DE69627880D1 - Diltiazemhaltige mikrogranulate mit verzögerter wirkstoffabgabe - Google Patents

Diltiazemhaltige mikrogranulate mit verzögerter wirkstoffabgabe

Info

Publication number
DE69627880D1
DE69627880D1 DE69627880T DE69627880T DE69627880D1 DE 69627880 D1 DE69627880 D1 DE 69627880D1 DE 69627880 T DE69627880 T DE 69627880T DE 69627880 T DE69627880 T DE 69627880T DE 69627880 D1 DE69627880 D1 DE 69627880D1
Authority
DE
Germany
Prior art keywords
diltiazic
microgranulates
active substances
delayed delivery
delayed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69627880T
Other languages
English (en)
Other versions
DE69627880T2 (de
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9485856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69627880(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Application granted granted Critical
Publication of DE69627880D1 publication Critical patent/DE69627880D1/de
Publication of DE69627880T2 publication Critical patent/DE69627880T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DE69627880T 1995-12-22 1996-12-23 Diltiazemhaltige mikrogranulate mit verzögerter wirkstoffabgabe Expired - Lifetime DE69627880T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9515361 1995-12-22
FR9515361A FR2742660B1 (fr) 1995-12-22 1995-12-22 Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
PCT/FR1996/002040 WO1997023219A1 (fr) 1995-12-22 1996-12-23 Microgranules a liberation prolongee contenant du diltiazem comme principe actif

Publications (2)

Publication Number Publication Date
DE69627880D1 true DE69627880D1 (de) 2003-06-05
DE69627880T2 DE69627880T2 (de) 2004-03-11

Family

ID=9485856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69627880T Expired - Lifetime DE69627880T2 (de) 1995-12-22 1996-12-23 Diltiazemhaltige mikrogranulate mit verzögerter wirkstoffabgabe

Country Status (27)

Country Link
US (3) US6228395B1 (de)
EP (1) EP0868184B1 (de)
JP (1) JP2000506500A (de)
KR (1) KR100354054B1 (de)
CN (1) CN1145488C (de)
AR (1) AR004410A1 (de)
AT (1) ATE238798T1 (de)
AU (1) AU721949B2 (de)
BG (1) BG63770B1 (de)
BR (1) BR9612225A (de)
CA (1) CA2242224C (de)
DE (1) DE69627880T2 (de)
DK (1) DK0868184T3 (de)
EA (1) EA001721B1 (de)
EE (1) EE04045B1 (de)
ES (1) ES2198505T3 (de)
FR (1) FR2742660B1 (de)
GE (1) GEP20022629B (de)
HK (1) HK1018400A1 (de)
HU (1) HU224214B1 (de)
IL (1) IL125047A (de)
NO (1) NO324680B1 (de)
NZ (1) NZ324739A (de)
PL (1) PL186621B1 (de)
PT (1) PT868184E (de)
WO (1) WO1997023219A1 (de)
ZA (1) ZA9610776B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2742660B1 (fr) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif
US6162463A (en) * 1997-05-01 2000-12-19 Dov Pharmaceutical Inc Extended release formulation of diltiazem hydrochloride
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
EP1064937A1 (de) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmazeutische Zusammensetzungen mit kontrollierten Freigabe enthaltend ein Hypnotikum mit kurzer Wirkung oder deren Salze
EP1064938A1 (de) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmazeutische Dosierungsformen zur kontrollierte Wirkstoffabgabe mit mindenstens ein pulsierendem Zeitverlauf
US7179483B2 (en) 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
FR2831546B1 (fr) * 2001-10-31 2007-03-23 Atofina Materiau polymere thermoplastique pour supports d'enregistrement d'informations audio et/ou optiques
JP5171038B2 (ja) * 2003-10-10 2013-03-27 エティファルム イチョウ・エキスを含む放出持続性の微小顆粒およびそのような顆粒の製造方法
WO2005065715A1 (ja) * 2003-12-25 2005-07-21 Takeda Pharmaceutical Company Limited 造粒性改善方法
JP2005306778A (ja) * 2004-04-21 2005-11-04 Basf Ag 徐放性製剤及びその製造方法
WO2006013431A1 (en) * 2004-07-29 2006-02-09 Pfizer Limited Stable controlled-release pharmaceutical formulation of eletriptan
US8778395B2 (en) * 2005-08-11 2014-07-15 Andrx Labs, Llc Diltiazem controlled release formulation and method of manufacture
SI2484346T1 (sl) * 2006-06-19 2017-05-31 Alpharma Pharmaceuticals Llc Farmacevtski sestavki
ITFI20110172A1 (it) 2011-08-08 2013-02-09 Valpharma Sa Formulazione multiparticolata a rilascio modificato di diltiazem hcl.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
IT1200217B (it) * 1986-09-30 1989-01-05 Valducci Roberto Membrana per uso farmaceutico ed industriale
DK173505B1 (da) * 1987-02-20 2001-01-15 Pharmatec Internat S R L Fremgangsmåde til fremstilling af en diltiazempellet med langsom afgivelse og anvendelse af således fremstillede pelleter t
JPH07552B2 (ja) * 1987-11-06 1995-01-11 田辺製薬株式会社 持効性製剤
FR2623714B1 (fr) * 1987-11-26 1990-04-20 Ethypharm Sa Forme a liberation prolongee du diltiazem, et son medicament ainsi obtenu
FR2624732B1 (fr) * 1987-12-21 1991-02-15 Synthelabo Formulation pharmaceutique a liberation prolongee
FR2630647B1 (fr) * 1988-04-27 1991-08-16 Sanofi Sa Microbilles de diltiazem, leur procede de fabrication et compositions pharmaceutiques a liberation prolongee les contenant
US5288505A (en) 1991-06-26 1994-02-22 Galephar P.R., Inc., Ltd. Extended release form of diltiazem
US5229135A (en) * 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
US5376384A (en) 1992-12-23 1994-12-27 Kinaform Technology, Inc. Delayed, sustained-release pharmaceutical preparation
US5834024A (en) * 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
FR2742660B1 (fr) * 1995-12-22 1998-04-03 Ethypharm Lab Prod Ethiques Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif

