ZA947948B - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
ZA947948B
ZA947948B ZA947948A ZA947948A ZA947948B ZA 947948 B ZA947948 B ZA 947948B ZA 947948 A ZA947948 A ZA 947948A ZA 947948 A ZA947948 A ZA 947948A ZA 947948 B ZA947948 B ZA 947948B
Authority
ZA
South Africa
Prior art keywords
indole derivatives
indole
derivatives
Prior art date
Application number
ZA947948A
Other languages
English (en)
Inventor
Alfredo Cugola
Romano Di Fabio
Giorgio Pentassuglia
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of ZA947948B publication Critical patent/ZA947948B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ZA947948A 1993-10-14 1994-10-12 Indole derivatives ZA947948B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939321221A GB9321221D0 (en) 1993-10-14 1993-10-14 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ZA947948B true ZA947948B (en) 1995-05-23

Family

ID=10743550

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA947948A ZA947948B (en) 1993-10-14 1994-10-12 Indole derivatives

Country Status (27)

Country Link
US (3) US5760059A (xx)
EP (1) EP0723541A1 (xx)
JP (1) JPH09503770A (xx)
CN (1) CN1070490C (xx)
AP (1) AP574A (xx)
AU (1) AU681194B2 (xx)
BG (1) BG61839B1 (xx)
CA (1) CA2171449A1 (xx)
CO (1) CO4290355A1 (xx)
CZ (1) CZ92396A3 (xx)
FI (1) FI961628A (xx)
GB (1) GB9321221D0 (xx)
HU (1) HU219710B (xx)
IL (1) IL111294A (xx)
IS (1) IS4219A (xx)
MY (1) MY112411A (xx)
NO (1) NO309861B1 (xx)
NZ (1) NZ274179A (xx)
OA (1) OA10578A (xx)
PE (1) PE21995A1 (xx)
PL (1) PL179568B1 (xx)
RU (1) RU2144535C1 (xx)
SG (1) SG49013A1 (xx)
SK (1) SK44996A3 (xx)
TW (1) TW283144B (xx)
WO (1) WO1995010517A1 (xx)
ZA (1) ZA947948B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
GB9704498D0 (en) * 1997-03-05 1997-04-23 Glaxo Wellcome Spa Chemical compound
GB9704499D0 (en) * 1997-03-05 1997-04-23 Glaxo Wellcome Spa Method of manufacture
CA2362700A1 (en) * 1999-03-23 2000-09-28 Nobuyuki Ae Tricyclic indole-2-carboxylic acid compound used as nmda receptor antagonist
DE10153346A1 (de) 2001-10-29 2004-04-22 Grünenthal GmbH Substituierte Indole
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
NZ548212A (en) 2003-12-29 2010-07-30 Sepracor Inc Pyrrole and pyrazole DAAO inhibitors
EP1904066B1 (en) 2005-07-06 2018-05-23 Sunovion Pharmaceuticals Inc. COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS
JP5432526B2 (ja) 2006-01-06 2014-03-05 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害剤としてのシクロアルキルアミン
KR101381768B1 (ko) * 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP2010516697A (ja) * 2007-01-18 2010-05-20 セプラコール インク. D−アミノ酸オキシダーゼ阻害剤
NZ580429A (en) 2007-05-31 2012-04-27 Sepracor Inc Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
EA201101307A1 (ru) * 2009-03-10 2012-03-30 Сантен Фармасьютикал Ко., Лтд. Профилактические или терапевтические средства для расстройств зрительного нерва, содержащие производные 4,6-дихлор-1н-индол-2-карбоновой кислоты или их соли в качестве активных ингредиентов
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2013055386A2 (en) 2011-10-03 2013-04-18 The University Of Utah Research Foundation Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome
IL248567B (en) 2014-04-30 2022-08-01 Univ Nat Taiwan Use of compounds known as d-amino acid oxidase inhibitors
WO2018053161A1 (en) 2016-09-14 2018-03-22 National Taiwan University Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256673A (en) * 1983-11-25 1993-10-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
EP0545478A1 (en) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
CZ181493A3 (en) * 1992-09-10 1994-03-16 Lilly Co Eli The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
SG49013A1 (en) 1998-05-18
AP9400685A0 (en) 1994-10-31
CO4290355A1 (es) 1996-04-17
CN1070490C (zh) 2001-09-05
TW283144B (xx) 1996-08-11
AP574A (en) 1997-01-30
EP0723541A1 (en) 1996-07-31
CN1133042A (zh) 1996-10-09
CZ92396A3 (en) 1996-08-14
NO961475L (no) 1996-04-12
NZ274179A (en) 1998-01-26
IL111294A0 (en) 1994-12-29
BG61839B1 (bg) 1998-07-31
US6100289A (en) 2000-08-08
NO961475D0 (no) 1996-04-12
HUT76065A (en) 1997-06-30
AU7813394A (en) 1995-05-04
IS4219A (is) 1995-04-15
RU2144535C1 (ru) 2000-01-20
AU681194B2 (en) 1997-08-21
PL313969A1 (en) 1996-08-05
OA10578A (en) 2002-06-07
PL179568B1 (pl) 2000-09-29
US5962496A (en) 1999-10-05
NO309861B1 (no) 2001-04-09
US5760059A (en) 1998-06-02
BG100511A (en) 1996-11-29
HU9600969D0 (en) 1996-06-28
IL111294A (en) 1998-12-06
FI961628A0 (fi) 1996-04-12
FI961628A (fi) 1996-04-12
MY112411A (en) 2001-06-30
PE21995A1 (es) 1995-08-14
JPH09503770A (ja) 1997-04-15
SK44996A3 (en) 1997-01-08
CA2171449A1 (en) 1995-04-20
HU219710B (hu) 2001-06-28
GB9321221D0 (en) 1993-12-01
WO1995010517A1 (en) 1995-04-20

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