BG61839B1 - Индолови производни като nmda-антагонисти - Google Patents
Индолови производни като nmda-антагонисти Download PDFInfo
- Publication number
- BG61839B1 BG61839B1 BG100511A BG10051196A BG61839B1 BG 61839 B1 BG61839 B1 BG 61839B1 BG 100511 A BG100511 A BG 100511A BG 10051196 A BG10051196 A BG 10051196A BG 61839 B1 BG61839 B1 BG 61839B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- solution
- indole
- carboxylic acid
- dichloro
- ylidenemethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939321221A GB9321221D0 (en) | 1993-10-14 | 1993-10-14 | Heterocyclic compounds |
| PCT/EP1994/003359 WO1995010517A1 (fr) | 1993-10-14 | 1994-10-12 | Derives d'indole utilises en tant qu'antagonistes de n-methyl-d-aspartate (nmda) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG100511A BG100511A (en) | 1996-11-29 |
| BG61839B1 true BG61839B1 (bg) | 1998-07-31 |
Family
ID=10743550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100511A BG61839B1 (bg) | 1993-10-14 | 1996-04-16 | Индолови производни като nmda-антагонисти |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US5760059A (fr) |
| EP (1) | EP0723541A1 (fr) |
| JP (1) | JPH09503770A (fr) |
| CN (1) | CN1070490C (fr) |
| AP (1) | AP574A (fr) |
| AU (1) | AU681194B2 (fr) |
| BG (1) | BG61839B1 (fr) |
| CA (1) | CA2171449A1 (fr) |
| CO (1) | CO4290355A1 (fr) |
| CZ (1) | CZ92396A3 (fr) |
| FI (1) | FI961628A (fr) |
| GB (1) | GB9321221D0 (fr) |
| HU (1) | HU219710B (fr) |
| IL (1) | IL111294A (fr) |
| IS (1) | IS4219A (fr) |
| MY (1) | MY112411A (fr) |
| NO (1) | NO309861B1 (fr) |
| NZ (1) | NZ274179A (fr) |
| OA (1) | OA10578A (fr) |
| PE (1) | PE21995A1 (fr) |
| PL (1) | PL179568B1 (fr) |
| RU (1) | RU2144535C1 (fr) |
| SG (1) | SG49013A1 (fr) |
| SK (1) | SK44996A3 (fr) |
| TW (1) | TW283144B (fr) |
| WO (1) | WO1995010517A1 (fr) |
| ZA (1) | ZA947948B (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
| GB9704498D0 (en) * | 1997-03-05 | 1997-04-23 | Glaxo Wellcome Spa | Chemical compound |
| GB9704499D0 (en) * | 1997-03-05 | 1997-04-23 | Glaxo Wellcome Spa | Method of manufacture |
| WO2000056711A1 (fr) * | 1999-03-23 | 2000-09-28 | Sumitomo Pharmaceuticals Co., Ltd. | Compose d'acide indole-2-carboxylique tricyclique utilise comme antagoniste du recepteur nmda |
| DE10153346A1 (de) | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
| US20030162825A1 (en) * | 2001-11-09 | 2003-08-28 | Sepracor Inc. | D-amino acid oxidase inhibitors for learning and memory |
| JP2007517056A (ja) | 2003-12-29 | 2007-06-28 | セプラコア インコーポレーテッド | ピロール及びピラゾールｄａａｏ阻害剤 |
| JP2009500425A (ja) | 2005-07-06 | 2009-01-08 | セプラコア インコーポレーテッド | エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法 |
| JP5438975B2 (ja) * | 2006-01-06 | 2014-03-12 | サノビオン ファーマシューティカルズ インク | テトラロン系モノアミン再取り込み阻害剤 |
| RU2430913C2 (ru) * | 2006-01-06 | 2011-10-10 | Сепракор Инк. | Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина |
| DK2013835T3 (en) | 2006-03-31 | 2015-12-14 | Sunovion Pharmaceuticals Inc | Preparation of chiral amides and AMINES |
| US7579370B2 (en) * | 2006-06-30 | 2009-08-25 | Sepracor Inc. | Fused heterocycles |
| US7884124B2 (en) * | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US20080082066A1 (en) * | 2006-10-02 | 2008-04-03 | Weyerhaeuser Co. | Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks |
| EP2074092A2 (fr) * | 2007-01-18 | 2009-07-01 | Sepracor Inc. | Inhibiteurs de la d-amino acide oxydase |
| US7902252B2 (en) * | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| MX2009012685A (es) | 2007-05-31 | 2009-12-14 | Sepracor Inc | Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina. |
| WO2010017418A1 (fr) * | 2008-08-07 | 2010-02-11 | Sepracor Inc. | Promédicaments d'inhibiteurs hétérocycliques fusionnés de la d-amino acide oxydase |
