10-10 2012-08-01 埃法尔姆公司 含有银杏提取物的持续释放微粒及其制备方法
EP1698349A4 (de) * 2003-12-25 2009-12-16 Takeda Pharmaceutical Verfahren zur verbesserung der eignung für die granulation
JP2005306778A (ja) * 2004-04-21 2005-11-04 Basf Ag 徐放性製剤及びその製造方法
WO2006013431A1 (en) * 2004-07-29 2006-02-09 Pfizer Limited Stable controlled-release pharmaceutical formulation of eletriptan
US8778395B2 (en) * 2005-08-11 2014-07-15 Andrx Labs, Llc Diltiazem controlled release formulation and method of manufacture
US8158156B2 (en) * 2006-06-19 2012-04-17 Alpharma Pharmaceuticals, Llc Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist
ITFI20110172A1 (it) 2011-08-08 2013-02-09 Valpharma Sa Formulazione multiparticolata a rilascio modificato di diltiazem hcl.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
IT1200217B (it) * 1986-09-30 1989-01-05 Valducci Roberto Membrana per uso farmaceutico ed industriale
DK173505B1 (da) * 1987-02-20 2001-01-15 Pharmatec Internat S R L Fremgangsmåde til fremstilling af en diltiazempellet med langsom afgivelse og anvendelse af således fremstillede pelleter t
JPH07552B2 (ja) * 1987-11-06 1995-01-11 田辺製薬株式会社 持効性製剤
FR2623714B1 (fr) * 1987-11-26 1990-04-20 Ethypharm Sa Forme a liberation prolongee du diltiazem, et son medicament ainsi obtenu
FR2624732B1 (fr) * 1987-12-21 1991-02-15 Synthelabo Formulation pharmaceutique a liberation prolongee
FR2630647B1 (fr) * 1988-04-27 1991-08-16 Sanofi Sa Microbilles de diltiazem, leur procede de fabrication et compositions pharmaceutiques a liberation prolongee les contenant
US5288505A (en) 1991-06-26 1994-02-22 Galephar P.R., Inc., Ltd. Extended release form of diltiazem
US5229135A (en) * 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
US5376384A (en) 1992-12-23 1994-12-27 Kinaform Technology, Inc. Delayed, sustained-release pharmaceutical preparation
US5834024A (en) * 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
FR2742660B1 (fr) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif

Also Published As

Publication number Publication date
NO982738L (no) 1998-08-21
EP0868184A1 (de) 1998-10-07
US6660296B2 (en) 2003-12-09
CN1145488C (zh) 2004-04-14
US6228395B1 (en) 2001-05-08
AU721949B2 (en) 2000-07-20
AR004410A1 (es) 1998-11-04
AU1198397A (en) 1997-07-17
ZA9610776B (en) 1997-06-30
PL327567A1 (en) 1998-12-21
IL125047A (en) 2003-05-29
KR19990076717A (ko) 1999-10-15
EA199800593A1 (ru) 1998-12-24
BR9612225A (pt) 1999-07-13
DE69627880D1 (de) 2003-06-05
JP2000506500A (ja) 2000-05-30
DK0868184T3 (da) 2003-08-25
HU224214B1 (hu) 2005-06-28
PL186621B1 (pl) 2004-02-27
CA2242224C (fr) 2004-01-13
IL125047A0 (en) 1999-01-26
PT868184E (pt) 2003-09-30
EA001721B1 (ru) 2001-08-27
CA2242224A1 (fr) 1997-07-03
US20020182253A1 (en) 2002-12-05
ATE238798T1 (de) 2003-05-15
HUP9904129A3 (en) 2000-11-28
NZ324739A (en) 2000-01-28
DE69627880T2 (de) 2004-03-11
HUP9904129A2 (hu) 2000-04-28
CN1207681A (zh) 1999-02-10
HK1018400A1 (en) 1999-12-24
FR2742660A1 (fr) 1997-06-27
NO324680B1 (no) 2007-12-03
NO982738D0 (no) 1998-06-12
BG102555A (en) 1999-02-26
EE04045B1 (et) 2003-06-16
FR2742660B1 (fr) 1998-04-03
ES2198505T3 (es) 2004-02-01
US6383516B1 (en) 2002-05-07
KR100354054B1 (ko) 2003-02-14
EE9800197A (et) 1998-12-15
WO1997023219A1 (fr) 1997-07-03
EP0868184B1 (de) 2003-05-02
GEP20022629B (en) 2002-02-25

Similar Documents

Publication Publication Date Title
JP2560019B2 (ja) 活性化合物の放出を制御する新規な製剤およびその製造法
US5246714A (en) Drug preparation
JP2518882B2 (ja) 被覆膜及びそれから調製された組成物
US4957745A (en) Pharmaceutical preparation
US4728512A (en) Formulations providing three distinct releases
US4904476A (en) Formulations providing three distinct releases
US4794001A (en) Formulations providing three distinct releases
NL194882C (nl) Langwerkend diclofenacnatriumpreparaat.
US5122384A (en) Oral once-per-day organic nitrate formulation which does not induce tolerance
CZ284924B6 (cs) Prostředek s řízeným uvolňováním, který obsahuje morfinovou sůl
JPH0643312B2 (ja) 薬学的調合剤
JPH0237327B2 (de)
CA2377605C (en) Stable benzimidazole formulation
BG63770B1 (bg) Микрогранули със забавено освобождаване, съдържащи дилтиазем като активен компонент
JP2002501895A (ja) 胃において保護されるオメプラゾール微粒子、その製造方法および医薬製剤
US6733789B1 (en) Multiparticulate bisoprolol formulation
WO2009002416A1 (en) Controlled release tamsulosin hydrochloride formulation
JP4296562B2 (ja) 硫酸モルヒネ微小顆粒、その調製方法およびそれを含有する組成物
CA2359709A1 (en) Multiparticulate bisoprolol formulation
RU2727721C2 (ru) Фармацевтическая композиция с замедленным высвобождением, содержащая ривастигмин
JP3456211B2 (ja) 持続性製剤
US5980952A (en) Pharmaceutical composition for the programmed release of dexfenfluramine
KR940008415B1 (ko) 코팅 막과 그로부터 제조된 조성물
JPH0710756A (ja) 塩酸ニカルジピン徐放製剤
IE990048A1 (en) Multiparticulate bisoprolol formulation