BG62083B1 - Hiv протеазни инхибитори във фармацевтични комбинации залечение на спин - Google Patents

Hiv протеазни инхибитори във фармацевтични комбинации залечение на спин Download PDF

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Publication number
BG62083B1
BG62083B1 BG100016A BG10001695A BG62083B1 BG 62083 B1 BG62083 B1 BG 62083B1 BG 100016 A BG100016 A BG 100016A BG 10001695 A BG10001695 A BG 10001695A BG 62083 B1 BG62083 B1 BG 62083B1
Authority
BG
Bulgaria
Prior art keywords
hydroxy
tert
phenylmethyl
aids
hiv
Prior art date
Application number
BG100016A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100016A (bg
Inventor
Joseph P. Vacca
James P. Guare
Bruce D. Dorsey
M. K. Holloway
Randall W. Hungate
Original Assignee
Merck & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. filed Critical Merck & Co.
Publication of BG100016A publication Critical patent/BG100016A/xx
Publication of BG62083B1 publication Critical patent/BG62083B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
BG100016A 1993-03-31 1995-09-20 Hiv протеазни инхибитори във фармацевтични комбинации залечение на спин BG62083B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4072993A 1993-03-31 1993-03-31
PCT/US1994/003209 WO1994022480A1 (en) 1993-03-31 1994-03-24 Hiv protease inhibitors in pharmaceutical combinations for the treatment of aids

Publications (2)

Publication Number Publication Date
BG100016A BG100016A (bg) 1996-04-30
BG62083B1 true BG62083B1 (bg) 1999-02-26

Family

ID=21912617

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100016A BG62083B1 (bg) 1993-03-31 1995-09-20 Hiv протеазни инхибитори във фармацевтични комбинации залечение на спин

Country Status (34)

Country Link
EP (1) EP0617968B1 (cs)
JP (1) JPH08508496A (cs)
KR (1) KR100311551B1 (cs)
CN (1) CN1090186C (cs)
AT (1) ATE230610T1 (cs)
AU (1) AU685772B2 (cs)
BG (1) BG62083B1 (cs)
BR (1) BR9406503A (cs)
CA (1) CA2120192A1 (cs)
CY (1) CY2326B1 (cs)
CZ (1) CZ286412B6 (cs)
DE (1) DE69431972T2 (cs)
DK (1) DK0617968T3 (cs)
DZ (1) DZ1766A1 (cs)
ES (1) ES2188604T3 (cs)
FI (1) FI954580A7 (cs)
HR (1) HRP940209B1 (cs)
HU (1) HUT74006A (cs)
IL (1) IL109166A (cs)
LV (1) LV13141B (cs)
NO (1) NO953876L (cs)
NZ (1) NZ265164A (cs)
PL (1) PL310895A1 (cs)
PT (1) PT617968E (cs)
RO (1) RO118000B1 (cs)
RU (1) RU2139052C1 (cs)
SA (1) SA94140745B1 (cs)
SG (1) SG64366A1 (cs)
SI (1) SI9420017B (cs)
SK (1) SK279471B6 (cs)
TW (1) TW307684B (cs)
WO (1) WO1994022480A1 (cs)
YU (1) YU49275B (cs)
ZA (1) ZA942255B (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69430385T2 (de) * 1993-12-15 2002-11-07 Merck & Co., Inc. Hiv-proteaseinhibitoren
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5476874A (en) * 1994-06-22 1995-12-19 Merck & Co., Inc. New HIV protease inhibitors
WO1996012492A1 (en) * 1994-10-25 1996-05-02 Merck & Co., Inc. Microbial synthesis of hiv protease inhibitors
US6689761B1 (en) 1995-02-01 2004-02-10 Merck & Co., Inc. Combination therapy for HIV infection
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6262093B1 (en) 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
US5900429A (en) 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
PE11499A1 (es) * 1997-05-16 1999-03-01 Procter & Gamble Tratamiento del hiv y cancer
US6506783B1 (en) 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
HU9701081D0 (en) * 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
WO2000002862A1 (en) 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
WO2000021565A1 (en) 1998-10-13 2000-04-20 Du Pont Pharmaceuticals Company Selective eradication of virally-infected cells by combined use of a cytotoxic agent and an antiviral agent
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6407105B1 (en) 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6608096B1 (en) 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EP1771169A1 (en) 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Methods for treating hepatitis c
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
AU2005275182A1 (en) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating Hepatitis C
RU2281297C2 (ru) * 2004-08-23 2006-08-10 Государственное учреждение Научно-исследовательский институт вирусологии им. Д.И. Ивановского Российской академии медицинских наук Полианионные производные норборнана, способ получения и ингибиторы репродукции вируса иммунодефицита человека на их основе
RU2520967C1 (ru) * 2013-02-08 2014-06-27 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) СИММЕТРИЧНЫЕ ДИИМИНЫ НА ОСНОВЕ КАМФОРЫ - ИНГИБИТОРЫ РЕПРОДУКЦИИ ВИРУСА ГРИППА (ШТАММ A/California/07/09 (H1N1)pdm09)
CN109528747A (zh) * 2018-12-13 2019-03-29 中国人民解放军总医院 扎西他滨在制备抗菌消炎药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
CA2032259A1 (en) * 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
CA2068327C (en) * 1990-09-11 2002-01-01 Nobutaka Fujii Polypeptide and anti-hiv drug prepared therefrom
IL99843A0 (en) * 1990-11-01 1992-08-18 Merck & Co Inc Synergistic combination of hiv reverse transcriptase inhibitors
JPH06508146A (ja) * 1991-06-04 1994-09-14 スミスクライン・ビーチャム・コーポレイション 炭素環および複素環式ｈｉｖプロテアーゼ抑制剤

