BG61059B2 - Аналози на дономицина - Google Patents

Аналози на дономицина Download PDF

Info

Publication number
BG61059B2
BG61059B2 BG098211A BG9821193A BG61059B2 BG 61059 B2 BG61059 B2 BG 61059B2 BG 098211 A BG098211 A BG 098211A BG 9821193 A BG9821193 A BG 9821193A BG 61059 B2 BG61059 B2 BG 61059B2
Authority
BG
Bulgaria
Prior art keywords
donosaminylc
demethoxydonomycinone
sepimers
epimers
racemic
Prior art date
Application number
BG098211A
Other languages
Bulgarian (bg)
English (en)
Inventor
Bianca Patelli
Luigi Bernardi
Federico Arcamone
Aurelio Marco
Original Assignee
Farmitalia Carlo Erba S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.
Publication of BG61059B2 publication Critical patent/BG61059B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BG098211A 1974-06-12 1993-11-11 Аналози на дономицина BG61059B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2608374A GB1467383A (en) 1974-06-12 1974-06-12 Daunomycin analogues

Publications (1)

Publication Number Publication Date
BG61059B2 true BG61059B2 (bg) 1996-09-30

Family

ID=10238087

Family Applications (1)

Application Number Title Priority Date Filing Date
BG098211A BG61059B2 (bg) 1974-06-12 1993-11-11 Аналози на дономицина

Country Status (17)

Country Link
US (1) US4046878A (cg-RX-API-DMAC7.html)
JP (1) JPS5840557B2 (cg-RX-API-DMAC7.html)
AT (1) AT337363B (cg-RX-API-DMAC7.html)
BE (1) BE830090A (cg-RX-API-DMAC7.html)
BG (1) BG61059B2 (cg-RX-API-DMAC7.html)
CH (1) CH611317A5 (cg-RX-API-DMAC7.html)
DE (2) DE19375027I2 (cg-RX-API-DMAC7.html)
DK (1) DK147304C (cg-RX-API-DMAC7.html)
ES (1) ES438431A1 (cg-RX-API-DMAC7.html)
FR (1) FR2274629A1 (cg-RX-API-DMAC7.html)
GB (1) GB1467383A (cg-RX-API-DMAC7.html)
HK (1) HK982A (cg-RX-API-DMAC7.html)
MY (1) MY103666A (cg-RX-API-DMAC7.html)
NL (1) NL173272C (cg-RX-API-DMAC7.html)
SE (1) SE423633B (cg-RX-API-DMAC7.html)
SU (1) SU645588A3 (cg-RX-API-DMAC7.html)
ZA (1) ZA753722B (cg-RX-API-DMAC7.html)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4161480A (en) * 1978-06-05 1979-07-17 G. D. Searle & Co. Intermediates for the synthesis of 4-demethoxydaunorubicin
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
IL55431A (en) * 1978-08-24 1982-07-30 Yeda Res & Dev Anthracycline type antibiotics,their preparation and pharmaceutical compositions comprising them
NL8001417A (nl) * 1979-03-17 1980-09-19 Erba Farmitalia Antitumorglycosiden.
JPS5673039A (en) * 1979-08-20 1981-06-17 Hoffmann La Roche Naphthacene derivative
ATE1101T1 (de) * 1979-09-01 1982-06-15 Farmitalia Carlo Erba S.P.A. Anthracyclin-glycoside, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzung.
DE3100968A1 (de) * 1980-01-16 1982-01-14 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
ZA814722B (en) * 1980-07-18 1982-07-28 Hoffmann La Roche Novel anthracycline glycosides
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
US4563444A (en) * 1982-05-26 1986-01-07 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides, use and compositions containing same
US4604381A (en) * 1982-07-16 1986-08-05 Farmitalia Carlo Erba S.P.A. 4-demethoxy-13-dihydrodaunorubicin and use thereof
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4564674A (en) * 1983-10-31 1986-01-14 Sagami Chemical Research Center Process for an anthracycline derivative, and an anthracyclinone derivative useful for the process
US4496485A (en) * 1983-11-25 1985-01-29 G. D. Searle & Co. Asymmetric 7-O-(substituted acetyl)-4-demethoxydaunomycinones
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
US4697005A (en) * 1985-03-20 1987-09-29 Ohio State University Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro anthracycline anticancer antibiotics
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
JPS63191263U (cg-RX-API-DMAC7.html) * 1987-05-29 1988-12-09
GB2212154B (en) * 1987-11-10 1991-03-27 Erba Carlo Spa New 4-demethoxy anthracycline derivatives
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
GB8818167D0 (en) * 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
JP2563080B2 (ja) * 1992-03-02 1996-12-11 フアイザー・インコーポレイテツド マクロライドの糖誘導体
AU2003299378A1 (en) * 2002-10-11 2004-05-04 Board Of Regents, The University Of Texas System Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
CN101146532B (zh) 2005-01-21 2012-05-09 阿斯泰克斯治疗有限公司 药物化合物
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
BRPI0923815A2 (pt) * 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
EP2376514A2 (en) * 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
EA019341B1 (ru) * 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
PL2719708T3 (pl) 2009-11-13 2018-04-30 Daiichi Sankyo Europe Gmbh Materiał i sposoby leczenia lub zapobiegania chorobom związanym z HER-3
LT2609923T (lt) 2010-03-31 2017-09-11 Gilead Pharmasset Llc (s)-izopropilo 2-(((s)-(perfluorfenoksi)(fenoksi)fosforil)amino)-propanoato kristalinimo būdas
WO2012018404A2 (en) 2010-08-06 2012-02-09 U3 Pharma Gmbh Use of her3 binding agents in prostate treatment
DE102011113652A1 (de) 2011-09-19 2013-03-21 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Idarubicinhydrochlorid
DK3311827T3 (da) 2011-10-03 2023-04-03 Canqura Oncology Ab Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærere for amfipatiske eller hydrofobe molekyler inden for det medicinske område, inklusiv cancerbehandling, samt fødevarerelaterede forbindelser
US9907846B2 (en) 2013-04-01 2018-03-06 Mx Adjuvac Ab Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3427300A (en) * 1965-11-12 1969-02-11 Merck & Co Inc Anti-inflammatory steroid 2'-acetamido-2'-deoxy-glucoside compounds
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US3686163A (en) * 1968-05-14 1972-08-22 Farmaceutici Italia Dihydrodaunomycin antibiotic and derivatives thereof

