BG62808B1 - Нови диарилметилиденфуранови производни, метод за тяхнотополучаване и използването им като лекарствени средства - Google Patents
Нови диарилметилиденфуранови производни, метод за тяхнотополучаване и използването им като лекарствени средства Download PDFInfo
- Publication number
- BG62808B1 BG62808B1 BG102771A BG10277198A BG62808B1 BG 62808 B1 BG62808 B1 BG 62808B1 BG 102771 A BG102771 A BG 102771A BG 10277198 A BG10277198 A BG 10277198A BG 62808 B1 BG62808 B1 BG 62808B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- formula
- phenyl
- radical
- crystals
- method described
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9604236A FR2747123B1 (fr) | 1996-04-04 | 1996-04-04 | Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique |
FR9607922A FR2747124B1 (fr) | 1996-04-04 | 1996-06-26 | Nouveaux derives diarylmethylidene furaniques, leurs procedes de preparation et leurs utilisations en therapeutique |
PCT/FR1997/000602 WO1997037984A1 (fr) | 1996-04-04 | 1997-04-03 | Nouveaux derives diarylmethylidene furaniques, leurs procedes de preparation et leurs utilisations en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
BG102771A BG102771A (en) | 1999-06-30 |
BG62808B1 true BG62808B1 (bg) | 2000-08-31 |
Family
ID=9490907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102771A BG62808B1 (bg) | 1996-04-04 | 1998-09-16 | Нови диарилметилиденфуранови производни, метод за тяхнотополучаване и използването им като лекарствени средства |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0891345B1 (et) |
JP (1) | JP2000508638A (et) |
KR (1) | KR20000005146A (et) |
CN (1) | CN1215396A (et) |
AR (1) | AR006539A1 (et) |
AT (1) | ATE204268T1 (et) |
AU (1) | AU717146B2 (et) |
BG (1) | BG62808B1 (et) |
BR (1) | BR9708510A (et) |
CA (1) | CA2248949A1 (et) |
CZ (1) | CZ318898A3 (et) |
DE (1) | DE69706157T2 (et) |
DK (1) | DK0891345T3 (et) |
EE (1) | EE03687B1 (et) |
ES (1) | ES2162678T3 (et) |
FR (2) | FR2747123B1 (et) |
GE (1) | GEP20032924B (et) |
IL (1) | IL126105A (et) |
NO (1) | NO984624L (et) |
NZ (1) | NZ331672A (et) |
PL (1) | PL329213A1 (et) |
PT (1) | PT891345E (et) |
RU (1) | RU2189979C2 (et) |
SI (1) | SI0891345T1 (et) |
SK (1) | SK283292B6 (et) |
TW (1) | TW353660B (et) |
WO (1) | WO1997037984A1 (et) |
ZA (1) | ZA972894B (et) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180651B1 (en) * | 1996-04-04 | 2001-01-30 | Bristol-Myers Squibb | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics |
CA2285567A1 (en) * | 1997-04-02 | 1998-10-08 | Merck Frosst Canada & Co. | Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors |
FR2775477B1 (fr) * | 1998-02-27 | 2000-05-19 | Union Pharma Scient Appl | Nouveaux derives diarylmethylene heterocycliques, leurs procedes de preparation et leurs utilisations en therapeutique |
CN1106392C (zh) * | 2000-10-24 | 2003-04-23 | 中国科学院上海有机化学研究所 | 一种β位不含取代基的丁烯酸内酯及其合成的方法 |
CA2504886C (en) * | 2002-11-05 | 2011-07-05 | Magnachem International Laboratories, Inc. | Synthetic lactone formulations and method of use |
CA2524568C (en) * | 2003-03-31 | 2012-07-17 | Council Of Scientific & Industrial Research | Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof |
ES2275218T3 (es) | 2003-05-07 | 2007-06-01 | Osteologix A/S | Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos. |
US8779168B2 (en) * | 2010-12-16 | 2014-07-15 | Transitions Optical, Inc. | Lactone compounds and materials made therefrom |
IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994015932A1 (en) * | 1993-01-15 | 1994-07-21 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5585504A (en) * | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
-
1996
- 1996-04-04 FR FR9604236A patent/FR2747123B1/fr not_active Expired - Fee Related
- 1996-06-26 FR FR9607922A patent/FR2747124B1/fr not_active Expired - Lifetime