Also Published As

Publication number Publication date
IL109166A0 (en) 1994-06-24
ES2188604T3 (es) 2003-07-01
RO118000B1 (ro) 2002-12-30
HRP940209A2 (en) 1998-02-28
PL310895A1 (en) 1996-01-08
SI9420017B (sl) 2003-12-31
ATE230610T1 (de) 2003-01-15
SG64366A1 (en) 1999-04-27
NO953876L (no) 1995-11-30
FI954580L (fi) 1995-09-27
SI9420017A (en) 1996-10-31
DE69431972D1 (de) 2003-02-13
AU685772B2 (en) 1998-01-29
CA2120192A1 (en) 1994-10-01
LV13141B (en) 2004-08-20
SK279471B6 (sk) 1998-11-04
AU5921394A (en) 1994-10-06
KR960701661A (ko) 1996-03-28
NO953876D0 (no) 1995-09-29
KR100311551B1 (ko) 2001-12-28
WO1994022480A1 (en) 1994-10-13
CZ286412B6 (en) 2000-04-12
CY2326B1 (en) 2003-11-14
HUT74006A (en) 1996-10-28
JPH08508496A (ja) 1996-09-10
NZ265164A (en) 1997-09-22
SA94140745B1 (ar) 2006-07-11
YU49275B (sh) 2005-03-15
DZ1766A1 (fr) 2002-02-17
EP0617968B1 (en) 2003-01-08
BR9406503A (pt) 1996-01-02
YU15994A (sh) 1999-06-15
HU9502860D0 (en) 1995-11-28
TW307684B (cs) 1997-06-11
PT617968E (pt) 2003-03-31
RU2139052C1 (ru) 1999-10-10
FI954580A0 (fi) 1995-09-27
BG100016A (bg) 1996-04-30
SK122595A3 (en) 1997-03-05
DK0617968T3 (da) 2003-02-24
CN1120316A (zh) 1996-04-10
CN1090186C (zh) 2002-09-04
IL109166A (en) 1999-08-17
CZ252895A3 (en) 1996-07-17
HK1009248A1 (en) 1999-05-28
EP0617968A1 (en) 1994-10-05
FI954580A7 (fi) 1995-09-27
ZA942255B (en) 1994-11-01
DE69431972T2 (de) 2003-08-28
HRP940209B1 (en) 2004-04-30

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