BG63204B1 - Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат - Google Patents

Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат Download PDF

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Publication number
BG63204B1
BG63204B1 BG102569A BG10256998A BG63204B1 BG 63204 B1 BG63204 B1 BG 63204B1 BG 102569 A BG102569 A BG 102569A BG 10256998 A BG10256998 A BG 10256998A BG 63204 B1 BG63204 B1 BG 63204B1
Authority
BG
Bulgaria
Prior art keywords
radical
carbon atoms
hydrogen atom
together form
radicals
Prior art date
Application number
BG102569A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102569A (en
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of BG102569A publication Critical patent/BG102569A/xx
Publication of BG63204B1 publication Critical patent/BG63204B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
BG102569A 1995-12-22 1998-06-22 Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат BG63204B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
BG102569A BG102569A (en) 1999-04-30
BG63204B1 true BG63204B1 (bg) 2001-06-29

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102569A BG63204B1 (bg) 1995-12-22 1998-06-22 Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат

Country Status (41)

Country Link
US (1) US5728849A (ro)
EP (1) EP0876362B1 (ro)
JP (1) JP3953106B2 (ro)
KR (1) KR100500351B1 (ro)
CN (1) CN1103766C (ro)
AR (1) AR005197A1 (ro)
AT (1) ATE250593T1 (ro)
AU (1) AU712597B2 (ro)
BG (1) BG63204B1 (ro)
BR (1) BR9612135A (ro)
CA (1) CA2238884C (ro)
CO (1) CO4520184A1 (ro)
CZ (1) CZ294972B6 (ro)
DE (1) DE69630145T2 (ro)
DK (1) DK0876362T3 (ro)
DZ (1) DZ2149A1 (ro)
EA (1) EA001533B1 (ro)
ES (1) ES2202490T3 (ro)
FR (1) FR2742751B1 (ro)
HK (1) HK1017895A1 (ro)
HU (1) HU225032B1 (ro)
IL (1) IL124994A (ro)
IN (4) IN186768B (ro)
MA (1) MA26412A1 (ro)
MX (1) MX9804688A (ro)
MY (1) MY113934A (ro)
NO (1) NO317358B1 (ro)
NZ (1) NZ324337A (ro)
OA (1) OA10700A (ro)
PE (1) PE25198A1 (ro)
PL (1) PL189311B1 (ro)
PT (1) PT876362E (ro)
RO (1) RO116194B1 (ro)
SK (1) SK282835B6 (ro)
TN (1) TNSN96169A1 (ro)
TR (1) TR199801179T2 (ro)
TW (1) TW371659B (ro)
UA (1) UA48205C2 (ro)
UY (1) UY24386A1 (ro)
WO (1) WO1997023473A1 (ro)
ZA (1) ZA9610737B (ro)

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AU782028B2 (en) 2000-02-02 2005-06-30 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes as antitumor agents
SK288003B6 (sk) * 2001-02-24 2012-10-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthin derivatives, method for the preparation thereof, pharmaceutical composition containing thereof and their use
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20080107721A1 (en) * 2003-05-20 2008-05-08 Jonathan Lewis Combination Chemotherapy Comprising A Liposomal Platinum Complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
CA2651089C (en) 2006-05-04 2018-02-20 Peter Sieger A polymeric form of 1-((4-methyl-quinazolin-2-yl)methyl)-3-7-(2-butyn-1-yl)-8-(3-(r)-aminopiperidin-1-yl)xanthine
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
CN101784278A (zh) * 2007-08-17 2010-07-21 贝林格尔.英格海姆国际有限公司 用于治疗fab-相关的疾病的嘌呤衍生物
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
ES2764251T3 (es) * 2008-08-15 2020-06-02 Boehringer Ingelheim Int Inhibidores de DPP-4 para uso en el tratamiento de curación de heridas en pacientes diabéticos
EP2344195A2 (en) 2008-09-10 2011-07-20 Boehringer Ingelheim International GmbH Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US8865729B2 (en) 2008-12-23 2014-10-21 Boehringer Ingelheim International Gmbh Salt forms of a xanthine compound
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR20120107080A (ko) 2009-11-27 2012-09-28 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
EP2566469B1 (en) 2010-05-05 2022-12-21 Boehringer Ingelheim International GmbH Combination therapy
EP3366304B1 (en) 2010-06-24 2020-05-13 Boehringer Ingelheim International GmbH Diabetes therapy
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
HUE061596T2 (hu) 2011-07-15 2023-07-28 Boehringer Ingelheim Int Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
WO2015128453A1 (en) 2014-02-28 2015-09-03 Boehringer Ingelheim International Gmbh Medical use of a dpp-4 inhibitor
EP3122757B1 (en) 2014-02-28 2023-09-06 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2017276758A1 (en) 2016-06-10 2018-11-08 Boehringer Ingelheim International Gmbh Combinations of Linagliptin and metformin
KR20220147720A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
EP0639186B1 (en) * 1992-04-17 1999-06-23 Abbott Laboratories Taxol derivatives
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them

