SK281390B6 - 2,3,4,5-tetrahydro-1h-benzazepíny, spôsob ich prípravy, farmaceutický prostriedok a použitie - Google Patents
2,3,4,5-tetrahydro-1h-benzazepíny, spôsob ich prípravy, farmaceutický prostriedok a použitie Download PDFInfo
- Publication number
- SK281390B6 SK281390B6 SK1000-94A SK100094A SK281390B6 SK 281390 B6 SK281390 B6 SK 281390B6 SK 100094 A SK100094 A SK 100094A SK 281390 B6 SK281390 B6 SK 281390B6
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- Slovakia
- Prior art keywords
- compound
- formula
- tetrahydro
- benzazepine
- chloro
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- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- MZBVNYACSSGXID-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-1-benzazepine Chemical compound N1CCCCC2=CC=CC=C21 MZBVNYACSSGXID-UHFFFAOYSA-N 0.000 title abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
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- MWVMYAWMFTVYED-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1CNCCC2=CC=CC=C21 MWVMYAWMFTVYED-UHFFFAOYSA-N 0.000 claims description 3
- MMKJPWSQPSHMOB-UHFFFAOYSA-N 5-(5-amino-2,3-dihydro-1-benzofuran-7-yl)-8-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical compound C1N(C)CCC2=CC(Cl)=C(O)C=C2C1C1=CC(N)=CC2=C1OCC2 MMKJPWSQPSHMOB-UHFFFAOYSA-N 0.000 claims description 3
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- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK92233A DK23392D0 (da) | 1992-02-24 | 1992-02-24 | Heterocykliske forbindelser, deres anvendelse og fremstilling |
| PCT/DK1993/000041 WO1993017012A1 (en) | 1992-02-24 | 1993-02-05 | 2,3,4,5-tetrahydro-1h-3-benzazepines and pharmaceutically acceptable acid addition salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK100094A3 SK100094A3 (en) | 1995-04-12 |
| SK281390B6 true SK281390B6 (sk) | 2001-03-12 |
Family
ID=8091236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1000-94A SK281390B6 (sk) | 1992-02-24 | 1993-02-05 | 2,3,4,5-tetrahydro-1h-benzazepíny, spôsob ich prípravy, farmaceutický prostriedok a použitie |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0628039B1 (cs) |
| JP (1) | JPH07504172A (cs) |
| KR (1) | KR100255739B1 (cs) |
| AT (1) | ATE152450T1 (cs) |
| AU (1) | AU667878B2 (cs) |
| BG (1) | BG62208B1 (cs) |
| CA (1) | CA2130678C (cs) |
| CZ (1) | CZ288626B6 (cs) |
| DE (1) | DE69310353T2 (cs) |
| DK (2) | DK23392D0 (cs) |
| ES (1) | ES2102019T3 (cs) |
| FI (1) | FI113770B (cs) |
| GR (1) | GR3023896T3 (cs) |
| HU (1) | HU221314B1 (cs) |
| IL (1) | IL104657A (cs) |
| NO (1) | NO310193B1 (cs) |
| NZ (1) | NZ249465A (cs) |
| RO (1) | RO116088B1 (cs) |
| RU (1) | RU2114839C1 (cs) |
| SK (1) | SK281390B6 (cs) |
| UA (1) | UA34451C2 (cs) |
| WO (1) | WO1993017012A1 (cs) |
| ZA (1) | ZA931099B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0750616B1 (en) * | 1994-03-16 | 2001-05-30 | CeNeS Limited | Acid addition salts of 2,3,4,5-tetrahydro-1h-3-benzazepine compounds |
| KR19990044648A (ko) * | 1995-09-15 | 1999-06-25 | 한센 핀 베네드, 안네 제헤르 | 2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 화합물의 산 부가염 |
| GB0130576D0 (en) * | 2001-12-20 | 2002-02-06 | Cenes Ltd | Dopamine D1 receptor agonist pro-drug compounds & derivatives |
| JP4584831B2 (ja) * | 2002-12-20 | 2010-11-24 | グラクソ グループ リミテッド | 神経系の疾患の治療用のベンズアゼピン誘導体 |
| PL2912019T3 (pl) | 2012-10-25 | 2021-11-02 | Tetra Discovery Partners Llc | Heteroarylowe inhibitory pde4 |
| WO2015048407A1 (en) * | 2013-09-26 | 2015-04-02 | Tetra Discovery Partners, LLC | Heteroaryl inhibitors of pde4 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK180485D0 (da) * | 1985-04-22 | 1985-04-23 | Novo Industri As | Nitrogenholdige forbindelser |
| DK325188D0 (da) * | 1988-06-15 | 1988-06-15 | Novo Industri As | Hidtil ukendte benzazepinderivater |
| DK67489D0 (da) * | 1989-02-14 | 1989-02-14 | Novo Industri As | Nye benzazepinderivater |
-
1992
- 1992-02-24 DK DK92233A patent/DK23392D0/da not_active Application Discontinuation
-
1993
- 1993-02-05 EP EP93905215A patent/EP0628039B1/en not_active Expired - Lifetime
- 1993-02-05 RO RO94-01400A patent/RO116088B1/ro unknown
- 1993-02-05 AT AT93905215T patent/ATE152450T1/de not_active IP Right Cessation
- 1993-02-05 JP JP5514460A patent/JPH07504172A/ja active Pending
- 1993-02-05 SK SK1000-94A patent/SK281390B6/sk unknown
- 1993-02-05 UA UA94085741A patent/UA34451C2/uk unknown
- 1993-02-05 DE DE69310353T patent/DE69310353T2/de not_active Expired - Fee Related
- 1993-02-05 DK DK93905215.5T patent/DK0628039T3/da active
- 1993-02-05 HU HU9402434A patent/HU221314B1/hu not_active IP Right Cessation
- 1993-02-05 RU RU94040719A patent/RU2114839C1/ru not_active IP Right Cessation
- 1993-02-05 ES ES93905215T patent/ES2102019T3/es not_active Expired - Lifetime
- 1993-02-05 WO PCT/DK1993/000041 patent/WO1993017012A1/en active IP Right Grant
- 1993-02-05 AU AU36265/93A patent/AU667878B2/en not_active Ceased
- 1993-02-05 NZ NZ249465A patent/NZ249465A/en unknown
- 1993-02-05 KR KR1019940702944A patent/KR100255739B1/ko not_active Expired - Fee Related
- 1993-02-05 CA CA002130678A patent/CA2130678C/en not_active Expired - Fee Related
- 1993-02-05 CZ CZ19941988A patent/CZ288626B6/cs not_active IP Right Cessation
- 1993-02-09 IL IL10465793A patent/IL104657A/en not_active IP Right Cessation
- 1993-02-17 ZA ZA931099A patent/ZA931099B/xx unknown
-
1994
- 1994-08-22 BG BG98993A patent/BG62208B1/bg unknown
- 1994-08-23 FI FI943875A patent/FI113770B/fi not_active IP Right Cessation
- 1994-08-24 NO NO19943123A patent/NO310193B1/no not_active IP Right Cessation
-
1997
- 1997-06-26 GR GR970401543T patent/GR3023896T3/el unknown
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