-
1997
- 1997-03-24 TW TW086103701A patent/TW353660B/zh active
- 1997-04-03 EP EP97919476A patent/EP0891345B1/fr not_active Expired - Lifetime
- 1997-04-03 SI SI9730222T patent/SI0891345T1/xx unknown
- 1997-04-03 PT PT97919476T patent/PT891345E/pt unknown
- 1997-04-03 WO PCT/FR1997/000602 patent/WO1997037984A1/fr not_active Application Discontinuation
- 1997-04-03 DK DK97919476T patent/DK0891345T3/da active
- 1997-04-03 DE DE69706157T patent/DE69706157T2/de not_active Expired - Lifetime
- 1997-04-03 SK SK1375-98A patent/SK283292B6/sk not_active IP Right Cessation
- 1997-04-03 ES ES97919476T patent/ES2162678T3/es not_active Expired - Lifetime
- 1997-04-03 NZ NZ331672A patent/NZ331672A/en unknown
- 1997-04-03 IL IL12610597A patent/IL126105A/xx not_active IP Right Cessation
- 1997-04-03 EE EE9800333A patent/EE03687B1/et unknown
- 1997-04-03 AU AU23933/97A patent/AU717146B2/en not_active Ceased
- 1997-04-03 GE GEAP19974555A patent/GEP20032924B/en unknown
- 1997-04-03 CA CA002248949A patent/CA2248949A1/fr not_active Abandoned
- 1997-04-03 PL PL97329213A patent/PL329213A1/xx unknown
- 1997-04-03 JP JP9535910A patent/JP2000508638A/ja active Pending
- 1997-04-03 RU RU98119887/04A patent/RU2189979C2/ru not_active IP Right Cessation
- 1997-04-03 CN CN97193543A patent/CN1215396A/zh active Pending
- 1997-04-03 AT AT97919476T patent/ATE204268T1/de active
- 1997-04-03 BR BR9708510A patent/BR9708510A/pt not_active IP Right Cessation
- 1997-04-03 CZ CZ983188A patent/CZ318898A3/cs unknown
- 1997-04-03 KR KR1019980707808A patent/KR20000005146A/ko not_active Application Discontinuation
- 1997-04-04 ZA ZA9702894A patent/ZA972894B/xx unknown
- 1997-04-04 AR ARP970101359A patent/AR006539A1/es not_active Application Discontinuation
-
1998
- 1998-09-16 BG BG102771A patent/BG62808B1/bg unknown
- 1998-10-02 NO NO984624A patent/NO984624L/no not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6180651B1 (en) | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics | |
CZ274996A3 (en) | Heterocyclic aromatic oxazole compounds, their oxime, ketone, ketonemethylene, ester and amide compounds, pharmaceutical preparations, cyclooxygenase inhibitors and antiphlogistic agents in which said oxazole compounds are comprised | |
CZ87297A3 (cs) | Inhibitory prostaglandin synthasy | |
US5807873A (en) | Diarylmethylidenefuran derivatives and their uses in therapeutics | |
BG63161B1 (bg) | Фенилхетероциклени съединения като инхибитори на циклооксигеназа-2 | |
BG63082B1 (bg) | Фенилови хетероциклени съединения като инхибиторина циклооксигеназа-2 | |
MXPA01010312A (es) | Derivados de 4,5-diaril-3/2h)-furanona como inhibidores de ciclooxigenasa 2. | |
TW520365B (en) | Novel 3,4-diarylthiazolin-2-one or -2-thione derivatives, their methods of preparation and their uses in therapeutics | |
AU729453B2 (en) | Novel carbocyclic diarylmethylene derivatives, methods for preparing same, and therapeutical uses thereof | |
BG62808B1 (bg) | Нови диарилметилиденфуранови производни, метод за тяхнотополучаване и използването им като лекарствени средства | |
JP3810091B2 (ja) | 2―(3h)―オキサゾロン誘導体およびcox―2阻害剤としてのそれらの使用 | |
JP4717211B2 (ja) | 2−フェニルピラン−4−オン誘導体 | |
US6004994A (en) | Heterocyclic diarylmethylene derivatives, methods of preparing them and their uses in therapeutics | |
US5972950A (en) | 1,2-diarylmethylene derivatives, their methods of preparation and their uses in therapeutics | |
US5840753A (en) | 1,2 diarylmethylene derivatives, their methods of preparation and their uses in therapeutics | |
CA2403732A1 (en) | Novel imidazole derivatives with anti-inflammatory activity | |
MXPA98008174A (en) | New derivatives of diarylemetilidene furanicos, methods of preparation and their use terapeut | |
US20030114456A1 (en) | Novel heterocylic compounds with anti-inflamatory activity |