Also Published As

Publication number Publication date
HU225032B1 (en) 2006-05-29
BR9612135A (pt) 1999-07-13
BG102569A (en) 1999-04-30
OA10700A (fr) 2002-11-27
PL189311B1 (pl) 2005-07-29
DZ2149A1 (fr) 2002-10-23
IN188469B (ro) 2002-09-28
FR2742751A1 (fr) 1997-06-27
IL124994A (en) 2000-12-06
US5728849A (en) 1998-03-17
TR199801179T2 (xx) 1998-10-21
EA199800588A1 (ru) 1998-12-24
AU1180997A (en) 1997-07-17
IL124994A0 (en) 1999-01-26
SK85398A3 (en) 1998-11-04
NO982580D0 (no) 1998-06-05
CZ294972B6 (cs) 2005-04-13
TW371659B (en) 1999-10-11
HK1017895A1 (en) 1999-12-03
CN1103766C (zh) 2003-03-26
IN188680B (ro) 2002-10-26
MX9804688A (es) 1998-10-31
UY24386A1 (es) 2001-08-27
CZ196198A3 (cs) 1998-09-16
DK0876362T3 (da) 2004-02-02
PT876362E (pt) 2004-02-27
HUP9904046A1 (hu) 2001-04-28
CA2238884A1 (fr) 1997-07-03
MA26412A1 (fr) 2004-12-20
IN186768B (ro) 2001-11-03
JP3953106B2 (ja) 2007-08-08
DE69630145T2 (de) 2004-07-15
JP2000502671A (ja) 2000-03-07
CO4520184A1 (es) 1997-10-15
IN188470B (ro) 2002-09-28
RO116194B1 (ro) 2000-11-30
KR100500351B1 (ko) 2005-12-21
ZA9610737B (en) 1997-06-27
AR005197A1 (es) 1999-04-14
DE69630145D1 (de) 2003-10-30
UA48205C2 (uk) 2002-08-15
NO317358B1 (no) 2004-10-18
PL327405A1 (en) 1998-12-07
EP0876362A1 (fr) 1998-11-11
CN1205697A (zh) 1999-01-20
EP0876362B1 (fr) 2003-09-24
AU712597B2 (en) 1999-11-11
MY113934A (en) 2002-06-29
PE25198A1 (es) 1998-05-10
KR19990076680A (ko) 1999-10-15
NZ324337A (en) 2000-03-27
TNSN96169A1 (fr) 2005-03-15
CA2238884C (fr) 2007-02-06
ES2202490T3 (es) 2004-04-01
FR2742751B1 (fr) 1998-01-30
SK282835B6 (sk) 2002-12-03
WO1997023473A1 (fr) 1997-07-03
NO982580L (no) 1998-06-05
HUP9904046A3 (en) 2001-08-28
ATE250593T1 (de) 2003-10-15
EA001533B1 (ru) 2001-04-23

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