Also Published As

Publication number Publication date
BG63770B1 (bg) 2002-12-29
PL327567A1 (en) 1998-12-21
ATE238798T1 (de) 2003-05-15
DE69627880T2 (de) 2004-03-11
US6660296B2 (en) 2003-12-09
KR19990076717A (ko) 1999-10-15
BG102555A (en) 1999-02-26
HU224214B1 (hu) 2005-06-28
EE9800197A (et) 1998-12-15
NO982738L (no) 1998-08-21
BR9612225A (pt) 1999-07-13
CA2242224C (fr) 2004-01-13
CA2242224A1 (fr) 1997-07-03
NO982738D0 (no) 1998-06-12
GEP20022629B (en) 2002-02-25
EA199800593A1 (ru) 1998-12-24
US6383516B1 (en) 2002-05-07
US6228395B1 (en) 2001-05-08
HK1018400A1 (en) 1999-12-24
JP2000506500A (ja) 2000-05-30
IL125047A0 (en) 1999-01-26
FR2742660A1 (fr) 1997-06-27
AR004410A1 (es) 1998-11-04
HUP9904129A3 (en) 2000-11-28
NZ324739A (en) 2000-01-28
AU1198397A (en) 1997-07-17
CN1145488C (zh) 2004-04-14
DK0868184T3 (da) 2003-08-25
HUP9904129A2 (hu) 2000-04-28
WO1997023219A1 (fr) 1997-07-03
PL186621B1 (pl) 2004-02-27
FR2742660B1 (fr) 1998-04-03
EP0868184B1 (de) 2003-05-02
PT868184E (pt) 2003-09-30
AU721949B2 (en) 2000-07-20
ZA9610776B (en) 1997-06-30
US20020182253A1 (en) 2002-12-05
NO324680B1 (no) 2007-12-03
EA001721B1 (ru) 2001-08-27
ES2198505T3 (es) 2004-02-01
EE04045B1 (et) 2003-06-16
KR100354054B1 (ko) 2003-02-14
IL125047A (en) 2003-05-29
CN1207681A (zh) 1999-02-10
EP0868184A1 (de) 1998-10-07

Similar Documents

Publication Publication Date Title
DE69901570D1 (de) Ranolazinhaltige arzneimittel mit verzögerter wirkstoffabgabe
DE69723303D1 (de) Arzneimittel mit verzögerter wirkstoffabgabe
DE69524214D1 (de) Azithromycin enthaltende arzneiverabreichungsformen mit gesteuerter wirkstoffabgabe
EE04293B1 (et) Stabiilsed lüofiliseeritud ravimvormid
DE69918074D1 (de) Makrolid-formulierung mit verzögerter wirkstoffabgabe
DE69928085D1 (de) Dosierungsform mit verlängerter wirkstoffabgabe
ATE201989T1 (de) Arzneimittel mit kontrollierter wirkstoffabgabe
ATE187063T1 (de) Arzneimittel
BR9607317A (pt) Peptídios e composição farmacêutica
DE69629755D1 (de) Irbesartanhaltiges Arzneimittel
DE69813602D1 (de) Venlafaxinhaltiges arzneimittel mit verlängerter wirkstoffabgabe
ID26340A (id) Kapsul ganda dengan penggunaan bahan-bahan aktif dalam berbagai macam pengobatan
FI961437A (fi) Vaikuttavan aineen luovuttava systeemi
DE69627880D1 (de) Diltiazemhaltige mikrogranulate mit verzögerter wirkstoffabgabe
GR3035382T3 (en) Active substance combinations comprising pyrethroids and insect-development inhibitors
DE69937891D1 (de) Fluvastatin-arzneimittel mit verzögerter wirkstoffabgabe
DE69829334D1 (de) Faserige strukturen mit labiler aktiver substanz
DE69534283D1 (de) Clonidinhaltiges arzneimittel mit verzögerter wirkstoffabgabe
DE59804823D1 (de) Arzneimittelformulierung mit kontrollierter wirkstofffreisetzung
DE69919490D1 (de) Puder mit fettlöslichem wirkstoff
DE59604270D1 (de) Selbstfahrender Mähdrescher mit verstellbarem Dreschkorb
FI943201A (fi) Vaikuttavaa ainetta luovuttava laite
DE69713505D1 (de) Arzneimittel enthaltend mizolastin mit verzögerter wirkstoffabgabe
FI103744B1 (fi) Menetelmä ja järjestely aktiivisuotimen kalibroimiseksi
PT1221845E (pt) Combinacoes de substancias activas com caracteristicas insecticidas e acaricidas

Legal Events

Date Code Title Description
8364 No opposition during term of opposition