Also Published As

Publication number Publication date
JPS518260A (cg-RX-API-DMAC7.html) 1976-01-23
SU645588A3 (ru) 1979-01-30
JPS5840557B2 (ja) 1983-09-06
SE423633B (sv) 1982-05-17
AT337363B (de) 1977-06-27
DK147304B (da) 1984-06-12
DE2525633A1 (de) 1976-01-02
NL173272B (nl) 1983-08-01
CH611317A5 (cg-RX-API-DMAC7.html) 1979-05-31
SE7506589L (sv) 1975-12-15
ATA437375A (de) 1976-10-15
GB1467383A (en) 1977-03-16
ES438431A1 (es) 1977-02-01
HK982A (en) 1982-01-22
DE19375027I2 (de) 2002-06-13
NL173272C (nl) 1984-01-02
AU8197975A (en) 1976-12-16
US4046878A (en) 1977-09-06
ZA753722B (en) 1976-09-29
BE830090A (fr) 1975-12-11
FR2274629B1 (cg-RX-API-DMAC7.html) 1980-01-11
DK256875A (da) 1975-12-13
DE2525633B2 (cg-RX-API-DMAC7.html) 1979-03-01
DE2525633C3 (cg-RX-API-DMAC7.html) 1979-10-18
NL7506745A (nl) 1975-12-16
FR2274629A1 (fr) 1976-01-09
DK147304C (da) 1984-12-17
MY103666A (en) 1993-08-28

Similar Documents

Publication Publication Date Title
BG61059B2 (bg) Аналози на дономицина
CA1041488A (en) Process for the preparation of analogues of daunomycin
US4960790A (en) Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US4730069A (en) Cis-platinum complexes with a pentaerythritol derivative as the ligand, a process for their preparation and a pharmaceutical agent containing these compounds
US5091521A (en) Cis-platinum complexes, a process for the preparation thereof, and pharmaceuticals containing these compounds
DK146626B (da) Analogifremgangsmaade til fremstilling af 4'-deoxydaunomycin
EP3505526B1 (en) Myricetin derivative and preparing method thereof, and application of same for treating colitis, preventing and treating colitis tumorigenesis, and treating colorectal cancer
DK146542B (da) Analogifremgangsmaade til fremstilling af daunosaminylanthracyclioner
US4031211A (en) Adriamycin esters, their preparation and use
US4188377A (en) Carminomycin derivatives, their preparation and use
CN113845551A (zh) 一种具有光动力抗三阴乳腺癌活性的Pt(Ⅱ)配合物及其制备方法和应用
KR102640022B1 (ko) 시클로부탄 디카르복실산 백금 착체, 그의 중간체, 그의 제조방법, 의약 조성물 및 사용
US4191755A (en) Novel daunomycin derivatives, their aglycones and the use thereof
US4133877A (en) Anthracycline ethers and use therefor
CN112409431B (zh) 阿糖胞苷结构类似物及其制备方法和用途
US4522815A (en) Anthracycline glycosides
RU2065863C1 (ru) Производные дезацетилколхицина, способ их получения и противоопухолевая композиция
JPS6054960B2 (ja) 抗しゆよう性セプタシジン類似体
JPS62135490A (ja) 宿主抵抗性促進剤としてのステロイド性グリコリピド
CN101307041B (zh) 一类具有抗肿瘤活性的紫杉烷卤代衍生物
CN119219650B (zh) 苯并[1,6]萘啶衍生物及其医药用途
CN112552358B (zh) 一种红景天苷-生物素小分子探针及其制备方法和应用
CN102070615A (zh) 氮氧自由基抗肿瘤药物
DK146541B (da) Analogifremgangsmaade til fremstilling af 4'-epi-daunomycin eller de individuelle alfa- eller beta-anomere deraf
HU195834B (en) Process for production of antibiotics with antitumor effect and medical compositions containing such active substances