BG62208B1 - 2,3,4,5-тетрахидро-1н-3-бензазепини, метод за получаванетоим, тяхното приложение и това на фармацевтично приемливите имприсъединителни с киселини соли - Google Patents
2,3,4,5-тетрахидро-1н-3-бензазепини, метод за получаванетоим, тяхното приложение и това на фармацевтично приемливите имприсъединителни с киселини соли Download PDFInfo
- Publication number
- BG62208B1 BG62208B1 BG98993A BG9899394A BG62208B1 BG 62208 B1 BG62208 B1 BG 62208B1 BG 98993 A BG98993 A BG 98993A BG 9899394 A BG9899394 A BG 9899394A BG 62208 B1 BG62208 B1 BG 62208B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- compound
- chloro
- tetrahydro
- benzazepine
- methyl
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims description 6
- MWVMYAWMFTVYED-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1CNCCC2=CC=CC=C21 MWVMYAWMFTVYED-UHFFFAOYSA-N 0.000 title description 7
- 150000008043 acidic salts Chemical class 0.000 title 1
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- 150000003839 salts Chemical class 0.000 claims description 11
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- HTTCBKVHUOBDSF-UHFFFAOYSA-N 8-chloro-3-methyl-5-(5-nitro-2,3-dihydro-1-benzofuran-7-yl)-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical compound C1N(C)CCC2=CC(Cl)=C(O)C=C2C1C1=CC([N+]([O-])=O)=CC2=C1OCC2 HTTCBKVHUOBDSF-UHFFFAOYSA-N 0.000 claims description 2
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- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004006 stereotypic behavior Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK92233A DK23392D0 (da) | 1992-02-24 | 1992-02-24 | Heterocykliske forbindelser, deres anvendelse og fremstilling |
| PCT/DK1993/000041 WO1993017012A1 (en) | 1992-02-24 | 1993-02-05 | 2,3,4,5-tetrahydro-1h-3-benzazepines and pharmaceutically acceptable acid addition salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG98993A BG98993A (bg) | 1995-05-31 |
| BG62208B1 true BG62208B1 (bg) | 1999-05-31 |
Family
ID=8091236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG98993A BG62208B1 (bg) | 1992-02-24 | 1994-08-22 | 2,3,4,5-тетрахидро-1н-3-бензазепини, метод за получаванетоим, тяхното приложение и това на фармацевтично приемливите имприсъединителни с киселини соли |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0628039B1 (cs) |
| JP (1) | JPH07504172A (cs) |
| KR (1) | KR100255739B1 (cs) |
| AT (1) | ATE152450T1 (cs) |
| AU (1) | AU667878B2 (cs) |
| BG (1) | BG62208B1 (cs) |
| CA (1) | CA2130678C (cs) |
| CZ (1) | CZ288626B6 (cs) |
| DE (1) | DE69310353T2 (cs) |
| DK (2) | DK23392D0 (cs) |
| ES (1) | ES2102019T3 (cs) |
| FI (1) | FI113770B (cs) |
| GR (1) | GR3023896T3 (cs) |
| HU (1) | HU221314B1 (cs) |
| IL (1) | IL104657A (cs) |
| NO (1) | NO310193B1 (cs) |
| NZ (1) | NZ249465A (cs) |
| RO (1) | RO116088B1 (cs) |
| RU (1) | RU2114839C1 (cs) |
| SK (1) | SK281390B6 (cs) |
| UA (1) | UA34451C2 (cs) |
| WO (1) | WO1993017012A1 (cs) |
| ZA (1) | ZA931099B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0750616B1 (en) * | 1994-03-16 | 2001-05-30 | CeNeS Limited | Acid addition salts of 2,3,4,5-tetrahydro-1h-3-benzazepine compounds |
| KR19990044648A (ko) * | 1995-09-15 | 1999-06-25 | 한센 핀 베네드, 안네 제헤르 | 2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 화합물의 산 부가염 |
| GB0130576D0 (en) * | 2001-12-20 | 2002-02-06 | Cenes Ltd | Dopamine D1 receptor agonist pro-drug compounds & derivatives |
| JP4584831B2 (ja) * | 2002-12-20 | 2010-11-24 | グラクソ グループ リミテッド | 神経系の疾患の治療用のベンズアゼピン誘導体 |
| PL2912019T3 (pl) | 2012-10-25 | 2021-11-02 | Tetra Discovery Partners Llc | Heteroarylowe inhibitory pde4 |
| WO2015048407A1 (en) * | 2013-09-26 | 2015-04-02 | Tetra Discovery Partners, LLC | Heteroaryl inhibitors of pde4 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK180485D0 (da) * | 1985-04-22 | 1985-04-23 | Novo Industri As | Nitrogenholdige forbindelser |
| DK325188D0 (da) * | 1988-06-15 | 1988-06-15 | Novo Industri As | Hidtil ukendte benzazepinderivater |
| DK67489D0 (da) * | 1989-02-14 | 1989-02-14 | Novo Industri As | Nye benzazepinderivater |
-
1992
- 1992-02-24 DK DK92233A patent/DK23392D0/da not_active Application Discontinuation
-
1993
- 1993-02-05 EP EP93905215A patent/EP0628039B1/en not_active Expired - Lifetime
- 1993-02-05 RO RO94-01400A patent/RO116088B1/ro unknown
- 1993-02-05 AT AT93905215T patent/ATE152450T1/de not_active IP Right Cessation
- 1993-02-05 JP JP5514460A patent/JPH07504172A/ja active Pending
- 1993-02-05 SK SK1000-94A patent/SK281390B6/sk unknown
- 1993-02-05 UA UA94085741A patent/UA34451C2/uk unknown
- 1993-02-05 DE DE69310353T patent/DE69310353T2/de not_active Expired - Fee Related
- 1993-02-05 DK DK93905215.5T patent/DK0628039T3/da active
- 1993-02-05 HU HU9402434A patent/HU221314B1/hu not_active IP Right Cessation
- 1993-02-05 RU RU94040719A patent/RU2114839C1/ru not_active IP Right Cessation
- 1993-02-05 ES ES93905215T patent/ES2102019T3/es not_active Expired - Lifetime
- 1993-02-05 WO PCT/DK1993/000041 patent/WO1993017012A1/en active IP Right Grant
- 1993-02-05 AU AU36265/93A patent/AU667878B2/en not_active Ceased
- 1993-02-05 NZ NZ249465A patent/NZ249465A/en unknown
- 1993-02-05 KR KR1019940702944A patent/KR100255739B1/ko not_active Expired - Fee Related
- 1993-02-05 CA CA002130678A patent/CA2130678C/en not_active Expired - Fee Related
- 1993-02-05 CZ CZ19941988A patent/CZ288626B6/cs not_active IP Right Cessation
- 1993-02-09 IL IL10465793A patent/IL104657A/en not_active IP Right Cessation
- 1993-02-17 ZA ZA931099A patent/ZA931099B/xx unknown
-
1994
- 1994-08-22 BG BG98993A patent/BG62208B1/bg unknown
- 1994-08-23 FI FI943875A patent/FI113770B/fi not_active IP Right Cessation
- 1994-08-24 NO NO19943123A patent/NO310193B1/no not_active IP Right Cessation
-
1997
- 1997-06-26 GR GR970401543T patent/GR3023896T3/el unknown
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