| JP2010235597A (ja) * | 2009-03-10 | 2010-10-21 | Santen Pharmaceut Co Ltd | ４，６−ジクロロ−１ｈ−インドール−２−カルボン酸誘導体又はその塩を有効成分として含有する視神経障害の予防又は治療剤 |
| WO2011017634A2 (fr) * | 2009-08-07 | 2011-02-10 | Sepracore Inc. | Promédicaments d'inhibiteurs hétérocycliques fusionnés de la d-aminoacide oxydase |
| EP2763676B1 (fr) | 2011-10-03 | 2019-12-25 | The University of Utah Research Foundation | Application d'antagonistes du récepteur 5-ht6 dans l'atténuation des déficits cognitifs liés au syndrome de down |
| US9868975B2 (en) | 2014-04-30 | 2018-01-16 | Yufeng Jane Tseng | Use of known compounds as D-amino acid oxidase inhibitors |
| CA3036250C (fr) | 2016-09-14 | 2023-09-26 | Yufeng Jane Tseng | Nouveaux derives de benzimidazole substitues utilises en tant qu'inhibiteurs de la d-amino-acide oxydase (daao) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
| US4960786A (en) * | 1989-04-24 | 1990-10-02 | Merrell Dow Pharmaceuticals Inc. | Excitatory amino acid antagonists |
| DE4101686A1 (de) * | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | Indolderivate |
| US5284862A (en) * | 1991-03-18 | 1994-02-08 | Warner-Lambert Company | Derivatives of 2-carboxyindoles having pharmaceutical activity |
| US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
| EP0545478A1 (fr) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Composés hétérocycliques comme tachykinine antagonistes |
| GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| EP0915090A1 (fr) * | 1992-09-10 | 1999-05-12 | Eli Lilly And Company | Thiazolidinones comme agents hypoglycemiants et pour le traitement de la maladie d'Alzheimer |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| GB9321221D0 (en) * | 1993-10-14 | 1993-12-01 | Glaxo Spa | Heterocyclic compounds |
-
1993
- 1993-10-14 GB GB939321221A patent/GB9321221D0/en active Pending
-
1994
- 1994-10-10 IS IS4219A patent/IS4219A/is unknown
- 1994-10-11 MY MYPI94002695A patent/MY112411A/en unknown
- 1994-10-12 ZA ZA947948A patent/ZA947948B/xx unknown
- 1994-10-12 WO PCT/EP1994/003359 patent/WO1995010517A1/fr not_active Application Discontinuation
- 1994-10-12 EP EP94928893A patent/EP0723541A1/fr not_active Withdrawn
- 1994-10-12 CO CO94046673A patent/CO4290355A1/es unknown
- 1994-10-12 RU RU96108920A patent/RU2144535C1/ru active
- 1994-10-12 PE PE1994252640A patent/PE21995A1/es not_active Application Discontinuation
- 1994-10-12 AU AU78133/94A patent/AU681194B2/en not_active Ceased
- 1994-10-12 AP APAP/P/1994/000685A patent/AP574A/en active
- 1994-10-12 PL PL94313969A patent/PL179568B1/pl unknown
- 1994-10-12 CA CA002171449A patent/CA2171449A1/fr not_active Abandoned
- 1994-10-12 US US08/619,510 patent/US5760059A/en not_active Expired - Fee Related
- 1994-10-12 SG SG1996005195A patent/SG49013A1/en unknown
- 1994-10-12 CN CN94193759A patent/CN1070490C/zh not_active Expired - Fee Related
- 1994-10-12 JP JP7511283A patent/JPH09503770A/ja active Pending
- 1994-10-12 CZ CZ96923A patent/CZ92396A3/cs unknown
- 1994-10-12 NZ NZ274179A patent/NZ274179A/en unknown
- 1994-10-12 SK SK449-96A patent/SK44996A3/sk unknown
- 1994-10-12 HU HU9600969A patent/HU219710B/hu not_active IP Right Cessation
- 1994-10-13 IL IL11129494A patent/IL111294A/en not_active IP Right Cessation
- 1994-11-18 TW TW083110700A patent/TW283144B/zh active
-
1996
- 1996-04-09 OA OA60812A patent/OA10578A/en unknown
- 1996-04-12 NO NO961475A patent/NO309861B1/no not_active IP Right Cessation
- 1996-04-12 FI FI961628A patent/FI961628A/fi unknown
- 1996-04-16 BG BG100511A patent/BG61839B1/bg unknown
-
1998
- 1998-05-29 US US09/086,522 patent/US5962496A/en not_active Expired - Lifetime
-
1999
- 1999-08-16 US US09/374,982 patent/US6100289A/en not_active Expired - Lifetime
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